DRUG: Lamivudine, nevirapine and zidovudine Help
Entry
Name
Lamivudine, nevirapine and zidovudine
Component
Class
Antiviral
DG03107 Anti-HIV agent
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02924 UGT substrate
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG02853 CYP3A/CYP3A4 inducer
Transporter substrate
DG02854 SLC22A2 substrate
DG02964 SLC47A1 substrate
DG03002 SLC47A2 substrate
Remark
Efficacy
Antiviral
Disease
Comment
Lamivudine is a substrate of OCT2, MATE1 and MATE2-K.
Nevirapine is a substrate and an inducer of CYP3A and CYP2B6.
Zidovudine is metabolized by UDP-glucuronosyltransferase (UGT).
Target
HIV-1 reverse transcriptase [KO:
K24802 ]
Pathway
Metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AR Antivirals for treatment of HIV infections, combinations
J05AR05 Zidovudine, lamivudine and nevirapine
D11521 Lamivudine, nevirapine and zidovudine
Drug groups [BR:br08330 ]
Antiviral
DG03107 Anti-HIV agent
D11521 Lamivudine, nevirapine and zidovudine
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
D11521 Lamivudine, nevirapine and zidovudine
DG01633 CYP3A/CYP3A4 substrate
D11521 Lamivudine, nevirapine and zidovudine
DG02924 UGT substrate
D11521 Lamivudine, nevirapine and zidovudine
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
D11521 Lamivudine, nevirapine and zidovudine
DG02853 CYP3A/CYP3A4 inducer
D11521 Lamivudine, nevirapine and zidovudine
Transporter substrate
DG02854 SLC22A2 substrate
D11521 Lamivudine, nevirapine and zidovudine
DG02964 SLC47A1 substrate
D11521 Lamivudine, nevirapine and zidovudine
DG03002 SLC47A2 substrate
D11521 Lamivudine, nevirapine and zidovudine
Antimicrobials [BR:br08307 ]
Antivirals
Genome replication inhibitor
HIV reverse transcriptase inhibitor
D11521 Lamivudine, nevirapine and zidovudine
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D11521
Drug transporters
D11521
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