KEGG ORTHOLOGY: K00718

ORTHOLOGY: K00718

Entry

K00718                      KO

Symbol

FUT1_2

Name

galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]

Pathway

map00601

Glycosphingolipid biosynthesis - lacto and neolacto series

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

map01100

Metabolic pathways

Reaction

R05968

R06024

R06027

R06031

R06035

R06041

R06085

R06086

R06089

R06090

R06156

R06170

galactoside alpha-1,2-L-fucosyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.69  type 1 galactoside alpha-(1,2)-fucosyltransferase
     K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Glycosyltransferases [BR:ko01003]
Glycan extension
  ABO blood group
   K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Membrane trafficking [BR:ko04131]
Endocytosis
  Others
   Fucosyltransferase
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2

Other DBs

GO:

0008107

CAZy:

GT11

Genes

HSA:	2523(FUT1) 2524(FUT2)

PTR:	104001169 468944(FUT2) 468947(FUT1)

PPS:	100990363(FUT1) 100991035 103785330

GGO:	101131113(FUT1) 101146871

PON:	100445051(FUT2)

NLE:	100589182 100589750(FUT2) 100592672(FUT1)

HMH:	116478236(FUT1) 116478240(FUT2) 116478242

MCC:	718252(FUT1) 718794 722582

MCF:	102121228 102121606 102125198(FUT1)

MTHB:

126943584 126943586 126943611

MNI:	105478651 105478653 105478657(FUT1)

CSAB:

103234986 103234988 103234996(FUT1)

CATY:

105595250 105595251 105595255(FUT1)

PANU:

101013578 101015696(FUT2)

TGE:	112612788 112613043(FUT1) 112613472

MLEU:

105539174(FUT1) 105539183

RRO:	104666550(FUT1) 104666555 104666558

RBB:	108523627 108523645(FUT2) 108523649(FUT1)

TFN:	117091518 117091519 117091525(FUT1)

PTEH:

111520070 111520123(FUT2) 111520144(FUT1)

CANG:

105514796(FUT1) 105514799(FUT2) 105514801

CJC:	100389529(FUT1) 100896666(FUT2)

SBQ:	101047116 101047433 101048065(FUT1)

CIMI:

108283885(FUT2) 108283894(FUT1)

CSYR:

103250047(FUT2) 103250056 103250472(FUT1)

MMUR:

105865666 105865678(FUT1) 105865687(FUT2) 105870481

LCAT:

123623855(FUT1) 123623859(FUT2) 123623862

PCOQ:

105809311(FUT1) 105809326 105809425(FUT2)

OGA:	100948058(FUT1) 100948992 100959714(FUT2)

MMU:	14343(Fut1) 14344(Fut2) 56546(Sec1)

MCAL:

110298382 110298509(Fut2) 110299147(Fut1)

MPAH:

110334098(Fut1) 110334752(Fut2) 110335813

RNO:	308586(Sec1) 58924(Fut2) 81919(Fut1)

MCOC:

116100499(Fut1) 116102215(Fut2) 116102218

ANU:	117694287 117714079(Fut1) 117724308(Fut2)

MUN:	110550459 110550494 110550500(Fut1)

CGE:	100751185(Fut2) 100757047(Fut1) 113836307

MAUA:

101823506 101841663(Fut1) 121136185(Fut2)

PROB:

127213939(Fut1) 127213941 127213946

PLEU:

114684672 114684692(Fut1) 114684704(Fut2)

MORG:

121449596(Fut1) 121450863 121452406

MFOT:

126488097 126488122 126488214

AAMP:

119802606(Fut2) 119802944 119803072(Fut1)

NGI:	103743624 103743625 103743628(Fut1)

HGL:	101709834(Fut1) 101710190(Fut2)

CPOC:

100728677(Fut1) 100729517 100732186(Fut2)

CCAN:

109682667(Fut2) 109682669(Fut1) 109682676

DORD:

105994138 105994139 105994140 105994357 105994359 105994380(Fut1)

DSP:	122125587 122125760(Fut1) 122125806 122125807 122125827 122125850

PLOP:

125338861(Fut1) 125338862 125368094 125368096

NCAR:

124966644 124967481

MMMA:

107151277(Fut1) 107151717 107151718

OCU:	100009290(RFT-II) 100009291(FUT1) 100349124

OPI:	101528747(FUT2) 101533603(FUT1) 101534586

TUP:	102471780 102474609(FUT1)

GVR:	103587747 103587749(FUT1) 103587776

CFA:	102151792 484396(FUT1) 484398(FUT2)

CLUD:

112645188(FUT1) 112645194(FUT2) 112645195

VVP:	112931221(FUT1) 112931228(FUT2)

VLG:	121484100 121485417(FUT1) 121485419(FUT2)

NPO:	129499635(FUT2) 129499872(FUT1) 129500309

AML:	100472596 100478397(FUT1) 100478902(FUT2)

UMR:	103657100(FUT1) 103657240 103657242

UAH:	113243333(FUT1) 113243338(FUT2) 113243340

UAR:	123776277(FUT1) 123776296(FUT2) 123776330

ELK:	111160712 111160713 111160721

LLV:	125088646 125088954 125088957

MPUF:

101671692(FUT2) 101671981 101692582(FUT1)

MNP:	132004756 132005251(FUT1) 132005746(FUT2)

MLK:	131818708 131818949(FUT1) 131818951(FUT2)

NVS:	122911857(FUT1) 122911858(FUT2) 122911865

ORO:	101374079(FUT1) 101374953(FUT2) 101375248

EJU:	114199504(FUT2) 114199506 114199624(FUT1)

ZCA:	113935287(FUT2) 113936331 113936763(FUT1)

MLX:	117998045(FUT2) 117998229 117998234(FUT1)

NSU:	110572840 110572845(FUT1) 123323182(FUT2)

LWW:	102727872(FUT1) 102728175 102747703

FCA:	101080847(FUT1) 101085847(FUT2)

PYU:	121018729(FUT2) 121018738(FUT1) 121026260

PCOO:

112851000(FUT1)

PBG:	122494860(FUT1) 122494868(FUT2) 122494869

PVIV:

125153069(FUT1) 125153413(FUT2) 125153414

LRUF:

124510939 124510940 124511820

PTG:	102962287(FUT2) 102969895(FUT1)

PPAD:

109253109(FUT1) 109253122(FUT2)

PUC:	125915148 125915780 125915781

AJU:	106988654 106988710 113593452

HHV:	120240643(FUT2) 120240672 120243441(FUT1)

BTA:	281174(FUT1) 281175(FUT2) 281483(SEC1)

BOM:	102282547(FUT1) 102283305(FUT2) 102283588

BIU:	109572956 109573030(FUT2) 109573041(FUT1)

BBUB:

102393140(FUT2) 102395162(FUT1) 102410181

BBIS:

104995617 104995618 104995621(FUT1)

CHX:	102178850 102185028 102185596(FUT1)

OAS:	101107465 101108248(FUT1) 105608435(FUT2)

BTAX:

128063786 128063792(FUT1) 128063999

ODA:	120872177(FUT1) 120872179(FUT2) 120872184

CCAD:

122420846 122420957(FUT1) 122421650(FUT2)

MBEZ:

129546587 129546588 129546591(FUT2)

SSC:	100524201(FUT2A) 397138(FUT1) 397139(FUT2)

CFR:	102521344(FUT1) 102522076(FUT2) 102522586 116661616

CBAI:

105062593 105062594 105062601(FUT1)

CDK:	105090616 105102900(FUT1) 105102904 105102922

VPC:	102530733 102531228 107033936(FUT1)

BACU:

103015344(FUT1)

BMUS:

118885425 118885442(FUT2) 118885708(FUT1)

LVE:	103080875(FUT2) 103081703(FUT1)

OOR:	101289561(FUT2)

DLE:	111180647(FUT1) 111180654(FUT2) 111180655

PCAD:

102973479(FUT1) 102996473(FUT2) 102996580

PSIU:

116744079 116744335(FUT1) 116744531(FUT2)

NASI:

112415333(FUT1) 112415664(FUT2) 112415665

ECB:	100054216 100054259 100054308 100054499(FUT1)

EPZ:	103544534 103553324(FUT1) 103553326(FUT2)

EAI:	106838254(FUT2) 106838255 106838257(FUT1)

MYB:	102257351(FUT1) 102259445(FUT2)

MYD:	102760565(FUT2) 102767518 102768655(FUT1)

MMYO:

118655350 118655402(FUT2) 118655429(FUT1)

MLF:	102425138 102430088(FUT1) 102433448 102433757

PKL:	118712167(FUT2) 118712169(FUT1) 118712177

EFUS:

103297654(FUT1) 103297656 103297782(FUT2)

MNA:	107531808(FUT2) 107531852(FUT1)

DRO:	112310077(FUT2) 112310079(FUT1)

AJM:	119043799(FUT1) 119044277(FUT2) 119059557

PDIC:

114511479 114511480 114511482(FUT1)

PHAS:

123830209(FUT1) 123830244 123830310(FUT2)

MMF:	118638875(FUT1) 118639085(FUT2) 118639300

PPAM:

129082692(FUT1) 129082792 129082793

HAI:	109391063(FUT2) 109391098(FUT1)

RFQ:	117034335(FUT1) 117035221(FUT2)

PALE:

102885708(FUT1) 102886704(FUT2)

PGIG:

120606939(FUT1) 120606992(FUT2)

PVP:	105301801(FUT1) 105301804(FUT2)

RAY:	107498802(FUT2) 107498851(FUT1)

MJV:	108393134 108393209(FUT2) 108400331(FUT1)

TOD:	119249527 119249528 119249532(FUT1)

SARA:

101558921(FUT1)

SETR:

126028611(FUT1)

LAV:	100662459 100674697(FUT1) 100675832(FUT2)

TMU:	101356480 101358508 101359037

ETF:	101648281 101648592(FUT2) 101649208(FUT1)

DNM:	101422926 101443440(FUT1) 101444337(FUT2)

MDO:	100009874 100009916 100010332 100010378 100010422 100015624(FUT1) 100018242

GAS:	123232152 123232153 123239882 123243077 123243086 123243105 123256126

SHR:	100930940 100931578(FUT1)

AFZ:	127548168 127556565

PCW:	110196105 110196106 110219782(FUT1)

OAA:	100080706 100085980 100681084

ASN:	102379237 102387217

AMJ:	102565316 102575664(FUT2) 102577364

CPOO:

109320810

PSS:	102452892 102460361 102460609 106732458

CMY:	102930615 102930836 102941010

CCAY:

125627898 125627915 125628449

DCC:	119847267 119847277 119847460 119847462

CPIC:

101931375 101931943 101933588 101933861 101936896 101949841 101950478 101950859 101953396

TST:	117888428 117888432 117888709 117888950 117888951

CABI:

116823121 116828793 116840050 116840062 116840063 116840072 116840074 116840075 116840076 116840077 116840142

MRV:	120388297 120388304 120388307 120388308 120388309 120388310 120388311 120388316 120388318 120388321 120388322 120388326

ACS:	100561462(fut2)

ASAO:

132779376(FUT2)

PVT:	110078544(FUT2)

SUND:

121934331(FUT2)

PBI:	103053688(FUT2)

PMUR:

107282448(FUT2)

CTIG:

120304493(FUT2)

TSR:	106538382(FUT2)

PGUT:

117669071(FUT2)

APRI:

131198518(FUT2)

PTEX:

113443732(FUT2)

NSS:	113418488(FUT2)

VKO:	123032081(FUT2)

PMUA:

114583227 114583228 114583229 114583232 114583233 114583234

PRAF:

128398891 128398892 128398893 128398895 128398896 128398897

ZVI:	118078806 118095493 118095494 118095495 118095498 118095499

HCG:	128329642 128331733 128331734 128332105(FUT2)

GJA:	107122202(FUT2)

STOW:

125444294 125444295

EMC:	129338430 129338638 129339526

XLA:	108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)

XTR:	100487812 100493351(fut2) 100497569 447958(fut1)

NPR:	108792625 108792632 108795149 108796048 108796049 108801078 108801079 108801081 108801082

RTEM:

120915317 120915828 120916049 120916521 120916523 120916524 120916525 120916526 120936079 120936080 120936081 120936083 120936086

BBUF:

120986925 120998931 120999020 121002347 121002358

BGAR:

122926147 122926616 122926697 122926698 122926699

MUO:	115464602 115465011 115465017 115465019 115466539 115466542 115466543 115466544

GSH:	117365462 117368079 117368667 117368675 117368676 117368677 117368679 117368716 117368717

ARUT:

117411838 117414304 117414310 117414311 117414321 117962737 117971578

LCM:	102356194 102357968(FUT1)

CMK:	103173436 103183767 103183768 103183770

RTP:

109912480

CPLA:

122539633 122561471

HOC:	132826575 132830762 132830763 132830764

LERI:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109540163 109540165 109542888 109542896

SOY:

115885653

AGRG:

126734434 126734435 126734494

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

108734594 108734597 108744520

PPYR:

116173637 116173643 116174628

OTU:

111421329

DCI:	103507867 103522072

PHU:	Phum_PHUM354220

FOC:

113208685

ZNE:	110826935 110834024

CSEC:

111866362 111869870

BROR:

134530846

IEL:	124153245 124154927 124155046 124167590

DPX:	DAPPUDRAFT_307215

DMK:

116929405

DPZ:	124328541 124340530

PVM:	113801332 113803224 113816156 113816158 113820062

PJA:	122244225 122244256 122245168 122249172 122250806 122259041 122259042 122264522 122264523 122265313

PCHN:

125040729 125041424 125041464 125041465 125042669 125047484

PMOO:

119588325 119589676 119591936

HAME:

121857928 121859712 121865565 121873191 121876429 121878319

PCLA:

123745380 123745839 123745855 123747543 123749803 123756248 123760817 123761082 123761209 123761439 123764310 123764311 123768844 123769133 123772508

CQD:	128685556 128685558 128689706 128700882 128703075

PTRU:

123503225 123503453 123503506 123503571 123503641 123503707 123503854 123506921 123507897 123520469

ESN:

126988039

MNZ:	135205632 135205767 135210404 135211191 135214440 135219154 135219163 135219168 135222828 135222829 135223332

HAZT:

108666313 108673714 108674749 108674892 108675421 108676677 108677708 108678420 108680766 108682691

EAF:	111697555 111698433 111698456 111700124 111700941 111701088 111703567 111703690 111708462 111709293 111713736

LSM:	121114872 121115871 121117554 121124525

PPOI:

119090213 119090214 119090217 119092029 119096627 119096629 119097540 119097541 119101623 119103070 119104293 119104529 119104540 119104706

CSCU:

111616725 111635294 111635298 111635299 111635300 111639905 111639907

PTEP:

107436408 107453824 107453825

ABRU:

129976331 129976523

UDV:

129224795

SDM:

118190819

LPOL:

106457771 106457772 106476526

PMEO:

129587364 129587582 129598752

HRO:	HELRODRAFT_110149 HELRODRAFT_113553 HELRODRAFT_158795 HELRODRAFT_164388 HELRODRAFT_164391 HELRODRAFT_164398 HELRODRAFT_173606 HELRODRAFT_173990 HELRODRAFT_174656

LGI:	LOTGIDRAFT_107563 LOTGIDRAFT_107907 LOTGIDRAFT_129925 LOTGIDRAFT_150955 LOTGIDRAFT_161584 LOTGIDRAFT_164689 LOTGIDRAFT_167590 LOTGIDRAFT_169777 LOTGIDRAFT_175102 LOTGIDRAFT_229229

PVUL:

126811086 126811216 126811992 126814935 126815621 126817392 126819265 126819266 126820434 126820900 126822531 126822688 126823435 126824875 126825149 126828496 130012509

BGT:	106050602 106050836 106059289 106064765 106065819 106066495 106067809 106077555 106078361 106080165

CVN:	111106526 111106863 111106977 111108056 111108149 111108539 111109325 111114790 111115005 111120678 111128195 111134347 111134834 111137720

CANU:

128158691 128159975 128159985 128160153 128160154 128165615 128165616 128165618 128165619 128172347 128178534 128179940 128180361 128180692 128181375 128187277

OED:	125646769 125648322 125651988 125651996 125652130 125652640 125654377 125656101 125656102 125657489 125660723 125660724 125669484 125672815 125672822

PMAX:

117315627 117315809 117315904 117315942 117316374 117316898 117320004 117320183 117320835 117322155 117324807 117336315 117336348 117337741 117338129 117339346 117339436 117341595

MMER:

123523565 123523771 123527929 123527930 123539602 123542382 123542599 123549943 123551987 123557094 123566230

RPHI:

132714121 132718384 132719141 132731407 132737299 132737569 132739401 132744264 132749977 132754589 132755520 132757785 132758061 132758307

DPOL:

127834834 127838058 127841322 127845359 127848546 127858400 127862968 127866168 127877154 127878513

OBI:	106868790 106869239 106871940 106875849 106877689

OSN:	115211963 115222189 115223466 115223552 115232568

LAK:	106150412 106153096 106158149 106158150 106158152 106158416 106158428 106158482 106159547 106164616 106167399 106174770 106179121 106179122 106179123 106179124 106179300 106179472

HSY:	130642079 130642080

» show all

Reference

PMID:2118655

Authors

Larsen RD, Ernst LK, Nair RP, Lowe JB

Title

Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.

Journal

Proc Natl Acad Sci U S A 87:6674-8 (1990)
DOI:10.1073/pnas.87.17.6674

Sequence

[hsa:2523]

Reference

PMID:7876235

Authors

Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB

Title

Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.

Journal

J Biol Chem 270:4640-9 (1995)
DOI:10.1074/jbc.270.9.4640

Sequence

[hsa:2524]

LinkDB

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