| Entry |
|
|---|
| Name |
Erythromycin gluceptate (USP);
Erythromycin glucoheptonate;
Ilotycin gluceptate (TN) |
|---|
| Formula |
C37H67NO13. C7H14O8
|
|---|
| Exact mass |
959.5301
|
|---|
| Mol weight |
960.108
|
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| Structure |
|
|---|
| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
|---|
| Target |
50S ribosomal subunit |
|---|
| Pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: ABCB1 [HSA: 5243]
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D02524 Erythromycin gluceptate (USP)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D02524 Erythromycin gluceptate (USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D02524 Erythromycin gluceptate (USP)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D02524 Erythromycin gluceptate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D02524 Erythromycin gluceptate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D02524 Erythromycin gluceptate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D02524 Erythromycin gluceptate
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D02524 Erythromycin gluceptate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02524
Drug transporters
D02524
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00436 Erythromycin
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 66
1 C1c C 33.7070 -21.6382
2 C1c C 34.9626 -22.3357
3 C1c C 32.5213 -22.3357
4 O1a O 33.7070 -20.2431
5 C1c C 36.1483 -21.6382
6 O1a O 34.8928 -23.7308
7 C1c C 31.2657 -21.6382
8 O1a O 32.5213 -23.7308
9 C6a C 37.3342 -22.3357
10 O1a O 36.1483 -20.2431
11 C1b C 30.0799 -22.3357
12 O1a O 31.2657 -20.2431
13 O6a O 37.3342 -23.7308
14 O6a O 38.5199 -21.6382
15 O1a O 28.8940 -21.7080
16 C1y C 21.3277 -17.1158
17 C1z C 21.3277 -15.7501
18 C1y C 20.1414 -17.7929
19 O2a O 23.3125 -17.8334
20 C1x C 20.1414 -15.0672
21 O1a O 22.3577 -14.7606
22 C1a C 22.6123 -16.1840
23 C1y C 20.1414 -19.1586
24 C1a C 19.1690 -16.7693
25 C1y C 24.8932 -17.1173
26 C1y C 20.1414 -13.6957
27 O2a O 20.8822 -20.5184
28 C1y C 18.9668 -19.8416
29 C1y C 26.0634 -17.8097
30 O2x O 24.9052 -15.7521
31 C5x C 18.9668 -13.0186
32 C1a C 21.3277 -13.0186
33 C1y C 22.4009 -20.9371
34 C7x C 17.7805 -19.1586
35 C1a C 18.9668 -21.2070
36 C1y C 27.2511 -17.1469
37 O1a O 26.0543 -19.1800
38 C1y C 26.0978 -15.0866
39 C1y C 17.7805 -13.6957
40 O5x O 18.9668 -11.6529
41 C1x C 22.4009 -22.2971
42 O2x O 23.5873 -20.2543
43 O7x O 17.7805 -17.7929
44 O6a O 16.7214 -20.1077
45 C1x C 27.2655 -15.7868
46 N1c N 28.4262 -17.8366
47 C1a C 26.1175 -13.7236
48 C1y C 17.7805 -15.0672
49 C1a C 16.6000 -13.0186
50 C1z C 23.5873 -22.9857
51 C1y C 24.7619 -20.9371
52 C1y C 16.6000 -17.1158
53 C1z C 16.6000 -15.7501
54 O1a O 18.9668 -15.7501
55 C1y C 24.7619 -22.2971
56 O2a O 23.5873 -24.3109
57 C1a C 25.0340 -23.9695
58 C1a C 25.9482 -20.2601
59 C1b C 15.4194 -17.7929
60 C1a C 15.3500 -16.3170
61 O1a O 15.3500 -15.0615
62 O1a O 25.9482 -22.9857
63 C1a C 24.6867 -25.2716
64 C1a C 15.4544 -18.9155
65 C1a C 29.6747 -17.1278
66 C1a C 28.4167 -19.2008
BOND 67
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 3 8 1 #Down
8 5 9 1
9 5 10 1 #Up
10 7 11 1
11 7 12 1 #Up
12 9 13 2
13 9 14 1
14 11 15 1
15 16 17 1
16 16 18 1
17 16 19 1 #Down
18 17 20 1
19 17 21 1 #Up
20 17 22 1 #Down
21 18 23 1
22 18 24 1 #Down
23 25 19 1 #Down
24 20 26 1
25 23 27 1 #Down
26 23 28 1
27 25 29 1
28 25 30 1
29 26 31 1
30 26 32 1 #Down
31 33 27 1 #Down
32 28 34 1
33 28 35 1 #Up
34 29 36 1
35 29 37 1 #Up
36 30 38 1
37 31 39 1
38 31 40 2
39 33 41 1
40 33 42 1
41 34 43 1
42 34 44 2
43 36 45 1
44 36 46 1 #Down
45 38 47 1 #Down
46 39 48 1
47 39 49 1 #Up
48 41 50 1
49 42 51 1
50 43 52 1
51 48 53 1
52 48 54 1 #Up
53 50 55 1
54 50 56 1 #Down
55 50 57 1
56 51 58 1 #Up
57 52 59 1 #Down
58 53 60 1 #Down
59 53 61 1 #Up
60 55 62 1 #Down
61 56 63 1
62 59 64 1
63 38 45 1
64 51 55 1
65 52 53 1
66 46 65 1
67 46 66 1
|
|---|
