| Entry |
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| Name |
Hydrocortisone sodium phosphate (JP18/USP);
Hydrocortone phosphate (TN) |
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| Formula |
C21H29O8P. 2Na
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| Exact mass |
486.1395
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| Mol weight |
486.4035
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2452 |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D00977 Hydrocortisone sodium phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2452 Cortisones
D00977 Hydrocortisone sodium phosphate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D00977 Hydrocortisone sodium phosphate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D00977 Hydrocortisone sodium phosphate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00977 Hydrocortisone sodium phosphate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00977 Hydrocortisone sodium phosphate (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00977 Hydrocortisone sodium phosphate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00977
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C1z C 13.5800 -13.7200
2 C1y C 13.5800 -15.0500
3 C1z C 14.7700 -13.0200
4 C1x C 12.3900 -13.0200
5 C1a C 13.5800 -12.3900
6 C1y C 12.4600 -15.7500
7 C1x C 15.9600 -15.0500
8 C1x C 15.9600 -13.7200
9 C5a C 14.7700 -11.6900
10 O1a O 16.1000 -12.7400
11 C1y C 11.2700 -13.7200
12 C1y C 11.2700 -15.1200
13 C1x C 12.4600 -17.1500
14 C1b C 15.9600 -10.9900
15 O5a O 13.5100 -10.9900
16 O1a O 10.0100 -13.0200
17 C1z C 10.0800 -15.7500
18 C1x C 11.2700 -17.7800
19 O2b O 17.1500 -11.7600
20 C2y C 10.0800 -17.1500
21 C1x C 8.8900 -15.1200
22 C1a C 10.0100 -14.4900
23 P1b P 18.4100 -11.0600
24 C2x C 8.9600 -17.8500
25 C1x C 7.7000 -15.7500
26 C5x C 7.7000 -17.2200
27 O5x O 6.5100 -17.8500
28 O1c O 18.9700 -12.3200 #-
29 O1c O 19.6000 -10.2900 #-
30 O1c O 17.6400 -9.8700
31 Z Na 20.7200 -12.3200 #+
32 Z Na 21.3500 -10.2900 #+
BOND 33
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 1
6 2 7 1
7 3 8 1
8 3 9 1 #Up
9 3 10 1 #Down
10 4 11 1
11 6 12 1
12 6 13 1
13 9 14 1
14 9 15 2
15 11 16 1 #Up
16 12 17 1
17 13 18 1
18 14 19 1
19 17 20 1
20 17 21 1
21 17 22 1 #Up
22 19 23 1
23 20 24 2
24 21 25 1
25 24 26 1
26 26 27 2
27 7 8 1
28 11 12 1
29 18 20 1
30 25 26 1
31 23 28 1
32 23 29 1
33 23 30 2
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