KEGG ORTHOLOGY: K02264

ORTHOLOGY: K02264

Entry

K02264                      KO

Symbol

COX5A

Name

cytochrome c oxidase subunit 5a

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04260

Cardiac muscle contraction

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00154

Cytochrome c oxidase

Disease

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02264  COX5A; cytochrome c oxidase subunit 5a
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K02264  COX5A; cytochrome c oxidase subunit 5a
  09159 Environmental adaptation
   04714 Thermogenesis
    K02264  COX5A; cytochrome c oxidase subunit 5a
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K02264  COX5A; cytochrome c oxidase subunit 5a
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02264  COX5A; cytochrome c oxidase subunit 5a
   05012 Parkinson disease
    K02264  COX5A; cytochrome c oxidase subunit 5a
   05014 Amyotrophic lateral sclerosis
    K02264  COX5A; cytochrome c oxidase subunit 5a
   05016 Huntington disease
    K02264  COX5A; cytochrome c oxidase subunit 5a
   05020 Prion disease
    K02264  COX5A; cytochrome c oxidase subunit 5a
   05022 Pathways of neurodegeneration - multiple diseases
    K02264  COX5A; cytochrome c oxidase subunit 5a
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K02264  COX5A; cytochrome c oxidase subunit 5a
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02264  COX5A; cytochrome c oxidase subunit 5a

Other DBs

TC:	3.D.4.11 3.D.4.8

Genes

HSA:	9377(COX5A)

PTR:	453750(COX5A)

PPS:

100988094

GGO:	101134792(COX5A)

PON:	100431194 100459812 100461926

NLE:	100582955 100588957

HMH:	116467991 116481919

MCC:	692061(COX5A) 697409

MCF:	102123322 102135848

MTHB:

126959142 126960028

MNI:	105473724 105490971

CSAB:

103245320(COX5A)

CATY:

105600051

PANU:

101001315 101006649(COX5A)

TGE:	112627705 112628394

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100401281 103795040

SBQ:

CIMI:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:	100948614 100950124 100952759 100957909

MMU:	102633230(Gm11633) 12858(Cox5a)

MCAL:

110301284

MPAH:

110328046

RNO:	100361008 252934(Cox5a)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:	102495433 106733330

GVR:

103603975

CFA:	478370(COX5A)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:	125084063 125105228

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:	102737233 102739940

FCA:	101081808 123386183

PYU:

121042004

PCOO:

112855929

PBG:	122468414 122485407

PVIV:

125168830 125169763

LRUF:

124508402 124517058

PTG:	102965948 102972662

PPAD:

109252223 109262678

PUC:

125910170

AJU:	106979393 128315574

HHV:	120221692 120235715

BTA:	444878(COX5A)

BOM:	102274326 102279149

BIU:

BBUB:

BBIS:

CHX:

OAS:	100170667(COX5A) 101117799

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100051391(COX5A)

EPZ:

103552342

EAI:

106831275

MYB:

102256974

MYD:	102759134 102775072

MMYO:

118675843 118676017

MLF:	102438422 102442031

PKL:	118710005 118728843

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:	117020379 117023549

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

TMU:

ETF:	101663125 105979674

DNM:	101412104 101421632 101433276

MDO:

100030045

GAS:	123232978 123236186

SHR:

AFZ:

PCW:

OAA:

GGA:	769735(COX5A)

MGP:

CJO:

TPAI:

LMUT:

NMEL:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108711316(cox5a.L) 443818(cox5a.S)

XTR:	549803(cox5a)

NPR:	108789014 108803003

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	326962(cox5ab) 554101(cox5aa)

SRX:	107713225 107716663 107753195 107753708

SANH:

107665137 107678975 107696286

SGH:	107576348 107595344 107598903

CCAR:

109050013 109050331 109051249 109072711

CAUA:

113043464 113066956 113118028

CGIB:

127946637 127977873 128014320

PTET:

122330327 122362498

LROH:

127157152 127180487

OMC:	131524533 131534534

PPRM:

120469259 120487569

RKG:

130104477

MAMB:

125247779 125254308

CIDE:

127499687 127500237 127507352

MASI:

127416631 127436132 127437716 127456488

TROS:

130551918 130562886

TDW:	130414258 130435675

MANU:

129419621 129434224

IPU:	108264777 108275329

IFU:	128606450 128618558

PHYP:

113526324 113530128

SMEO:

124392912 124395325

TFD:	113650741 113660088

TVC:	132851576 132856888

TRN:	134310891 134323041

AMEX:

103042980 103046663

CMAO:

118811748 118818263

EEE:	113576589 113582551

CHAR:

105912564 105912624

TRU:	101061120 101080058

TFS:	130521522 130535811

TNG:	GSTEN00022428G001 GSTEN00029807G001

LCO:	104920739 104940605

NCC:

104942717

TBEN:

117471227 117482644 117491857 117496657 117496659 117496969 117496979

CGOB:

115004834 115009131

PGEO:

117441804 117444777 117448585

GACU:

117538909 117554941 117554943 117557579 117557581

EMAC:

134858343 134863659

ELY:	117251262 117261818

EFO:	125881257 125887767

PLEP:

121944560 121950221

SLUC:

116037644 116038550

ECRA:

117945705 117949671

ESP:	116691962 116694269

PFLV:

114556787 114560169

GAT:	120809289 120832109

PPUG:

119196625 119198478

AFB:	129104910 129108405

CLUM:

117728879 117732663

PSWI:

130192191 130195241

MSAM:

119890004 119893947 119917853

SCHU:

122874725 122879974

CUD:	121513664 121514613

ALAT:

119017508 119024807

MZE:	101467933 101479677 112430040

ONL:	100697142 100707142

OAU:	116325569 116332710

OLA:	101170179 101170993

OML:	112152838 112160863

CSAI:

133421842 133443748

XMA:	102219286 102234756

XCO:	114133329 114143184

XHE:	116710856 116718149

PRET:

103462609 103466419

PFOR:

103149865 103150244 107833048

PLAI:

106940652 106949857 106961258

PMEI:

106907661 106908883 106911009 106920157

GAF:	122836239 122840672

PPRL:

129364106 129366964

CVG:	107096723 107097411

CTUL:

119775815 119797361

GMU:	124867291 124877668

NFU:	107382043 107388450

KMR:	108229904 108243325

ALIM:

106526837 106536482

NWH:	119416365 119430159

AOCE:

111587412 111587615

MCEP:

125004969 125015509

CSEM:

103379310 103380452

POV:	109624165 109624879

SSEN:

122760719 122772069

HHIP:

117755185 117762884

HSP:	118110196 118113908

PPLT:

128437737 128444321

SMAU:

118302787 118315548

LCF:	108876744 108897646 108899935

SDU:	111219760 111229626

SLAL:

111652361 111658526 111672239

XGL:	120793685 120800213

HCQ:	109507663 109513891

SSCV:

125966744 125970808

SBIA:

133498216 133502478

PEE:	133402818 133415721

PTAO:

133474038 133478584

BPEC:

110159545 110169588 110175446

MALB:

109969944 109974104

BSPL:

114852099 114857206

SJO:	128356287 128359334

SASA:

106561721 106562120 106584709(COX5A) 106587211(COX5A)

STRU:

115167309 115192860 115197693 115203038

OTW:	112236257 112249137 112263663 112266675

OMY:	110506495 110521232 110526359

OGO:	124033792 124035773 124037507

ONE:	115112201 115113623 115121311 115144689

OKI:	109884273 109887203 109895423 109897696

OKE:	118359089 118377452 118393822 127921832

SALP:

111972027 111975129 112069896 112071844

SNH:	120025351 120046637 120052341 120066456

CCLU:

121540790 121555739

ELS:	105015703 105018312

SFM:

108926272

PKI:	111847963 111848197

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG14724(COX5A)

DER:

6553989

DSE:

6606765

DSI:	Dsimw501_GD18785(Dsim_CoVa)

DYA:	Dyak_GE24204

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10146

DNV:

DHE:

DVI:

CCAT:

BOD:	106627685 106627789

BDR:	105226066 105226068

RZE:	108370500 108380468 108380479

AOQ:	129235614 129236119

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	5565701 5574761

AALB:

109411963 109426306

ASUA:

134223730 134227424

CQU:	CpipJ_CPIJ008200 CpipJ_CPIJ008921

CPII:

120416497 120423165 120426911 120429731

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100114682(Cox5a)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109533883 109540068

SOY:	115876637 115888643 115890445

AGRG:

126745869 126748993

ATD:	109601425 109608956

CSET:

123313519 123321366

AGB:	108912153 108916454

LDC:	111508607 111513416

DVV:	114326521 126881972

NVL:	108556291 108563496 108567106

APLN:

108737331 108738305

PPYR:

116165652 116168867 116170742

OTU:	111416739 111417254

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103506449 103510081

CLEC:

106665059 106666647

HHAL:

106689023

NLU:	111045039 111056141 120356043

HVI:

124354559

MQU:

128996629

PHU:	Phum_PHUM477570

FOC:	113202228 113209903

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:

DPX:	DAPPUDRAFT_55751

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_Y37D8A.14(cox-5A)

CBR:	CBG_15765(Cbr-cco-2)

CRQ:	GCK72_010959

NAI:	NECAME_09395

BMY:	BM_BM6383(Bma-cox-5A)

LOA:	LOAG_17383

TSP:

Tsp_01228

HRO:	HELRODRAFT_70304

LGI:	LOTGIDRAFT_157909

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_148800

SHX:	MS3_00000489(COX5A_1) MS3_00004713(COX5A_2)

OVI:	T265_11550

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

TAD:	TRIADDRAFT_22356

AQU:

100638045

SCE:	YHR051W(COX6)

SEUB:

DI49_2456

SPAO:

SPAR_H00940

AGO:	AGOS_ACL110W

ERC:

Ecym_7367

KLA:	KLLA0_F21890g

KMX:	KLMA_40253(COX6)

LTH:	KLTH0G06842g

VPO:	Kpol_1051p18

ZRO:	ZYRO0G16192g

CGR:	CAGL0J00429g

NCS:	NCAS_0A06610(NCAS0A06610)

NDI:	NDAI_0D01650(NDAI0D01650)

TPF:	TPHA_0E02230(TPHA0E02230)

TBL:	TBLA_0C03120(TBLA0C03120)

TGB:	HG536_0E03570

TDL:	TDEL_0E03460(TDEL0E03460)

KAF:	KAFR_0J00510(KAFR0J00510)

KNG:	KNAG_0B04930(KNAG0B04930)

ZMK:	HG535_0A04600

PPA:	PAS_chr3_0824

DHA:	DEHA2E20658g

PIC:	PICST_82299(COX6)

SPAA:

SPAPADRAFT_60839

LEL:	PVL30_001253(COX6)

CAL:	CAALFM_C203470CA(COX6)

CTP:	CTRG_01195

COT:	CORT_0A10820

CDU:	CD36_18220

CTEN:

CANTEDRAFT_116091

YLI:	YALI0E10144g

CLUS:

A9F13_23g00198

CAUR:

CJI96_0005297

PKZ:	C5L36_0C02290

BNN:	FOA43_004176(COX6)

BBRX:

BRETT_001950(COX6)

OPA:	HPODL_01334

SLUD:

SCDLUD_004441

NCR:	NCU06695(cox-6)

NTE:	NEUTE1DRAFT115792(NEUTE1DRAFT_115792)

SMP:	SMAC_06640

PAN:	PODANSg9012

PBEL:

QC761_211540(COX6)

PPSD:

QC762_211540(COX6)

PPSP:

QC763_211540(COX6)

PPSA:

QC764_211540(COX6)

TTT:	THITE_2107570

MTM:	MYCTH_2301316

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_5834

SSCK:

SPSK_05525

FPU:	FPSE_04156

FPOA:

FPOAC1_011133(COX6)

FVN:	FVRRES_12160

FVR:	FVEG_07914

FOX:	FOXG_01556

NHE:	NECHADRAFT_101622

FFC:	NCS54_01144700

FKR:	NCS57_01135200

FMU:	J7337_003031(COX6)

TRE:	TRIREDRAFT_53318

TRR:	M419DRAFT_119953

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_07952

PTKZ:

JDV02_005141(COX6)

VAL:	VDBG_04168

VDA:	VDAG_01394

CFJ:	CFIO01_09534

CLUP:

CLUP02_07802

CHIG:

CH63R_04117

SAPO:

SAPIO_CDS8935

ELA:	UCREL1_4633

PFY:	PFICI_10903

SSL:	SS1G_01396

BFU:	BCIN_02g04250(Bccox6)

MBE:

MBM_08438

PSCO:

LY89DRAFT_696793

GLZ:	GLAREA_11699

ANI:	ANIA_08118

AFM:	AFUA_5G02750

ACT:	ACLA_002410

NFI:	NFIA_039350

ANG:	An02g09930

AFV:	AFLA_011838

ALUC:

AKAW2_10843S(COX6)

ACHE:

ACHE_50975S(COX6)

APUU:

APUU_60905S(COX6)

PDP:	PDIP_51150

POU:	POX_a00120

TMF:	EYB26_004132

TRG:	TRUGW13939_10811

CIM:	CIMG_06473

CPW:	CPC735_029640

URE:	UREG_03945

PBL:	PAAG_07246

PBN:	PADG_05750

ABE:	ARB_06710(cox6)

TVE:

TRV_04052

AJE:	HCAG_00437

BGH:	BDBG_01464

PNO:	SNOG_10938

PTE:

PTT_07840

BZE:	COCCADRAFT_33771

BSC:	COCSADRAFT_34139

BOR:	COCMIDRAFT_39488

AALT:

CC77DRAFT_1018465

ARAB:

EKO05_0010075

ZTR:	MYCGRDRAFT_45721

PFJ:	MYCFIDRAFT_70565

FFU:	CLAFUR5_07297

CBET:

CB0940_09082

BCOM:

BAUCODRAFT_36368

NPA:	UCRNP2_7017

TML:	GSTUM_00003834001

SPO:	SPAC1B2.04(cox6)

SOM:	SOMG_02343(cox6)

CNE:

CNB03500

CNB:

CNBB2200

CNG:	CNAG_03861

CGI:	CGB_A2610W

CDEU:

CNBG_5600

TMS:	TREMEDRAFT_56899

TASA:

A1Q1_00810

CCAC:

CcaHIS019_0501780(COX6)

TVS:	TRAVEDRAFT_33262

PCO:	PHACADRAFT_266189

SHS:	STEHIDRAFT_71985

HIR:	HETIRDRAFT_121282

PSQ:	PUNSTDRAFT_59158

ADL:	AURDEDRAFT_128739

GTR:	GLOTRDRAFT_123935

RSX:	RhiXN_09868

LBC:	LACBIDRAFT_163968 LACBIDRAFT_230418

CCI:	CC1G_10112

ABP:	AGABI1DRAFT82054(COX5A)

ABV:	AGABI2DRAFT189180(COX5A)

PCUB:

JR316_0000111

MRR:	Moror_14624

E1B28_001877 E1B28_008425

SCM:	SCHCO_02644501(SCHCODRAFT_02644501)

CPUT:

CONPUDRAFT_162852

SLA:	SERLADRAFT_454020(COX5)

WSE:	WALSEDRAFT_59705

WIC:	J056_004228

UMA:	UMAG_02477

PFP:	PFL1_01550

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_19036

PTRC:

PtA15_8A431

PSTR:

Pst134EA_015818 Pst134EA_015824

MBR:	MONBRDRAFT_9557

SRE:	PTSG_09364

» show all

Reference

PMID:18197981

Authors

Uddin M, Opazo JC, Wildman DE, Sherwood CC, Hof PR, Goodman M, Grossman LI

Title

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

Journal

BMC Evol Biol 8:8 (2008)
DOI:10.1186/1471-2148-8-8

Sequence

[hsa:9377] [ptr:453750]

LinkDB

DBGET integrated database retrieval system