KEGG ORTHOLOGY: K02271

ORTHOLOGY: K02271

Entry

K02271                      KO

Symbol

COX7B

Name

cytochrome c oxidase subunit 7b

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04260

Cardiac muscle contraction

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00154

Cytochrome c oxidase

Disease

H01904

Microphthalmia with linear skin defects syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02271  COX7B; cytochrome c oxidase subunit 7b
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09159 Environmental adaptation
   04714 Thermogenesis
    K02271  COX7B; cytochrome c oxidase subunit 7b
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05012 Parkinson disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05014 Amyotrophic lateral sclerosis
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05016 Huntington disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05020 Prion disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05022 Pathways of neurodegeneration - multiple diseases
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02271  COX7B; cytochrome c oxidase subunit 7b

Other DBs

TC:

3.D.4.11

Genes

HSA:	1349(COX7B) 170712(COX7B2)

PTR:	100615314(COX7B2) 465727(COX7B)

PPS:	100982199 100986707 117976096 117977251

GGO:	101133386 101147253 109024487

PON:	100172849(COX7B) 100451432

NLE:	100591930 100602515 115837591

HMH:	116456710 116458524 116460740 116811106 116812505 116812582

MCC:	100428437(COX7B2) 706099(COX7B)

MCF:	102123270 102124180 123573477

MTHB:

126942189 126946324 126955253

MNI:	105464285 105471304 105487680

CSAB:

103232235(COX7B) 103246147(COX7B2)

CATY:

105596112 105596144

PANU:

101013709 103884346 116269782

TGE:	112614586 112615961 112625015

MLEU:

105530782 105538264

RRO:	104669550 104671254 104680071 115900678

RBB:	108519915 108530029 108535638

TFN:	117076746 117078522 117085655

PTEH:

111536059 111548777 111550927

CANG:

105501404 105512711 105515614

CJC:	100390732 100414729(COX7B2) 118153966

SBQ:	101048999 101052499

CIMI:

108292295 108297237 108312415

CSYR:

103267420 103274382

MMUR:

105859339 109729584 109730255

LCAT:

123621919 123624263

PCOQ:

105806701 105826189

OGA:	100951826 100953844 100958320 100965534

MMU:	66142(Cox7b) 78174(Cox7b2)

MCAL:

110286765 110295372

MPAH:

110313979 110330226

RNO:	100361960(Cox7b2) 303393(Cox7b)

MCOC:

116071167 116087988

ANU:	117694048 117712474 117718642

MUN:	110541746 110541909 110543482 110565114 132647959

CGE:	100764866 100772782 113834565

MAUA:

101829663 101834758

PROB:

127217663

PLEU:

114689841 114690723 114694791 114704883

MORG:

121442733 121444814 121451002 121457965 121460628 121465057

MFOT:

126493461 126506197

AAMP:

119804752 119807117 119821824 119824561

NGI:	103737829 103737882

HGL:	101715696 101719726 101722775 106010133

CPOC:

100719234 100723369

CCAN:

109680062 109686755

DORD:

105980179 105995218

DSP:	122097646 122106921

PLOP:

125344094 125357365 125364518

NCAR:

124972073 124978951 124994104

MMMA:

107138951 107159289

OCU:	100339628 100342996 100348984 100353320 100356786 100357660

OPI:	101517779 101519995 101529981 101533664 101535821

TUP:	102475894 102498058

GVR:

103609950

CFA:	100683076 100684842 100684983 100686510 100687434(COX7B2) 102152785

CLUD:

112643473 112650945 112652117 112664558 112671885 112678421 118352292

VVP:	112909193 112933364

VLG:	121474273 121477994 121478414 121482288 121497750

NPO:	129503871 129510926 129517518 129517615 129518990

AML:	100466075 100475526

UMR:	103656462 103672701 103675819

UAH:	113242144 113253709 113262375

UAR:	123794870 123799314 123803988

ELK:	111146524 111149314 111149315 111156868 111160926

LLV:	125078870 125091810 125094364 125097679

MPUF:

101672021 101691909

MNP:	132001951 132007782 132015566

MLK:	131809285 131821722 131824398

NVS:	122889784 122897159 122900125

ORO:	101370574 101371666 101377905 101383837

EJU:	114200424 114207401 114210260

ZCA:	113914243 113915131 113919563 113925088 113931503 118356894

MLX:	118010248 118015405 118026049

NSU:	110578761 110590872

LWW:	102738272 102748999

FCA:	101085531 101098629(COX7B2)

PYU:	121025331 121036249

PCOO:

112858534 112870951

PBG:	122477015 122478926

PVIV:

125157951 125164161

LRUF:

124509547 124519930

PTG:	102951800 102970291

PPAD:

109245506 109258957

PUC:	125922726 125931786

AJU:	106986098 106986669

HHV:	120220950 120224488 120234430

BTA:	100300550(COX7B) 767916(COX7B2)

BOM:	102265796 102277731

BIU:	109560438 109561950

BBUB:

102395589 102396784 102401698 102406515 102411142 102413395

BBIS:

104992608 104995784 105002319

CHX:	102184512 102186286

OAS:	101108109 101111228 101116886 101121518

BTAX:

128070083

ODA:	120862086 120863879 120879600 120881948

CCAD:

122422191 122427709 122435324 122444030

MBEZ:

129534867

SSC:	100516480 100517408

CFR:	102506447 102509421

CBAI:

105065507 105074919

CDK:	105095562 105096479

VPC:	102527993 102540595

BACU:

103011737 103017687 103019246

BMUS:

118889202 118889263 118891901 118896060

LVE:	103071977 103079623 103082153

OOR:	101272241 101275626 101278311

DLE:	111171524 111178277

PCAD:

102977966 102986020

PSIU:

116747406 116747960 116754418

NASI:

112390686 112390687 112400382

ECB:	100629332(COX7B2) 100630758

EPZ:	103541818 103551834

EAI:	106841238 106846922

MYB:	102248066 102249757 102256817 102257114

MYD:	102769655 102770550

MMYO:

118651610 118654460

MLF:	102419247 102433141

PKL:	118707200 118717822 118719979

EFUS:

103284939 103291503 103300104 103303650

MNA:	107532759 107533317

DRO:	112316645 112317931

SHON:

118978653 118980993

AJM:	119039407 119039459 119046078

PDIC:

114493439 114504937 118501211

PHAS:

123815903 123817363 123818042 123824316

MMF:	118615384 118618411 118627002 118635961 118640230

PPAM:

129065349 129074346 129077717 129084869 129086072

HAI:	109385653 109395055

RFQ:	117017505 117022452 117025637 117034361

PALE:

102883692 102883704 102888814

PGIG:

120588028 120588365 120591688

PVP:	105293916 105294928 105308883

RAY:	107503849 107519004

MJV:	108384221 108396709

TOD:	119232300 119242999 119246658 119261139

SARA:

101551046

SETR:

125999312 126020094

LAV:	100658215 100666763

TMU:	101347679 101353725 101355622 111821449

ETF:	101650318 101655666

DNM:	101423721 101432149 111759679 111764174

MDO:

100012618

GAS:	123234978 123253359

SHR:

AFZ:

PCW:

OAA:

GGA:	771947(COX7B)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:	100219756(COX7B)

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

DNE:

ASN:

AMJ:	102572384(COX7B)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ASAO:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108700072(cox7b.S) 447278(cox7b.L)

XTR:	779702(cox7b)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:	117349441 117351978 117361645

DRE:	563476(cox7b)

SRX:	107713147 107726769

SANH:

107675192 107697350

SGH:	107582003 107598778

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00014630G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

106568019(COX7B) 106603475(CX7B2)

STRU:

115148809 115154278

OTW:

112257912

OMY:

110537530

OGO:	123994618 123998740

ONE:	115105494 115136485

OKI:

109892782

OKE:	118391117 127933114

SALP:

111951107 111980259

SNH:	120030632 120056509

CCLU:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

Reference

PMID:23122588

Authors

Indrieri A, van Rahden VA, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M, Franco B

Title

Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.

Journal

Am J Hum Genet 91:942-9 (2012)
DOI:10.1016/j.ajhg.2012.09.016

Reference

PMID:8382530

Authors

Sadlock JE, Lightowlers RN, Capaldi RA, Schon EA

Title

Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase.

Journal

Biochim Biophys Acta 1172:223-5 (1993)
DOI:10.1016/0167-4781(93)90301-S

Sequence

[hsa:1349]

LinkDB

DBGET integrated database retrieval system