| Entry |
|
|---|
| Name |
Amlodipine benzoate;
Katerzia (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C20H25ClN2O5. C7H6O2
|
|---|
| Exact mass |
530.182
|
|---|
| Mol weight |
530.9972
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00322): | D00615<JP/US> D11881<US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA01 Amlodipine
D11881 Amlodipine benzoate <US>
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00322 Amlodipine
D11881 Amlodipine benzoate
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00322 Amlodipine
D11881 Amlodipine benzoate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00322 Amlodipine
D11881 Amlodipine benzoate
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D11881 Amlodipine benzoate
DG03231 Antihypertensive
D11881 Amlodipine benzoate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D11881 Amlodipine benzoate <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11881
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00322 Amlodipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00322 Amlodipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00322 Amlodipine
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 37
1 C1y C 17.5124 -15.0607
2 C2y C 18.7032 -14.3602
3 C2y C 16.3215 -14.3602
4 C8y C 17.5124 -17.3723
5 C2y C 18.7032 -12.9592
6 C7a C 19.8941 -15.0607
7 C2y C 16.3215 -12.9592
8 C7a C 15.1307 -14.9906
9 C8y C 18.7032 -18.0728
10 C8x C 16.3215 -18.0728
11 N1x N 17.5124 -12.2587
12 C1b C 19.8941 -12.2587
13 O7a O 21.0849 -14.3602
14 O6a O 19.8941 -16.3215
15 C1a C 15.1307 -12.2587
16 O7a O 13.9399 -14.3602
17 O6a O 15.1307 -16.3215
18 C8x C 18.7032 -19.4037
19 X Cl 19.8941 -17.3723
20 C8x C 16.3215 -19.4037
21 O2a O 21.0849 -12.9592
22 C1b C 22.2758 -15.0607
23 C1a C 12.7490 -14.9906
24 C8x C 17.5124 -20.1042
25 C1b C 22.2758 -12.2587
26 C1a C 23.4666 -14.3602
27 C1b C 23.4666 -12.9592
28 N1a N 24.5874 -12.2587
29 C8x C 26.2500 -18.0600
30 C8x C 26.2500 -19.4600
31 C8x C 27.4624 -20.1600
32 C8x C 28.6749 -19.4600
33 C8x C 28.6749 -18.0600
34 C8y C 27.4624 -17.3600
35 C6a C 27.4624 -15.9602
36 O6a O 26.2332 -15.2503
37 O6a O 28.6580 -15.2698
BOND 38
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 1
11 5 12 1
12 6 13 1
13 6 14 2
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 2
18 9 19 1
19 10 20 1
20 12 21 1
21 13 22 1
22 16 23 1
23 18 24 1
24 21 25 1
25 22 26 1
26 25 27 1
27 27 28 1
28 7 11 1
29 20 24 2
30 29 30 2
31 30 31 1
32 31 32 2
33 32 33 1
34 33 34 2
35 29 34 1
36 34 35 1
37 35 36 2
38 35 37 1
|
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