KEGG ORTHOLOGY: K00603

ORTHOLOGY: K00603

Entry

K00603                      KO

Symbol

fctD

Name

glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2]

Pathway

map00340

Histidine metabolism

map00670

One carbon pool by folate

map01100

Metabolic pathways

Module

M00045

Histidine degradation, histidine => N-formiminoglutamate => glutamate

Reaction

R02287

5-formiminotetrahydrofolate:L-glutamate N-formiminotransferase

R02301

5-formyltetrahydrofolate cyclo-ligase (ADP-forming)

R03189

5-formyltetrahydrofolate:L-glutamate N-formiminotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00340 Histidine metabolism
    K00603  fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00603  fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.5  glutamate formimidoyltransferase
     K00603  fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.2  5-formyltetrahydrofolate cyclo-ligase
     K00603  fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase

Other DBs

COG:

COG3643

GO:	0030409 0030272

Genes

BBAY:

A4V04_09620

HNI:	W911_06225

FIL:	BN1229_v1_0522

FIY:	BN1229_v1_0525

DLM:	DPPLL_09310

DBK:	DGMP_20080

DML:	Dmul_14120(ftcD1)

DMM:	dnm_068630(ftcD)

SAT:

SYN_00461

SPY:

SPy_2083

SPZ:	M5005_Spy1772

SPYM:

M1GAS476_1820

SPYA:

A20_1815(ftcD)

SPM:	spyM18_2142

SPG:	SpyM3_1774

SPS:

SPs1771

SPH:	MGAS10270_Spy1838

SPI:	MGAS10750_Spy1864

SPJ:	MGAS2096_Spy1805

SPK:	MGAS9429_Spy1783

SPF:

SpyM51730

SPA:	M6_Spy1769

SPB:	M28_Spy1756

STG:	MGAS15252_1616(fctD)

STX:	MGAS1882_1677(fctD)

SOZ:	Spy49_1725

STZ:	SPYALAB49_001753(ftcD)

SPYH:

L897_08810

SPYO:

STAB901_08620

SSA:

SSA_0434

SGO:	SGO_1806(ftcD)

SDS:

SDEG_2057

SDG:	SDE12394_10380

SDA:

GGS_1889

SDC:	SDSE_2157(FTCD)

SDQ:	SDSE167_2155

STK:

STP_0392

SCP:	HMPREF0833_11149(ftcD)

SCF:

Spaf_1717

SOI:	I872_01190

SIK:

K710_1368

SIQ:	DQ08_06340

SIO:	DW64_06335

SIZ:	SI82_06490

SIG:	N596_05530

SIP:	N597_07385

SKI:	D7D50_05080(ftcD)

SCAI:

NCTC12191_00728

SPSU:

NCTC13786_01894

SPOC:

NCTC10925_01269

SAUP:

NCTC3168_01110(ftcD)

SVF:	NCTC3166_01638(ftcD)

SRUN:

LPB404_08775(ftcD)

ETH:	CK496_05180(ftcD)

ESG:	EsVE80_00960

EMS:	P3T75_13190(ftcD)

VTE:	BHY08_07575

VCP:	H9L18_10740(ftcD)

VHY:	G7082_10050(ftcD)

VFV:	K5K99_06915(ftcD)

VLC:	G314FT_20330

VIE:	OL234_06095(ftcD)

ASAN:

AWM72_05025

IRU:	M0R79_03585(ftcD)

CTC:

CTC_02305

CTET:

BN906_02518

CLJ:	CLJU_c21500

CAH:	CAETHG_0237(ftcD)

CSQ:

CSCA_3654

CACE:

CACET_c03050(ftcD) CACET_c32550

CCK:	Ccar_23050

CEU:	A7L45_08075

CFM:	BJL90_01680

CARG:

RSJ17_08200

CDRK:

B9W14_01350

CCOH:

SAMEA4530647_1981

CLOS:

DMR38_11055(ftcD)

CCAA:

KQH81_06235(ftcD)

CTAG:

LL095_12210(ftcD)

CALE:

FDN13_08360(ftcD)

CALD:

PWK10_12135(ftcD) PWK10_12285(ftcD)

CRS:	FQB35_01070(ftcD) FQB35_12570(ftcD) FQB35_13075(ftcD)

CPRF:

K7H06_14430(ftcD) K7H06_17205(ftcD)

CRAS:

KVH43_02155(ftcD)

OCW:	OW730_12135(ftcD)

PROQ:

P6M73_12275(ftcD)

OVA:	OBV_12230 OBV_12330

LASA:

L9O85_05265(ftcD) L9O85_05280(ftcD)

STH:

STH3192

SALQ:

SYNTR_1301

DOR:	Desor_5015

DAI:	Desaci_4226

DMI:	Desmer_4009

FWA:	DCMF_10675

AACX:

DEACI_0871

ACAE:

HYG86_08725(ftcD)

SAY:

TPY_0925

SAP:	Sulac_2720

STHR:

BXT84_08480

HFV:

R50_1799

FMS:	M1R53_06030(ftcD)

PROM:

QO263_02260(ftcD) QO263_10045(ftcD)

BYL:	A4V09_10310

BHAN:

CGC63_11335(ftcD)

BLAU:

DQQ01_11205(ftcD)

BPRO:

PMF13cell1_03209

BLAR:

LC508_07945(ftcD)

BCOC:

BLCOC_23010

CSO:

CLS_36910

STOM:

QU660_02440(ftcD)

VGU:	HYG85_18620(ftcD)

VPY:	HZI73_17935(ftcD)

AMIJ:

EQM06_00460(ftcD)

AMIC:

Ami3637_06870(ftcD)

ABUT:

Ami103574_01595(ftcD)

ETM:	CE91St48_01390

AMT:	Amet_4073 Amet_4586

AOE:	Clos_0361 Clos_0580

GFE:	Gferi_10445 Gferi_16125

CSPO:

QNI18_11595(ftcD)

PBIF:

KXZ80_02950(ftcD) KXZ80_09885(ftcD)

PSOR:

RSJ16_02900

TEM:	JW646_12585(ftcD) JW646_19355(ftcD)

TGC:	L0P85_09005 L0P85_15095(ftcD)

TMY:	TEMA_23020

TEB:

T8CH_2476

THYR:

P4S50_04685(ftcD)

IBR:	NQ514_05495(ftcD)

PBQ:	C3V37_06710(ftcD)

EAC:	EAL2_808p06030

CST:	CLOST_1282

TTE:

TTE0450

TEX:	Teth514_0390

THX:

Thet_0437

TPD:	Teth39_1836

TIT:

Thit_0420

TMT:	Tmath_0502

TBO:	Thebr_1884

TWI:	Thewi_0507

CHY:	CHY_0695(ftcD)

TPZ:	Tph_c20440(ftcd)

GEK:	kuro4_08460

TTM:

Tthe_2241

TTO:	Thethe_02323

TXY:	Thexy_1941

TSH:

Tsac_0044

TEP:	TepRe1_0775

TAE:	TepiRe1_0840

BACG:

D2962_04785(ftcD)

TOC:

Toce_1474

NTH:	Nther_2818

HPK:	Hprae_0089

AAR:	Acear_1939

AFT:	BBF96_15240

KME:	H0A61_01271

HPRF:

HLPR_02750(ftcD_1) HLPR_12700(ftcD_2)

PED:	ING2D1G_0116 ING2D1G_0162(ftcd)

PHAR:

NCTC13077_00302

PEQU:

O6R05_01160(ftcD)

MHAP:

JFY71_01555(ftcD)

CAD:	Curi_c03010(ftcD)

SPOA:

EQM13_04095(ftcD)

KPAR:

JL105_06140(ftcD)

CAZO:

G3A45_08665(ftcD)

TIS:	P3962_00475(ftcD) P3962_11985(ftcD) P3962_14425(ftcD)

TIZ:	RBU61_09360(ftcD) RBU61_18615(ftcD)

SEDZ:

JYG23_06485(ftcD)

ECOU:

M1R54_08080(ftcD)

PUF:

PFT:

MANA:

STED:

AFN:	Acfer_0235

AIN:

Acin_0279

ERL:	AOC36_11475

FCZ:	IMF26_09645(ftcD)

MANR:

MPAN_001580

MBJ:	KQ51_00528

XCL:	G4Z02_03225(ftcD)

TBK:	HF295_08655(ftcD)

TBM:	BK010_00795

TBZ:	BK011_00685

ABAI:

IMCC26256_112007

RMAR:

GBA65_11780 GBA65_11785

BSOL:

BALA:

CWO:

PARN:

PBAJ:

TALU:

AFO:

ATQ:	GH723_01895

AQZ:	KSP35_19245

IAM:	HC251_02120

GLJ:

GKIL_4221

ABAO:

BEQ56_10165

CAP:	CLDAP_31470

PMET:

G4Y79_13140(ftcD)

CCZ:	CCALI_01998

FGI:	OP10G_2267

NPY:	NPRO_03700

CCOT:

CCAX7_42550

VAB:

WPS_14010

UAM:	UABAM_00804

PBAP:

Pla133_14560(fchA)

TDE:

TDE_0296

TPED:

TPE_0827

TPK:	JO40_03990

TPHG:

FUT81_11925(ftcD)

ACA:	ACP_0519(ftcD)

ACM:	AciX9_1907

GMA:	AciX8_3182

GRW:	FTO74_06925(ftcD)

GRB:	GOB94_14845(ftcD)

TSA:	AciPR4_1516

TRS:	Terro_2108 Terro_2472

TALB:

FTW19_15490(ftcD)

ABAS:

ACPOL_1045

EDA:	GWR55_04165(ftcD)

EDG:	H7846_10120(ftcD)

ADIN:

H7849_09925(ftcD)

ORP:	MOP44_19640(ftcD)

CTM:	Cabther_A1910

CVL:	J8C06_02265(ftcD)

CHLO:

J8C02_09390(ftcD)

LUB:	TBR22_A31840

SCOR:

J3U87_06830(ftcD)

FNU:	FN0741 FN1407

FNC:	HMPREF0946_00225

FNT:	HMPREF0405_01030

FUS:	HMPREF0409_00839

FNE:	FSDG_00338

FHW:	RN87_06640

FPD:	CTM68_09850(ftcD)

FGO:	C4N16_03620(ftcD)

FNF:	BSQ88_01990(ftcD)

FPEI:

C4N17_03035(ftcD)

FCI:	I6I83_07900(ftcD) I6I83_10065(ftcD)

FPOL:

ERS445057_01493

CSOM:

MKD34_10675(ftcD)

TAI:

Taci_0915

CPOR:

BED41_03785 BED41_07870

ACO:	Amico_0715 Amico_1539

AMIZ:

RBH88_01935(ftcD) RBH88_08170(ftcD) RBH88_11280(ftcD)

TLI:

Tlie_0373

AMO:	Anamo_0712

PPIO:

CE91St28_23720

PYY:	RAH42_00075(ftcD) RAH42_12980(ftcD)

ARAM:

KAR29_01655(ftcD)

BTH:

BT_2693

BTHO:

Btheta7330_00393

BFR:

BF4147

BFS:	BF9343_3864(ftcD)

BFG:	BF638R_4006(ftcD)

BFB:	VU15_19090

BHL:	Bache_1091

BXY:

BXY_18190

BOA:	Bovatus_02751

BCEL:

BcellWH2_03451

BZG:	C4H11_10240(ftcD)

BHF:	C3V43_06990(ftcD)

BIS:	DXK01_007975(ftcD)

BUN:	Bun01g_11760

BEG:	INE88_02103

BSTE:

K6V31_09200(ftcD)

BFE:	K6V30_02370(ftcD)

BNO:	K8P02_15595(ftcD)

BHUM:

JXR92_006175(ftcD)

BFC:	BacF7301_02090(ftcD)

BSAL:

K6V25_01835(ftcD)

BVU:

BVU_0334

BDO:	EL88_21085

BDH:	GV66_01880

PGI:

PG_0329

PGN:

PGN_1633

PGT:	PGTDC60_1448

PAH:	Poras_1353

PCRE:

NCTC12858_00154

PCAG:

NCTC12856_00371

PEND:

LA319_01865(ftcD)

PSOE:

CE91St14_17200

PBT:	ING2E5B_1142(ftcd)

PET:	PEIBARAKI_5434

PSAC:

PSM36_1609(ftcd)

PROJ:

KDN43_13340(ftcD)

PDI:

BDI_3645

PARC:

CI960_01370(ftcD)

PMER:

INE87_02075

PGOL:

K6V26_18345(ftcD)

PJO:	LK449_00110(ftcD)

TFO:	BFO_0770(ftcD)

TOH:	BCB71_03440(ftcD)

ANF:

AQPE_3842

THEO:

IMW88_00635(ftcD)

PPEC:

H9W90_03765(ftcD)

PHG:	KCTC32516_01875

LUY:	QZH61_09495(ftcD)

SHYR:

LA303_02980(ftcD)

TMA:

TM0843

TMM:	Tmari_0845

TMI:	THEMA_00425

TMW:

TMQ:

TMX:

TPT:

TNP:

TRQ:

TNA:

THQ:	T2812B_00425

THZ:	CELL2_00450

THR:	TRQ7_00425

TLE:

Tlet_1282

TTA:	Theth_0981

PHY:	AJ81_09910

TME:

Tmel_1173

TAF:	THA_1560(ftcD)

THP:	BG95_06670

THER:

Y592_06750

TFE:	JYK00_01350(ftcD)

FNO:

Fnod_0808

FPE:	Ferpe_1011

FIA:	NA23_05005(ftcD)

FRR:	IB67_09415

OCY:	OSSY52_03880

PMO:	Pmob_0241 Pmob_1367

DTN:	DTL3_1345(ftcd) DTL3_1638

OCS:	OF820_10140(ftcD)

KOL:

Kole_1720

KPF:	IX53_04625

MPG:	Theba_0352

MINF:

MESINF_1752

ASAC:

ATHSA_1311

CPO:	COPRO5265_1036

CEX:

CSE_13370

NKF:	Nkreftii_000807

NTI:	DNFV4_04155

NALL:

PP769_01590(ftcD)

NNEO:

PQG83_12790(ftcD)

ALAM:

RT761_02637

BANA:

BARAN1_0275

BIH:	BIP78_1563

TAC:

Ta1476

TVO:	TVG0092631(TVG0092631)

PTO:

PTO1242

FAC:	FACI_IFERC01G0470

FAI:

FAD_1385

CDIV:

CPM_0208

BARC:

AOA65_0374

FLT:	Sv326_1019

LOKI:

Lokiarch_22020

LOB:	NEF87_002879

» show all

Reference

PMID:20952389

Authors

Jeanguenin L, Lara-Nunez A, Pribat A, Mageroy MH, Gregory JF 3rd, Rice KC, de Crecy-Lagard V, Hanson AD

Title

Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase.

Journal

J Biol Chem 285:41557-66 (2010)
DOI:10.1074/jbc.M110.190504

Sequence

[spy:SPy_2083]

LinkDB

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