| Entry |
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| Name |
Fluphenazine decanoate (JAN/USP);
Prolixin decanoate (TN) |
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| Product |
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| Generic |
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| Formula |
C32H44F3N3O2S
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| Exact mass |
591.3106
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| Mol weight |
591.7709
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
| Therapeutic category: | 1172 |
| Product (DG00874): | D00791<US> D00793<JP/US> D02163<JP> |
|
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| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
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| Disease |
|
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| Comment |
Phenothiazine derivative
Active form of prodrug: Fluphenazine [DR: D07977]
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB02 Fluphenazine
D00793 Fluphenazine decanoate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Fluphenazine
D00793 Fluphenazine decanoate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1172 Phenothiazines
D00793 Fluphenazine decanoate (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
D00793 Fluphenazine decanoate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
D00793 Fluphenazine decanoate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
D00793 Fluphenazine decanoate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00793 Fluphenazine decanoate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00793
Prodrugs [br08324.html]
D00793
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 41
1 C8y C 21.6455 -18.0808
2 N1y N 22.8369 -17.3800
3 C8y C 21.6455 -19.4824
4 C8x C 20.4542 -17.3800
5 C8y C 24.0983 -18.0808
6 S2x S 22.8369 -20.1833
7 C8x C 20.4542 -20.1833
8 C8x C 19.1927 -18.0808
9 C8y C 24.0983 -19.4824
10 C8x C 25.2897 -17.3800
11 C8x C 19.1927 -19.4824
12 C8x C 25.2897 -20.1833
13 C8y C 26.4811 -18.0808
14 C8x C 26.4811 -19.4824
15 C1d C 27.6724 -17.3800
16 X F 28.8638 -16.6792
17 X F 26.9716 -16.1887
18 X F 28.3733 -18.5714
19 C1b C 22.8369 -15.9784
20 C1b C 24.0283 -15.2776
21 C1b C 24.0283 -13.8760
22 N1y N 25.2196 -13.1752
23 C1x C 25.2196 -11.7736
24 C1x C 26.4110 -13.8760
25 C1x C 26.4110 -11.0728
26 C1x C 27.6724 -13.1752
27 N1y N 27.6724 -11.7736
28 C1b C 28.8638 -11.0728
29 C1b C 30.0552 -11.7736
30 O7a O 31.2466 -11.0728
31 C7a C 32.5080 -11.7736
32 C1b C 33.6994 -11.0728
33 O6a O 32.5080 -13.1752
34 C1b C 35.0307 -11.7736
35 C1a C 36.3622 -11.0728
36 C1b C 33.6994 -11.0728
37 C1b C 35.0307 -11.7736
38 C1b C 33.6994 -11.0728
39 C1b C 35.0307 -11.7736
40 C1b C 33.6994 -11.0728
41 C1b C 35.0307 -11.7736
BOND 44
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 3 6 1
6 3 7 1
7 4 8 2
8 5 9 2
9 5 10 1
10 7 11 2
11 9 12 1
12 10 13 2
13 12 14 2
14 6 9 1
15 8 11 1
16 13 14 1
17 13 15 1
18 15 16 1
19 15 17 1
20 15 18 1
21 2 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 22 24 1
27 23 25 1
28 24 26 1
29 25 27 1
30 27 28 1
31 28 29 1
32 29 30 1
33 30 31 1
34 31 33 2
35 26 27 1
36 31 32 1
37 32 34 1
38 34 36 1
39 36 37 1
40 37 38 1
41 38 39 1
42 39 40 1
43 40 41 1
44 41 35 1
BRACKET 1 33.3900 -12.4600 33.3900 -10.7800
1 35.0700 -10.7800 35.0700 -12.4600
1 4
ORIGINAL 1 32 34
REPEAT 1 36 37 38 39 40 41
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