KEGG ORTHOLOGY: K00445

ORTHOLOGY: K00445

Entry

K00445                      KO

Symbol

WNT6

Name

wingless-type MMTV integration site family, member 6

Pathway

map04150

mTOR signaling pathway

map04310

Wnt signaling pathway

map04390

Hippo signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04916

Melanogenesis

map04934

Cushing syndrome

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05217

Basal cell carcinoma

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   04390 Hippo signaling pathway
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   04150 mTOR signaling pathway
    K00445  WNT6; wingless-type MMTV integration site family, member 6
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K00445  WNT6; wingless-type MMTV integration site family, member 6
09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K00445  WNT6; wingless-type MMTV integration site family, member 6
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05205 Proteoglycans in cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05226 Gastric cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05217 Basal cell carcinoma
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05224 Breast cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05022 Pathways of neurodegeneration - multiple diseases
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00445  WNT6; wingless-type MMTV integration site family, member 6
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K00445  WNT6; wingless-type MMTV integration site family, member 6
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Morphogens
   K00445  WNT6; wingless-type MMTV integration site family, member 6

Other DBs

GO:

0005109

Genes

HSA:	7475(WNT6)

PTR:	742467(WNT6)

PPS:	100987794(WNT6)

GGO:	101132496(WNT6)

PON:	100440643(WNT6)

NLE:	100606818(WNT6)

HMH:	116810282(WNT6)

MCC:	700573(WNT6)

MCF:	102132660(WNT6)

MTHB:

126933008

MNI:	105481234(WNT6)

CSAB:

103217884(WNT6)

CATY:

105587053(WNT6)

PANU:

100997506(WNT6)

TGE:	112636290(WNT6)

MLEU:

105528048(WNT6)

RRO:	104660036(WNT6)

RBB:	108518481(WNT6)

TFN:	117094509(WNT6)

PTEH:

111546073(WNT6)

CANG:

105504714(WNT6)

CJC:	100394855(WNT6)

SBQ:	101028364(WNT6)

CIMI:

108309074(WNT6)

CSYR:

103261268(WNT6)

MMUR:

105857713(WNT6)

LCAT:

123643997(WNT6)

PCOQ:

105808766(WNT6)

OGA:	100947622(WNT6)

MMU:	22420(Wnt6)

MCAL:

110299810(Wnt6)

MPAH:

110321884(Wnt6)

RNO:	316526(Wnt6)

MCOC:

116088584(Wnt6)

ANU:	117705525(Wnt6)

MUN:	110566399(Wnt6)

CGE:	100751289(Wnt6)

MAUA:

101842149(Wnt6)

PROB:

127226446(Wnt6)

PLEU:

114709311(Wnt6)

MORG:

121447393(Wnt6)

MFOT:

126492951

AAMP:

119821641(Wnt6)

NGI:	103727729(Wnt6)

HGL:	101698823(Wnt6)

CPOC:

100713618(Wnt6)

CCAN:

109693790(Wnt6)

DORD:

106003030(Wnt6)

DSP:	122107573(Wnt6)

PLOP:

125349902(Wnt6)

NCAR:

124981136

MMMA:

107138480(Wnt6)

OCU:

100348986

OPI:	101518428(WNT6)

TUP:	102483667(WNT6)

GVR:	103600246(WNT6)

CFA:	488527(WNT6)

CLUD:

112656503(WNT6)

VVP:	112922542(WNT6)

VLG:	121480717(WNT6)

NPO:	129523023(WNT6)

AML:	100467896(WNT6)

UAR:	123779462(WNT6)

ELK:

111145739

LLV:

125095143

MPUF:

101692089(WNT6)

MNP:	132012885(WNT6)

MLK:	131827444(WNT6)

NVS:	122901741(WNT6)

ORO:	101374890(WNT6)

EJU:	114200140(WNT6)

ZCA:	113920632(WNT6)

MLX:	118011751(WNT6)

NSU:	110592208(WNT6)

LWW:	102749681(WNT6)

FCA:	101099392(WNT6)

PYU:	121031083(WNT6)

PCOO:

112867051(WNT6)

PBG:	122481782(WNT6)

PVIV:

125174071(WNT6)

LRUF:

124514572

PPAD:

109265051(WNT6)

PUC:

125911162

AJU:

106970073

HHV:	120232462(WNT6)

BTA:	505075(WNT6)

BOM:	102286828(WNT6)

BIU:	109570782(WNT6)

BBUB:

102407032(WNT6)

BBIS:

105003779(WNT6)

CHX:	108637658(WNT6)

OAS:	101111785(WNT6)

BTAX:

128043631(WNT6)

ODA:	120854363(WNT6)

CCAD:

122426705(WNT6)

MBEZ:

129538448(WNT6)

SSC:	100622044(WNT6)

CFR:	102511574(WNT6)

CBAI:

105064094(WNT6)

CDK:	105096131(WNT6)

VPC:	102527223(WNT6)

BACU:

102997453(WNT6)

BMUS:

118898154(WNT6)

LVE:	103079243(WNT6)

OOR:	101288015(WNT6)

DLE:	111172090(WNT6)

PCAD:

102993713(WNT6)

PSIU:

116756869(WNT6)

NASI:

112411853(WNT6)

ECB:	100058824(WNT6)

EPZ:	103567913(WNT6)

EAI:	106838461(WNT6)

MYB:	102256374(WNT6)

MYD:	102757803(WNT6)

MMYO:

118662211(WNT6)

MLF:	102420490(WNT6)

PKL:	118709830(WNT6)

EFUS:

103289308(WNT6)

MNA:	107524769(WNT6)

DRO:	112308052(WNT6)

SHON:

118975399(WNT6)

AJM:	119056890(WNT6)

PDIC:

114494424(WNT6)

PHAS:

123829242(WNT6)

MMF:	118625699(WNT6)

PPAM:

129080635(WNT6)

HAI:	109380535(WNT6)

RFQ:	117025515(WNT6)

PALE:

102882368(WNT6)

PGIG:

120587668(WNT6)

PVP:	105291052(WNT6)

RAY:	107516780(WNT6)

MJV:	108390505(WNT6)

TOD:	119256219(WNT6)

SARA:

101552930(WNT6)

SETR:

126000878(WNT6)

LAV:	100675069(WNT6)

TMU:

101341737

ETF:	101661610(WNT6)

DNM:	101415471(WNT6)

MDO:	100010861(WNT6)

GAS:	123241934(WNT6)

SHR:	100933826(WNT6)

AFZ:

127553094

PCW:	110219493(WNT6)

OAA:	100089786(WNT6)

GGA:	395235(WNT6)

PCOC:

116227318(WNT6)

MGP:	100540128(WNT6)

CJO:	107317037(WNT6)

TPAI:

128077166(WNT6)

LMUT:

125697002(WNT6)

NMEL:

110400365(WNT6)

APLA:

101803438(WNT6)

ACYG:

106039313(WNT6)

CATA:

118252626(WNT6)

AFUL:

116490876(WNT6)

TGU:	100230318(WNT6)

LSR:	110468403(WNT6)

SCAN:

103814356(WNT6)

PMOA:

120496894(WNT6)

OTC:	121335765(WNT6)

PRUF:

121356613(WNT6)

GFR:	102035490(WNT6)

FAB:	101819686(WNT6)

OMA:	130255568(WNT6)

PHI:	102100841(WNT6)

PMAJ:

107207801(WNT6)

CCAE:

111931742(WNT6) 111943653

CCW:	104693964(WNT6)

CBRC:

103625542(WNT6)

ETL:	114055668(WNT6)

ZAB:	102065522(WNT6)

ZLE:	135450565(WNT6)

ACHL:

103808537(WNT6)

SVG:	106860272(WNT6)

MMEA:

130574382(WNT6)

HRT:	120755393(WNT6)

FPG:	101921385(WNT6)

FCH:	102054753(WNT6)

CLV:	102085008(WNT6)

EGZ:	104132404(WNT6)

NNI:	104010067(WNT6)

PCRI:

104039066(WNT6)

EHS:	104505552(WNT6)

ACUN:

113482396(WNT6)

TALA:

104358758(WNT6)

PADL:

103917663(WNT6)

AFOR:

103895375(WNT6)

ACHC:

115343354(WNT6)

HLE:	104832139(WNT6)

AGEN:

126039864

CCRI:

104155736(WNT6)

CMAC:

104485222(WNT6)

MUI:	104545872(WNT6)

BREG:

104634340(WNT6)

FGA:	104078926(WNT6)

LDI:	104353999(WNT6)

OHA:	104339152(WNT6)

NNT:	104405658(WNT6)

SHAB:

115608340(WNT6)

DPUB:

104309743(WNT6)

ACAR:

104523467

CPEA:

104387335(WNT6)

AVIT:

104270342(WNT6)

CVF:	104285339(WNT6)

RTD:	128913068(WNT6)

CUCA:

104056318(WNT6)

TEO:	104374240(WNT6)

BRHI:

104498258(WNT6)

AAM:	106499139(WNT6)

AROW:

112972031(WNT6)

NPD:	112942802(WNT6)

DNE:	112980272(WNT6)

ASN:	102377243(WNT6)

AMJ:	106737397(WNT6)

CMY:	114019617(WNT6)

CCAY:

125644598(WNT6)

DCC:	119863445(WNT6)

CPIC:

101949600(WNT6)

CABI:

116815230(WNT6)

MRV:	120374730(WNT6)

ACS:	100565609(wnt6)

ASAO:

132773776(WNT6)

PVT:	110078170(WNT6)

SUND:

121937348(WNT6)

PBI:	103054454(WNT6)

PMUR:

107292513(WNT6)

CTIG:

120318344(WNT6)

TSR:	106540757(WNT6)

PGUT:

117675267(WNT6)

PTEX:

113441136(WNT6)

NSS:	113410669(WNT6)

VKO:	123027422(WNT6)

PMUA:

114603052(WNT6)

PRAF:

128420168(WNT6)

ZVI:	118090869(WNT6)

HCG:	128340136(WNT6)

GJA:	107107564(WNT6)

STOW:

125427400

EMC:	129324530(WNT6)

XLA:	108701298(wnt6.L) 378676(wnt6.S)

XTR:	101733784(wnt6)

NPR:	108801546(WNT6)

RTEM:

120944204(WNT6)

BBUF:

121007458(WNT6)

BGAR:

122944945(WNT6)

MUO:	115474050(WNT6)

GSH:	117361668(WNT6)

DRE:	100332722(wnt6a) 561831(wnt6b)

SRX:	107705533 107720729 107748544 107749898(wnt6)

SANH:

107660140 107663826 107672249 107688914

SGH:	107560470 107562106 107566314 107566782

CCAR:

109055483 109095710 109097087

CAUA:

113053582 113093768 113108755

CGIB:

127960149 127965398 128020318

PTET:

122346417(wnt6a) 122351327(wnt6b)

LROH:

127166453(wnt6a) 127170910(wnt6b)

OMC:	131542488(wnt6a) 131546949(wnt6b)

PPRM:

120466700(wnt6b) 120491709(wnt6a)

RKG:	130076664(wnt6b) 130101358(wnt6a)

MAMB:

125270047(wnt6b) 125274299(wnt6a)

CIDE:

127514355 127518247

MASI:

127446627 127447195 127447880

TROS:

130556049(wnt6b) 130556440(wnt6a)

TDW:	130425271(wnt6a) 130427423(wnt6b)

MANU:

129450313(wnt6a) 129451844(wnt6b)

IPU:	108266110(wnt6b) 108273177(wnt6a)

IFU:	128608433(wnt6b) 128616173(wnt6a)

PHYP:

113523750(wnt6) 113538450

SMEO:

124383390(wnt6b) 124392807(wnt6a)

TFD:	113634433(wnt6a) 113644038(wnt6b)

TVC:	132844021(wnt6a) 132850501(wnt6b)

TRN:	134316463(wnt6a) 134324112(wnt6b)

AMEX:

103038704(wnt6a) 103041984(wnt6b)

CMAO:

118807474(wnt6a) 118812145(wnt6b)

EEE:	113574053 113591172(wnt6)

CHAR:

105902653(wnt6b) 105907597

TRU:	101062888(wnt6)

TFS:	130531699(wnt6b)

TNG:	GSTEN00031611G001

LCO:	104919603(wnt6)

NCC:	104943745(wnt6)

TBEN:

117485579(wnt6b)

CGOB:

115026789(wnt6)

PGEO:

117466240(wnt6b)

GACU:

117553349(wnt6b)

EMAC:

134867534(wnt6b)

ELY:	117251051(wnt6b)

EFO:	125899940(wnt6b)

PLEP:

121949226(wnt6b)

SLUC:

116037787(wnt6b)

ECRA:

117953529(wnt6b)

ESP:	116698144(wnt6)

PFLV:

114564177(wnt6)

GAT:	120834467(wnt6b)

PPUG:

119229296(wnt6b)

AFB:	129104659(wnt6b)

CLUM:

117750470(wnt6b)

PSWI:

130207725(wnt6b)

MSAM:

119903884(wnt6b)

SCHU:

122885941(wnt6b)

CUD:	121522835(wnt6b)

ALAT:

119026491(wnt6b)

MZE:	101474169(wnt6)

ONL:	100695021(wnt6)

OAU:	116312607(wnt6b)

OLA:	101174712(wnt6)

OML:	112155468(wnt6b)

CSAI:

133446144(wnt6b)

XMA:	102234174(wnt6)

XCO:	114148282(wnt6)

XHE:	116723283(wnt6)

PRET:

103460530(wnt6)

PFOR:

103145323(wnt6)

PLAI:

106948454(wnt6)

PMEI:

106917208(wnt6)

GAF:	122840212(wnt6b)

PPRL:

129361481(wnt6b)

CVG:	107092662(wnt6)

CTUL:

119785174(wnt6b)

GMU:	124871939(wnt6b)

NFU:	107390192(wnt6)

KMR:	108238486(wnt6b)

ALIM:

106523158(wnt6)

NWH:	119419040(wnt6b)

AOCE:

111580967(wnt6)

MCEP:

125017242(wnt6b)

CSEM:

103392496

POV:	109631098(wnt6)

SSEN:

122760557(wnt6b)

HHIP:

117754979(wnt6b)

HSP:	118120291(wnt6b)

PPLT:

128455955(wnt6b)

SMAU:

118282986(wnt6b)

LCF:	108902815(wnt6b)

SDU:	111218508(wnt6)

SLAL:

111668743(wnt6)

XGL:	120801651(wnt6b)

HCQ:	109522420(wnt6)

SSCV:

125973797

SBIA:

133512371(wnt6b)

PEE:	133410472(wnt6b)

PTAO:

133486763(wnt6b)

BPEC:

110156189(wnt6)

MALB:

109964395(wnt6)

BSPL:

114847627(wnt6b)

SJO:	128367925(wnt6b)

SASA:

106581837(wnt6) 106586152

STRU:

115156104 115160681

OTW:	112225157 112235519

OMY:	101268914 110504149

OGO:	124042034 124043804

ONE:	115115270 115139101

OKI:	109871286 109904146

OKE:	118367144 118385962

SALP:

111972696 111974089(wnt6)

SNH:	120057846 120063851

CCLU:

121536676 121551654

ELS:	105029531(wnt6)

SFM:	108927964(wnt6)

PKI:	111848415(wnt6) 111858301

AANG:

118214470 118222883

LOC:	102696070(wnt6)

PSPA:

121321402 121322785(wnt6b)

ARUT:

117413004 117426563

PSEX:

120531727(wnt6b)

LCM:	102350297 102352652(WNT6)

CMK:	103188488(wnt6b) 103190982

RTP:	109913260 109924631

CPLA:

122543424 122551802

HOC:	132805716 132817723

LERI:

129714681 129716130

PMRN:

116948997(WNT6) 116954729

LRJ:	133345243(WNT6)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100313763(Wnt6)

DME:	Dmel_CG4969(Wnt6)

DER:

6542672

DSE:

6611515

DSI:	Dsimw501_GD23460(Dsim_wg)

DYA:	Dyak_GE14461

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23666

DAZ:

DNV:

DHE:

DVI:

MDE:

SCAC:

LCQ:

LSQ:	119608003 119613024

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

109419325 109623251 115265604

ASUA:

134217569

CQU:	CpipJ_CPIJ005838

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	656429(Wnt6)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:	108909120 108915533

LDC:

DVV:

NVL:

APLN:

OTU:

BMOR:

BMAN:

MSEX:

115456310 119190270 119190271

DPL:	KGM_214293

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

BTAB:

DCI:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM151640

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_290641(WNT6)

DMK:

116915929

DPZ:

124327205

PVM:	113812192 113827793

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

PPOI:

ISC:	121832983 8029105

DSV:

119442520

RSAN:

119387060 119387164

RMP:

119159437

TUT:	107364078 107364164 107370619

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_136505

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:	5496534 5508902 5509528 5509554 5509555

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

RES:

Reference

PMID:11350055

Authors

Kirikoshi H, Sekihara H, Katoh M

Title

WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells.

Journal

Biochem Biophys Res Commun 283:798-805 (2001)
DOI:10.1006/bbrc.2001.4855

Sequence

[hsa:7475]

Reference

PMID:22370641

Authors

Yuan G, Regel I, Lian F, Friedrich T, Hitkova I, Hofheinz RD, Strobel P, Langer R, Keller G, Rocken C, Zimmermann W, Schmid RM, Ebert MP, Burgermeister E

Title

WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells.

Journal

Oncogene 32:375-87 (2013)
DOI:10.1038/onc.2012.40

Sequence

[hsa:7475]

LinkDB

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