KEGG ORTHOLOGY: K04404

ORTHOLOGY: K04404

Entry

K04404                      KO

Symbol

MAP3K7IP2, TAB2

Name

TAK1-binding protein 2

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04064

NF-kappa B signaling pathway

map04214

Apoptosis - fly

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05135

Yersinia infection

map05140

Leishmaniasis

map05145

Toxoplasmosis

map05161

Hepatitis B

map05162

Measles

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05417

Lipid and atherosclerosis

Disease

H02199

Congenital heart defects, multiple type

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04013 MAPK signaling pathway - fly
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04064 NF-kappa B signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04668 TNF signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04624 Toll and Imd signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04621 NOD-like receptor signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04657 IL-17 signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05161 Hepatitis B
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05171 Coronavirus disease - COVID-19
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05162 Measles
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05168 Herpes simplex virus 1 infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05169 Epstein-Barr virus infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05132 Salmonella infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05131 Shigellosis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05135 Yersinia infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05140 Leishmaniasis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2

Genes

HSA:	23118(TAB2)

PTR:	463057(TAB2)

PPS:	100992480(TAB2)

GGO:	101126531(TAB2)

PON:	100174071(TAB2)

NLE:	100597932(TAB2)

HMH:	116463159 116463202

MCC:	696875(TAB2)

MCF:	101865975(TAB2)

MTHB:

126952491

MNI:	105489001(TAB2)

CSAB:

103240159(TAB2)

CATY:

105588814(TAB2)

PANU:

100997900(TAB2)

TGE:	112622975(TAB2)

MLEU:

105528775(TAB2)

RRO:	104676257(TAB2) 115899261

RBB:	108536673(TAB2)

TFN:	117097302(TAB2)

PTEH:

111523666(TAB2)

CANG:

105515555(TAB2)

CJC:	100414129(TAB2)

SBQ:	101040230(TAB2)

CIMI:

108287389(TAB2)

CSYR:

103254079(TAB2)

MMUR:

105868645(TAB2)

LCAT:

123633357(TAB2)

PCOQ:

105819344(TAB2)

OGA:	100955970(TAB2)

MMU:	68652(Tab2)

MCAL:

110303600(Tab2)

MPAH:

110338176(Tab2)

RNO:	308267(Tab2)

MCOC:

116097745(Tab2)

ANU:	117700141(Tab2)

MUN:	110540621(Tab2)

CGE:	100759882(Tab2)

MAUA:

101844616(Tab2)

PROB:

127237647(Tab2)

PLEU:

114686371(Tab2)

MORG:

121466422(Tab2)

MFOT:

126513299

AAMP:

119820349(Tab2)

NGI:	103731917(Tab2)

HGL:	101698406(Tab2)

CPOC:

100717911(Tab2)

CCAN:

109692528(Tab2)

DORD:

105993663(Tab2)

DSP:	122102982(Tab2)

PLOP:

125357392(Tab2)

NCAR:

124988761

MMMA:

107156048(Tab2)

OCU:

100342249

OPI:	101517735(TAB2)

TUP:	102478674(TAB2)

GVR:	103593058(TAB2)

CFA:	484028(TAB2)

CLUD:

112644286(TAB2)

VVP:	112919509(TAB2)

VLG:	121482257(TAB2)

NPO:	129499952(TAB2)

AML:	100468085(TAB2)

UMR:	103666926(TAB2)

UAH:	113259542(TAB2)

UAR:	123797428(TAB2)

ELK:

111147521

LLV:

125101867

MPUF:

101690549(TAB2)

MNP:	132018229(TAB2)

MLK:	131833695(TAB2)

NVS:	122905565(TAB2)

ORO:	101369627(TAB2)

EJU:	114209197(TAB2)

ZCA:	113927705(TAB2)

MLX:	118001048(TAB2)

NSU:	110583336(TAB2)

LWW:	102732150(TAB2)

FCA:	101098714(TAB2)

PYU:	121013336(TAB2)

PCOO:

112862397(TAB2)

PBG:	122490077(TAB2)

PVIV:

125165360(TAB2)

LRUF:

124528760

PTG:	102959790(TAB2)

PPAD:

109252493(TAB2)

PUC:

125938017

AJU:

106987183

HHV:	120237570(TAB2)

BTA:	540203(TAB2)

BOM:	102278516(TAB2)

BIU:	109564026(TAB2)

BBUB:

102413796(TAB2)

BBIS:

105004816(TAB2)

CHX:	102187405(TAB2)

OAS:	101122114(TAB2)

BTAX:

128053126(TAB2)

ODA:	120862594(TAB2)

CCAD:

122433842(TAB2)

MBEZ:

129560692(TAB2)

SSC:	100156182(TAB2)

CFR:	102516031(TAB2)

CBAI:

105077308(TAB2)

CDK:	105100906(TAB2)

VPC:	102534039(TAB2)

BACU:

102997501(TAB2)

BMUS:

118905110(TAB2)

LVE:	103074334(TAB2)

OOR:	101284365(TAB2)

DLE:	111166813(TAB2)

PCAD:

102996495(TAB2)

PSIU:

116763460(TAB2)

NASI:

112401606(TAB2)

ECB:	100060433(TAB2)

EPZ:	103548723(TAB2)

EAI:	106837218(TAB2)

MYB:	102248925(TAB2)

MYD:	102770532(TAB2)

MMYO:

118659738(TAB2)

MLF:	102439412(TAB2)

PKL:	118705059(TAB2)

EFUS:

103302357(TAB2)

MNA:	107545742(TAB2)

DRO:	112297111(TAB2)

SHON:

118978986(TAB2)

AJM:	119057909(TAB2)

PDIC:

114495234(TAB2)

PHAS:

123821688(TAB2)

MMF:	118620813(TAB2)

PPAM:

129067833(TAB2)

HAI:	109380888(TAB2)

RFQ:	117020204(TAB2)

PALE:

102898592(TAB2)

PGIG:

120589386(TAB2)

PVP:	105289440(TAB2)

RAY:	107518453(TAB2)

MJV:	108395672(TAB2)

TOD:	119252963(TAB2)

SARA:

101539336(TAB2)

SETR:

126031061(TAB2)

LAV:	100656450(TAB2)

TMU:

101355146

ETF:	101642439(TAB2)

DNM:	101447376(TAB2)

MDO:	100026855(TAB2)

GAS:	123243627(TAB2)

SHR:	100930713(TAB2)

AFZ:

127562312

PCW:	110208533(TAB2)

OAA:	100074866(TAB2)

GGA:	421622(TAB2)

PCOC:

116241586(TAB2)

MGP:	100540789(TAB2)

CJO:	107311553(TAB2)

TPAI:

128079938(TAB2)

LMUT:

125689225(TAB2)

NMEL:

110395593(TAB2)

APLA:

101790309(TAB2)

ACYG:

106034268(TAB2)

CATA:

118244069(TAB2)

AFUL:

116487122(TAB2)

TGU:	100225126(TAB2)

LSR:	110468849(TAB2)

SCAN:

103818533(TAB2)

PMOA:

120501238(TAB2)

OTC:	121346041(TAB2)

PRUF:

121354820(TAB2)

GFR:	102037601(TAB2)

FAB:	101808905(TAB2)

OMA:	130250537(TAB2)

PHI:	102109164(TAB2)

PMAJ:

107202278(TAB2)

CCAE:

111926823(TAB2)

CCW:	104689165(TAB2)

CBRC:

103617060(TAB2)

ETL:	114059183(TAB2)

ZAB:	102062120(TAB2)

ZLE:	135445632(TAB2)

ACHL:

103804172(TAB2)

SVG:	106858498(TAB2)

MMEA:

130572351(TAB2)

HRT:	120750531(TAB2)

FPG:	101920039(TAB2)

FCH:	102047715(TAB2)

CLV:	102092362(TAB2)

EGZ:	104133546(TAB2)

NNI:	104013777(TAB2)

PCRI:

104028690(TAB2)

PLET:

104624032(TAB2)

EHS:	104508000(TAB2)

PCAO:

104046505(TAB2)

ACUN:

113478283(TAB2)

TALA:

104358632(TAB2)

PADL:

103917026(TAB2)

AFOR:

103900674(TAB2)

ACHC:

115345137(TAB2)

HALD:

104325173(TAB2)

HLE:	104840741(TAB2)

AGEN:

126038499

GCL:

127014098

CCRI:

104167306(TAB2)

CSTI:

104561184(TAB2)

CMAC:

104484103(TAB2)

MUI:	104536892(TAB2)

BREG:

104641813(TAB2)

FGA:	104083593(TAB2)

GSTE:

104263509(TAB2)

LDI:	104346900(TAB2)

MNB:	103780878(TAB2)

OHA:	104328697(TAB2)

NNT:	104402341(TAB2)

SHAB:

115614010(TAB2)

DPUB:

104297166(TAB2)

PGUU:

104461660(TAB2)

ACAR:

104530967(TAB2)

CPEA:

104390776(TAB2)

AVIT:

104276537(TAB2)

CVF:	104284909(TAB2)

RTD:	128906691(TAB2)

CUCA:

104056809(TAB2)

TEO:	104382407(TAB2)

BRHI:

104496992(TAB2)

AAM:	106486816(TAB2)

AROW:

112974544(TAB2)

NPD:	112951648(TAB2)

TGT:	104569901(TAB2)

DNE:	112983277(TAB2)

SCAM:

104151181(TAB2)

ASN:	102386987(TAB2)

AMJ:	102567745(TAB2)

CPOO:

109320128(TAB2)

GGN:	109304564(TAB2)

PSS:	102451479(TAB2)

CMY:	102941166(TAB2)

CCAY:

125634062(TAB2)

DCC:	119852884(TAB2)

CPIC:

101945138(TAB2)

TST:	117874855(TAB2)

CABI:

116819784(TAB2)

MRV:	120400767(TAB2)

ACS:	100553005(tab2)

ASAO:

132761043(TAB2)

PVT:	110087432(TAB2)

SUND:

121916815(TAB2)

PBI:

103054952

PMUR:

107287407(TAB2)

CTIG:

120309542(TAB2)

TSR:	106552457(TAB2)

PGUT:

117666352(TAB2)

APRI:

131191591(TAB2)

PTEX:

113439674(TAB2)

NSS:	113411242(TAB2)

VKO:	123019868(TAB2)

PMUA:

114594237(TAB2)

PRAF:

128410637(TAB2)

ZVI:	118082025(TAB2)

HCG:	128343120(TAB2)

GJA:	107114113(TAB2)

STOW:

125428599(TAB2)

EMC:	129334528(TAB2)

XLA:	108716751(tab2.L) 108717890(tab2.S)

XTR:	100037849(tab2)

NPR:	108789386(TAB2)

RTEM:

120937397(TAB2)

BBUF:

120998562(TAB2)

BGAR:

122935018(TAB2)

MUO:	115466654(TAB2)

GSH:	117356936(TAB2)

DRE:	494163(tab2)

SRX:	107708311 107739913

SANH:

107688309(tab2) 107696859

SGH:	107558968 107568749(tab2)

CCAR:

109070678 109113241

CAUA:

113037720 113063485

CGIB:

127983822

PTET:

122324605(tab2)

LROH:

127162147(tab2)

OMC:	131526712(tab2)

PPRM:

120468311(tab2)

RKG:	130077856(tab2)

MAMB:

125278955(tab2)

CIDE:

127502214

MASI:

127409886 127416155

TROS:

130565416(tab2)

TDW:	130434055(tab2)

IPU:

108275278

IFU:	128619228(tab2)

PHYP:

113529084(tab2)

SMEO:

124401369(tab2)

TFD:	113660549(tab2)

TVC:	132854466(tab2)

TRN:	134319847(tab2)

AMEX:

103032786(tab2)

CMAO:

118815291(tab2)

EEE:	113589932(tab2)

CHAR:

105897093(tab2)

TRU:	101069621(tab2)

TFS:	130515883(tab2)

TNG:	GSTEN00003790G001

LCO:	104918319(tab2)

NCC:	104941014(tab2)

TBEN:

117498309(tab2)

CGOB:

115028960(tab2)

PGEO:

117440205(tab2)

GACU:

117538684(tab2)

EMAC:

134876983(tab2)

ELY:	117270933(tab2)

EFO:	125897007(tab2)

PLEP:

121955308(tab2)

SLUC:

116040322(tab2)

ECRA:

117961933(tab2)

ESP:	116705943(tab2)

PFLV:

114573158(tab2)

GAT:	120807983(tab2)

PPUG:

119195078(tab2)

AFB:	129107031(tab2)

CLUM:

117727088(tab2)

PSWI:

130203221(tab2)

MSAM:

119908779(tab2)

SCHU:

122863405(tab2)

CUD:	121521210(tab2)

ALAT:

119012337(tab2)

MZE:	101482482(tab2)

ONL:	100700219(tab2)

OAU:	116316818(tab2)

OLA:	101168511(tab2)

OML:	112158259(tab2)

CSAI:

133418574(tab2)

XMA:	102236763(tab2)

XCO:	114158125(tab2)

XHE:	116734627(tab2)

PRET:

103458018(tab2)

PFOR:

103140747(tab2)

PLAI:

106953813(tab2)

PMEI:

106904317(tab2)

GAF:	122824823(tab2)

PPRL:

129369168(tab2)

CVG:	107093279(tab2)

CTUL:

119789456(tab2)

GMU:	124881924(tab2)

NFU:	107396012(tab2)

KMR:	108246525(tab2)

ALIM:

106537013(tab2)

NWH:	119418724(tab2)

AOCE:

111578164(tab2)

MCEP:

124998805(tab2)

CSEM:

103380596(tab2)

POV:	109632543(tab2)

SSEN:

122784290(tab2)

HHIP:

117758625(tab2)

HSP:	118099163(tab2)

PPLT:

128460487(tab2)

SMAU:

118289901(tab2)

LCF:

108899320

SDU:	111216386(tab2)

SLAL:

111645234(tab2)

XGL:	120789016(tab2)

HCQ:	109524845(tab2)

SSCV:

125990574

SBIA:

133496742(tab2)

PEE:	133416740(tab2)

PTAO:

133468019(tab2)

BPEC:

110158440(tab2)

MALB:

109968091(tab2)

BSPL:

114849544(tab2)

SJO:	128377212(tab2)

SASA:

106571309 106607744

STRU:

115174890 115194003

OTW:	112217538 112250087

OMY:	110522153 110529530

OGO:	123990682 123995018

ONE:	115107680 115139492

OKI:	109866705(tab2) 109900675

OKE:	118386818(tab2) 118398736

SALP:

111954242 112068181

SNH:	120019676 120024108

CCLU:

121548996 121552425

ELS:	105017897(tab2)

SFM:	108929403(tab2)

PKI:	111843039(tab2)

AANG:

118230136(tab2) 118237107

LOC:	102694529(tab2)

PSPA:

121315825 121316944(tab2)

ARUT:

117403068 117411419

PSEX:

120525344(tab2)

LCM:	102364705(TAB2)

CMK:	103179281(tab2)

RTP:	109917334(tab2)

CPLA:

122553035(tab2)

HOC:	132819859(tab2)

LERI:

129699346(tab2)

PMRN:

116953394(TAB2)

LRJ:	133351950(TAB2)

CIN:

100186829

SCLV:

120347167

SPU:

591886

DME:	Dmel_CG7417(Tab2)

DER:

6547204

DSE:

6609916

DSI:	Dsimw501_GD11443(Dsim_GD11443)

DYA:	Dyak_GE12037

DAN:

DSR:

DPO:

DPE:

DMN:	108160270 117193439

DWI:

6637980

DGR:

6568788

DMO:	Dmoj_GI18499

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000820

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:	657352(Tab2)

DPA:

SOY:

ATD:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200977

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:	105381746 105382097

LGLY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

NLU:

PHU:	Phum_PHUM268290

FOC:

ZNE:

BROR:

DMK:

PJA:

PCHN:

PCLA:

LSM:

DSV:

VDE:

VJA:

CSCU:

PTEP:

SDM:

LGI:	LOTGIDRAFT_154664

BGT:

HRF:

HRJ:

CRG:

PMAX:

ATEN:

Reference

PMID:10882101

Authors

Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K

Title

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

Journal

Mol Cell 5:649-58 (2000)
DOI:10.1016/S1097-2765(00)80244-0

Sequence

[hsa:23118]

LinkDB

DBGET integrated database retrieval system