| Entry |
|
|---|
| Name |
Pilocarpine borate;
pilolarpin ophtha (TN) |
|---|
| Formula |
C11H16N2O2. xH3BO3
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG01719 Parasympathomimetic agent
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
|
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| Remark |
| Product (DG00992): | D02200<JP/US> |
|
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| Efficacy |
Miotic, Muscrinic receptor agonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
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| Interaction |
|
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| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AX Other parasympathomimetics
N07AX01 Pilocarpine
D08376 Pilocarpine borate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB01 Pilocarpine
D08376 Pilocarpine borate
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00992 Pilocarpine
D08376 Pilocarpine borate
DG01719 Parasympathomimetic agent
DG00992 Pilocarpine
D08376 Pilocarpine borate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00992 Pilocarpine
D08376 Pilocarpine borate
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00992 Pilocarpine
D08376 Pilocarpine borate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM2
D08376 Pilocarpine borate
CHRM3
D08376 Pilocarpine borate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08376
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00992 Pilocarpine
DG01719 Parasympathomimetic agent
DG00992 Pilocarpine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00992 Pilocarpine
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00992 Pilocarpine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 19
1 C1y C 18.3400 -18.5500
2 C1y C 16.8700 -18.5500
3 C1b C 19.5300 -19.2500
4 C1x C 18.7600 -17.2200
5 C7x C 16.4500 -17.2200
6 C1b C 16.1000 -19.7400
7 C8y C 20.5800 -18.6200
8 O7x O 17.6400 -16.3800
9 O6a O 15.1200 -16.8000
10 C1a C 14.7000 -19.7400
11 N4y N 22.0500 -18.6200
12 C8x C 20.1600 -17.2200
13 C8x C 22.4700 -17.2200
14 C1a C 22.8200 -19.7400
15 N5x N 21.2800 -16.3800
16 Z B 29.8900 -18.4800
17 O1a O 29.8900 -17.0800
18 O1a O 28.6776 -19.1800
19 O1a O 31.1024 -19.1800
BOND 19
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 4 8 1
8 5 9 2
9 6 10 1
10 7 11 1
11 7 12 2
12 11 13 1
13 11 14 1
14 12 15 1
15 5 8 1
16 13 15 2
17 16 17 1
18 16 18 1
19 16 19 1
BRACKET 1 26.8800 -19.8100 26.8800 -16.0300
1 32.9000 -16.0300 32.9000 -19.8100
1 x
ORIGINAL 1 16 17 18 19
REPEAT 1
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