| Entry |
|
|---|
| Name |
Vindesine (USAN/INN) |
|---|
| Formula |
C43H55N5O7
|
|---|
| Exact mass |
753.4101
|
|---|
| Mol weight |
753.9261
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00691): | D01769<JP> |
|
|---|
| Efficacy |
Antineoplastic, Tubulin polymerization inhibitor |
|---|
| Comment |
Semisynthetic vinblastine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CA Vinca alkaloids and analogues
L01CA03 Vindesine
D06304 Vindesine (USAN/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00691 Vindesine
D06304 Vindesine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00691 Vindesine
D06304 Vindesine
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D06304 Vindesine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06304
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00691 Vindesine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00691 Vindesine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 55
1 C1z C 22.0469 -23.5691
2 C1y C 23.1775 -22.9024
3 C1y C 22.0527 -24.8739
4 C8y C 19.7971 -23.5691
5 C1x C 21.2120 -22.4907
6 C1z C 24.3200 -23.5634
7 N1y N 23.1659 -21.5803
8 C1z C 23.1891 -25.5233
9 N1y N 20.9162 -25.5233
10 C8y C 19.7971 -24.8739
11 C8x C 18.6605 -22.9197
12 C1x C 21.8730 -21.5750
13 C1y C 24.2616 -24.8797
14 C2x C 25.4507 -22.8908
15 C1b C 25.4159 -24.1955
16 C1x C 24.3141 -20.9193
17 C5a C 24.0822 -26.7021
18 O1a O 22.6963 -27.4253
19 C1a C 20.9026 -26.8991
20 C8x C 18.6605 -25.5292
21 C8y C 17.5530 -23.5634
22 O1a O 26.7632 -25.7276
23 C2x C 25.4564 -21.5687
24 C1a C 26.5291 -23.5577
25 N1a N 24.0714 -27.9720
26 C8y C 17.5530 -24.8739
27 C1z C 15.1281 -21.3939
28 O2a O 16.4397 -25.5117
29 C8y C 14.0033 -20.6343
30 C1x C 16.3921 -20.6576
31 C7a C 14.7686 -22.6929
32 C1a C 15.3265 -24.8622
33 C8y C 14.0033 -19.2891
34 N4x N 12.8783 -21.3070
35 C1y C 16.3921 -19.3703
36 O7a O 13.3307 -23.1510
37 O6a O 15.5977 -23.7251
38 C8y C 11.6896 -19.2891
39 C1x C 13.2784 -18.1873
40 C8y C 11.6896 -20.6343
41 C1x C 15.2557 -18.7557
42 C1x C 17.4760 -18.5527
43 C1a C 12.4608 -24.5716
44 C8x C 10.5473 -18.6224
45 C1x C 14.0495 -17.2016
46 C8x C 10.5473 -21.3070
47 N1y N 15.2557 -17.5147
48 C1z C 17.5171 -17.4105
49 C8x C 9.4688 -19.2891
50 C8x C 9.4688 -20.6343
51 C1x C 16.3864 -16.7610
52 C1b C 19.0248 -17.9381
53 O1a O 18.3579 -16.1173
54 C1a C 20.0858 -17.3003
55 O5a O 25.3876 -26.1698
BOND 63
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 1
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 2
10 4 11 1
11 5 12 1
12 6 13 1
13 6 14 1
14 6 15 1 #Down
15 7 16 1
16 8 17 1 #Down
17 8 18 1 #Up
18 9 19 1
19 10 20 1
20 11 21 2
21 13 22 1 #Up
22 14 23 2
23 15 24 1
24 17 25 1
25 20 26 2
26 27 21 1 #Down
27 26 28 1
28 27 29 1
29 27 30 1
30 27 31 1 #Up
31 28 32 1
32 29 33 2
33 29 34 1
34 30 35 1
35 31 36 1
36 31 37 2
37 33 38 1
38 33 39 1
39 34 40 1
40 35 41 1 #Down
41 35 42 1
42 36 43 1
43 38 44 1
44 39 45 1
45 40 46 1
46 47 41 1 #Down
47 42 48 1
48 44 49 2
49 46 50 2
50 47 51 1
51 48 52 1 #Down
52 48 53 1 #Up
53 52 54 1
54 7 12 1
55 8 13 1
56 9 10 1
57 16 23 1
58 21 26 1
59 38 40 2
60 45 47 1
61 48 51 1
62 49 50 1
63 17 55 2
|
|---|
