KEGG   ORTHOLOGY: K03390
Entry
K03390                      KO                                     
Symbol
hdrC2
Name
heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
map00680  Methane metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Reaction
R11928  CoB,CoM,ferredoxin:coenzyme F420 oxidoreductase
R11931  CoB,CoM:ferredoxin oxidoreductase
R11943  CoB,CoM,ferredoxin:H2 oxidoreductase
R11944  coenzyme B,coenzyme M,ferredoxin:formate oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03390  hdrC2; heterodisulfide reductase subunit C2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
Other DBs
COG: COG1150
Genes
TIG: THII_2279
THIS: HZT40_21390
TUN: J9260_16775
TLO: J9253_18175
TSB: HMY34_11230
TANI: J8380_05660
TWN: L2Y54_05840
TLC: RCF98_07605
TSJ: L3K52_04630
TVI: Thivi_3112
TMB: Thimo_0247
TSY: THSYN_16430
HHC: M911_11220 M911_11240
EBS: ECTOBSL9_0283 ECTOBSL9_0287
TGR: Tgr7_2212 Tgr7_2216
TKM: TK90_0632 TK90_0636
TNI: TVNIR_3245(hdlC_[H]) TVNIR_3249
TVR: TVD_10630 TVD_10650
APRS: BI364_13795 BI364_13815
AAEO: BJI67_04060 BJI67_04080
AFY: BW247_09915 BW247_09935
TBN: TBH_C2776
EPS: L0Y14_00990 L0Y14_11945
SEDS: AAY24_12125
SLIM: SCL_2521
ACII: C4901_01550 C4901_12960 C4901_12980
ATY: A9R16_001320 A9R16_003990 A9R16_004010
REV: HUE57_00440
ENM: EBS_2144(hdrC)
SHD: SUTH_02768(hdrC)
NPV: OHM77_12520 OHM77_12785
TBD: Tbd_1646
SDR: SCD_n01882(hdrC)
SULF: CAP31_01840 CAP31_01860
SPLB: SFPGR_13330 SFPGR_29430(hdrC) SFPGR_29470
SNIV: SFSGTM_27270(hdrC) SFSGTM_27310
SLAC: SKTS_06170 SKTS_11880
DDZ: DSYM_23130
HDN: Hden_0689 Hden_0693
BLAG: BLTE_14840
RHC: RGUI_1279 RGUI_1283
AEP: AMC99_00776 AMC99_00780
QSO: IRL76_11075 IRL76_11095
RAP: RHOA_4371
VSU: P3M64_01090
AFR: AFE_2551 AFE_2555
AFE: Lferr_2185
ACU: Atc_2348 Atc_2352
ACZ: Acaty_c2191 Acaty_c2195
AFI: Acife_2472 Acife_2476
AFJ: AFERRID_05110 AFERRID_05150
ATX: GCD22_03146(hdlC) GCD22_03150
AFP: K1Y48_09025 K1Y48_09045
ACIY: MQE22_02740 MQE22_02760
GSU: GSU0092(hdrC)
GSK: KN400_0067(hdrC)
GME: Gmet_3424(hdrC)
GPI: GPICK_06750 GPICK_15685
GAO: A2G06_15980
GBZ: JZM60_06220
GEM: GM21_0031
GEB: GM18_0028 GM18_3237
GEF: FO488_02645
GUR: Gura_0151 Gura_3581
GEO: Geob_3725(hdrC)
GLO: Glov_0861
TAMM: GEAMG1_2375
GBM: Gbem_0032(hdrC)
GBN: GEOBRER4_00300(hdrC)
GER: KP004_19750
GSUB: KP001_16565
GNT: KP003_19740
GPL: M1B72_22215
DDS: Ddes_2098
DFI: AXF13_12655
DPG: DESPIGER_1700
DEF: CNY67_01590
DTR: RSDT_0565(hdrC)
DFL: DFE_0754 DFE_2491
PSYF: N1030_00475 N1030_03925
DSB: LN040_10950 LN040_16905
DMA: DMR_01900(hdrC)
DCB: C3Y92_00555
DGG: DGI_1048(hdrC)
DDE: Dde_1207 Dde_3524
DMS: E8L03_01890 E8L03_02840 E8L03_07125 E8L03_12005
DSA: Desal_0602
DHY: DESAM_21332
DAF: Desaf_1862 Desaf_2883
DAS: Daes_0783
DPI: BN4_11858(hdrC)
DEJ: AWY79_02115 AWY79_07315
PSEL: GM415_09680 GM415_15605
DDN: DND132_1388
PSEF: PSDVSF_30240(hdrC)
PPOR: JCM14722_30780 JCM14722_31290(hdrC)
PNW: SYK_07280
PTHE: LF599_14180
DSX: GD604_00985 GD604_12435
DSD: GD606_02350 GD606_06810 GD606_11680
PBIZ: LWC08_06290
DVU: DVU_2404(hdrC)
DVL: Dvul_0826
DVM: DvMF_0322
DVG: Deval_2225
CLIH: KPS_000423
DBA: Dbac_0848 Dbac_2344
DOA: AXF15_11210
DESU: NLA06_01265 NLA06_04405
THEW: TDMWS_00870(hdrC)
DRT: Dret_0198 Dret_0417 Dret_2317
DSF: UWK_01755
DLM: DPPLL_25820 DPPLL_26240
DAK: DaAHT2_1634
DPR: Despr_0009
DEO: CAY53_08850
DBK: DGMP_38700(hdrC)
DDU: GF1_00860
ECOM: QTN59_02650 QTN59_16375
DOL: Dole_1161
DAT: HRM2_22760(hdrD2)
DTO: TOL2_C17910(hdlC)
DOV: DSCO28_20250(hdrC) DSCO28_27600
DWD: DSCW_42550 DSCW_61100
DALK: DSCA_54690
DML: Dmul_28880(hdrC)
DLI: dnl_31760 dnl_49490
DMM: dnm_100770
DEK: DSLASN_10530 DSLASN_24470 DSLASN_32840 DSLASN_44310
DAO: Desac_0667 Desac_0824 Desac_1102
DTI: Desti_0009 Desti_0171 Desti_4258
SFU: Sfum_0820 Sfum_1806 Sfum_4092
DAX: FDQ92_07510
DBR: Deba_0985
DMP: FAK_04480 FAK_04750
TID: Thein_0804 Thein_1780 Thein_2187
TCM: HL41_09200 HL41_09235
THET: F1847_06845 F1847_06875
CTHI: THC_1758
TAV: G4V39_00790 G4V39_01675
TMAI: FVE67_00255
BTS: Btus_2498
KYR: CVV65_12500
CEU: A7L45_12275
CTHD: CDO33_09915
RCH: RUM_10970
RUM: CK1_05050
SMAN: C12CBH8_20540
SWO: Swol_0394
SLP: Slip_1199 Slip_1202 Slip_2075
SALQ: SYNTR_0261
DMT: DESME_05485 DESME_05500 DESME_05505
SGY: Sgly_1902
DOR: Desor_3500 Desor_3503 Desor_4441
DAI: Desaci_2521
DCA: Desca_0814 Desca_2381
PTH: PTH_1413(GlpC)
DRM: Dred_0358 Dred_0633 Dred_1325
DRU: Desru_2700 Desru_3380
DFG: B0537_03635 B0537_06275
DAE: Dtox_1348 Dtox_1351 Dtox_3574
DKU: Desku_0191 Desku_1436 Desku_1485 Desku_1502 Desku_3102 Desku_3119
DAU: Daud_0563 Daud_1252 Daud_1882
TFR: BR63_02765 BR63_10495
FWA: DCMF_10325
AACX: DEACI_0470 DEACI_0906 DEACI_2406 DEACI_2891 DEACI_2892
TJR: TherJR_1777 TherJR_1955
DGI: Desgi_0795 Desgi_1603 Desgi_2165 Desgi_3698
HMO: HM1_2006
HCV: FTV88_1702
SAY: TPY_3531
SAP: Sulac_1384
STHR: BXT84_01300 BXT84_01320 BXT84_06250
HFV: R50_0688 R50_0692 R50_1169
CTHM: CFE_1265 CFE_1631 CFE_1754
BYL: A4V09_16720
BPRO: PMF13cell1_01671(rsxC_1)
BLAB: EYS05_14045
BWX: NQ550_09260
BMAS: LK422_10000
BLAR: LC508_15295
BLUI: Blut17040_18880
BCOC: BLCOC_07530
MFOR: NQ534_19205
CMIU: B1H56_01480
CHY: CHY_0927 CHY_1228
ADG: Adeg_1335
TPZ: Tph_c15480
MAS: Mahau_0894
MTA: Moth_0439 Moth_0809 Moth_1196
MTHO: MOTHE_c03750(glpC1) MOTHE_c07540 MOTHE_c11720
MTHZ: MOTHA_c04640(glpC1) MOTHA_c08480 MOTHA_c12590
NTH: Nther_2663
NCD: ACONDI_01671 ACONDI_03088
MANA: MAMMFC1_00470
STED: SPTER_13740
CALK: HUE98_11615
SHI: Shel_17750
PARN: NBH00_11855
AFO: Afer_0964
CAN: Cyan10605_2789 Cyan10605_2792
SYL: AWQ21_15425 AWQ21_15440
CYC: PCC7424_1697 PCC7424_1700
PPSU: NO713_02683(hdrC) NO713_02687(hdrC1)
OAC: Oscil6304_5893 Oscil6304_5898
NOP: Nos7524_5055 Nos7524_5058
RSIN: B6N60_02610 B6N60_02613
DLY: Dehly_0732
DEW: DGWBC_1420
DFO: Dform_00943(hdrC)
DETH: HX448_06345
ABAT: CFX1CAM_1234
PSUB: Pelsub_P0985
THUG: KNN16_08285
TRO: trd_0155
TNR: Thena_0462 Thena_1331
TACI: TDSAC_0438 TDSAC_1308
OTE: Oter_3675
FPES: NXS98_02655
TTF: THTE_4307
TSU: Tresu_1315
TBE: Trebr_2035
TRC: DYE49_06640
TPER: IWA51_04950
MSIL: METEAL_37380(hdrC)
MSEA: METESE_33950(hdrC)
FVA: FV113G1_17830
FUL: C4N20_13320
FMO: C4N19_02855
IPO: Ilyop_2565
BOA: Bovatus_04656
BCEL: BcellWH2_01253
DYS: G7050_05245
DYH: G7051_05505
APS: CFPG_238
OSP: Odosp_0423
BUY: D8S85_20550
BVIR: I6J59_08955
BFH: F1611_02865
AFD: Alfi_2099
ASH: AL1_26650
ALD: GFH31_00865 GFH31_08505
AOK: A3BBH6_05110
ACOU: A5CBH24_14810
ADA: A5CPEGH6_16740
AIT: AI2BBH_11670
APUT: L6V35_06375
ASEN: NQ519_03365
AIU: NQ491_07885
BACC: BRDCF_p1058 BRDCF_p1819(hdrC)
ANF: AQPE_4791
ALKQ: M9189_04050
CTS: Ctha_0138
AAE: aq_391 aq_398(hdrC)
HYA: HY04AAS1_1078 HY04AAS1_1082
HHO: HydHO_1073 HydHO_1077
HYS: HydSN_1100 HydSN_1104
HTH: HTH_1879(hdrC1) HTH_1883(hdrC2)
HTE: Hydth_1861 Hydth_1865
TAL: Thal_1344 Thal_1348
TRD: THERU_00165 THERU_00185
TTK: TST_1518(hdrC)
CABY: Cabys_1919
TYE: THEYE_A1369
ALAM: RT761_02171(glpC)
BANA: BARAN1_0333(hdrC)
BIH: BIP78_0149
SCHV: BRCON_0022
FSH: Q2T83_12635 Q2T83_12655
MJA: MJ_0744 MJ_0864
MFE: Mefer_1062 Mefer_1124
MVU: Metvu_0281 Metvu_0443
MFS: MFS40622_1298
MIF: Metin_0497
MJH: JH146_1036
MESG: MLAUSG7_0226(hdrC) MLAUSG7_1016(hdrC)
MESA: MLASG1_0761(hdrC) MLASG1_1449(hdrC)
MIG: Metig_0267 Metig_0422
MMP: MMP1054(hdrC2) MMP1154(hdrC1)
MMQ: MmarC5_0433 MmarC5_0539
MMX: MmarC6_1517 MmarC6_1604
MMZ: MmarC7_0308 MmarC7_0402
MMD: GYY_06110 GYY_06615
MMAK: MMKA1_12190(hdrC) MMKA1_13320(hdrC)
MMAO: MMOS7_11490(hdrC) MMOS7_12620(hdrC)
MMAD: MMJJ_16910 MMJJ_17960
MAE: Maeo_0307
MVN: Mevan_0377 Mevan_0474
MVO: Mvol_0795 Mvol_0807
MOK: Metok_0031
METF: CFE53_02215(hdrC) CFE53_06415(hdrC)
MTH: MTH_1878
MMG: MTBMA_c04490(hdrC)
MWO: MWSIV6_0409(hdrC)
MTEE: MTTB_11780
METC: MTCT_1716
METE: tca_01814
METZ: METMT2_0212
METK: FVF72_02315(hdrC)
MTHM: FZP57_01920(hdrC)
METJ: FZP68_06950(hdrC)
MST: Msp_1014(hdrC1)
METB: AW729_10825
MRU: mru_0816(hdrC)
MSI: Msm_0796
MEB: Abm4_1309(hdrC2)
MMIL: sm9_1717(hdrC2)
MEYE: TL18_07640
MOL: YLM1_0404
MARO: MarbSA_07070
METV: K4897_07515(hdrC)
MEL: Metbo_0700
MEW: MSWAN_1553
METH: MBMB1_1275
MFC: BRM9_0491(hdrC1)
MFI: DSM1535_0472(hdrC)
MCUB: MCBB_1490(hdrC3)
MSUB: BK009_05290
METN: BK008_00835
METT: CIT01_08465(hdrC)
METO: CIT02_11680(hdrC)
MEME: HYG87_08905(hdrC)
MFEG: GCM10025860_26200
MFV: Mfer_0740
MKA: MK0573(hdrC)
AFU: AF_1376
AFG: AFULGI_00014880
APO: Arcpr_1554
AVE: Arcve_1119
AST: Asulf_01080 Asulf_01821
FPL: Ferp_0837 Ferp_1394
GAC: GACE_0707 GACE_0932
GAH: GAH_01704
MBA: Mbar_A0640
MBY: MSBRM_3201
MBW: MSBRW_0363
MBAR: MSBR2_3161
MBAK: MSBR3_3157
MAC: MA_4236(hdrC)
MMA: MM_0979
MMAZ: MmTuc01_1009
MMJ: MSMAS_0320
MMAC: MSMAC_0324 MSMAC_2577
MVC: MSVAZ_3215
MEK: MSKOL_3183
MLS: MSLAZ_2784
METM: MSMTP_0365
MEF: MSWH1_2877
MEQ: MSWHS_2115
MSJ: MSSAC_3850
MSZ: MSSIH_3382
MSW: MSSIT_3451
MTHR: MSTHT_1572
MTHE: MSTHC_1717
MHOR: MSHOH_0418 MSHOH_1799
MFZ: AOB57_006955(hdrC)
MBU: Mbur_1516(hdrC)
MMET: MCMEM_1991
MELO: J7W08_08850(hdrC)
MMH: Mmah_1787
MHAZ: BHR79_04735
MPOT: BKM01_00865
MEV: Metev_1473
MZH: Mzhil_0329
MPY: Mpsy_1376 Mpsy_2938
MZI: HWN40_01885(hdrC)
MMAV: RE476_08385(hdrC)
MSEB: RE474_01420 RE474_04980(hdrC)
MHZ: Metho_0300
MEHF: MmiHf6_05710
MEES: MmiEs2_04310
MTP: Mthe_1574
MCJ: MCON_3282(hdrC)
MHI: Mhar_0605
MHU: Mhun_1836
MRTJ: KHC33_05225(hdrC)
MLA: Mlab_0239
MEM: Memar_0625
MBG: BN140_1726(hdrC)
MEMA: MMAB1_2221(hdrC)
MCHK: MchiMG62_07540
MSUM: OH143_09845(hdrC)
MRC: R6Y96_02590(hdrC)
MPI: Mpet_2473 Mpet_2479
MEFW: F1737_00655(hdrC)
MAQE: RJ40_06035(hdrC)
MFK: E2N92_06165(hdrC)
MOU: OU421_03590(hdrC)
MESB: L1S32_07190(hdrC)
MANQ: L1994_01130(hdrC)
MBN: Mboo_0590
MFO: Metfor_2601
MPL: Mpal_2241
MPD: MCP_1578(hdrC-1) MCP_2770(hdrC-3)
MEZ: Mtc_2475(hdrC-2)
RCI: RCIX594(hdrC-2) RRC256(hdrC-3)
MELU: MTLP_03940
TAR: TALC_01277
MAX: MMALV_13670
MER: MMINT_03240
MEAR: Mpt1_c02960(hdrC1) Mpt1_c08840(hdrC2)
MEUZ: KRP56_06645(hdrC)
MARC: AR505_0273
ABI: Aboo_0975
ACF: AciM339_1133
STO: STK_18710 STK_18750
SOH: D1869_10545 D1869_10565
SSO: SSO1127(hdrC-1) SSO1134(hdrC-2)
SOL: Ssol_2099 Ssol_2103
SSOA: SULA_2130 SULA_2134
SSOL: SULB_2131 SULB_2135
SSOF: SULC_2129 SULC_2133
SSHI: J5U23_02351 J5U23_02355
SCAS: SACC_10170 SACC_10210
SAI: Saci_0326 Saci_0334(hdrC)
SACN: SacN8_01600 SacN8_01640
SACR: SacRon12I_01600 SacRon12I_01640
SACS: SUSAZ_01660 SUSAZ_01700
SIS: LS215_1194 LS215_1198
SIA: M1425_1097 M1425_1101
SIM: M1627_1161 M1627_1165
SID: M164_1087 M164_1091
SIY: YG5714_1093 YG5714_1097
SIN: YN1551_1761 YN1551_1765
SII: LD85_1215 LD85_1219
SIH: SiH_1058 SiH_1062
SIR: SiRe_0971 SiRe_0975
SIC: SiL_0977 SiL_0981
SULA: BFU36_00900 BFU36_00920
SULE: GFS03_06305 GFS03_06325
SULO: GFS33_11685 GFS33_11705
SULL: EWF20_12025 EWF20_12045
MSE: Msed_1543 Msed_1547
MEMJ: MJ1HA_1760 MJ1HA_1764
MCN: Mcup_0684 Mcup_0688
MHK: DFR87_11005 DFR87_11025
MPRU: DFR88_10565 DFR88_10585
MTEN: GWK48_01310 GWK48_01330
MJN: MjAS7_2641 MjAS7_2645
AHO: Ahos_1692 Ahos_1696
AMAN: B6F84_12580 B6F84_12600
ABRI: DFR85_11425 DFR85_11445
ASUL: DFR86_10760 DFR86_10780
AAMB: D1866_03540 D1866_03560
ACIH: HS5_01350 HS5_01390
SACD: HS1genome_0376 HS1genome_0380
SAZO: D1868_10010 D1868_10030
CSTY: KN1_04060 KN1_04100
STEP: IC006_0775 IC006_0779
SMET: RQ359_001049 RQ359_001053
SAHS: HS7_01150 HS7_01190
VDI: Vdis_0690
KCR: Kcr_0766
BARC: AOA65_0030(hdrC_1) AOA65_1400(hdrC_2) AOA65_1888(hdrC_3) AOA65_1994(hdrC_4)
BARB: AOA66_1508(hdrC_1) AOA66_1732(hdrC_2)
LOKI: Lokiarch_01250(hdrC_1) Lokiarch_03060(hdrC_2) Lokiarch_23580(hdrC_3) Lokiarch_23870(hdrC_4) Lokiarch_39160(hdrC_5) Lokiarch_45500(hdrC_6)
LOB: NEF87_000188 NEF87_001641 NEF87_002005 NEF87_002032 NEF87_003202 NEF87_003526
PSYT: DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01162(hdrC_3) DSAG12_02806(hdrC_4) DSAG12_03218(hdrC_5) DSAG12_03726(hdrC_6) DSAG12_03953(hdrC_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
[mmg:MTBMA_c04490]
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
[mmg:MTBMA_c04490]
Reference
PMID:15009189
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1554]
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