KEGG   DRUG: Codeine polistirex
Entry
D03579                      Drug                                   
Name
Codeine polistirex (USAN)
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
ATC code: R05DA04
Chemical structure group: DG01076
Product (DG01076): D02101<JP> D03580<US>
Efficacy
Antitussive, Opioid receptor agonist
Comment
Opium alkaloid
Active form of prodrug: Morphine [DR:D08233]
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
    R05DA Opium alkaloids and derivatives
     R05DA04 Codeine
      D03579  Codeine polistirex (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG01076  Codeine
     D03579  Codeine polistirex
 Analgesic
  DG01984  Opioid analgesics
   DG01076  Codeine
    D03579  Codeine polistirex
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG01076  Codeine
    D03579  Codeine polistirex
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01076  Codeine
     D03579  Codeine polistirex
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    DG01076  Codeine
     D03579  Codeine polistirex
   DG03190  UGT2B7 substrate
    DG01076  Codeine
     D03579  Codeine polistirex
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D03579  Codeine polistirex (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03579
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG01076  Codeine
 Analgesic
  DG01984  Opioid analgesics
   DG01076  Codeine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG01076  Codeine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01076  Codeine
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    DG01076  Codeine
   DG03190  UGT2B7 substrate
    DG01076  Codeine
Prodrugs [br08324.html]
 DG01076
Other DBs
PubChem: 47205863
LinkDB

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