KEGG   DISEASE: Atopic dermatitis
Entry
H01358                      Disease                                
Name
Atopic dermatitis
Description
Atopic dermatitis (ATOD) is a relapsing chronic inflammatory skin disease characterized by eczematous skin lesions and intense pruritus. A genetic defect in the filaggrin (FLG) protein and/or environmental factors are thought to cause AD by disrupting the epidermis. This disruption, in turn, results in contact between immune cells in the dermis and antigens from the external environment leading to intense itching, scratching, and inflammation. Apart from FLG, recent genome-wide association studies (GWASs) have identified many susceptibility loci of atopic dermatitis with genome-wide significance.
Category
Immune system disease; Skin disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Dermatitis and eczema
    EA80  Atopic eczema
     H01358  Atopic dermatitis
Pathway
hsa04621  NOD-like receptor signaling pathway
hsa04620  Toll-like receptor signaling pathway
hsa04151  PI3K-Akt signaling pathway
Gene
(ATOD2) FLG [HSA:2312] [KO:K10384]
Pathogen
Staphylococcus aureus
Malassezia sympodialis [GN:msym]
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Hydrocortisone butyrate [DR:D01619]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Doxepin hydrochloride [DR:D00814]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Desonide [DR:D03696]
Tacrolimus [DR:D00107]
Pimecrolimus [DR:D05480]
Dupilumab [DR:D10354]
Crisaborole [DR:D10873]
Tralokinumab [DR:D09979]
Abrocitinib [DR:D11400]
Ruxolitinib phosphate [DR:D09960]
Cortisone acetate [DR:D00973]
Upadacitinib hydrate [DR:D11048]
Hydroxyzine hydrochloride [DR:D00672]
Hydroxyzine pamoate [DR:D01096]
Other DBs
ICD-11: EA80
ICD-10: L20
MeSH: D003876
OMIM: 603165 605803
Reference
PMID:23473856
  Authors
Kabashima K
  Title
New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity.
  Journal
J Dermatol Sci 70:3-11 (2013)
DOI:10.1016/j.jdermsci.2013.02.001
Reference
PMID:23439055
  Authors
Tamari M, Tanaka S, Hirota T
  Title
Genome-wide association studies of allergic diseases.
  Journal
Allergol Int 62:21-8 (2013)
DOI:10.2332/allergolint.13-RAI-0539
Reference
PMID:21518425
  Authors
Bussmann C, Weidinger S, Novak N
  Title
Genetics of atopic dermatitis.
  Journal
J Dtsch Dermatol Ges 9:670-6 (2011)
DOI:10.1111/j.1610-0387.2011.07656.x
Reference
PMID:20109730
  Authors
Barnes KC
  Title
An update on the genetics of atopic dermatitis: scratching the surface in 2009.
  Journal
J Allergy Clin Immunol 125:16-29.e1-11; quiz 30-1 (2010)
DOI:10.1016/j.jaci.2009.11.008
Reference
PMID:22962911
  Authors
Berke R, Singh A, Guralnick M
  Title
Atopic dermatitis: an overview.
  Journal
Am Fam Physician 86:35-42 (2012)
Reference
PMID:16550169 (FLG)
  Authors
Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O'Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH
  Title
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
  Journal
Nat Genet 38:441-6 (2006)
DOI:10.1038/ng1767
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