| Entry |
|
|---|
| Name |
Fluphenazine hydrochloride (JAN/USP);
Prolixin (TN) |
|---|
| Product |
|
|---|
| Generic |
FLUPHENAZINE HYDROCHLORIDE (Ajanta Pharma USA), FLUPHENAZINE HYDROCHLORIDE (American Health Packaging), FLUPHENAZINE HYDROCHLORIDE (American Health Packaging), FLUPHENAZINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), FLUPHENAZINE HYDROCHLORIDE (Apotex Corp.), FLUPHENAZINE HYDROCHLORIDE (Aurobindo Pharma Limited), FLUPHENAZINE HYDROCHLORIDE (AvPAK), FLUPHENAZINE HYDROCHLORIDE (AvPAK), FLUPHENAZINE HYDROCHLORIDE (Chartwell RX), FLUPHENAZINE HYDROCHLORIDE (Dr. Reddy's Laboratories), FLUPHENAZINE HYDROCHLORIDE (Fresenius Kabi USA), FLUPHENAZINE HYDROCHLORIDE (Glenmark Pharmaceuticals), FLUPHENAZINE HYDROCHLORIDE (Golden State Medical Supply), FLUPHENAZINE HYDROCHLORIDE (Lannett Company), FLUPHENAZINE HYDROCHLORIDE (Major Pharmaceuticals), FLUPHENAZINE HYDROCHLORIDE (Marlex Pharmaceuticals), FLUPHENAZINE HYDROCHLORIDE (Northstar Rx LLC), FLUPHENAZINE HYDROCHLORIDE (Novadoz Pharmaceuticals LLC), FLUPHENAZINE HYDROCHLORIDE (Novitium Pharma LLC), FLUPHENAZINE HYDROCHLORIDE (PAI Holdings), FLUPHENAZINE HYDROCHLORIDE (Pharmaceutical Associates), FLUPHENAZINE HYDROCHLORIDE (Proficient Rx LP), FLUPHENAZINE HYDROCHLORIDE (REMEDYREPACK), FLUPHENAZINE HYDROCHLORIDE (REMEDYREPACK), FLUPHENAZINE HYDROCHLORIDE (REMEDYREPACK), FLUPHENAZINE HYDROCHLORIDE (REMEDYREPACK), FLUPHENAZINE HYDROCHLORIDE (REMEDYREPACK), FLUPHENAZINE HYDROCHLORIDE (TWi Pharmaceuticals), FLUPHENAZINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), FLUPHENAZINE HYDROCHLORIDE (Upsher-Smith Laboratories), FLUPHENAZINE HYDROCHLORIDE (Zameer Pharmaceuticals LLC), FLUPHENAZINE HYDROCHLORIDE (Zydus Lifesciences Limited), FLUPHENAZINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)) |
|---|
| Formula |
C22H26F3N3OS. 2HCl
|
|---|
| Exact mass |
509.1282
|
|---|
| Mol weight |
510.4434
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00874): | D00791<US> D00793<JP/US> D02163<JP> |
|
|---|
| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivarives
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB02 Fluphenazine
D00791 Fluphenazine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Fluphenazine
D00791 Fluphenazine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
D00791 Fluphenazine hydrochloride
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
D00791 Fluphenazine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
D00791 Fluphenazine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00791 Fluphenazine hydrochloride (JAN/USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00791
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 32
1 C8y C 17.5906 -18.6799
2 N1y N 18.8104 -17.9762
3 C8y C 17.5906 -20.0874
4 C8x C 16.3709 -17.9762
5 C8y C 20.0771 -18.6799
6 C1b C 18.8104 -16.5688
7 S2x S 18.8104 -20.7441
8 C8x C 16.3709 -20.7441
9 C8x C 15.1981 -18.6799
10 C8y C 20.0771 -20.0404
11 C8x C 21.2969 -17.9762
12 C1b C 20.0771 -15.8651
13 C8x C 15.1981 -20.0404
14 C8x C 21.2969 -20.7441
15 C8y C 22.5166 -18.7269
16 C1b C 20.0771 -14.4106
17 C8x C 22.5166 -20.0404
18 N1y N 21.2969 -13.7069
19 C1x C 21.2969 -12.3464
20 C1x C 22.4697 -14.4106
21 C1x C 22.5166 -11.6427
22 C1x C 23.7363 -13.7069
23 N1y N 23.7363 -12.3464
24 C1b C 25.0031 -11.6896
25 C1d C 23.7377 -18.0443
26 X F 24.9535 -17.3633
27 X F 24.4615 -19.2609
28 X F 23.0559 -16.8714
29 C1b C 26.2106 -12.4238
30 O1a O 27.4410 -11.7503
31 X Cl 29.1469 -18.8393
32 X Cl 29.1469 -18.8393
BOND 33
1 18 19 1
2 18 20 1
3 19 21 1
4 20 22 1
5 21 23 1
6 23 24 1
7 7 10 1
8 9 13 1
9 15 17 1
10 22 23 1
11 1 2 1
12 1 3 2
13 1 4 1
14 2 5 1
15 2 6 1
16 3 7 1
17 3 8 1
18 4 9 2
19 5 10 2
20 5 11 1
21 6 12 1
22 8 13 2
23 10 14 1
24 11 15 2
25 12 16 1
26 14 17 2
27 16 18 1
28 15 25 1
29 25 26 1
30 25 27 1
31 25 28 1
32 24 29 1
33 29 30 1
BRACKET 1 27.6500 -19.5300 27.6500 -17.6400
1 29.9600 -17.6400 29.9600 -19.5300
1 2
ORIGINAL 1 31
REPEAT 1 32
|
|---|
