KEGG ORTHOLOGY: K02268

ORTHOLOGY: K02268

Entry

K02268                      KO

Symbol

COX6C

Name

cytochrome c oxidase subunit 6c

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04260

Cardiac muscle contraction

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00154

Cytochrome c oxidase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02268  COX6C; cytochrome c oxidase subunit 6c
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K02268  COX6C; cytochrome c oxidase subunit 6c
  09159 Environmental adaptation
   04714 Thermogenesis
    K02268  COX6C; cytochrome c oxidase subunit 6c
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K02268  COX6C; cytochrome c oxidase subunit 6c
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02268  COX6C; cytochrome c oxidase subunit 6c
   05012 Parkinson disease
    K02268  COX6C; cytochrome c oxidase subunit 6c
   05014 Amyotrophic lateral sclerosis
    K02268  COX6C; cytochrome c oxidase subunit 6c
   05016 Huntington disease
    K02268  COX6C; cytochrome c oxidase subunit 6c
   05020 Prion disease
    K02268  COX6C; cytochrome c oxidase subunit 6c
   05022 Pathways of neurodegeneration - multiple diseases
    K02268  COX6C; cytochrome c oxidase subunit 6c
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K02268  COX6C; cytochrome c oxidase subunit 6c
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02268  COX6C; cytochrome c oxidase subunit 6c

Genes

HSA:	1345(COX6C)

PTR:	741071(COX6C)

PPS:

100994763

GGO:

101144243

PON:	100172239(COX6C) 112130512

PPYG:

NLE:

HMH:

SSYN:

MCC:	100424587 100428417(COX6C) 106994954 703685

MCF:	102137297(COX6C) 123573614

MTHB:

126954498 126961151

MNI:	105476076 112427459

CSAB:

103237200

CATY:

105586528

PANU:

101013819 108586074

TGE:	112624362 112629896

MLEU:

105529563

RRO:	104679876 115892804 115893203 115894606 115895267

RBB:	108526140 108536532 108538160 108541227 108543345

TFN:

117078869

PTEH:

111520904 111524216 111525843 111534970 111554066 111554207 113219478 113222372

CANG:

105504339

SBQ:

104651513

CIMI:

108281471 108286901 108295926 108312576

ANAN:

105719661 110567054

CSYR:

103268110 110595091 110596061 110596332 110596375 110596503 110596727

MMUR:

109729382 109729580 109729728 109730662 109730744 109730745 109730976 109730981 109731077 109731090 109731103 109731316

LCAT:

123627957 123640204 123640642 123641584 123644332 123644675

ERUF:

138381722(COX6C)

PCOQ:

105809747

MMU:	12864(Cox6c)

MCAL:

110305545 110310606

MPAH:

110335202

RNO:	120098258 54322(Cox6c)

MCOC:

116082439

ANU:	117718463(Cox6c)

ASYL:

127667922 127672085 127680207 127686310

MUN:	110549789 110563852

CGE:

103161269

MAUA:

106021169 110341366

PROB:

127235327

PLEU:

114694673 114703635 114704190 114708619

PMAV:

102924537(Cox6c)

MORG:

121437587

MFOT:

126514379

AAMP:

119804134 119823502

CNL:	130867336 130889050

NGI:

103732827

HGL:	101699151 101708302 101716380 101718512

CPOC:

100717856 100733853

CCAN:

109690697

DORD:

105981213 105982753 105988921

DSP:	122102359 122112426 122112583 122114643

DMER:

138805895(Cox6c)

NCAR:

124961590 124979038 124984069

SVUL:

306653387(COX6C) 306664019(ACX6B4_026451)

MMMA:

107142829

ITI:	101963489 101970194

OCU:	100340645 100352363 108176887

OPI:

101523181

OCZ:

121151313

TUP:	102473676 102474121 102477164 102480389 102481250 102483892 102495237 102495328 102499736 102500176 102502668

CLUD:

VVP:

VLG:

NPO:

UMR:

ELK:	111146812 111147664

MPUF:

101693169

MNP:

132020824

NVS:	122896390 122914073

ORO:	101362231 101363251 101380418 101381368

EJU:	114197981 114213397

ZCA:	113910988 113922735 118356769

MLX:	118005417 118025026

MANO:

123834381 123853541

NSU:	110585078 110593289

LWW:	115937189 115938872

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:	120220913 120234592

CCRU:

144218313(COX6C)

BTA:	132342342 132344161 132345058 614700(COX6C) 782486

BOM:	102269295(COX6C)

BIU:

109568427

BJV:

133260159

BBUB:

102398794 123329348 123333121

BKE:	129627029 129631576 129641804

BBIS:

105005500

CHX:

102173770

OAS:	105609918 114110816 121816491 121817235 121817503 121818807

OCAN:

138419707 138424134 138426616 138439030 138445942(COX6C)

CSUM:

138082384 138082607 138088667 138088771(COX6C) 138089990 138095781

ODA:	120854882 120861918 120864707 120872800 120878268 120878438

CCAD:

122451325

MREE:

136144996(COX6C)

OVR:	110151303(COX6C)

MBEZ:

129559906

SSC:	100037989(COX6C) 102157773

CFR:

CBAI:

CDK:

VPC:

BMUS:

118883721 118894139 118895908

LVE:

103073864

OOR:	117202988 117203493

LALB:

132504207 132508338 132529089

GMF:	115856596(COX6C) 138842406 138842578 138842844

DDP:	132413176(COX6C)

SCOO:

307176160(COX6C) 307182532(ACYUVP_007805) 307193667(ACYUVP_018940)

DLE:	111173965 111177953 111180389

PSIU:

116738889 116742758 116749600 116749681 116760307

PPHC:

136119289 136124773 136131496 136137250(COX6C)

NASI:

112394363 112398864 112407288 112413993

ECB:

100055813

EPZ:	103564642(COX6C)

EAI:	106842364 123285498

MYB:	102241508 102243868 102258861

MYD:	102761581 102766586 102768725

MMYO:

118670671 118671315

MLF:	102418419 102422714 102424653

MDT:	132216537 132219682 132222142

MYUM:

138992961(COX6C) 139008149

PKL:	118703213 118718183

EFUS:

103292313 103292495

POTS:

308252450(AC0HY7_019283)

MNA:

107526132

DRO:	112304781 112315524

SHON:

118988553 119000024

AJM:

119038600

PDIC:

114490344 114514888

PHAS:

123808926 123811244 123811371 123811375 123833100

MMF:	118617840 118631656

PPAM:

129084242

HAI:	109382796 109384073 109387394 109392382 109395579

RFQ:	117016215 117018742 117022352 117027440 117029880 117034035

PALE:

PGIG:

PVP:

RAY:

MJV:	108383998(COX6C)

TOD:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:	101419806 111763815

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138156101(COX6C)

MLAO:

141493437 141497773(COX6C)

OAA:

100074669

TACU:

119926536

GGA:	420243(COX6C)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137851344(COX6C)

OJA:

118162835

ACYG:

106035328(COX6C)

CATA:

118247935

AFUL:

116486304

TGU:	100223119(COX6C)

LSR:	110470070(COX6C)

VMC:

128817889

VCHA:

128798453

AIB:	137470544(COX6C)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139587318(COX6C)

MATE:

118684268

MAEN:

136555137(COX6C)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138105363(COX6C)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136370607(COX6C)

CFAI:

136286420(COX6C)

CCIC:

NNT:

SHAB:

POCC:

FPG:

FCH:

FRS:

CCRI:

ACUN:

ANOC:

141957330(COX6C)

SURA:

141950479(COX6C)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142029211(COX6C)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

IIN:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PARX:

142053615(COX6C)

PADL:

103916121

AFOR:

103895784

FGA:

104081134

CBOR:

142078606(COX6C)

GSTE:

104257252

CBOY:

140647478(COX6C)

MAME:

142406307(COX6C)

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

PCUR:

138719303(COX6C)

TEO:

BREG:

GAME:

OHA:

ACAR:

CEUR:

306717207(COX6C)

CPEA:

CVF:

RTD:

CRID:

LMIC:

141739724(COX6C)

NARQ:

141463288(COX6C)

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102566130(COX6C)

CPOO:

109320904

GGN:

109305087

PSS:	102462108(COX6C)

CIZ:	142009196(COX6C)

CMY:

102947738

CCAY:

125632720

LKP:	140906463(COX6C)

NDS:	141982192(COX6C)

DCC:

119851856

CPIC:

101939637

TST:

117873706

CABI:

116818233(COX6C)

MRV:

120399498

EMQ:	137146089(COX6C)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139315681(COX6C)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:	118090416 118091547

HCG:

GJA:

STOW:

EMC:

XLA:	108719345 414706(cox6c.S)

XTR:	100489195 496600(cox6c)

NPR:	108788294 108789260

RTEM:

120910339 120941420

ACAT:

141127137 141145401(COX6C)

PADS:

140330594(COX6C)

BBUF:

121001969

BGAR:

122933312 122938720

DTC:	141053123(COX6C)

PWL:	138282710(COX6C)

MUO:	115479356(COX6C)

GSH:	117355887(COX6C)

DRE:	494577(cox6c)

DAES:

130230217

SRX:	107708078 107723905

SANH:

107666035

SGH:	107580333 107580788 107584200

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141347237(cox6c) 141347315

OMC:

131542468

PPRM:

120493958

RKG:

130104032

SCEP:

307166082(cox6c)

CIDE:

127513959

CERY:

137011300(cox6c)

MASI:

127446445 127449497

TROS:

130557000

MANU:

129451084(cox6c)

PDAB:

135769996(cox6c)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:	115246437(cox6c)

TFS:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117256693(cox6c)

EFO:

125895862

PLEP:

121950641

SLUC:

116034549

SVIT:

144517278(cox6c)

ECRA:

ESP:

PFLV:

PFLT:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137796639(cox6c)

CVE:	137880657(cox6c)

AMIR:

142941549(cox6c)

MSAM:

119885605

SCHU:

122870269

EARM:

139283154(cox6c)

CUD:

121505946

SPUL:

138606073(cox6c)

LMIX:

132977158

HTC:	141792234(cox6c)

ALAT:

119020564

ASTR:

137595937(cox6c)

PKLU:

139216604(cox6c)

LCO:

104938908

MZE:	101483030(cox6c)

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:	116709757 116710624

PRET:

103464817(cox6c)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:	140302991(cox6c)

MCEP:

125006866

AOCE:

111568420

EJA:	138210459(cox6c)

BFRE:

138629154(cox6c)

LCF:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

SDU:

SLAL:

XGL:

HCQ:	109522156 109522374

SSCV:

125977580(cox6c)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140365386(cox6c)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137180941(cox6c)

GMH:

115557154

SASA:

106565035(COX6C)

STRU:

115151091(cox6c) 115208425

OTW:	112254135 112266676

OMY:	110493851 110527679

OGO:	124003541 124007737

ONE:	115143646 115145288

OKI:	109890784 109890944

OKE:	118370031 118388892

OMM:	135539520 135542342

OCLA:

139369708 139414195

SALP:

111969652 112067724

SNH:	120026745 120065643

SFON:

129814785

CCLU:

121575625 123492100 123492101

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:	102354360 102366957

CMK:

103175179

RTP:

125482880

CPLA:

122549144 122556618

CPUN:

140477204(cox6c)

HOC:	132815393 132824670 132835023

SCAU:

119972761(cox6c)

LERI:

129696732

HAKA:

140730736(cox6c)

PMRN:

LRJ:

BBEL:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

DME:	Dmel_CG14028(cype) Dmel_CG31644(COX6CL)

DER:	113564224 6540623 6542919

DSE:	116803546 6613530

DSI:	Dsimw501_GD22629(Dsim_GD22629) Dsimw501_GD27165(Dsim_GD27165)

DYA:	Dyak_GE18976 Dyak_GE25385

DAN:

6497214

DSR:	110177658 110187391

DPO:	4817161 4817899

DPE:	6588817 6589288

DMN:	108161574 108162267

DWI:	6642234 6651790

DGR:	6562583 6566904

DMO:	Dmoj_GI13379 Dmoj_GI17627

DAZ:	108609876 108611185

DNV:	115563023 115565404

DHE:	111596317 111603932

DVI:	6628100(cype)

CCAT:

101451628 101456971

BOD:	106616710(COX6CL) 106622951(cype)

BDR:	105224872 125778287

RZE:	108371899 108377141

AOQ:	129239324 129248619

ALUD:

128856516 128863678

TDA:

119662070

MDE:	101895442 101900765

SCAC:

106081310 106087073

LCQ:	111681398 111687593

LSQ:

119606911

CVJ:	135951123(cype) 135956235

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ANIL:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000470

CPII:

120413609

CBRI:

134831491

CNS:	116338945 116341081

BCOO:

LLL:

PPAP:

CFEL:

BMOR:

BMAN:

MSEX:

DPL:	KGM_216158

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

ECLR:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

TCA:	100141523 656279(cox-b) 656527(cox-a)

DPA:	109543839 109543859

ESIM:

136413696 136413758

EFOR:

136339804 136339805

SOY:

115884935

RFG:	143196156 143196157 143196158

ATD:	109597450 109601435 126264201 126264528

CSET:

123307658

HAXR:

123688860

AGB:	108908530 108917535

LDC:

DVV:

NVL:

PPYR:

CCRN:

123298422 123298455 123298463

AME:	100359410(Cox6c)

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BPYO:

FVI:

CCAL:

OBB:

OLG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108727719(cype)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139101405(Cype)

TAME:

143894123(Cype)

HST:

105185989

DQU:

106741711

FEX:

115239261

OBO:	105278546(cype)

PFUC:

122514948

VVE:

124955999

NVI:	100359347(Cox6c) 116416380

TPRE:

LBD:

MDL:

FAS:

CCIN:

NFB:

NVG:

AROA:

API:

DNX:

AGS:

RMD:

DVT:

BTAB:

DCI:

CLEC:

NLU:

LDA:	142318211 142325169

HVI:

TPAL:

ZNE:

CSEC:

HAMR:

DPX:	DAPPUDRAFT_301871

DMK:

116929588

AFRA:

136041939

LSM:	121115794(cype)

PVM:

PJA:

PCHN:

PMOO:

HAME:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

OOT:

DPTE:

ABRU:

PMEO:

CEL:	CELE_F29C4.2(cox-6C)

CBR:

CBG_01648

CRQ:	GCK72_014659

NAI:	NECAME_12028

HRO:	HELRODRAFT_83384

PCAN:

112553704 112553705

LSAX:

138967409 138975947

BARL:

143279926 143282206 143282548 143294791

HRF:

HASI:

HCRA:

OED:

LJP:

LLON:

Reference

PMID:2849755

Authors

Otsuka M, Mizuno Y, Yoshida M, Kagawa Y, Ohta S

Title

Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc.

Journal

Nucleic Acids Res 16:10916 (1988)
DOI:10.1093/nar/16.22.10916

Sequence

[hsa:1345]

LinkDB

DBGET integrated database retrieval system