KEGG ORTHOLOGY: K00103

ORTHOLOGY: K00103

Entry

K00103                      KO

Symbol

GULO

Name

L-gulonolactone oxidase [EC:1.1.3.8]

Pathway

map00053

Ascorbate and aldarate metabolism

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Module

M00129

Ascorbate biosynthesis, animals, glucose-1P => ascorbate

Reaction

R03184

L-gulono-1,4-lactone:oxygen 2-oxidoreductase

R10053

L-gulono-1,4-lactone:oxygen 3-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K00103  GULO; L-gulonolactone oxidase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.8  L-gulonolactone oxidase
     K00103  GULO; L-gulonolactone oxidase

Other DBs

GO:

0050105

Genes

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	268756(Gulo)

MCAL:

110308887

MPAH:

110325590

RNO:	60671(Gulo)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:	113924112 113929666

MLX:	118009683 118022113

NSU:	110588464 123324322

LWW:

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	286812(GULO)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:	120860354 120866108

CCAD:

122432065

MBEZ:

129556922

SSC:	396759(GULO)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

PMOA:

OTC:

FAB:

OMA:

PHI:

CCAE:

CBRC:

ETL:	114072263 114072641 114073445

ACHL:

SVG:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

EHS:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:	104349619 104349628

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

DNE:

SCAM:

104154090(EPHX2)

ASN:

AMJ:

CPOO:

GGN:

PSS:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:

XTR:

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

LOC:

PSPA:

ARUT:

PSEX:

CMK:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:	118408636 118410004 118412674

BBEL:

109466823 109478142 109485933

CIN:

100180753

SPU:	100888205 115917982 764246

LPIC:

129263690 129263691 129281596

APLC:

AJC:

SKO:

CLON:

BCOO:

119067169 119069683 119072841 119072842 119072843 119072844 119072988 119076319 119078184 119079045 119081314 119084179 119084182 119084848 119084850 119085182

CSEC:

111874443

BROR:

134532170

FCD:	110843230 110844959 110857910 110860799

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LGI:	LOTGIDRAFT_208933

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:	124268692 124278077

CANU:

128161217 128161736 128162190

LAK:

106161198

NVE:	5496930 5516954

EPA:

110254170

ATEN:

116306443

ADF:	107336978 107354754

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_18858

AQU:

100633693

ATH:	AT1G32300(GulLO1) AT2G46740(GulLO5) AT2G46750(GulLO2) AT2G46760(GulLO6) AT5G11540(GulLO3) AT5G56470(GulLO7) AT5G56490(GulLO4)

ALY:	9300533 9307550 9316330 9318153 9318154 9321645 9327042

CRB:	111831458 17876581 17881389 17888997 17889214 17898641

CSAT:

104705420 104726195 104733303 104733318 104733335 104735167 104763518 104763519 104769386 104773365 104773373 104784633 104784635 104788736 104793653

EUS:	EUTSA_v10001364mg EUTSA_v10001763mg EUTSA_v10002773mg EUTSA_v10002834mg EUTSA_v10013068mg

BRP:	103845085 103850775 103851822 103866436 103866437 103866439

BNA:	106370317 106383023 106383183 106383563 106412350 106414144 106415381 106418293 106441738 106450477 106450478 106454421

BOE:	106318605 106321214 106322885 106337761 106339293 106340076

RSZ:	108806751 108807290 108810407 108817344 108824642 108837749 108842920

THJ:	104814776 104817396 104824215

CPAP:

110808475 110817648

CIT:	102613738 102618839 102619065

CIC:	CICLE_v10007892mg CICLE_v10019421mg CICLE_v10031018mg

PVY:	116109016 116114638

MINC:

123194448 123216243 123222778

TCC:	18587950 18613903

GRA:	105763150 105763957

GHI:	107919393 107923325 107953839

GAB:	108472389 108478560

HSYR:

120114866 120127291 120192889 120207121 120211969

DZI:	111284673 111305985 111313977

EGR:	104421946 104437765 104442399

GMX:	100778616 100787286 100789425 100790483 100791439 100799814 100801515 100806810

GSJ:	114388930 114389546 114390298 114394243 114398327 114399603 114407834 114418271

PVU:	PHAVU_001G074300g PHAVU_009G257400g PHAVU_009G257600g PHAVU_010G118400g

VRA:	106760021 106760022 106760023 106764193 106780334

VAR:	108322237 108322273 108336890 108346983

VUN:	114164180 114164578 114166177 114193442

VUM:	124841793 124843112 124843113 124843114 124846202

CCAJ:

109797626 109802335 109806109

APRC:

113847457 113851070 113862093 113863005

MTR:	11440416 25500629

TPRA:

123883488

CAM:	101495962 101505780 101507144

PSAT:

127076131 127129437 127132180

VVO:	131610775 131612949 131623796

LJA:	Lj1g3v5060530.1(Lj1g3v5060530.1) Lj1g3v5060540.1(Lj1g3v5060540.1) Lj2g3v3250000.1(Lj2g3v3250000.1) Lj3g3v0462020.1(Lj3g3v0462020.1) Lj3g3v0462290.1(Lj3g3v0462290.1) Lj3g3v2483050.1(Lj3g3v2483050.1)

ADU:	107472904 107491831 107495150 107495223

AIP:	107605189 107605190 107624247 107648068

AHF:	112695261 112726583 112734285 112754172 112755425 112755430 112755578 112755579

LANG:

109337324 109337326 109344618 109351734 109357115

PCIN:

129288659 129289773 129290337 129290401 129291580

QSA:	O6P43_018535 O6P43_018536 O6P43_027428

FVE:	101306399 101309401 101309682

RCN:	112172675 112181889 112195429 112196598

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103415463 103420706 103434065 103441169

MSYL:

126601846 126627138 126629799 126631721

PXB:	103937841 103956368 103957464

ZJU:	107403832 107404356 107420638 107423797 107423798 107423856 107423858 125423703

MNT:	21390658 21406194

CSAV:

115704179 115704660 115704717 115704776 115705069

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8266308 8271194 8284093

JCU:

105643326

HBR:	110661050 110667924 110672771

MESC:

110610798 110615155

POP:	112323644 7458969

PEU:	105126260 105126261 105127151

PALZ:

118051029 118063447 118063448

JRE:	108979173 109007376

CILL:

122301949 122313823 122314588 122318042

CAVE:

132186273 132186621 132187609 132190093

QSU:	112008333 112008334 112025667

QLO:	115954459 115954461 115956976 115969929

TWL:	119996183 120003532 120003765

VVI:	100247576 100260872

VRI:	117912408 117931768

SLY:	101256030 101261840

SPEN:

107027329 107029833

SOT:	102582456 102585226 102586137 102587810 102603855

SSTN:

125843268 125851474 125854735 125856139 125870734

SDUL:

129881541 129888408

CANN:

107843037 107879723

LBB:	132630585 132630849 132630857 132635636

NTA:	107764580 107768458 107777550 107784038 107803386 107811679 107824953

NSY:	104213025 104234660 104245144

NTO:	104091950 104093860 104107894

NAU:	109213786 109214899 109229242

INI:	109175297 109175341 109178643 109178731 109178732

ITR:	116001767 116001970 116001971 116006391 116012272

SIND:

105156090 105164756 105178927

OEU:	111379529 111391130

EGT:	105963955 105967143

SSPL:

121767404 121778219 121780982 121782090

SMIL:

130994611 131015247

SHIS:

125210684 125216006

APAN:

127250745 127266329

HAN:	110874959 110879630 110879631 110883880 110900985

ECAD:

122598455 122610424

LSV:	111879985 111885866

CCAV:

112523679

DCR:	108208095 108209257 108225989

CSIN:

114266476 114268684 114276226 114321799

RVL:	131307593 131307597 131307628 131316732

AEW:	130756181 130780420 130780539

BVG:	104885147 104892369 104892687 104903879 104903969 104907984

SOE:	110775241 110778450 110778451 110782212 110784305

CQI:	110705857 110711421 110714229 110714524 110722103 110722104 110731645 110731774

ATRI:

130810541

MOF:

131166076

NNU:	104593673 104595141 104604665

MING:

122073468 122076863 122093392 122093453

TSS:	122655975 122656118 122666101

PSOM:

113298738 113313591 113327844 113340946 113342608 113348225 113348226 113349135 113352362 113357463 113361107

OSA:	4327936 4328142 4328143 4333257 4344509 4346054

DOSA:

Os01t0687800-00(Os01g0687800) Os02t0124400-01(Os02g0124400) Os02t0124600-00(Os02g0124600) Os03t0563100-01(Os03g0563100) Os04t0360500-01(Os04g0360500) Os04t0361500-00(Os04g0361500) Os08t0114300-01(Os08g0114300) Os08t0519100-01(Os08g0519100)

OBR:	102704284 102714071 102715368 102717331 102718199

OGL:	127752817 127761873 127763774 127767697 127781666 127782374

BDI:	100824967 100831264 100833703 100839560 100840029 100846108 104583572

ATS:	109741952 109742231 109742755 109745928 109746445 109759156 109762936 109762941 109765633 109765918 109770978 109771109 109772774 109774088 109774089 109783075 109784390 109785934 109787576

TUA:	125506456 125511676 125516204 125516306 125521250 125521998 125523318 125535264 125535347 125541072 125554781 125555883

LPER:

127300857 127301158 127301160 127314284 127314292 127315916 127326120 127331152

LRD:	124653052 124653243 124655599 124670234 124673103 124683249 124683254 124695843 124695845 124700701

SBI:	8065667 8068565 8069704 8081626

ZMA:	100286152 100501771 103640501 103653136

SITA:

101756668 101758891 101760109 101767367 101776642 101777017

SVS:	117834550 117834554 117836368 117843721 117860010 117861505

PVIR:

120648401 120655450 120667685 120678572 120678668 120679522 120693536 120698286 120707520 120711194 120712184 120712304

PHAI:

112873947 112895835 112896340 112896444 112896569 112902233

PDA:	103696384 103706838 103707507

EGU:	105042184 105047414 105055864 105059298

MUS:	103976003 103976004 103976375 103976376 103976377 103981555 103981650 108952122

ZOF:	121972732 121981092 121984901 122001966 122008737 122011480 122011795 122014446 122031546

DCT:	110098544 110113778

PEQ:	110018048 110033379

AOF:	109819924 109819925 109828244 109835304 109837064 109848476

MSIN:

131224121 131227428 131227445 131230426 131230435 131230441 131233596 131237564 131248623

NCOL:

116260054 116263615 116263966 116263991 116263996 116264555 116267246

ATR:	18426700 18430107 18436500

PPP:	112274181 112280369 112283902 112284099 112285475

MNG:	MNEG_3620 MNEG_4091 MNEG_4092 MNEG_5061 MNEG_8588

GSL:	Gasu_21710

PAN:	PODANSg2036

MTM:	MYCTH_44863

MGR:

MGG_02420

TMN:	UCRPA7_4838

FGR:	FGSG_12106

FPU:	FPSE_00272

FVR:	FVEG_13531

FOX:	FOXG_07143 FOXG_14711

NHE:	NECHADRAFT_89432

CMT:

CCM_00852

VAL:	VDBG_01857

VDA:	VDAG_01698

CFJ:	CFIO01_02936

ELA:	UCREL1_857

PFY:	PFICI_03033

MBE:

MBM_05135

BGH:	BDBG_07089

BSC:	COCSADRAFT_156375

FFU:	CLAFUR5_08886

NPA:	UCRNP2_4485

CNE:

CNN01640

CNB:

CNBN1590

CNG:	CNAG_06439

CGI:	CGB_N2380W

CDEU:

CNBG_5022

TMS:	TREMEDRAFT_45215

TASA:

A1Q1_02359

CCAC:

CcaHIS019_0206810(ALO1)

TVS:	TRAVEDRAFT_30092

DSQ:	DICSQDRAFT_155883

PCO:	PHACADRAFT_261187

SHS:	STEHIDRAFT_123099

HIR:	HETIRDRAFT_174060 HETIRDRAFT_63784

PSQ:	PUNSTDRAFT_106850 PUNSTDRAFT_110662

ADL:	AURDEDRAFT_138376 AURDEDRAFT_79130

FME:	FOMMEDRAFT_80869

GTR:	GLOTRDRAFT_121214 GLOTRDRAFT_78381

LBC:	LACBIDRAFT_248838 LACBIDRAFT_254417

CCI:	CC1G_11199

ABP:	AGABI1DRAFT115961(AGABI1DRAFT_115961)

ABV:	AGABI2DRAFT195196(AGABI2DRAFT_195196)

PCUB:

JR316_0010828

MRR:	Moror_5342 Moror_765

E1B28_013525

SCM:	SCHCO_01160309(SCHCODRAFT_01160309) SCHCO_0237513(SCHCODRAFT_0237513)

CPUT:

CONPUDRAFT_139415

SLA:	SERLADRAFT_366246

WSE:	WALSEDRAFT_16718

WIC:	J056_004700

UMA:	UMAG_10013

PFP:	PFL1_00180

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_07192

PTRC:

PtA15_11A74

PSTR:

Pst134EA_017939

MLR:	MELLADRAFT_25325

ACAN:

ACA1_367390

GTT:	GUITHDRAFT_122678

TBR:	Tb927.5.2650

TBG:	TbgDal_V3730

TCR:	507047.150

LMA:	LMJF_17_1360

LIF:	LINJ_17_1470

LDO:	LDBPK_171470

LMI:	LMXM_17_1360

LBZ:	LBRM_17_1490

LPAN:

LPMP_171320

NGR:	NAEGRDRAFT_62943

VCY:	IX92_07100

VCT:	JV59_31390

VAQ:	FIV01_07260(xyoA)

MII:	BTJ40_09190

MICT:

FIU95_07405

MICZ:

GL2_31180

MVB:	MJO52_13895

HCH:

HCH_04675

HAHE:

ENC22_09430

BSAN:

CHH28_09040

LIT:	FPZ52_18145

CYT:

cce_4306

RIV:	Riv7116_6302

SFC:	Spiaf_0243

KDI:	Krodi_2009

DOD:	DCS32_01750

PRN:	BW723_08345

PHAL:

H9I45_13120

WFU:	AXE80_11085

» show all

Reference

PMID:14962674

Authors

Ha MN, Graham FL, D'Souza CK, Muller WJ, Igdoura SA, Schellhorn HE

Title

Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase.

Journal

Genomics 83:482-92 (2004)
DOI:10.1016/j.ygeno.2003.08.018

Sequence

[mmu:268756]

LinkDB

DBGET integrated database retrieval system