KEGG ORTHOLOGY: K04415

ORTHOLOGY: K04415

Entry

K04415                      KO

Symbol

MAP3K8, COT

Name

mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04620

Toll-like receptor signaling pathway

map04660

T cell receptor signaling pathway

map04668

TNF signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
   04668 TNF signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
   04660 T cell receptor signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  Other
   K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8

Other DBs

GO:

0004709

Genes

HSA:	1326(MAP3K8)

PTR:	450384(MAP3K8)

PPS:	100978161(MAP3K8)

GGO:	101133328(MAP3K8)

PON:	103889401(MAP3K8)

NLE:	100579516(MAP3K8)

HMH:	116462065(MAP3K8)

MCC:	696936(MAP3K8)

MCF:	102132599(MAP3K8)

MTHB:

126963358

MNI:	105479953(MAP3K8)

CSAB:

103247459(MAP3K8)

CATY:

105596958(MAP3K8)

PANU:

101024944(MAP3K8)

TGE:	112632119(MAP3K8)

MLEU:

105537669(MAP3K8)

RRO:	104657273(MAP3K8)

RBB:	108528065(MAP3K8)

TFN:	117082018(MAP3K8)

PTEH:

111546640(MAP3K8)

CANG:

105521962(MAP3K8)

CJC:	100385107(MAP3K8)

SBQ:	101046566(MAP3K8)

CIMI:

108309141(MAP3K8)

CSYR:

103276430(MAP3K8)

MMUR:

105884788(MAP3K8)

LCAT:

123624815(MAP3K8)

PCOQ:

105818749 105818750

OGA:	100953651(MAP3K8)

MMU:	26410(Map3k8)

MCAL:

110284809(Map3k8)

MPAH:

110333248(Map3k8)

RNO:	116596(Map3k8)

MCOC:

116086796(Map3k8)

ANU:	117714402(Map3k8)

MUN:	110558401(Map3k8)

CGE:	100759538(Map3k8)

MAUA:

101833636(Map3k8)

PROB:

127237406(Map3k8)

MORG:

121440744(Map3k8)

MFOT:

126507798

AAMP:

119817321(Map3k8)

NGI:	103747991(Map3k8)

HGL:	101710286(Map3k8)

CPOC:

100725834(Map3k8)

CCAN:

109695913(Map3k8)

DORD:

105984525(Map3k8)

DSP:	122113201(Map3k8)

PLOP:

125367139(Map3k8)

NCAR:

124961556

MMMA:

107140424(Map3k8)

OCU:

100355566

OPI:	101520715(MAP3K8)

TUP:	102493021(MAP3K8)

GVR:	103601711(MAP3K8)

CFA:	487085(MAP3K8)

CLUD:

112670385(MAP3K8)

VVP:	112921580(MAP3K8)

VLG:	121498006(MAP3K8)

NPO:	129515595(MAP3K8)

AML:	100480593(MAP3K8)

UMR:	103656496(MAP3K8)

UAH:	113244248(MAP3K8)

UAR:	123802264(MAP3K8)

ELK:

111158620

LLV:

125107123

MPUF:

101671137(MAP3K8)

MNP:	132020058(MAP3K8)

MLK:	131838106(MAP3K8)

NVS:	122891627(MAP3K8)

ORO:	101385184(MAP3K8)

EJU:	114222423(MAP3K8)

ZCA:	113922054(MAP3K8)

MLX:	117998440(MAP3K8)

NSU:	110577249(MAP3K8)

LWW:	102739290(MAP3K8)

FCA:	101090624(MAP3K8)

PYU:	121014663(MAP3K8)

PCOO:

112867639(MAP3K8)

PBG:	122473980(MAP3K8)

PVIV:

125170753(MAP3K8)

LRUF:

124501424

PTG:	102961042(MAP3K8)

PPAD:

109276338(MAP3K8)

PUC:

125918661

AJU:

106977317

HHV:	120221616(MAP3K8)

BTA:	535622(MAP3K8)

BOM:	102278856(MAP3K8)

BIU:	109568007(MAP3K8)

BBUB:

102399287(MAP3K8)

BBIS:

105003067(MAP3K8)

CHX:	102188512(MAP3K8)

OAS:	101117094(MAP3K8)

BTAX:

128058726(MAP3K8)

ODA:	120869009(MAP3K8)

CCAD:

122448564(MAP3K8)

MBEZ:

129558685(MAP3K8)

SSC:	100622217(MAP3K8)

CFR:	102518335(MAP3K8)

CBAI:

105071706(MAP3K8)

CDK:	105096296(MAP3K8)

VPC:	102533792(MAP3K8)

BACU:

103010611(MAP3K8)

BMUS:

118890000(MAP3K8)

LVE:	103070441(MAP3K8)

OOR:	101269575(MAP3K8)

DLE:	111178133(MAP3K8)

PCAD:

102988471(MAP3K8)

PSIU:

116748892(MAP3K8)

NASI:

112402871(MAP3K8)

ECB:	100063602(MAP3K8)

EPZ:	103541518(MAP3K8)

EAI:	106837968(MAP3K8)

MYB:	102248363(MAP3K8)

MYD:	102775461(MAP3K8)

MMYO:

118677055(MAP3K8)

MLF:	102428565(MAP3K8)

PKL:	118727591(MAP3K8)

EFUS:

103294008(MAP3K8)

MNA:	107524427(MAP3K8)

DRO:	112316842(MAP3K8)

SHON:

118995176(MAP3K8)

AJM:

119063905

PDIC:

114491904(MAP3K8)

PHAS:

123831179(MAP3K8)

MMF:	118639002(MAP3K8)

PPAM:

129085670(MAP3K8)

HAI:	109389111(MAP3K8)

RFQ:	117022645(MAP3K8)

PALE:

102896654(MAP3K8)

PGIG:

120584101(MAP3K8)

PVP:	105298317(MAP3K8)

RAY:	107518939(MAP3K8)

MJV:	108392181(MAP3K8)

TOD:	119244638(MAP3K8)

SARA:

101550491(MAP3K8)

SETR:

126014144(MAP3K8)

LAV:	100662383(MAP3K8)

TMU:

101343130

ETF:	101649071(MAP3K8)

DNM:	101422236(MAP3K8)

MDO:	100018684(MAP3K8)

GAS:	123249099(MAP3K8)

SHR:	100925633(MAP3K8)

AFZ:

127564555

PCW:	110211269(MAP3K8)

OAA:	100076215(MAP3K8)

GGA:	420479(MAP3K8)

PCOC:

116244402(MAP3K8)

MGP:	100541097(MAP3K8)

CJO:	107308936(MAP3K8)

TPAI:

128086352(MAP3K8)

LMUT:

125696289(MAP3K8)

NMEL:

110393429(MAP3K8)

APLA:

101791769(MAP3K8)

ACYG:

106042681(MAP3K8)

CATA:

118247484(MAP3K8)

AFUL:

116486568(MAP3K8)

TGU:	100230596(MAP3K8)

LSR:	110477339(MAP3K8)

SCAN:

103812752(MAP3K8)

PMOA:

120503915(MAP3K8)

OTC:	121338045(MAP3K8)

PRUF:

121364572(MAP3K8)

GFR:	102035976(MAP3K8)

FAB:	101819414(MAP3K8)

OMA:	130249884(MAP3K8)

PHI:	102114163(MAP3K8)

PMAJ:

107200816(MAP3K8)

CCAE:

111924099(MAP3K8)

CCW:	104686470(MAP3K8)

CBRC:

103620627(MAP3K8)

ETL:	114060299(MAP3K8)

ZAB:	102070099(MAP3K8)

ZLE:	135443034(MAP3K8)

ACHL:

103804394(MAP3K8)

SVG:	106855578(MAP3K8)

MMEA:

130578235(MAP3K8)

HRT:	120754335(MAP3K8)

FPG:	101921040(MAP3K8)

FCH:	102055830(MAP3K8)

CLV:	102087091(MAP3K8)

EGZ:	104133587(MAP3K8)

NNI:	104022250(MAP3K8)

PCRI:

104028584(MAP3K8)

PLET:

104621251(MAP3K8)

EHS:	104504620(MAP3K8)

PCAO:

104052481(MAP3K8)

ACUN:

113476643(MAP3K8)

TALA:

104366750(MAP3K8)

PADL:

103918240(MAP3K8)

AFOR:

103895567(MAP3K8)

ACHC:

115339876(MAP3K8)

HALD:

104314762(MAP3K8)

HLE:	104842599(MAP3K8)

AGEN:

126037792

GCL:

127013069

CCRI:

104156094(MAP3K8)

CSTI:

104556476(MAP3K8)

CMAC:

104478361(MAP3K8)

MUI:	104537994(MAP3K8)

BREG:

104639876(MAP3K8)

FGA:	104083296(MAP3K8)

GSTE:

104261364(MAP3K8)

LDI:	104344174(MAP3K8)

MNB:	103772670(MAP3K8)

OHA:	104339011(MAP3K8)

NNT:	104407006(MAP3K8)

SHAB:

115609510(MAP3K8)

DPUB:

104298496(MAP3K8)

PGUU:

104466443(MAP3K8)

ACAR:

104525613(MAP3K8)

CPEA:

104397055(MAP3K8)

AVIT:

104275816(MAP3K8)

CVF:	104295358(MAP3K8)

RTD:	128906081(MAP3K8)

CUCA:

104066653(MAP3K8)

TEO:	104375373(MAP3K8)

BRHI:

104501562(MAP3K8)

AAM:	106489958(MAP3K8)

AROW:

112963216(MAP3K8)

NPD:	112955469(MAP3K8)

TGT:	104570213(MAP3K8)

DNE:	112984070(MAP3K8)

SCAM:

104147176(MAP3K8)

ASN:	102387437(MAP3K8)

AMJ:	102566471(MAP3K8)

CPOO:

109307420(MAP3K8)

GGN:	109291286(MAP3K8)

PSS:	102449623(MAP3K8)

CMY:	102936511(MAP3K8)

CCAY:

125631303(MAP3K8)

DCC:	119852255(MAP3K8)

CPIC:

101941097(MAP3K8)

TST:	117872092(MAP3K8)

CABI:

116815634(MAP3K8)

MRV:	120397005(MAP3K8)

ACS:	100562883(map3k8)

ASAO:

132778938(MAP3K8)

PVT:	110082918(MAP3K8)

SUND:

121935259(MAP3K8)

PBI:	103064348(MAP3K8)

PMUR:

107282828(MAP3K8)

CTIG:

120317307(MAP3K8)

TSR:	106548362(MAP3K8)

PGUT:

117654976(MAP3K8)

APRI:

131198334(MAP3K8)

PTEX:

113442468(MAP3K8)

NSS:	113415002(MAP3K8)

VKO:	123020769(MAP3K8)

PMUA:

114607849(MAP3K8)

PRAF:

128424340(MAP3K8)

ZVI:	118091971(MAP3K8)

HCG:	128328763(MAP3K8)

GJA:	107107910(MAP3K8)

STOW:

125440990(MAP3K8)

EMC:	129337658(MAP3K8)

XLA:	108718772(map3k8.L) 108719849(map3k8.S)

XTR:	100493069(map3k8)

NPR:	108788845(MAP3K8)

RTEM:

120940043(MAP3K8)

BBUF:

121002791(MAP3K8)

BGAR:

122938804(MAP3K8)

MUO:	115467485(MAP3K8)

GSH:	117354262(MAP3K8)

DRE:	563727(map3k8)

SRX:	107738976 107749374

SANH:

107665890 107686375

SGH:	107549410 107584407

CCAR:

109096626 109099537

CAUA:

113056113 113111840

CGIB:

127969125 128025254

PTET:

122332144(map3k8)

LROH:

127174075(map3k8)

OMC:	131550508(map3k8)

PPRM:

120471533 120471534

RKG:	130088671(map3k8)

MAMB:

125255242(map3k8)

CIDE:

127523392

MASI:

127422763 127427465

TROS:

130569227(map3k8)

TDW:	130439348(map3k8)

MANU:

129420945(map3k8)

IPU:

108274187

IFU:	128617277(map3k8)

PHYP:

113527715(map3k8)

SMEO:

124388915(map3k8)

TFD:	113662603(map3k8)

TVC:	132864038(map3k8)

TRN:	134321849(map3k8)

AMEX:

103031259(map3k8)

CMAO:

118809321(map3k8)

EEE:	113588627(map3k8)

CHAR:

105897242(map3k8)

TRU:	101069247(map3k8)

TFS:	130514185(map3k8)

TNG:	GSTEN00016563G001

LCO:	104928818(map3k8)

NCC:	104953904(map3k8)

TBEN:

117500007(map3k8)

CGOB:

115025450(map3k8)

PGEO:

117460500(map3k8)

GACU:

117549977(map3k8)

EMAC:

134884047(map3k8)

ELY:	117264380(map3k8)

EFO:	125881579(map3k8)

PLEP:

121960813(map3k8)

SLUC:

116048931(map3k8)

ECRA:

117937733(map3k8)

ESP:	116671912(map3k8)

PFLV:

114549165(map3k8)

GAT:	120811623(map3k8)

PPUG:

119198773(map3k8)

AFB:	129110714(map3k8)

PSWI:

130206121(map3k8)

MSAM:

119906521(map3k8)

SCHU:

122866695(map3k8)

CUD:	121527631(map3k8)

ALAT:

119008523(map3k8)

MZE:	101484222(map3k8)

ONL:	100710682(map3k8)

OAU:	116327470(map3k8)

OLA:	101159779(map3k8)

OML:	112151368(map3k8)

CSAI:

133423060(map3k8)

XMA:	102235260(map3k8)

XCO:	114137073(map3k8)

XHE:	116711854(map3k8)

PRET:

103482391(map3k8)

GAF:	122824156(map3k8)

PPRL:

129364962(map3k8)

CVG:	107085276(map3k8)

CTUL:

119793560(map3k8)

GMU:	124857687(map3k8)

NFU:	107377426(map3k8)

KMR:	108247128(map3k8)

ALIM:

106524835(map3k8)

AOCE:

111571049(map3k8)

MCEP:

124996063(map3k8)

CSEM:

103376862(map3k8)

POV:	109629507(map3k8)

SSEN:

122778030(map3k8)

HHIP:

117753979(map3k8)

HSP:	118098891(map3k8)

PPLT:

128425753(map3k8)

SMAU:

118291167(map3k8)

LCF:	108894681 108898340

SDU:	111228231(map3k8)

SLAL:

111669238(map3k8)

XGL:	120790247(map3k8)

HCQ:	109514181(map3k8)

SSCV:

125985669

SBIA:

133492719(map3k8)

PEE:	133396444(map3k8)

PTAO:

133470340(map3k8)

MALB:

109974520(map3k8)

BSPL:

114854157(map3k8)

SJO:	128382266(map3k8)

SASA:

100380500(m3k8) 106578553

STRU:

115153850 115195881

OTW:	112215597(map3k8) 112228040

OMY:	110490026 110535550

OGO:	124016988 124039846

ONE:	115105104 115130447

OKI:	109899545 109908729

OKE:	118361568 118374792

SALP:

111953230 111973334

SNH:	120027948 120050434

CCLU:

121549952 121569803

ELS:	105019416(map3k8)

SFM:	108927787(map3k8) 108937580

PKI:	111840193 111850109(map3k8)

AANG:

118226179(map3k8)

LOC:	102695077(map3k8)

PSPA:

121311604 121314104

ARUT:

117399861 117435608

PSEX:

120529757(map3k8)

LCM:	102367513(MAP3K8)

CMK:	103186428(map3k8)

RTP:	109916936(map3k8)

CPLA:

122550070

HOC:	132816133(map3k8)

LERI:

129715114(map3k8)

PTRU:

123498178

HRJ:

124270401

» show all

Reference

PMID:7681591

Authors

Patriotis C, Makris A, Bear SE, Tsichlis PN

Title

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation.

Journal

Proc Natl Acad Sci U S A 90:2251-5 (1993)
DOI:10.1073/pnas.90.6.2251

Sequence

[rno:116596]

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

LinkDB

DBGET integrated database retrieval system