KEGG ENZYME: 7.5.2.2

ENZYME: 7.5.2.2

Entry

EC 7.5.2.2                  Enzyme

Name

ABC-type oligosaccharide transporter;
oligosaccharide-transporting ATPase

Class

Translocases;
Catalysing the translocation of carbohydrates and their derivatives;
Linked to the hydrolysis of a nucleoside triphosphate

Sysname

ATP phosphohydrolase (ABC-type, oligosaccharide-importing)

Reaction(IUBMB)

ATP + H2O + oligosaccharide-[oligosaccharide-binding protein][side 1] = ADP + phosphate + oligosaccharide[side 2] + [oligosaccharide-binding protein][side 1]

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001];
oligosaccharide-[oligosaccharide-binding protein][side 1]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
oligosaccharide[side 2];
[oligosaccharide-binding protein][side 1]

Comment

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of lactose, melibiose and raffinose.

History

EC 7.5.2.2 created 2000 as EC 3.6.3.18, transferred 2018 to EC 7.5.2.2

Reference

1 [PMID:1282354]

Authors

Higgins CF.

Title

ABC transporters: from microorganisms to man.

Journal

Annu Rev Cell Biol 8:67-113 (1992)
DOI:10.1146/annurev.cb.08.110192.000435

Reference

2 [PMID:1630315]

Authors

Williams SG, Greenwood JA, Jones CW.

Title

Molecular analysis of the lac operon encoding the binding-protein-dependent lactose transport system and beta-galactosidase in Agrobacterium radiobacter.

Journal

Mol Microbiol 6:1755-68 (1992)
DOI:10.1111/j.1365-2958.1992.tb01348.x

Sequence

[agc:BSY240_3350 BSY240_3351 BSY240_3352 BSY240_3354]

Reference

3 [PMID:8336670]

Authors

Tam R, Saier MH Jr.

Title

Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.

Journal

Microbiol Rev 57:320-46 (1993)

Reference

4 [PMID:7569321]

Authors

Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.

Title

Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.

Journal

Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3

Reference

5 [PMID:9889977]

Authors

Saier MH Jr.

Title

Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.

Journal

Adv Microb Physiol 40:81-136 (1998)
DOI:10.1016/s0065-2911(08)60130-7

Other DBs

ExplorEnz - The Enzyme Database:

7.5.2.2

IUBMB Enzyme Nomenclature:

7.5.2.2

ExPASy - ENZYME nomenclature database:

7.5.2.2

BRENDA, the Enzyme Database:

7.5.2.2

LinkDB

DBGET integrated database retrieval system