KEGG   ORTHOLOGY: K00492
Entry
K00492            Tight     KO                                     
Symbol
tmuM
Name
1,3,7-trimethyluric acid 5-monooxygenase [EC:1.14.13.212]
Pathway
map00232  Caffeine metabolism
map01120  Microbial metabolism in diverse environments
Reaction
R11153  1,3,7-trimethylurate,NADH:oxygen oxidoreductase (1,3,7-trimethyl-5-hydroxyisourate forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K00492  tmuM; 1,3,7-trimethyluric acid 5-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.212  1,3,7-trimethyluric acid 5-monooxygenase
     K00492  tmuM; 1,3,7-trimethyluric acid 5-monooxygenase
Genes
AG: AFO10115(tmuM)
Reference
  Authors
Mohanty SK, Yu CL, Das S, Louie TM, Gakhar L, Subramanian M
  Title
Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism.
  Journal
J Bacteriol 194:3872-82 (2012)
DOI:10.1128/JB.00597-12
  Sequence
LinkDB

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