Entry |
|
Name |
Erythromycin ethylsuccinate (JP18/USP); E.E.S. (TN); Eryped (TN); Erythrocin W (TN) |
Product |
|
Generic |
|
Formula |
C43H75NO16
|
Exact mass |
861.5086
|
Mol weight |
862.0527
|
Structure |
|
Simcomp |
|
Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
Remark |
Therapeutic category: | 6141 |
Product (DG00436): | D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US> |
|
Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
Disease |
|
Comment |
Active form of prodrug: Erythromycin [DR: D00140]
|
Target |
50S ribosomal subunit |
Pathway |
|
Metabolism |
|
Interaction |
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: ABCB1 [HSA: 5243]
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Macrolides
Erythromycin
D01361 Erythromycin ethylsuccinate (JP18/USP)
Dermatological Agents
Topical Anti-infectives
Antibacterials, dermatological
Erythromycin
D01361 Erythromycin ethylsuccinate (JP18/USP)
Ophthalmic Agents
Ophthalmic Anti-Infectives
Antibacterials, Ophthalmic
Erythromycin
D01361 Erythromycin ethylsuccinate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6141 Erythromycins
D01361 Erythromycin ethylsuccinate (JP18/USP)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D01361 Erythromycin ethylsuccinate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D01361 Erythromycin ethylsuccinate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D01361 Erythromycin ethylsuccinate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D01361 Erythromycin ethylsuccinate
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D01361 Erythromycin ethylsuccinate
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01361 Erythromycin ethylsuccinate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01361
Drug transporters
D01361
Prodrugs [br08324.html]
D01361
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00436 Erythromycin
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 60
1 C1y C 26.6685 -9.4688
2 C1z C 26.6685 -8.1507
3 C1y C 25.5236 -10.1224
4 O2a O 29.1257 -10.4999
5 C1x C 25.5236 -7.4916
6 O1a O 27.6627 -7.1957
7 C1a C 27.9085 -8.5695
8 C1y C 25.5236 -11.4405
9 C1a C 24.5850 -9.1345
10 C1y C 30.3129 -7.8458
11 C1y C 25.5236 -6.1679
12 O2a O 26.2385 -12.7531
13 C1y C 24.3898 -12.0997
14 C1y C 31.4424 -8.5142
15 O2x O 30.3246 -6.5282
16 C5x C 24.3898 -5.5143
17 C1a C 26.6685 -5.5143
18 C1y C 27.7044 -13.1571
19 C7x C 23.2448 -11.4405
20 C1a C 24.3898 -13.4176
21 C1y C 32.6564 -7.8745
22 O7a O 31.5013 -10.6489
23 C1y C 31.4756 -5.8858
24 C1y C 23.2448 -6.1679
25 O5x O 24.3898 -4.1962
26 C1x C 27.7044 -14.4698
27 O2x O 28.8495 -12.4982
28 O7x O 23.2448 -10.1224
29 O6a O 22.2226 -12.3565
30 C1x C 32.6027 -6.5617
31 N1c N 33.7229 -8.5401
32 C1a C 31.4946 -4.5703
33 C1y C 23.2448 -7.4916
34 C1a C 22.1055 -5.5143
35 C1z C 28.8495 -15.1344
36 C1y C 29.9831 -13.1571
37 C1y C 22.1055 -9.4688
38 C1z C 22.1055 -8.1507
39 O1a O 24.3898 -8.1507
40 C1y C 29.9831 -14.4698
41 O2a O 28.8495 -16.4135
42 C1a C 30.2457 -16.0840
43 C1a C 31.1282 -12.5038
44 C1b C 20.9659 -10.1224
45 C1a C 20.8990 -8.6979
46 O1a O 20.8990 -7.4861
47 O1a O 31.1282 -15.1344
48 C1a C 29.9106 -17.3407
49 C1a C 20.9998 -11.2059
50 C1a C 34.9280 -7.8560
51 C7a C 32.6580 -11.3274
52 O6a O 32.6580 -12.6811
53 C1b C 33.7987 -10.6741
54 C1b C 34.9498 -11.3443
55 C1a C 33.7229 -9.8938
56 C7a C 36.1516 -10.6561
57 O7a O 37.3309 -11.3426
58 O6a O 36.0870 -9.2405
59 C1b C 38.5311 -10.6552
60 C1a C 39.7112 -11.3421
BOND 62
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 2 7 1 #Down
7 3 8 1
8 3 9 1 #Down
9 10 4 1 #Down
10 5 11 1
11 8 12 1 #Down
12 8 13 1
13 10 14 1
14 10 15 1
15 11 16 1
16 11 17 1 #Down
17 18 12 1 #Down
18 13 19 1
19 13 20 1 #Up
20 14 21 1
21 14 22 1 #Up
22 15 23 1
23 16 24 1
24 16 25 2
25 18 26 1
26 18 27 1
27 19 28 1
28 19 29 2
29 21 30 1
30 21 31 1 #Down
31 23 32 1 #Down
32 24 33 1
33 24 34 1 #Up
34 26 35 1
35 27 36 1
36 28 37 1
37 33 38 1
38 33 39 1 #Up
39 35 40 1
40 35 41 1 #Down
41 35 42 1
42 36 43 1 #Up
43 37 44 1 #Down
44 38 45 1 #Down
45 38 46 1 #Up
46 40 47 1 #Down
47 41 48 1
48 44 49 1
49 23 30 1
50 36 40 1
51 37 38 1
52 31 50 1
53 22 51 1
54 51 52 2
55 51 53 1
56 53 54 1
57 31 55 1
58 54 56 1
59 56 57 1
60 56 58 2
61 57 59 1
62 59 60 1
|