| Entry |
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| Name |
Haloperidol decanoate (JAN/USP);
Halomonth (TN) |
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| Product |
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| Generic |
HALOPERIDOL DECANOATE (BluePoint Laboratories), HALOPERIDOL DECANOATE (Fresenius Kabi USA), HALOPERIDOL DECANOATE (Fresenius Kabi USA), HALOPERIDOL DECANOATE (Gland Pharma Limited), HALOPERIDOL DECANOATE (Hikma Pharmaceuticals USA), HALOPERIDOL DECANOATE (Lifestar Pharma LLC), HALOPERIDOL DECANOATE (Meitheal Pharmaceuticals), HALOPERIDOL DECANOATE (Mylan Institutional LLC), HALOPERIDOL DECANOATE (NorthStar RxLLC), HALOPERIDOL DECANOATE (Patriot Pharmaceuticals LLC), HALOPERIDOL DECANOATE (REMEDYREPACK), HALOPERIDOL DECANOATE (REMEDYREPACK), HALOPERIDOL DECANOATE (Sagent Pharmaceuticals), HALOPERIDOL DECANOATE (Somerset Therapeutics), HALOPERIDOL DECANOATE (Zydus Lifesciences Limited), HALOPERIDOL DECANOATE (Zydus Pharmaceuticals USA) |
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| Formula |
C31H41ClFNO3
|
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| Exact mass |
529.2759
|
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| Mol weight |
530.1135
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00885): | D00136<JP/US> D01898<JP/US> D08035<US> |
|
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| Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist |
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| Disease |
|
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| Comment |
Butyrophenone derivative
Active form of prodrug: Haloperidol [DR: D00136]
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07031 | Antipsychotics - butyrophenones |
| map07213 | Dopamine receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AD Butyrophenone derivatives
N05AD01 Haloperidol
D01898 Haloperidol decanoate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Haloperidol
D01898 Haloperidol decanoate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01898 Haloperidol decanoate (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00885 Haloperidol
D01898 Haloperidol decanoate
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
DG00885 Haloperidol
D01898 Haloperidol decanoate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00885 Haloperidol
D01898 Haloperidol decanoate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00885 Haloperidol
D01898 Haloperidol decanoate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01898 Haloperidol decanoate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01898
Prodrugs [br08324.html]
D01898
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00885 Haloperidol
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
DG00885 Haloperidol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00885 Haloperidol
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00885 Haloperidol
Prodrugs [br08324.html]
DG00885
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 C1b C 16.3100 -17.5700
2 C1b C 17.5000 -16.8700
3 C1b C 18.6900 -17.5700
4 N1y N 19.9500 -16.8700
5 C1x C 19.9500 -15.4700
6 C1x C 21.1400 -17.5700
7 C1x C 21.1400 -14.7700
8 C1x C 22.3300 -16.8700
9 C1z C 22.3300 -15.4700
10 C8y C 23.5900 -14.7700
11 C8x C 23.5900 -13.4400
12 C8x C 24.7800 -15.4700
13 C8x C 24.7800 -12.7400
14 C8x C 25.9700 -14.8400
15 C8y C 25.9700 -13.4400
16 X Cl 27.1600 -12.7400
17 C5a C 15.0500 -16.8700
18 C8y C 13.7900 -17.5700
19 O5a O 15.0500 -15.4000
20 C8x C 13.7900 -18.9700
21 C8x C 12.6000 -19.6700
22 C8y C 11.3400 -18.9700
23 C8x C 11.3400 -17.5700
24 C8x C 12.6000 -16.8700
25 X F 10.0800 -19.6700
26 O7a O 23.5200 -16.1700
27 C7a C 23.5200 -17.5700
28 C1b C 24.7100 -18.2700
29 O6a O 22.2600 -18.2700
30 C1b C 25.9000 -17.6400
31 C1b C 27.0900 -18.2700
32 C1b C 28.2800 -17.6400
33 C1b C 29.4700 -18.2700
34 C1b C 30.8000 -17.6400
35 C1b C 31.9900 -18.2700
36 C1b C 33.1800 -17.6400
37 C1a C 34.3700 -18.2700
BOND 39
1 1 17 1
2 1 2 1
3 17 18 1
4 2 3 1
5 17 19 2
6 3 4 1
7 4 5 1
8 4 6 1
9 5 7 1
10 6 8 1
11 18 20 1
12 20 21 2
13 21 22 1
14 22 23 2
15 23 24 1
16 24 18 2
17 7 9 1
18 22 25 1
19 9 10 1
20 10 11 1
21 10 12 2
22 11 13 2
23 12 14 1
24 13 15 1
25 15 16 1
26 8 9 1
27 14 15 2
28 9 26 1
29 26 27 1
30 27 28 1
31 27 29 2
32 28 30 1
33 30 31 1
34 31 32 1
35 32 33 1
36 33 34 1
37 34 35 1
38 35 36 1
39 36 37 1
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