| Entry |
|
|---|
| Name |
Diclofenac epolamine;
Diclofenac hydroxyethylpyrrolidine;
Flector (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C14H11Cl2NO2. C6H13NO
|
|---|
| Exact mass |
410.1164
|
|---|
| Mol weight |
411.3222
|
|---|
| Structure |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
Transporter inhibitor
DG02866 SLC22A8 inhibitor
|
|---|
| Remark |
| Product (DG00441): | D00903<US> D00904<JP/US> D07818<US> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
Transporter inhibition: SLC22A8 [HSA: 9376]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AX Other dermatologicals
D11AX18 Diclofenac
D07818 Diclofenac epolamine <US>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB05 Diclofenac
D07818 Diclofenac epolamine <US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA15 Diclofenac
D07818 Diclofenac epolamine <US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC03 Diclofenac
D07818 Diclofenac epolamine <US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Diclofenac
D07818 Diclofenac epolamine
Dermatological Agents
Dermatological Agents, Other
Warts and Actinic Keratosis Agents
Diclofenac
D07818 Diclofenac epolamine
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
Diclofenac
D07818 Diclofenac epolamine
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
D07818 Diclofenac epolamine
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
D07818 Diclofenac epolamine
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
D07818 Diclofenac epolamine
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D07818 Diclofenac hydroxyethylpyrrolidine
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D07818 Diclofenac epolamine <US>
PTGS2 (COX2)
D07818 Diclofenac epolamine <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07818
Drug transporters
D07818
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C8x C 17.4300 -19.3900
2 C8x C 17.4300 -20.7900
3 C8x C 18.6200 -21.4900
4 C8x C 19.8800 -20.7900
5 C8y C 19.8800 -19.3900
6 C8y C 18.6200 -18.6900
7 C1b C 21.1400 -18.6900
8 C6a C 22.3300 -19.3200
9 O6a O 23.5200 -18.6900
10 O6a O 22.3300 -20.7900
11 N1b N 18.6200 -17.2200
12 C8y C 17.3600 -16.5200
13 C8y C 17.3600 -15.1200
14 C8x C 16.1700 -14.4200
15 C8x C 14.9800 -15.1200
16 C8x C 14.9800 -16.5200
17 C8y C 16.1700 -17.2200
18 X Cl 18.6200 -14.4200
19 X Cl 16.1700 -18.6900
20 C1x C 28.7605 -19.0933
21 C1x C 29.1683 -20.4326
22 C1x C 30.5680 -20.4587
23 C1x C 31.0254 -19.1355
24 N1y N 29.9083 -18.2916
25 C1b C 29.9083 -16.8916
26 C1b C 31.1161 -16.1942
27 O1a O 32.3429 -16.9029
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 8 10 2
11 6 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 12 17 1
19 13 18 1
20 17 19 1
21 20 21 1
22 21 22 1
23 22 23 1
24 23 24 1
25 20 24 1
26 24 25 1
27 25 26 1
28 26 27 1
|
|---|
