| Entry |
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| Name |
Methylprednisolone (JP19/USP/INN);
Medrol (TN) |
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| Product |
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| Generic |
METHYLPREDNISOLONE (A-S Medication Solutions), METHYLPREDNISOLONE (A-S Medication Solutions), METHYLPREDNISOLONE (Advanced Rx Pharmacy of Tennessee), METHYLPREDNISOLONE (Advanced Rx Pharmacy of Tennessee), METHYLPREDNISOLONE (Advanced Rx Pharmacy of Tennessee), METHYLPREDNISOLONE (American Health Packaging), METHYLPREDNISOLONE (Asclemed USA), METHYLPREDNISOLONE (Asclemed USA), METHYLPREDNISOLONE (BluePoint Laboratories), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Chartwell RX), METHYLPREDNISOLONE (Direct_Rx), METHYLPREDNISOLONE (Doc Rx), METHYLPREDNISOLONE (Endo USA), METHYLPREDNISOLONE (Epic Pharma), METHYLPREDNISOLONE (Major Pharmaceuticals), METHYLPREDNISOLONE (Mylan Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (PD-Rx Pharmaceuticals), METHYLPREDNISOLONE (PHOENIX RX LLC), METHYLPREDNISOLONE (Preferred Pharmaceuticals), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (REMEDYREPACK), METHYLPREDNISOLONE (REMEDYREPACK), METHYLPREDNISOLONE (ST. MARY'S MEDICAL PARK PHARMACY), METHYLPREDNISOLONE (Sportpharm LLC), METHYLPREDNISOLONE (Tianjin Tianyao Pharmaceuticals), METHYLPREDNISOLONE (Zydus Lifesciences Limited), METHYLPREDNISOLONE (Zydus Pharmaceuticals USA) |
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| Formula |
C22H30O5
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| Exact mass |
374.2093
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| Mol weight |
374.47
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2456 |
| Product (DG00410): | D00407<JP/US> D00751<JP/US> D00979<JP/US> |
| Product (mixture): | D04250<JP> |
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| Efficacy |
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
Congenital adrenal hyperplasia [DS: H00216] Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Ankylosing spondylitis [DS: H01674] Psoriatic arthritis [DS: H01507] Systemic lupus erythematosus [DS: H00080] Systemic dermatomyositis and polymyositis [DS: H01604] Bullous dermatitis herpetiformis [DS: H01362] Erythema multiforme [DS: H01695] Stevens-Johnson syndrome [DS: H01694] Seborrheic dermatitis [DS: H01652] Mycosis fungoides [DS: H01463] Pemphigus [DS: H01648] Severe psoriasis [DS: H01656] Seasonal or perennial allergic rhinitis [DS: H01360] Contact dermatitis [DS: H01357] Bronchial asthma [DS: H00079] Atopic dermatitis [DS: H01358] Optic neuritis [DS: H01717] Pulmonary tuberculosis [DS: H00342] Acquired (autoimmune) hemolytic anemia [DS: H01585] Nephrotic syndrome [DS: H01657] Ulcerative colitis [DS: H01466] Multiple sclerosis [DS: H01490] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA01 Methylprednisolone
D00407 Methylprednisolone (JP19/USP/INN) <JP/US>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA02 Methylprednisolone
D00407 Methylprednisolone (JP19/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB04 Methylprednisolone
D00407 Methylprednisolone (JP19/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Methylprednisolone
D00407 Methylprednisolone (JP19/USP/INN)
Inflammatory Bowel Disease Agents
Glucocorticoids
Methylprednisolone
D00407 Methylprednisolone (JP19/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2456 Prednisolones
D00407 Methylprednisolone (JP19/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
D00407 Methylprednisolone
Dermatological agent
DG03243 Atopic dermatitis agent
D00407 Methylprednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
D00407 Methylprednisolone
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00407 Methylprednisolone
Dermatological agent
DG03243 Atopic dermatitis agent
D00407 Methylprednisolone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00407 Methylprednisolone (JP19/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00407 Methylprednisolone
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00407
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 27
1 C2x C 26.6700 -18.6900
2 C5x C 26.6700 -20.0900
3 C2x C 27.8600 -20.7900
4 C2y C 29.1200 -20.0900
5 C1z C 29.1200 -18.6900
6 C2x C 27.8600 -17.9900
7 C1y C 30.3100 -20.7900
8 C1x C 31.5000 -20.0900
9 C1y C 31.5000 -18.6900
10 C1y C 30.3100 -17.9900
11 C1y C 32.7600 -17.9900
12 C1z C 32.7600 -16.5900
13 C1x C 31.5000 -15.8900
14 C1y C 30.3100 -16.5900
15 C1x C 35.1400 -17.9900
16 C1x C 35.1400 -16.5900
17 C1z C 33.9500 -15.8900
18 O5x O 25.4800 -20.7900
19 C1a C 29.1200 -17.2900
20 O1a O 29.1200 -15.8900
21 C1a C 32.7600 -15.1900
22 C5a C 33.9500 -14.2100
23 C1a C 30.3100 -22.1900
24 O1a O 35.1400 -15.1900
25 C1b C 35.1400 -13.5100
26 O5a O 32.7600 -13.5100
27 O1a O 36.3300 -14.2100
BOND 30
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 17 22 1 #Up
26 7 23 1 #Down
27 17 24 1 #Down
28 22 25 1
29 22 26 2
30 25 27 1
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