KEGG   DISEASE: Allergic rhinitis
Entry
H01360                      Disease                                
Name
Allergic rhinitis
Description
Allergic rhinitis (AR) is an inflammation of nasal mucosa mediated by IgE-associated processes, which is characterised by pruritus, sneezing, rhinorrhoea, and nasal congestion. The development of AR entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. Single-nucleotide polymorphism studies involving genes encoding for molecules implicated in the pathogenesis of AR have also been made. Such molecules comprise chemokines and their receptors, interleukins and their receptors, eosinophil peroxidase and leukotrienes, among others.
Category
Immune system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 12 Diseases of the respiratory system
  Upper respiratory tract disorders
   CA08  Vasomotor or allergic rhinitis
    H01360  Allergic rhinitis
Pathway
hsa04060  Cytokine-cytokine receptor interaction
Gene
IL13 [HSA:3596] [KO:K05435]
FOXJ1 [HSA:2302] [KO:K09402]
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Budesonide [DR:D00246]
Beclomethasone dipropionate [DR:D00689]
Beclomethasone dipropionate monohydrate [DR:D11572]
Promethazine hydrochloride [DR:D00480]
Clemastine fumarate [DR:D00666]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Mometasone furoate [DR:D00690]
Fluticasone furoate [DR:D06315]
Cortisone acetate [DR:D00973]
Azithromycin [DR:D06390]
Azelastine hydrochloride [DR:D00659]
Olopatadine hydrochloride [DR:D01192]
Ciclesonide [DR:D01703]
Fexofenadine hydrochloride and pseudoephedrine hydrochloride [DR:D10252]
Desloratadine and pseudoephedrine sulfate [DR:D10850]
Montelukast sodium [DR:D00529]
Carbinoxamine maleate [DR:D01336]
Dexchlorpheniramine maleate [DR:D00668]
Levocetirizine dihydrochloride [DR:D08118]
Cyproheptadine hydrochloride [DR:D02234]
Fexofenadine hydrochloride [DR:D00671]
Desloratadine [DR:D03693]
Azelastine hydrochloride and fluticasone propionate [DR:D11656]
Olopatadine and mometasone furoate [DR:D12501]
Other DBs
ICD-11: CA08.0
ICD-10: J30
MeSH: C567078
OMIM: 607154
Reference
PMID:22053313
  Authors
Pawankar R, Mori S, Ozu C, Kimura S
  Title
Overview on the pathomechanisms of allergic rhinitis.
  Journal
Asia Pac Allergy 1:157-67 (2011)
DOI:10.5415/apallergy.2011.1.3.157
Reference
PMID:21784174
  Authors
Mandhane SN, Shah JH, Thennati R
  Title
Allergic rhinitis: an update on disease, present treatments and future prospects.
  Journal
Int Immunopharmacol 11:1646-62 (2011)
DOI:10.1016/j.intimp.2011.07.005
Reference
PMID:31955459 (IL33)
  Authors
Korppi M, Terasjarvi J, Lauhkonen E, Huhtala H, Nuolivirta K, He Q
  Title
IL33 rs1342326 gene variation is associated with allergic rhinitis at school age after infant bronchiolitis.
  Journal
Acta Paediatr 109:2112-2116 (2020)
DOI:10.1111/apa.15175
Reference
PMID:16518568 (FOXJ1)
  Authors
Li CS, Chae SC, Lee JH, Zhang Q, Chung HT
  Title
Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.
  Journal
J Hum Genet 51:292-297 (2006)
DOI:10.1007/s10038-006-0359-8
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