KEGG   DRUG: Chlorpheniramine polistirex and codeine polistirex
Entry
D12313            Mixture   Drug                                   
Name
Chlorpheniramine polistirex and codeine polistirex;
Tuzistra (TN)
Component
Chlorpheniramine polistirex [DR:D03475], Codeine polistirex [DR:D03579]
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
ATC code: R06AB54
Efficacy
Antitussive
Comment
Codeine is metabolized by UGT2B7, UGT2B4, CYP3A4 and CYP2D6.
Chlorpheniramine is metabolized by CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB54 Chlorphenamine, combinations
      D12313  Chlorpheniramine polistirex and codeine polistirex
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D12313  Chlorpheniramine polistirex and codeine polistirex
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D12313  Chlorpheniramine polistirex and codeine polistirex
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D12313  Chlorpheniramine polistirex and codeine polistirex
   DG03190  UGT2B7 substrate
    D12313  Chlorpheniramine polistirex and codeine polistirex
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12313
LinkDB

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