KEGG ORTHOLOGY: K02514

ORTHOLOGY: K02514

Entry

K02514                      KO

Symbol

HS6ST1

Name

heparan sulfate 6-O-sulfotransferase HS6ST1 [EC:2.8.2.-]

Pathway

map00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

Disease

H00255

Hypogonadotropic hypogonadism

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    K02514  HS6ST1; heparan sulfate 6-O-sulfotransferase HS6ST1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K02514  HS6ST1; heparan sulfate 6-O-sulfotransferase HS6ST1
Glycosyltransferases [BR:ko01003]
Unclassified
  Sulfotransferases
   K02514  HS6ST1; heparan sulfate 6-O-sulfotransferase HS6ST1

Other DBs

GO:

0017095

Genes

HSA:	9394(HS6ST1)

PTR:	470530(HS6ST1)

PPS:	100995830(HS6ST1)

GGO:	101126711(HS6ST1)

PON:	100440521(HS6ST1)

NLE:	100598530(HS6ST1) 115835066

HMH:	116464089 116464090

MCC:	715479(HS6ST1)

MCF:	102117719(HS6ST1) 102134788

MTHB:

126932583 126949794

MNI:	105492412(HS6ST1)

CSAB:

103216864(HS6ST1)

CATY:

105592105(HS6ST1)

PANU:

101012197

TGE:	112636554(HS6ST1)

MLEU:

105540008(HS6ST1)

RRO:	104662417(HS6ST1)

RBB:	108526548(HS6ST1)

TFN:	117073352 117095180(HS6ST1)

PTEH:

111551575(HS6ST1)

CANG:

105511530(HS6ST1)

CJC:	100394849(HS6ST1)

SBQ:	101052254(HS6ST1)

CIMI:

108317773(HS6ST1)

MMUR:

105863176(HS6ST1)

LCAT:

123643472(HS6ST1)

PCOQ:

105814847(HS6ST1)

OGA:	100951303(HS6ST1)

MMU:	50785(Hs6st1)

MCAL:

110294646(Hs6st1)

MPAH:

110321390(Hs6st1)

RNO:	316325(Hs6st1)

MCOC:

116088290(Hs6st1)

ANU:	117722444(Hs6st1)

MUN:	110563655(Hs6st1)

CGE:	100689173(Hs6st1)

MAUA:

101836538(Hs6st1)

PROB:

127236564(Hs6st1)

PLEU:

114690524(Hs6st1)

MORG:

121450754(Hs6st1)

MFOT:

126496944

AAMP:

119822655(Hs6st1)

NGI:	103731391(Hs6st1)

HGL:	101717791(Hs6st1)

CPOC:

100720104(Hs6st1)

CCAN:

109700103(Hs6st1)

DORD:

105995165(Hs6st1)

DSP:	122112428(Hs6st1)

PLOP:

125350801(Hs6st1)

NCAR:

124980565

MMMA:

107136801(Hs6st1)

OCU:

100340145

OPI:	101522563(HS6ST1)

TUP:	102475531(HS6ST1)

GVR:	103595920(HS6ST1) 103596783

CFA:	100688113(HS6ST1)

CLUD:

112652418(HS6ST1)

VVP:	112932722(HS6ST1)

VLG:	121481872(HS6ST1)

NPO:	129503939(HS6ST1)

AML:	100479264(HS6ST1)

UMR:	121099892(HS6ST1)

UAH:	113263500(HS6ST1)

UAR:	123779490(HS6ST1)

ELK:

111160877

LLV:

125096090

MPUF:

101693571(HS6ST1)

MNP:	132013986(HS6ST1)

MLK:	131826882(HS6ST1)

NVS:	122902775(HS6ST1)

ORO:	101365536(HS6ST1)

EJU:	114207351(HS6ST1)

ZCA:	113919680(HS6ST1)

MLX:	118012584(HS6ST1)

NSU:	110585676(HS6ST1)

LWW:

102750582

FCA:	101091388(HS6ST1)

PYU:	121030384(HS6ST1)

PCOO:

112865473(HS6ST1)

PBG:	122481211(HS6ST1)

PVIV:

125172488(HS6ST1)

LRUF:

124515842

PPAD:

109278814(HS6ST1)

PUC:

125911722

AJU:

106966411

HHV:	120245956(HS6ST1)

BTA:	518563(HS6ST1)

BOM:	102284070(HS6ST1)

BIU:	109565131(HS6ST1)

BBUB:

102407484(HS6ST1)

CHX:	106502605(HS6ST1)

OAS:	105611800(HS6ST1)

BTAX:

128065360(HS6ST1)

ODA:	120854061(HS6ST1)

CCAD:

122453637(HS6ST1)

MBEZ:

129537782(HS6ST1)

SSC:	100156717(HS6ST1)

CFR:	102513303(HS6ST1)

CBAI:

105068859(HS6ST1)

CDK:	105084502(HS6ST1)

BACU:

102999462(HS6ST1)

BMUS:

118898074(HS6ST1)

LVE:	103080048(HS6ST1)

OOR:	101273791(HS6ST1)

DLE:	111183337(HS6ST1)

PCAD:

102982595(HS6ST1)

PSIU:

116756651(HS6ST1)

NASI:

112395010(HS6ST1)

ECB:	100068973(HS6ST1)

EPZ:	103539995(HS6ST1)

EAI:	106841536(HS6ST1)

MYB:	102250173(HS6ST1)

MMYO:

118661135(HS6ST1)

MLF:	102418297(HS6ST1)

PKL:	118708843(HS6ST1)

EFUS:

103301220(HS6ST1)

MNA:	107528572(HS6ST1)

DRO:	112313178(HS6ST1)

SHON:

119003699(HS6ST1)

AJM:	119049013(HS6ST1)

PDIC:

114494210(HS6ST1)

PHAS:

123810341(HS6ST1)

MMF:	118625475(HS6ST1)

PPAM:

129071766(HS6ST1)

HAI:	109374067(HS6ST1)

RFQ:	117020082(HS6ST1)

PALE:

102890908(HS6ST1)

PGIG:

120592523(HS6ST1)

PVP:

105310188

RAY:	107516886(HS6ST1)

MJV:	108384911(HS6ST1)

TOD:	119255720(HS6ST1)

SETR:

126002078(HS6ST1)

LAV:	100662872(HS6ST1)

TMU:

101352824

ETF:	101654283(HS6ST1)

DNM:	101443636(HS6ST1)

MDO:	100018375(HS6ST1)

GAS:	123242315(HS6ST1)

SHR:	100935034(HS6ST1)

AFZ:

127554280

PCW:	110194658(HS6ST1)

OAA:	100682202(HS6ST1)

GGA:	395141(HS6ST1)

PCOC:

116236385(HS6ST1)

MGP:	100545798(HS6ST1)

CJO:	107317923(HS6ST1)

TPAI:

128081870(HS6ST1)

LMUT:

125697561(HS6ST1)

NMEL:

110397487(HS6ST1)

APLA:

101800720(HS6ST1)

ACYG:

106040313(HS6ST1)

CATA:

118246918(HS6ST1)

AFUL:

116492411(HS6ST1)

TGU:	100224452(HS6ST1)

LSR:	110474548(HS6ST1)

SCAN:

108961891(HS6ST1)

PMOA:

120511192(HS6ST1)

OTC:	121342110(HS6ST1)

PRUF:

121364017(HS6ST1)

GFR:	102044194(HS6ST1)

FAB:	101807511(HS6ST1)

OMA:	130256670(HS6ST1)

PHI:	102109915(HS6ST1)

PMAJ:

107208810(HS6ST1)

CCAE:

111933812(HS6ST1)

CCW:	109143189(HS6ST1)

CBRC:

103612020(HS6ST1)

ETL:	114065410(HS6ST1)

ZAB:

102066145

ZLE:	135451538(HS6ST1)

ACHL:

103798505(HS6ST1)

SVG:	106849622(HS6ST1)

MMEA:

130580576(HS6ST1)

HRT:	120757073(HS6ST1)

FPG:	101912433(HS6ST1)

CLV:	102097887(HS6ST1)

EGZ:	104126907(HS6ST1)

NNI:	104023690(HS6ST1)

PCRI:

104036182

PLET:

104622805

EHS:

104511020

PCAO:

104041788(HS6ST1)

ACUN:

113483703(HS6ST1)

TALA:

104356214(HS6ST1)

PADL:

103912602(HS6ST1)

AFOR:

103903145(HS6ST1)

ACHC:

115347082(HS6ST1)

HALD:

104320224(HS6ST1)

HLE:	104832182(HS6ST1)

AGEN:

126039464

GCL:

127020086

CCRI:

104164438(HS6ST1)

CSTI:

104561720(HS6ST1)

CMAC:

104480911(HS6ST1)

MUI:	104547964(HS6ST1)

BREG:

104634886

FGA:	104082150(HS6ST1)

GSTE:

104252935(HS6ST1)

LDI:	104353313(HS6ST1)

MNB:	103781376(HS6ST1)

OHA:	104327850(HS6ST1)

NNT:	104401718(HS6ST1)

SHAB:

115611468(HS6ST1)

DPUB:

104300648(HS6ST1)

PGUU:

104468639(HS6ST1)

ACAR:

104519004(HS6ST1)

CPEA:

104387932

AVIT:

104271267(HS6ST1)

CVF:	104282354(HS6ST1)

RTD:	128911407(HS6ST1)

CUCA:

104066386(HS6ST1)

TEO:

104381325

BRHI:

104499590(HS6ST1)

AAM:	106484464(HS6ST1)

AROW:

112972885(HS6ST1)

NPD:

112949222

TGT:	104571559(HS6ST1)

DNE:	112988879(HS6ST1)

SCAM:

104140744(HS6ST1)

ASN:	102382272(HS6ST1)

AMJ:	102564849(HS6ST1)

CPOO:

109315293(HS6ST1)

GGN:	109288245(HS6ST1)

PSS:

102448542

CMY:	102932625(HS6ST1)

CCAY:

125642423(HS6ST1)

DCC:	119861636(HS6ST1)

CPIC:

101950565(HS6ST1)

TST:	117883388(HS6ST1)

CABI:

116815943(HS6ST1)

MRV:	120371699(HS6ST1)

ACS:	100552061(hs6st1)

ASAO:

132770816(HS6ST1)

PVT:	110075833(HS6ST1)

SUND:

121926959(HS6ST1)

PBI:	103061438(HS6ST1)

PMUR:

107287664(HS6ST1)

CTIG:

120309675(HS6ST1)

TSR:	106540904(HS6ST1)

PGUT:

117678553(HS6ST1)

APRI:

131201367(HS6ST1)

PTEX:

113436722(HS6ST1)

NSS:	113420775(HS6ST1)

VKO:	123026336(HS6ST1)

PMUA:

114597637(HS6ST1)

PRAF:

128414395(HS6ST1)

ZVI:	118083725 118093512(HS6ST1)

HCG:	128350379(HS6ST1)

GJA:	107123586(HS6ST1)

STOW:

125438357(HS6ST1)

EMC:	129332052(HS6ST1)

XLA:	108717161(hs6st1.L) 373566(hs6st1.S)

XTR:	550071(hs6st1)

NPR:	108792357(HS6ST1)

RTEM:

120936395(HS6ST1)

BBUF:

120997503(HS6ST1)

BGAR:

122934730(HS6ST1)

GSH:	117367132(HS6ST1)

DRE:	553162(hs6st1a) 791107(hs6st1b)

SRX:	107727332 107729660 107748934 107757697

SANH:

107677314 107678693 107697682

SGH:	107558548 107588870 107590258 107602601

CCAR:

109046859 109048005 109048009 109048996 109072282 109097620

CAUA:

113042493 113045130 113066146 113120041

CGIB:

127934028 127946351 127950731 128013232

PTET:

122326062 122330208(hs6st1b) 122352021

LROH:

127155621(hs6st1b) 127178373(hs6st1a)

OMC:	131533456(hs6st1b) 131552654(hs6st1a)

PPRM:

120465062(hs6st1a) 120488246(hs6st1b)

RKG:	130084028(hs6st1b)

MAMB:

125252018(hs6st1a) 125257676(hs6st1b)

CIDE:

127506441 127524613

MASI:

127431624 127434607 127440510 127441922

TROS:

130546922(hs6st1b) 130554541(hs6st1a)

TDW:	130413671(hs6st1b) 130418160(hs6st1a)

MANU:

129425500(hs6st1b) 129442870(hs6st1a)

IPU:	108256600(hs6st1b) 108267822(hs6st1a)

IFU:	128599459(hs6st1b) 128609666(hs6st1a)

PHYP:

113540596 113541223

SMEO:

124375542(hs6st1b) 124387336(hs6st1a)

TFD:	113644026(hs6st1a) 113660238(hs6st1b)

TVC:	132840040(hs6st1b) 132848299(hs6st1a)

TRN:	134300825(hs6st1b) 134311294(hs6st1a)

AMEX:

103031564 103047608

CMAO:

118798733(hs6st1b) 118825850(hs6st1a)

EEE:

113573814

CHAR:

105889400(hs6st1b) 105907200(hs6st1a)

TRU:

101062077

TFS:	130540417(hs6st1a)

TNG:	GSTEN00031952G001

LCO:

104933412

NCC:

104965962

TBEN:

117493288(hs6st1a)

CGOB:

115027287

PGEO:

117467273(hs6st1a)

GACU:

117540590(hs6st1a)

EMAC:

134881593(hs6st1a)

ELY:	117267031(hs6st1a)

EFO:	125900906(hs6st1a)

PLEP:

121953282(hs6st1a)

SLUC:

116057390(hs6st1a)

ECRA:

117935672(hs6st1a)

ESP:	116670094(hs6st1)

PFLV:

114546962(hs6st1)

GAT:	120832836(hs6st1a)

PPUG:

119227228(hs6st1a)

AFB:	129103518(hs6st1a)

CLUM:

117725145(hs6st1a)

PSWI:

130202034

MSAM:

119909966(hs6st1a)

SCHU:

122862070(hs6st1a)

CUD:	121526054(hs6st1a)

ALAT:

119034369(hs6st1a)

MZE:

101467320

ONL:

100707002

OAU:	116326062(hs6st1a)

OLA:

101166175

OML:	112150391(hs6st1a)

CSAI:

133461875(hs6st1a)

XMA:	102225263(hs6st1)

XCO:	114134240(hs6st1)

XHE:	116709143(hs6st1)

PRET:

103460498(hs6st1)

PFOR:

103155216(hs6st1)

PLAI:

106953017(hs6st1)

PMEI:

106925427(hs6st1)

GAF:	122846626(hs6st1a)

PPRL:

129365140(hs6st1a)

CVG:

107096186

CTUL:

119775485(hs6st1a)

GMU:	124855243(hs6st1a)

NFU:	107392113(hs6st1)

KMR:	108236315(hs6st1a)

ALIM:

106518468 106536962

NWH:	119427886(hs6st1a)

AOCE:

111571670

MCEP:

125023343(hs6st1a)

CSEM:

103380197(hs6st1)

POV:

109636356

SSEN:

122782749(hs6st1a)

HHIP:

117755814(hs6st1a)

HSP:	118116583(hs6st1a)

PPLT:

128450518(hs6st1a)

SMAU:

118286729(hs6st1a)

LCF:	108874857(hs6st1a)

SDU:	111225638(hs6st1)

SLAL:

111647397

XGL:	120795509(hs6st1a)

HCQ:

109517390

SSCV:

125981032

SBIA:

133513137(hs6st1a)

PEE:

133412606

PTAO:

133487805(hs6st1a)

BPEC:

110153653

MALB:

109968041(hs6st1)

BSPL:

114849058(hs6st1a)

SJO:	128375941(hs6st1a)

SASA:

106574514 106575379 106579591 106590359

STRU:

115150426 115179310 115195546 115196165

OTW:	112227755 112232697(hs6st1b) 112253703 112266405

OMY:	110489724 110495749 110528787 110535286(hs6st1b)

OGO:	123991360(hs6st1b) 124008649 124011244 124039603

ONE:	115104893 115129797 115130178

OKI:	109884371 109899302 109909827 116374161

OKE:	118361759(hs6st1b) 118370621 127914030 127916693

SALP:

111953472 111953564 111973013

SNH:	120028097(hs6st1b) 120033544 120051014 120051354

CCLU:

121549643 121560556(hs6st1a) 121569200

ELS:	105019984 105027306(hs6st1)

SFM:	108927599 108936631

PKI:	111832834 111847397

AANG:

118225329 118230000(hs6st1a)

LOC:	102687855(hs6st1)

PSPA:

121322928 121326799

ARUT:

117417269 117423570

PSEX:

120536018(hs6st1a)

LCM:	102356920(HS6ST1)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

CIN:

SPU:

APLC:

DME:	Dmel_CG4451(Hs6st)

DER:

6553948

DSI:	Dsimw501_GD20088(Dsim_mira)

DYA:	Dyak_GE25098

DSR:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10319

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:	108354318 108359423 108378358

AOQ:

TDA:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012168 CpipJ_CPIJ012169

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

113370324 113371668 113381031

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM168390

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_303886

DMK:

DPZ:

PVM:

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119441304 119442284

RSAN:

119386552

RMP:	119159620 119178113

VDE:

VJA:

TUT:

DPTE:

DFR:

PTEP:

107439851 107439852 107440482

ABRU:

129965861 129966730 129967017

UDV:	129216135 129221852 129224467

SDM:	118199620 118204481 118204484

LPOL:

106465871 106465872 106475642

NAI:	NECAME_00660

TSP:

Tsp_04388

LGI:	LOTGIDRAFT_72154 LOTGIDRAFT_73915

PVUL:

126819474

BGT:

106055787

GAE:

121385481

HRF:	124150063 124151548

HRJ:

124259606

CANU:

128180977

MMER:

123554372 123555011

RPHI:

132741066 132755038 132759964

DPOL:

127834391

MAEA:

128218788 128220560 128228822 128241263

OBI:

106875812

LJP:

135479178

SMM:	Smp_124020

SHX:	MS3_00002589(HS6ST1B)

OVI:	T265_03761

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HSY:

RES:

AQU:	100634555 109580425

SRE:	PTSG_07644

FCY:	FRACYDRAFT_181435

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Reference

PMID:10644753

Authors

Habuchi H, Tanaka M, Habuchi O, Yoshida K, Suzuki H, Ban K, Kimata K

Title

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.

Journal

J Biol Chem 275:2859-68 (2000)
DOI:10.1074/jbc.275.4.2859

Sequence

[mmu:50785]

LinkDB

DBGET integrated database retrieval system