| Entry |
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| Name |
Codeine (USP);
Codeine hydrate |
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| Formula |
C18H21NO3. H2O
|
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| Exact mass |
317.1627
|
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| Mol weight |
317.3795
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| Structure |
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| Simcomp |
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| Source |
Papaver somniferum [TAX: 3469]
|
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| Class |
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| Remark |
| Product (DG01076): | D02101<JP> D03580<US> |
| Product (mixture): | D11852<US> D11860<US> |
|
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| Efficacy |
Analgesic (narcotic), Antitussive, Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
Active form of prodrug: Morphine [DR: D08233]
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
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| Other map |
| map00982 | Drug metabolism - cytochrome P450 |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA04 Codeine
D00195 Codeine (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Codeine
D00195 Codeine (USP)
Second-class OTC drugs
Inorganic and organic chemicals
Codeine
D00195 Codeine (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
D00195 Codeine
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
D00195 Codeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
D00195 Codeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
D00195 Codeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
D00195 Codeine
DG03190 UGT2B7 substrate
DG01076 Codeine
D00195 Codeine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D00195 Codeine (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00195
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
DG03190 UGT2B7 substrate
DG01076 Codeine
Prodrugs [br08324.html]
DG01076
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 23
1 O0 O 32.4662 -13.2509
2 C1z C 24.7589 -14.6309
3 C8y C 24.7589 -13.3059
4 C1y C 25.9444 -15.3282
5 C1y C 23.6431 -15.2585
6 C1x C 25.9444 -14.0033
7 C8y C 23.6431 -12.6783
8 C8y C 25.9444 -12.6783
9 C1y C 27.0602 -14.6309
10 C2x C 25.9444 -16.5835
11 O2x O 22.3182 -13.9335
12 C1y C 23.6431 -16.5835
13 C1x C 28.1759 -14.0033
14 C8y C 23.6431 -11.3533
15 C1x C 27.0602 -13.3756
16 C8x C 25.9444 -11.3533
17 N1y N 28.1759 -15.3282
18 C2x C 24.7589 -17.2808
19 O1a O 22.5274 -17.2808
20 C8x C 24.8286 -10.7257
21 O2a O 22.5274 -10.7257
22 C1a C 21.3419 -11.3533
23 C1a C 29.5759 -15.3282
BOND 26
1 2 3 1
2 2 4 1
3 2 5 1
4 2 6 1 #Up
5 3 7 2
6 3 8 1
7 4 9 1
8 4 10 1
9 5 11 1 #Down
10 5 12 1
11 6 13 1
12 7 14 1
13 8 15 1
14 8 16 2
15 9 17 1 #Up
16 10 18 2
17 12 19 1 #Down
18 14 20 2
19 14 21 1
20 21 22 1
21 7 11 1
22 9 15 1
23 12 18 1
24 13 17 1
25 16 20 1
26 17 23 1
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