| Entry |
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| Name |
Haloperidol lactate;
Haldol (TN) |
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| Product |
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| Generic |
HALOPERIDOL (Cardinal Health 107), HALOPERIDOL (Fresenius Kabi USA), HALOPERIDOL (Fresenius Kabi USA), HALOPERIDOL (Gland Pharma Limited), HALOPERIDOL (HF Acquisition Co LLC), HALOPERIDOL (Hikma Pharmaceuticals USA), HALOPERIDOL (Hikma Pharmaceuticals USA), HALOPERIDOL (Lannett Company), HALOPERIDOL (Major Pharmaceuticals), HALOPERIDOL (PAI Holdings), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (Sagent Pharmaceuticals), HALOPERIDOL LACTATE (Cardinal Health 107), HALOPERIDOL LACTATE (Henry Schein), HALOPERIDOL LACTATE (Mylan Institutional LLC), HALOPERIDOL LACTATE (REMEDYREPACK) |
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| Formula |
C21H23ClFNO2. C3H6O3
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| Exact mass |
465.1718
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| Mol weight |
465.9422
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00885): | D00136<JP/US> D01898<JP/US> D08035<US> |
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| Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist |
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| Disease |
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| Comment |
Butyrophenone derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07031 | Antipsychotics - butyrophenones |
| map07213 | Dopamine receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AD Butyrophenone derivatives
N05AD01 Haloperidol
D08035 Haloperidol lactate <US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Haloperidol
D08035 Haloperidol lactate
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00885 Haloperidol
D08035 Haloperidol lactate
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
DG00885 Haloperidol
D08035 Haloperidol lactate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00885 Haloperidol
D08035 Haloperidol lactate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00885 Haloperidol
D08035 Haloperidol lactate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D08035 Haloperidol lactate <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08035
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00885 Haloperidol
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
DG00885 Haloperidol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00885 Haloperidol
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00885 Haloperidol
Prodrugs [br08324.html]
DG00885
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C1b C 7.9175 -18.0667
2 C1b C 9.1779 -17.3664
3 C1b C 10.4384 -18.0667
4 N1y N 11.6288 -17.3664
5 C1x C 11.6288 -15.9659
6 C1x C 12.8192 -18.0667
7 C1x C 12.8192 -15.2657
8 C1x C 14.0096 -17.3664
9 C1z C 14.0096 -15.9659
10 C8y C 15.2000 -15.2657
11 C8x C 15.2000 -13.9352
12 C8x C 16.4604 -15.9659
13 C8x C 16.4604 -13.2350
14 C8x C 17.6508 -15.2657
15 C8y C 17.6508 -13.9352
16 X Cl 18.8413 -13.2350
17 C5a C 6.7271 -17.3664
18 C8y C 5.5367 -18.0667
19 O5a O 6.7271 -15.8959
20 C8x C 5.5367 -19.4671
21 C8x C 4.2762 -20.1674
22 C8y C 3.0158 -19.4671
23 C8x C 3.0158 -18.0667
24 C8x C 4.2762 -17.3664
25 X F 1.8254 -20.1674
26 O1a O 15.2000 -16.6662
27 C6a C 21.2800 -18.3400
28 O6a O 22.4924 -19.0400
29 C1c C 20.0676 -19.0400
30 O6a O 21.2800 -16.9400
31 O1a O 18.8721 -18.3496
32 C1a C 20.0675 -20.4398
BOND 33
1 9 10 1
2 10 11 1
3 10 12 2
4 11 13 2
5 12 14 1
6 13 15 1
7 15 16 1
8 8 9 1
9 14 15 2
10 1 17 1
11 1 2 1
12 17 18 1
13 2 3 1
14 17 19 2
15 3 4 1
16 4 5 1
17 4 6 1
18 5 7 1
19 6 8 1
20 18 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 23 24 1
25 24 18 2
26 7 9 1
27 22 25 1
28 9 26 1
29 27 28 1
30 27 29 1
31 27 30 2
32 29 31 1
33 29 32 1
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