KEGG   DRUG: Butalbital, aspirin, caffeine and codeine
Entry
D11860            Mixture   Drug                                   
Name
Butalbital, aspirin, caffeine and codeine;
Fiorinal with codeine (TN)
Product
  Generic
ASCOMP WITH CODEINE (Breckenridge Pharmaceutical), BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE (Amneal Pharmaceuticals of New York), BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE (Bryant Ranch Prepack), BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE (Lannett Company)
Component
Butalbital [DR:D03182], Aspirin [DR:D00109], Caffeine [DR:D00528], (Codeine phosphate [DR:D02101] | Codeine [DR:D00195])
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
Product: D11860<US>
Efficacy
Analgesic
Comment
Codeine is metabolized by UGT2B7, UGT2B4, CYP3A4 and CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
USP drug classification [BR:br08302]
 Analgesics
  Analgesics Combinations
   Aspirin/ Butalbital/ Caffeine/ Codeine
    D11860  Butalbital, aspirin, caffeine and codeine
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D11860  Butalbital, aspirin, caffeine and codeine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11860  Butalbital, aspirin, caffeine and codeine
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D11860  Butalbital, aspirin, caffeine and codeine
   DG03190  UGT2B7 substrate
    D11860  Butalbital, aspirin, caffeine and codeine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11860
LinkDB

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