Entry
Name
ethylmalonyl-CoA mutase;
Ecm
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(2R)-ethylmalonyl-CoA CoA-carbonylmutase
Reaction(IUBMB)
(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA [RN:
R09292 ]
Reaction(KEGG)
Substrate
(2R)-ethylmalonyl-CoA [CPD:
C20238 ]
Product
(2S)-methylsuccinyl-CoA [CPD:
C18324 ]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires adenosylcobalamin for activity.
History
EC 5.4.99.63 created 2015
Pathway
ec00630 Glyoxylate and dicarboxylate metabolism
Orthology
K14447 ethylmalonyl-CoA mutase
Genes
RBS : RHODOSMS8_02644(scpA)
MAQU : Maq22A_1p32005(meaA)
FIL : BN1229_v1_1371(meaA)
FIY : BN1229_v1_1370(meaA)
TSV : DSM104635_01212(scpA_1)
RLI : RLO149_c030730(mutB2)
PHP : PhaeoP97_02971(mutB)
PPIC : PhaeoP14_00302(mutB)
OAT : OAN307_c41380(mutB2)
SINL : DSM14862_02474(mutB)
SPSE : SULPSESMR1_00407(scpA)
RMM : ROSMUCSMR3_01834(scpA)
LALG : LentiSH36_00622(mutB)
LVS : LOKVESSMR4R_02788(mutB)
SAMB : SAM23877_6066(meaA)
SLE : sle_13030(sle_13030)
SHUN : DWB77_01616(scpA_1)
SXT : KPP03845_105977(mutB_2)
NAQU : ENKNEFLB_01864(mutB_2)
ACTU : Actkin_05108(scpA_3)
BALA : DSM104299_01919(ecm)
SBAE : DSM104329_01837(ecm)
LKB : LPTSP3_g37080(mcm2_1)
» show all
Taxonomy
Reference
Authors
Erb TJ, Retey J, Fuchs G, Alber BE
Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 5.4.99.63
LinkDB
All DBs