| Entry |
|
|---|
| Name |
Levobunolol hydrochloride (JAN/USP);
Betagan (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C17H25NO3. HCl
|
|---|
| Exact mass |
327.1601
|
|---|
| Mol weight |
327.8462
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Therapeutic category: | 1319 |
| Product (DG01136): | D01025<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, alpha1/beta-Adrenergic receptor antagonist |
|---|
| Disease |
Open-angle glaucoma [DS: H00612] |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01ED Beta blocking agents
S01ED03 Levobunolol
D01025 Levobunolol hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Beta-adrenergic Blocking Agents, Ophthalmic
Levobunolol
D01025 Levobunolol hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D01025 Levobunolol hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01136 Levobunolol
D01025 Levobunolol hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01136 Levobunolol
D01025 Levobunolol hydrochloride
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D01025 Levobunolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01025 Levobunolol hydrochloride (JAN/USP) <JP/US>
ADRB
D01025 Levobunolol hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01025
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01136 Levobunolol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01136 Levobunolol
|
|---|
| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 X Cl 27.6087 -32.8813
2 C1d C 27.4400 -26.6700
3 C1a C 28.6524 -27.3700
4 N1b N 26.2276 -27.3700
5 C1b C 25.0321 -26.6796
6 C1c C 23.8447 -27.3651
7 C1b C 22.6535 -26.6771
8 O2a O 21.4640 -27.3638
9 C1a C 27.4400 -25.2700
10 C1a C 28.6524 -25.9700
11 O1a O 23.8445 -28.7698
12 C8y C 21.4640 -28.7638
13 C8y C 20.2686 -29.4542
14 C8y C 20.2689 -30.8542
15 C8x C 21.4814 -31.5540
16 C8x C 22.6768 -30.8636
17 C8x C 22.6766 -29.4636
18 C1x C 19.0560 -28.7545
19 C1x C 17.8437 -29.4547
20 C1x C 17.8440 -30.8547
21 C5x C 19.0566 -31.5545
22 O5x O 19.0570 -32.9699
BOND 22
1 2 3 1
2 2 4 1
3 4 5 1
4 5 6 1
5 6 7 1
6 7 8 1
7 2 9 1
8 2 10 1
9 6 11 1 #Down
10 8 12 1
11 12 13 2
12 13 14 1
13 14 15 2
14 15 16 1
15 16 17 2
16 12 17 1
17 13 18 1
18 18 19 1
19 19 20 1
20 20 21 1
21 14 21 1
22 21 22 2
|
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