Homo sapiens (human): 81027
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Entry
81027 CDS
T01001
Symbol
TUBB1, MACTHC1
Name
(RefSeq) tubulin beta 1 class VI
KO
K07375
tubulin beta
Organism
hsa
Homo sapiens (human)
Pathway
hsa04145
Phagosome
hsa04540
Gap junction
hsa04814
Motor proteins
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
Network
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06515
Regulation of kinetochore-microtubule interactions
Element
N00976
Retrograde axonal transport
N00977
Mutation-caused aberrant Htt to retrograde axonal transport
N00978
Anterograde axonal transport
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
N01055
Mutation-caused aberrant SNCA to anterograde axonal transport
N01158
Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285
Microtubule-RHOA signaling pathway
N01286
Escherichia EspG to Microtubule-RHOA signaling pathway
N01295
Rab7-regulated microtubule minus-end directed transport
N01297
Arl8-regulated microtubule plus-end directed transport
N01298
Salmonella SifA to microtubule plus-end directed transport
N01299
Salmonella PipB2 to microtubule plus-end directed transport
N01403
Zn to anterograde axonal transport
N01414
Iron to anterograde axonal transport
N01535
Kinetochore microtubule attachment
N01544
Microtubule nucleation
N01547
Kinetochore fiber organization
N01549
Branching microtubule nucleation
N01553
Promotion of microtubule growth
N01561
Microtubule depolymerization
N01562
Microtubule depolymerization at the minus ends
Disease
H01740
Macrothrombocytopenia
Drug target
Anvatabart opadotin:
D12583
Avanbulin:
D11681
Batabulin (
DG01412
):
D03059
D06560
Belantamab mafodotin:
D11595
<US>
Brentuximab vedotin:
D09587
<JP/US>
Cabazitaxel (
DG00695
):
D09755
D10452
<JP/US>
Cantuzumab mertansine:
D03364
Cantuzumab ravtansine:
D10454
Cevipabulin (
DG01413
):
D06576
D08889
Colchicine:
D00570
<JP/US>
Denintuzumab mafodotin:
D11232
Docetaxel (
DG00694
):
D02165
<JP/US>
D07866
<JP/US>
Enfortumab vedotin:
D11525
<JP/US>
Eribulin:
D08914
<JP/US>
Estramustine (
DG00724
):
D02398
D04066
D06397
<JP/US>
Farletuzumab ecteribulin:
D12183
Glembatumumab vedotin:
D09912
Indibulin:
D10013
Ixabepilone:
D04645
<US>
Lexibulin:
D10073
Lifastuzumab vedotin:
D11238
Lisavanbulin:
D11494
Lorvotuzumab mertansine:
D09927
Maytansine:
D04864
Mecbotamab vedotin:
D12220
Mirvetuximab soravtansine:
D10954
<US>
Mivobulin isethionate:
D05062
Opadotin:
D12582
Ozuriftmab vedotin:
D12210
Paclitaxel:
D00491
<JP/US>
Paclitaxel poliglumex:
D05333
Sabizabulin (
DG03253
):
D12519
D12520
Soblidotin:
D01919
Soravtansine:
D11228
Taltobulin:
D06001
Tasidotin hydrochloride:
D06009
Tirbanibulin (
DG03082
):
D11691
<US>
D11692
Tisotumab vedotin:
D11814
<US>
Trastuzumab emtansine:
D09980
<JP/US>
Tusamitamab ravtansine:
D12310
Vedotin:
D09691
Verubulin (
DG01411
):
D10029
D10030
Vinblastine (
DG00689
):
D01068
<JP/US>
D08675
Vincristine (
DG00690
):
D02197
<JP/US>
D08679
Vindesine (
DG00691
):
D01769
<JP>
D06304
Vinepidine sulfate:
D06305
Vinflunine:
D09032
Vinglycinate sulfate:
D06306
Vinleurosine sulfate:
D06307
Vinorelbine (
DG00692
):
D01935
<JP/US>
D08680
Vinrosidine sulfate:
D06308
Vinzolidine sulfate:
D06309
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
81027 (TUBB1)
09144 Cellular community - eukaryotes
04540 Gap junction
81027 (TUBB1)
09142 Cell motility
04814 Motor proteins
81027 (TUBB1)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
81027 (TUBB1)
05132 Salmonella infection
81027 (TUBB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
81027 (TUBB1)
05012 Parkinson disease
81027 (TUBB1)
05014 Amyotrophic lateral sclerosis
81027 (TUBB1)
05016 Huntington disease
81027 (TUBB1)
05020 Prion disease
81027 (TUBB1)
05022 Pathways of neurodegeneration - multiple diseases
81027 (TUBB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
81027 (TUBB1)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
81027 (TUBB1)
04147 Exosome [BR:
hsa04147
]
81027 (TUBB1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
81027 (TUBB1)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
81027 (TUBB1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
81027 (TUBB1)
Exosomal proteins of colorectal cancer cells
81027 (TUBB1)
Exosomal proteins of bladder cancer cells
81027 (TUBB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Tubulin
Tubulin_C
Misat_Tub_SegII
Tubulin_2
Tubulin_3
Motif
Other DBs
NCBI-GeneID:
81027
NCBI-ProteinID:
NP_110400
OMIM:
612901
HGNC:
16257
Ensembl:
ENSG00000101162
UniProt:
Q9H4B7
LinkDB
All DBs
Position
20:59016438..59026654
Genome browser
AA seq
451 aa
AA seq
DB search
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
NT seq
1356 nt
NT seq
+upstream
nt +downstream
nt
atgcgtgaaattgtccatattcagattggccagtgtggcaaccagatcggagccaagttc
tgggagatgattggtgaggaacacgggatcgacttggctgggagcgaccgcggggcctcg
gccttgcagctggagagaatcagcgtgtactacaacgaagcctacggtaggaaatatgtg
ccccgagcagtcttggtggacctagaacctgggacgatggacagcattcgatctagcaaa
ttaggagctctctttcaacccgacagttttgtccatggtaactctggggctggcaacaac
tgggccaaaggccactacacggagggagccgagctgatcgagaatgtcctagaggtggtg
aggcacgagagtgagagctgtgactgcctgcagggcttccagatcgtccactccctgggc
gggggcacaggctccgggatgggcactctgctcatgaacaagattagagaggagtacccg
gaccggatcatgaattccttcagcgtcatgccttctcccaaggtgtcggacactgtggtg
gagccctacaacgcggttctgtctatccaccagctgattgagaatgcagatgcctgtttc
tgcattgacaatgaggccctctatgacatctgcttccgtaccctgaagctgacgacaccc
acctatggggatctcaaccacctagtgtccttgaccatgagcggcataaccacctccctc
cggttcccgggtcagctcaacgcagacctgcgcaagctggcggtgaacatggtccccttc
ccccgcctgcacttctttatgcccggctttgccccactcacggcccagggcagccagcag
taccgagccctctccgtggccgagctcacccagcagatgttcgatgcccgcaataccatg
gctgcctgtgacctccgccgtggccgctacctcacagtggcctgcattttccggggcaag
atgtccaccaaggaagtggaccagcaactgctctccgtgcagaccaggaacagcagctgc
tttgtggagtggattcccaacaacgtcaaggtggctgtctgcgacatcccgccccggggg
ctgagcatggccgccaccttcattggcaacaacacggccatccaagagatctttaatagg
gtctctgagcatttctcagccatgttcaaaaggaaagcttttgtgcactggtacaccagc
gaagggatggacataaacgaatttggggaagctgaaaataacatccatgatttggtatcc
gagtaccaacaatttcaagatgccaaagcagttctagaggaagatgaagaggtcacggag
gaggcagaaatggagccagaagataagggacattaa
DBGET
integrated database retrieval system