| Entry |
|
|---|
| Name |
Beclomethasone dipropionate monohydrate;
Beconase aq (TN) |
|---|
| Product |
|
|---|
| Formula |
C28H37ClO7. H2O
|
|---|
| Exact mass |
538.2333
|
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| Mol weight |
539.0575
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00097): | D00689<JP/US> D11572<US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA07 Beclometasone
D11572 Beclomethasone dipropionate monohydrate <US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC15 Beclometasone
D11572 Beclomethasone dipropionate monohydrate <US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD01 Beclometasone
D11572 Beclomethasone dipropionate monohydrate <US>
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA01 Beclometasone
D11572 Beclomethasone dipropionate monohydrate <US>
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00097 Beclometasone
D11572 Beclomethasone dipropionate monohydrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D11572 Beclomethasone dipropionate monohydrate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D11572 Beclomethasone dipropionate monohydrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D11572 Beclomethasone dipropionate monohydrate <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11572
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00097 Beclometasone
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 C1z C 20.4617 -15.7826
2 C1z C 19.2745 -16.4111
3 C1y C 21.6489 -16.4810
4 C5a C 20.4617 -13.9669
5 O7a O 21.6489 -15.0843
6 C1y C 19.2745 -17.8078
7 C1x C 18.0873 -15.7128
8 C1a C 19.2745 -15.0145
9 C1x C 21.6489 -17.8078
10 C1a C 22.8361 -17.1095
11 C1b C 19.2745 -13.2686
12 O5a O 21.7187 -13.2686
13 C7a C 23.0456 -15.0843
14 C1y C 18.0873 -18.4364
15 C1y C 16.9002 -16.4111
16 O7a O 18.0873 -13.9669
17 C1b C 23.6741 -13.8971
18 O6a O 23.6741 -16.2715
19 C1z C 16.9002 -17.7380
20 C1x C 18.0873 -19.7632
21 O1a O 15.7828 -15.7128
22 C7a C 16.9002 -13.2686
23 C1a C 25.0708 -13.8971
24 C1z C 15.7130 -18.4364
25 X Cl 16.9002 -19.1347
26 C1x C 16.9002 -20.4616
27 C1b C 15.7130 -13.9669
28 O6a O 16.9002 -11.8719
29 C2y C 15.7130 -19.7632
30 C2x C 14.5956 -17.7380
31 C1a C 15.7130 -17.0397
32 C1a C 14.5258 -13.2686
33 C2x C 14.5956 -20.4616
34 C2x C 13.4084 -18.4364
35 C5x C 13.4084 -19.7632
36 O5x O 12.2212 -20.4616
37 O0 O 26.0400 -20.0900
BOND 39
1 1 2 1
2 1 3 1
3 1 4 1 #Up
4 1 5 1 #Down
5 2 6 1
6 2 7 1
7 2 8 1 #Up
8 3 9 1
9 3 10 1 #Up
10 4 11 1
11 4 12 2
12 5 13 1
13 6 14 1
14 7 15 1
15 11 16 1
16 13 17 1
17 13 18 2
18 14 19 1
19 14 20 1
20 15 21 1 #Up
21 16 22 1
22 17 23 1
23 19 24 1
24 19 25 1 #Down
25 20 26 1
26 22 27 1
27 22 28 2
28 24 29 1
29 24 30 1
30 24 31 1 #Up
31 27 32 1
32 29 33 2
33 30 34 2
34 33 35 1
35 35 36 2
36 6 9 1
37 15 19 1
38 26 29 1
39 34 35 1
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