KEGG   DRUG: Cabazitaxel acetonate
Entry
D10452                      Drug                                   
Name
Cabazitaxel acetonate (JAN);
Cabazitaxel acetone;
Jevtana (TN)
Product
JEVTANA (Sanofi-Aventis U.S. LLC)
Formula
C45H57NO14. C3H6O
Exact mass
893.4198
Mol weight
894.0115
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 4240
ATC code: L01CD04
Chemical structure group: DG00695
Product (DG00695): D10452<JP/US>
Efficacy
Antineoplastic, Tubulin depolymerization inhibitor
  Disease
Prostate cancer [DS:H00024]
Comment
Taxane derivative
Target
TUBB [HSA:10381 10382 10383 203068 347688 347733 7280 81027 84617] [KO:K07375]
  Pathway
hsa04540  Gap junction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CD Taxanes
     L01CD04 Cabazitaxel
      D10452  Cabazitaxel acetonate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Cabazitaxel
    D10452  Cabazitaxel acetonate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   424  Plant extract preparations
    4240  Plant extract preparations
     D10452  Cabazitaxel acetonate (JAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00695  Cabazitaxel
    D10452  Cabazitaxel acetonate
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D10452  Cabazitaxel acetonate (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10452
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10452
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10452
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10452
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10452
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00695  Cabazitaxel
Other DBs
CAS: 1426815-65-7
PubChem: 172232545
LinkDB
KCF data

ATOM        64
            1   C1y C    17.1500  -14.0700
            2   C1z C    18.2700  -14.7000
            3   C1y C    16.3800  -14.9100
            4   C1z C    17.1500  -12.7400
            5   C1y C    19.3900  -14.0700
            6   C1x C    19.4600  -15.4000
            7   O7a O    18.2700  -16.9400
            8   C1z C    14.0000  -14.9100
            9   O7a O    16.3800  -17.2200
            10  C5x C    15.5400  -11.7600
            11  C1y C    18.2700  -12.1800
            12  O2x O    20.4400  -14.7700
            13  C1x C    19.3900  -12.7400
            14  C7a C    19.4600  -17.6400
            15  C1z C    14.0000  -13.5800
            16  C1x C    12.8800  -15.5400
            17  O1a O    14.0000  -16.1000
            18  C7a C    15.2600  -17.8500
            19  C1y C    12.8800  -11.7600
            20  O5x O    15.5400  -10.3600
            21  C1a C    20.6500  -16.9400
            22  O6a O    19.4600  -19.0400
            23  C2y C    12.8800  -12.9500
            24  C1a C    14.9800  -12.6000
            25  C1a C    14.9800  -14.0700
            26  C1y C    11.7600  -14.9100
            27  C8y C    15.2600  -19.1100
            28  O6a O    14.2800  -17.1500
            29  C2y C    11.7600  -13.5800
            30  O7a O    10.3600  -15.6100
            31  C1a C    10.7100  -12.6700
            32  C7a C     9.1700  -14.9800
            33  C1c C     8.0500  -15.6100
            34  O6a O     9.1700  -13.6500
            35  C1c C     6.9300  -14.9800
            36  O1a O     8.0500  -16.9400
            37  C8y C     5.7400  -15.6100
            38  N1b N     6.9300  -13.6500
            39  C8x C     4.6200  -14.9800
            40  C8x C     5.7400  -16.9400
            41  C7a C     5.7400  -12.9500
            42  C8x C     3.5000  -15.6100
            43  C8x C     4.6200  -17.6400
            44  O7a O     5.7400  -11.6900
            45  O6a O     4.6200  -13.6500
            46  C8x C     3.5000  -16.9400
            47  C1d C     4.5500  -11.0600
            48  C1a C     4.5500   -9.6600
            49  C1a C     3.4300  -11.6900
            50  C1a C     3.4300  -10.3600
            51  C8x C    14.1400  -19.7400
            52  C8x C    14.1400  -21.1400
            53  C8x C    15.2600  -21.8400
            54  C8x C    16.4500  -21.2100
            55  C8x C    16.4500  -19.8100
            56  O2a O    18.2700  -10.7800
            57  C1a C    19.4600  -10.0800
            58  C1a C    17.0100  -11.3400
            59  O2a O    11.6200  -11.0600
            60  C1a C    11.6200   -9.6600
            61  C5a C    25.9700  -15.3300
            62  C1a C    27.1824  -16.0300
            63  C1a C    24.7576  -16.0300
            64  O5a O    25.9700  -13.9300
BOND        68
            1     2   7 1 #Down
            2     3   8 1
            3     3   9 1 #Down
            4     4  10 1
            5     4  11 1
            6     5  12 1 #Up
            7     5  13 1
            8     7  14 1
            9     8  15 1
            10    8  16 1
            11    8  17 1 #Up
            12    9  18 1
            13   10  19 1
            14   10  20 2
            15   14  21 1
            16   14  22 2
            17   15  23 1
            18   15  24 1
            19   15  25 1
            20   16  26 1
            21   18  27 1
            22   18  28 2
            23   23  29 2
            24   26  30 1 #Down
            25   29  31 1
            26   30  32 1
            27   32  33 1
            28   32  34 2
            29   33  35 1
            30   33  36 1 #Down
            31   35  37 1
            32   35  38 1 #Down
            33   37  39 2
            34   37  40 1
            35   38  41 1
            36   39  42 1
            37   40  43 2
            38   41  44 1
            39   41  45 2
            40   42  46 2
            41    6  12 1
            42   11  13 1
            43   19  23 1
            44   26  29 1
            45   43  46 1
            46   44  47 1
            47    1   2 1
            48   47  48 1
            49    1   3 1
            50   47  49 1
            51    1   4 1
            52   47  50 1
            53    2   5 1
            54    2   6 1 #Up
            55   27  51 2
            56   51  52 1
            57   52  53 2
            58   53  54 1
            59   54  55 2
            60   27  55 1
            61   11  56 1 #Up
            62   56  57 1
            63    4  58 1 #Up
            64   19  59 1 #Up
            65   59  60 1
            66   61  62 1
            67   61  63 1
            68   61  64 2

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