 | | DRUG: Levocetirizine dihydrochloride | |
| Entry |
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| Name |
Levocetirizine dihydrochloride (USP);
Levocetirizine hydrochloride (JAN);
Xyzal (TN) |
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| Product |
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| Generic |
LEVOCETIRIZINE DIHYDROCHLORIDE (A-S Medication Solutions), LEVOCETIRIZINE DIHYDROCHLORIDE (A-S Medication Solutions), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Camber Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Camber Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Chartwell RX), LEVOCETIRIZINE DIHYDROCHLORIDE (Denton Pharma), LEVOCETIRIZINE DIHYDROCHLORIDE (Dr.Reddy's laboratories), LEVOCETIRIZINE DIHYDROCHLORIDE (Glenmark Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Macleods Pharmaceuticals Limited), LEVOCETIRIZINE DIHYDROCHLORIDE (Marlex Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Micro Labs Limited), LEVOCETIRIZINE DIHYDROCHLORIDE (Northwind Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Northwind Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (NuCare Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (PD-Rx Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (PD-Rx Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Padagis Israel Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Preferred Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Preferred Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (REMEDYREPACK), LEVOCETIRIZINE DIHYDROCHLORIDE (ScieGen Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), LEVOCETIRIZINE DIHYDROCHLORIDE (Teva Pharmaceuticals USA), LEVOCETIRIZINE DIHYDROCHLORIDE (Vensun Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Westminster Pharmaceuticals) |
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| Formula |
C21H25ClN2O3. 2HCl
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| Exact mass |
460.1087
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| Mol weight |
461.8097
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| Structure |
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| Simcomp |
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 4490 |
| Product (DG01108): | D08118<JP/US> |
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| Efficacy |
Antiallergic, H1 receptor antagonist |
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| Disease |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AE Piperazine derivatives
R06AE09 Levocetirizine
D08118 Levocetirizine dihydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
Levocetirizine
D08118 Levocetirizine dihydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
449 Miscellaneous
4490 Miscellaneous
D08118 Levocetirizine dihydrochloride (USP); Levocetirizine hydrochloride (JAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01108 Levocetirizine
D08118 Levocetirizine dihydrochloride
Dermatological agent
DG03243 Atopic dermatitis agent
D08118 Levocetirizine dihydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01108 Levocetirizine
D08118 Levocetirizine dihydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D08118 Levocetirizine dihydrochloride
Dermatological agent
DG03243 Atopic dermatitis agent
D08118 Levocetirizine dihydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08118 Levocetirizine dihydrochloride (USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D08118
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08118
Rx-to-OTC switch list in the USA [br08315.html]
D08118
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01108 Levocetirizine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01108 Levocetirizine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 C8x C 21.4819 -20.8517
2 C8y C 21.4819 -22.2511
3 C8x C 22.7413 -22.9508
4 C8x C 23.9309 -22.2511
5 C8y C 23.9309 -20.8517
6 C8x C 22.7413 -20.1519
7 C8x C 26.3799 -22.2511
8 C8y C 26.3799 -20.8517
9 C1c C 25.1204 -20.1519
10 C8x C 27.5694 -22.9508
11 C8x C 28.7589 -22.2511
12 C8x C 28.7589 -20.8517
13 C8x C 27.5694 -20.1519
14 N1y N 25.1204 -18.7525
15 C1x C 26.3799 -18.0528
16 C1x C 26.3799 -16.6534
17 N1y N 25.1204 -15.8837
18 C1x C 23.9309 -16.6534
19 C1x C 23.9309 -18.0528
20 X Cl 20.2923 -22.9508
21 C1b C 25.1204 -14.4843
22 C1b C 26.3799 -13.7845
23 O2a O 27.5694 -14.4843
24 C1b C 28.7589 -13.8545
25 C6a C 29.9484 -14.4843
26 O6a O 31.1379 -13.8545
27 O6a O 29.9484 -15.9537
28 X Cl 31.9074 -18.9624
29 X Cl 31.8376 -21.1315
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 9 8 1 #Down
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 2 20 1
23 17 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 25 26 1
29 25 27 2
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