KEGG ORTHOLOGY: K00214

ORTHOLOGY: K00214

Entry

K00214                      KO

Symbol

BLVRA, bvdR

Name

biliverdin reductase [EC:1.3.1.24]

Pathway

map00860

Porphyrin metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R02391

bilirubin:NAD+ oxidoreductase

R02393

bilirubin:NADP+ oxidoreductase

Disease

H01936

Hyperbiliverdinemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K00214  BLVRA, bvdR; biliverdin reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.24  biliverdin reductase
     K00214  BLVRA, bvdR; biliverdin reductase

Other DBs

COG:

COG0673

GO:

0004074

Genes

HSA:	644(BLVRA)

PTR:	463366(BLVRA)

PPS:	100976517(BLVRA)

GGO:	101145695(BLVRA)

PON:	100434664(BLVRA)

NLE:	100581836(BLVRA)

HMH:	116812504(BLVRA)

MCC:	700980(BLVRA)

MCF:	102136439(BLVRA)

MTHB:

126950173

MNI:	105494198(BLVRA)

CSAB:

103226154(BLVRA)

CATY:

105596923(BLVRA)

PANU:

101016751(BLVRA)

TGE:	112621432(BLVRA)

MLEU:

105541931(BLVRA)

RRO:	104676702(BLVRA)

RBB:	108544019(BLVRA)

TFN:	117073278(BLVRA) 117073745

PTEH:

111552284(BLVRA)

CANG:

105523790(BLVRA)

CJC:	100404177(BLVRA)

SBQ:	101051509(BLVRA)

CIMI:

108293799(BLVRA)

CSYR:

103259601(BLVRA)

MMUR:

105858418(BLVRA)

LCAT:

123646929(BLVRA)

PCOQ:

105812487(BLVRA)

OGA:	100950640(BLVRA)

MMU:	109778(Blvra)

MCAL:

110289426(Blvra)

MPAH:

110318000(Blvra)

RNO:	116599(Blvra)

MCOC:

116090867(Blvra)

ANU:	117702625(Blvra)

MUN:	110560916(Ap4e1)

CGE:	100751522(Blvra)

MAUA:

101830950(Blvra)

PROB:

127221498(Blvra)

PLEU:

114709079(Blvra)

MORG:

121460306 121465757

MFOT:

126494384

AAMP:

119814714(Blvra)

NGI:	103733050(Blvra)

HGL:	101722954(Blvra)

CPOC:

100720346(Blvra)

CCAN:

109682461(Blvra)

DORD:

105998315 105998325(Blvra)

DSP:	122120733 122120751

PLOP:

125346651 125346664 125346666

NCAR:

124990712

MMMA:

107146206(Blvra)

OCU:

100346798

OPI:	101521301(BLVRA)

TUP:	102476728(BLVRA)

GVR:

103582108

CFA:	475867(BLVRA)

CLUD:

112661285(BLVRA)

VVP:	112925818(BLVRA)

VLG:	121471481 121478308

NPO:	129494434(BLVRA)

AML:	100474311(BLVRA)

UMR:	103674578(BLVRA)

UAH:	113257951(BLVRA)

UAR:	123789449(BLVRA)

ELK:

111157033

LLV:

125081067

MPUF:

101684368(BLVRA)

MNP:	132016108(BLVRA)

MLK:	131829147(BLVRA)

NVS:	122904644(BLVRA)

ORO:	101385773(BLVRA)

EJU:	114213694(BLVRA)

ZCA:	113911751(BLVRA)

MLX:	118024538(BLVRA)

NSU:	110592624(BLVRA)

LWW:	102744280(BLVRA)

FCA:	101088735(BLVRA)

PYU:	121022250(BLVRA)

PBG:	122487694(BLVRA)

PVIV:

125156476(BLVRA)

LRUF:

124524619

PTG:	102957548(BLVRA)

PPAD:

109267994(BLVRA)

PUC:

125929795

AJU:

106977737

HHV:	120234066(BLVRA)

BTA:	504596(BLVRA)

BOM:	102279089(BLVRA)

BIU:	109557549(BLVRA)

BBUB:

102400165(BLVRA)

BBIS:

104980384(BLVRA)

CHX:	102186555(BLVRA)

OAS:	101118353(BLVRA)

BTAX:

128043362 128046452(BLVRA) 128056746

ODA:	120877506(BLVRA)

CCAD:

122437815(BLVRA) 122445143

MBEZ:

129552569(BLVRA) 129562566

SSC:	100515289(BLVRA)

CFR:	102503539(BLVRA)

CBAI:

105080543(BLVRA)

CDK:	105092327(BLVRA)

VPC:	102531101(BLVRA)

BACU:

103006819(BLVRA)

BMUS:

118900646(BLVRA)

LVE:	103073162(BLVRA)

OOR:	101285825(BLVRA)

DLE:	111184507(BLVRA)

PCAD:

102976583(BLVRA)

PSIU:

116759469(BLVRA)

NASI:

112400705(BLVRA)

ECB:	100064761(BLVRA)

EPZ:	103555616(BLVRA)

EAI:	106839159(BLVRA)

MYB:	102243524(BLVRA)

MYD:	102775325(BLVRA)

MMYO:

118666497(BLVRA) 118666507

MLF:	102420568(BLVRA)

PKL:	118711468(BLVRA)

EFUS:

103295941(BLVRA)

MNA:	107536706(BLVRA)

DRO:	112302634(BLVRA)

SHON:

118979366(BLVRA)

AJM:	119045632(BLVRA)

PDIC:

114507877(BLVRA)

PHAS:

123811438(BLVRA)

MMF:	118619652(BLVRA)

PPAM:

129063352(BLVRA)

HAI:	109375451(BLVRA)

RFQ:	117012367(BLVRA)

PALE:

102892087(BLVRA)

PGIG:

120612211(BLVRA)

PVP:	105310146(BLVRA)

RAY:	107507069(BLVRA)

MJV:	108395290(BLVRA)

TOD:	119241601(BLVRA)

LAV:	100660266(BLVRA)

TMU:

101359133

ETF:	101659942(BLVRA)

DNM:	101438042(BLVRA)

MDO:	100029544(BLVRA)

GAS:	123247440(BLVRA)

SHR:	100915926(BLVRA)

AFZ:

127553356

PCW:	110204985(BLVRA)

OAA:	100076047(BLVRA)

GGA:	420776(BLVRA)

PCOC:

116232777(BLVRA)

MGP:	100542635(BLVRA)

CJO:	107309812(BLVRA)

TPAI:

128088448(BLVRA)

LMUT:

125696297(BLVRA)

NMEL:

110393199(BLVRA)

APLA:

101793149(BLVRA)

ACYG:

106042895(BLVRA)

CATA:

118250934(BLVRA)

AFUL:

116486003(BLVRA)

TGU:	100231163(BLVRA)

LSR:	110471167(BLVRA)

SCAN:

103819361(BLVRA)

PMOA:

120504986(BLVRA)

OTC:	121346985(BLVRA)

PRUF:

121352902(BLVRA)

GFR:	102043974(BLVRA)

FAB:	101818701(BLVRA)

OMA:	130249468(BLVRA)

PHI:	102102005(BLVRA)

PMAJ:

107200264(BLVRA)

CCAE:

111923662(BLVRA)

CCW:	104688918(BLVRA)

CBRC:

103615756(BLVRA)

ETL:	114066665(BLVRA)

ZAB:	102067314(BLVRA)

ACHL:

103809049(BLVRA)

SVG:	106857417(BLVRA)

MMEA:

130573117(BLVRA)

HRT:	120759130(BLVRA)

FPG:	101924606(BLVRA)

FCH:	102055391(BLVRA)

CLV:	102097224(BLVRA)

EGZ:	104125204(BLVRA)

NNI:	104012409(BLVRA)

PCRI:

104038641(BLVRA)

PLET:

104621190(BLVRA)

EHS:	104507709(BLVRA)

PCAO:

104051371(BLVRA)

ACUN:

113477524(BLVRA)

TALA:

104358092(BLVRA)

PADL:

103914851(BLVRA)

AFOR:

103895345(BLVRA)

ACHC:

115338915(BLVRA)

HALD:

104324748(BLVRA)

HLE:	104840678(BLVRA)

AGEN:

126045462

GCL:

127013673

CCRI:

104162133(BLVRA)

CSTI:

104561932(BLVRA)

CMAC:

104482223(BLVRA)

MUI:	104540328(BLVRA)

BREG:

104641661(BLVRA)

FGA:	104077789(BLVRA)

GSTE:

104261203(BLVRA)

LDI:	104348874(BLVRA)

MNB:	103773233(BLVRA)

OHA:	104337145(BLVRA)

NNT:	104410210(BLVRA)

SHAB:

115605447(BLVRA)

DPUB:

104298257(BLVRA)

PGUU:

104464311(BLVRA)

ACAR:

104532175(BLVRA)

CPEA:

104392164(BLVRA)

AVIT:

104272407(BLVRA)

CVF:	104290330(BLVRA)

RTD:	128905863(BLVRA)

CUCA:

104065936(BLVRA)

TEO:	104381068(BLVRA)

BRHI:

104490550(BLVRA)

AAM:	106495280(BLVRA)

AROW:

112970681(BLVRA)

NPD:	112953621(BLVRA)

TGT:	104576394(BLVRA)

DNE:	112996103(BLVRA)

SCAM:

104147046(BLVRA)

ASN:	102371445(BLVRA)

AMJ:	102567480(BLVRA)

CPOO:

109310473(BLVRA)

GGN:	109291883(BLVRA)

PSS:	102463244(BLVRA)

CMY:	102933712(BLVRA)

CCAY:

125631824(BLVRA)

DCC:	119851122(BLVRA)

CPIC:

101950655(BLVRA)

TST:	117872616(BLVRA)

CABI:

116832633(BLVRA)

MRV:	120397944(BLVRA)

ACS:	100564394(blvra)

ASAO:

132778529(BLVRA)

PVT:	110081583(BLVRA)

SUND:

121935151(BLVRA)

PBI:	103049956(BLVRA)

PMUR:

107285970(BLVRA)

CTIG:

120305224(BLVRA)

TSR:	106554646(BLVRA)

PGUT:

117664992(BLVRA)

APRI:

131197609(BLVRA)

PTEX:

113437351(BLVRA)

NSS:	113422096(BLVRA)

VKO:	123035600(BLVRA)

PMUA:

114607647(BLVRA)

PRAF:

128424165(BLVRA)

ZVI:	118077685(BLVRA)

HCG:	128329333(BLVRA)

GJA:	107109993(BLVRA)

STOW:

125441181(BLVRA)

EMC:	129337654(BLVRA)

XLA:	100137674(blvra.L)

XTR:	448743(blvra)

NPR:	108797466(BLVRA)

RTEM:

120940417(BLVRA)

BBUF:

121001623(BLVRA)

BGAR:

122939192(BLVRA)

MUO:	115460162(BLVRA)

GSH:	117353855(BLVRA)

DRE:	767661(blvra)

SRX:	107713657(blvra) 107757787

SANH:

107656146(blvra)

SGH:	107599292 107600218(blvra)

CCAR:

109049161 109103811

CAUA:

113045342 113113305

CGIB:

127935988 127950552

PTET:

122341767(blvra)

LROH:

127154922(blvra)

OMC:	131550914(blvra)

RKG:	130087208(blvra)

MAMB:

125251391(blvra)

CIDE:

127497671

MASI:

127441552 127443175

TROS:

130554769(blvra)

TDW:	130417825(blvra)

MANU:

129441661(blvra)

IPU:	100528810(blvra)

IFU:	128609679(blvra)

PHYP:

113540050(blvra)

SMEO:

124387103(blvra)

TFD:	113644061(blvra)

TVC:	132848289(blvra)

TRN:	134311299(blvra)

AMEX:

103037727(blvra)

CMAO:

118825906(blvra)

EEE:	113584243(blvra)

CHAR:

105906987(blvra)

TRU:	101070243(blvra)

TFS:	130539302(blvra)

TNG:	GSTEN00005221G001

LCO:	104930153(blvra)

TBEN:

117470078 117470079

PGEO:

117457256(blvra)

GACU:

117534890 117534891 117534897 117537556 117557372

EMAC:

134865757(blvra)

ELY:	117271967(blvra)

EFO:	125902825(blvra)

PLEP:

121951682(blvra)

SLUC:

116043927(blvra)

ECRA:

117954643(blvra)

ESP:	116699657(blvra)

PFLV:

114565488(blvra)

GAT:	120816012(blvra)

PPUG:

119209594(blvra)

AFB:	129088866(blvra)

CLUM:

117746774(blvra)

PSWI:

130197866(blvra)

MSAM:

119898414 119902545

SCHU:

122886470(blvra)

CUD:	121520165(blvra)

ALAT:

119010937(blvra)

MZE:	101473603(blvra)

ONL:	100707226(blvra)

OAU:	116334117(blvra)

OLA:	101175193(blvra)

OML:	112151831(blvra)

CSAI:

133452309(blvra)

XMA:	102229366(blvra)

XCO:	114147006(blvra)

XHE:	116721392(blvra)

PRET:

103479218(blvra)

PFOR:

103132196 103132198

PMEI:

106912489

GAF:	122840784(blvra)

PPRL:

129361580(blvra)

CVG:	107099251(blvra)

CTUL:

119781479(blvra)

GMU:	124869467(blvra)

NFU:	107384337(blvra)

AOCE:

111570374(blvra)

MCEP:

125010503(blvra)

POV:	109637664(blvra)

SSEN:

122781407(blvra)

HHIP:

117777785(blvra)

HSP:	118117736(blvra)

PPLT:

128455107(blvra)

SMAU:

118311213(blvra)

LCF:	108873329 108896723(blvra)

SDU:	111233913(blvra)

SLAL:

111648412(blvra)

XGL:	120799498(blvra)

HCQ:	109515486(blvra)

SSCV:

125985518

SBIA:

133511069(blvra)

PEE:	133411408(blvra)

PTAO:

133488583(blvra)

BPEC:

110168032(blvra)

MALB:

109971399(blvra)

BSPL:

114845037(blvra)

SJO:	128369249(blvra)

SASA:

106569211(blvra) 106599287

STRU:

115157081(blvra) 115169698

OTW:	112226884 112260526

OMY:	110508670 110530384(blvra)

OGO:	124009326(blvra) 124041810

ONE:	115103034 115114471(blvra)

OKI:	109872337 109874927(blvra)

OKE:	118394717 118402049

SALP:

111956520(blvra) 111979178

SNH:	120020327 120055899

CCLU:

121535274(blvra)

ELS:	105024256(blvra)

SFM:	108934031(blvra)

PKI:	111851401(blvra)

AANG:

118234043(blvra)

LOC:	102697502(blvra)

PSPA:

121314565(blvra)

ARUT:

117435450(blvra)

PSEX:

120529583(blvra)

CMK:	103181265(blvra)

RTP:	109932707(blvra)

CPLA:

122550255(blvra)

HOC:	132815746(blvra)

LERI:

129710086(blvra)

PMRN:

116945062(BLVRA)

LRJ:	133345393(BLVRA)

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111104201 111104210 111104634 111104780

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

NVE:

ATEN:

AMIL:

PDAM:

SPIS:

SYN:	slr1784(bvdR)

SYZ:	MYO_12210(bvdR)

SYY:	SYNGTS_0221(bvdR)

SYT:	SYNGTI_0221(bvdR)

SYS:	SYNPCCN_0221(bvdR)

SYQ:	SYNPCCP_0221(bvdR)

SYJ:	D082_05120(bvdR)

SYO:	C7I86_01140

CYA:

CYA_2461

CYB:

CYB_1431

SYNP:

Syn7502_02676

DSL:	Dacsa_2266

WNA:	KA717_27555

CMP:	Cha6605_2462

CEP:	Cri9333_0116

TSZ:	OOK60_12310

LEN:	LEP3755_11850

LET:	O77CONTIG1_00600(ydgJ)

LBO:	LBWT_24670

KOV:	K9N68_27525

LSC:	KIK02_22810

LSK:	J5X98_17000

HHG:	XM38_017200(ydgJ)

PSEU:

Pse7367_2209

PSER:

ABRG53_1076

PGX:	OA858_10320

THEU:

HPC62_14710

TOG:	HNI00_17595

TSIN:

OXH18_03040

GLP:	Glo7428_0283

CHON:

NIES4102_33910

GDU:	P0S91_10795

GEN:	GM3709_2746

GEE:	GM3708_551

CAN:	Cyan10605_2173

CSN:	Cyast_1886

CYL:	AA637_13445(bvdR)

SYP:	SYNPCC7002_A2324(bvdR)

SYV:	AWQ23_11570

SYL:	AWQ21_12925

LEP:	Lepto7376_2097

SYNN:

NIES970_00050(bvdR)

MAR:	MAE_61890(bvdR)

MPK:

VL20_2197

MIQ:	B5D77_11890

MVZ:	myaer102_33990(bvdR)

HAO:	PCC7418_3675

ENN:	FRE64_16160

CYT:	cce_1608(bvdR)

CWA:	CwatDRAFT_1271

CYP:	PCC8801_1204

CYH:	Cyan8802_1233

CYC:	PCC7424_1770

CYJ:	Cyan7822_0090

TER:

Tery_0913

ARP:	NIES39_B00110(bvdR)

PAGH:

NIES204_35780

PPSU:

NO713_02938(Blvra)

PRUN:

PCC7821_00106(ydgJ)

OXY:	HCG48_06440

MVAG:

D0A34_04130

LFS:	HFV01_01140

OAC:	Oscil6304_4400

ONI:	Osc7112_4818

MPRO:

BJP34_19335

PHOR:

JWS08_18805

PYH:	NEA10_14015

MIC:	Mic7113_3639

GEI:	GEI7407_2687

GVI:	glr0850(bvdR)

GLJ:	GKIL_1362(bvdR)

GML:	ISF26_10610

ANA:	alr4149(bvdR)

NPU:	Npun_R3726

NOS:	Nos7107_2542

NOP:	Nos7524_0955

NON:	NOS3756_15210

NFL:	COO91_03826

NOE:	CLI64_06725

NSH:

GXM_05714

NED:	HUN01_21975

NPZ:	ACX27_09990

AVA:

Ava_0755

NAZ:

Aazo_0182

ANB:	ANA_C11517

ACY:	Anacy_0624

AWA:	AA650_24650

ANN:	EH233_04545

CSG:	Cylst_4447

RSIN:

B6N60_00447

HBQ:	QI031_15220

CALO:

CALT:

CALH:

CALN:

CALS:

RIV:	Riv7116_4314

FIS:	FIS3754_15940

NSPH:

BDGGKGIB_01111(ydgJ)

DOU:	BMF77_04781(ligC)

DFS:	HGD76_20120

DHT:	NG743_11180

CCUR:

IAR63_09680

CRK:	L3I90_14075

AFLO:

HEQ12_14655

STOQ:

K2F26_11820

AEE:	IM676_10265

RCS:	NIES932_04580

TOQ:	HCG51_33235

ALAX:

NIES50_58200

NCN:	BZZ01_06600

CTHE:

Chro_2639

PLP:	Ple7327_4594

SCS:	Sta7437_2854

STAN:

STA3757_01550

GLT:	GlitD10_2915(bvdR)

GCY:	LQF76_08290

CEO:	ETSB_0923(bvdR)

CER:	RGRSB_0875(bvdR)

CEEC:

P3F56_04540

MTAR:

DF168_00959(yjhC_1)

CTM:	Cabther_A1380

CVL:	J8C06_02540

CHLO:

J8C02_06680

» show all

Reference

PMID:9153203

Authors

Schluchter WM, Glazer AN

Title

Characterization of cyanobacterial biliverdin reductase. Conversion of biliverdin to bilirubin is important for normal phycobiliprotein biosynthesis.

Journal

J Biol Chem 272:13562-9 (1997)
DOI:10.1074/jbc.272.21.13562

Sequence

[syn:slr1784]

Reference

PMID:8950184

Authors

Komuro A, Tobe T, Nakano Y, Yamaguchi T, Tomita M

Title

Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase.

Journal

Biochim Biophys Acta 1309:89-99 (1996)
DOI:10.1016/S0167-4781(96)00099-1

Sequence

[hsa:644]

LinkDB

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