| Entry |
|
|---|
| Name |
Ciprofloxacin hydrate (JAN);
Ciprofloxacin hemiheptahydrate |
|---|
| Formula |
(C17H18FN3O3)2. 7H2O
|
|---|
| Exact mass |
788.3404
|
|---|
| Mol weight |
788.79
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
|
|---|
| Remark |
| Product (DG00617): | D00186<JP/US> D02216<JP/US> |
|
|---|
| Efficacy |
Antibacterial, Nucleic acid biosynthesis inhibitor |
|---|
| Target |
|
|---|
| Interaction |
CYP inhibition: CYP1A2 [HSA: 1544]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01M QUINOLONE ANTIBACTERIALS
J01MA Fluoroquinolones
J01MA02 Ciprofloxacin
D10822 Ciprofloxacin hydrate (JAN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AE Fluoroquinolones
S01AE03 Ciprofloxacin
D10822 Ciprofloxacin hydrate (JAN)
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA15 Ciprofloxacin
D10822 Ciprofloxacin hydrate (JAN)
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03A ANTIINFECTIVES
S03AA Antiinfectives
S03AA07 Ciprofloxacin
D10822 Ciprofloxacin hydrate (JAN)
Drug groups [BR:br08330]
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
DG00617 Ciprofloxacin
D10822 Ciprofloxacin hydrate
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00617 Ciprofloxacin
D10822 Ciprofloxacin hydrate
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Fluoroquinolone
D10822 Ciprofloxacin hydrate (JAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10822
Drug groups [BR:br08330]
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
DG00617 Ciprofloxacin
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00617 Ciprofloxacin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Fluoroquinolone
DG00617 Ciprofloxacin
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 55
1 C8y C 16.8474 -14.8819
2 C8y C 16.8474 -16.2858
3 C8x C 18.0407 -16.9878
4 C8y C 19.3042 -16.2858
5 C8y C 19.3042 -14.8819
6 C8x C 18.0407 -14.1799
7 N4y N 20.4976 -16.9878
8 C8x C 21.6909 -16.2858
9 C8y C 21.6909 -14.8819
10 C8y C 20.4976 -14.1799
11 N1y N 15.6540 -16.9878
12 C1x C 14.4607 -16.2858
13 C1x C 13.1971 -16.9878
14 N1x N 13.1971 -18.3917
15 C1x C 14.3905 -19.0937
16 C1x C 15.6540 -18.3917
17 X F 15.6540 -14.1799
18 O5x O 20.4976 -12.7760
19 C6a C 22.8843 -14.1799
20 O6a O 24.0776 -14.8819
21 O6a O 22.8843 -12.7760
22 C1y C 20.4976 -18.3917
23 C1x C 21.1995 -19.5850
24 C1x C 19.7956 -19.5850
25 O0 O 29.6800 -19.4600
26 C8y C 16.8474 -14.8819
27 C8y C 16.8474 -16.2858
28 C8x C 18.0407 -16.9878
29 C8y C 19.3042 -16.2858
30 C8y C 19.3042 -14.8819
31 C8x C 18.0407 -14.1799
32 C8y C 20.4976 -14.1799
33 C8y C 21.6909 -14.8819
34 C8x C 21.6909 -16.2858
35 N4y N 20.4976 -16.9878
36 C1y C 20.4976 -18.3917
37 C1x C 21.1995 -19.5850
38 C1x C 19.7956 -19.5850
39 C6a C 22.8843 -14.1799
40 O6a O 24.0776 -14.8819
41 O6a O 22.8843 -12.7760
42 O5x O 20.4976 -12.7760
43 N1y N 15.6540 -16.9878
44 C1x C 14.4607 -16.2858
45 C1x C 13.1971 -16.9878
46 N1x N 13.1971 -18.3917
47 C1x C 14.3905 -19.0937
48 C1x C 15.6540 -18.3917
49 X F 15.6540 -14.1799
50 O0 O 29.6800 -19.4600
51 O0 O 29.6800 -19.4600
52 O0 O 29.6800 -19.4600
53 O0 O 29.6800 -19.4600
54 O0 O 29.6800 -19.4600
55 O0 O 29.6800 -19.4600
BOND 54
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 5 10 1
12 2 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 11 16 1
19 1 17 1
20 10 18 2
21 9 19 1
22 19 20 1
23 19 21 2
24 7 22 1
25 22 23 1
26 22 24 1
27 23 24 1
28 26 27 2
29 27 28 1
30 28 29 2
31 29 30 1
32 30 31 2
33 26 31 1
34 29 35 1
35 35 34 1
36 34 33 2
37 33 32 1
38 30 32 1
39 27 43 1
40 43 44 1
41 44 45 1
42 45 46 1
43 46 47 1
44 47 48 1
45 43 48 1
46 26 49 1
47 32 42 2
48 33 39 1
49 39 40 1
50 39 41 2
51 35 36 1
52 36 37 1
53 36 38 1
54 37 38 1
BRACKET 1 12.1800 -20.2300 12.1800 -11.5500
1 24.9200 -11.5500 24.9200 -20.2300
1 2
ORIGINAL 1 1 2 3 4 5 6 10 9 8 7 22 23 24 19 20 21
1 18 11 12 13 14 15 16 17
REPEAT 1 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41
1 42 43 44 45 46 47 48 49
2 27.3000 -20.2300 27.3000 -18.4100
2 30.5900 -18.4100 30.5900 -20.2300
2 7
ORIGINAL 2 25
REPEAT 2 50 51 52 53 54 55
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