KEGG ORTHOLOGY: K04418

ORTHOLOGY: K04418

Entry

K04418                      KO

Symbol

MAP3K10, MLK2

Name

mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10
   05022 Pathways of neurodegeneration - multiple diseases
    K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  MLK family
   K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10

Other DBs

GO:

0004709

Genes

HSA:	4294(MAP3K10)

PTR:	468880(MAP3K10)

PPS:	100977883(MAP3K10)

GGO:	101148067(MAP3K10)

PON:	100450681(MAP3K10)

PPYG:

129019693(MAP3K10)

NLE:	100588522(MAP3K10)

HMH:	116464513 116464517 116480038(MAP3K10)

SSYN:

129466468(MAP3K10)

MCC:	700477(MAP3K10)

MCF:	102132262(MAP3K10)

MTHB:

126941969

MNI:	105495346(MAP3K10)

CSAB:

103234697(MAP3K10)

CATY:

105597970(MAP3K10)

PANU:

101023378(MAP3K10)

TGE:	112613610(MAP3K10)

MLEU:

105542645(MAP3K10)

RRO:	104676124(MAP3K10)

RBB:	108539086(MAP3K10)

TFN:	117091958(MAP3K10)

PTEH:

111554068(MAP3K10)

CANG:

105519235(MAP3K10)

CJC:	100395802(MAP3K10)

SBQ:	101038631(MAP3K10)

CIMI:

108285672(MAP3K10)

ANAN:

105723414(MAP3K10)

CSYR:

103263969(MAP3K10)

MMUR:

105876773(MAP3K10)

LCAT:

123624324(MAP3K10)

ERUF:

138374480(MAP3K10)

PCOQ:

105820593(MAP3K10)

OGA:	100960652(MAP3K10)

MMU:	269881(Map3k10)

MCAL:

110298678(Map3k10)

MPAH:

110327052(Map3k10)

RNO:	308463(Map3k10)

MCOC:

116101890(Map3k10)

ANU:	117707223(Map3k10)

ASYL:

127672750(Map3k10)

MUN:	110556721(Map3k10)

CGE:	100768062(Map3k10)

MAUA:

101832508(Map3k10)

PROB:

127238881(Map3k10)

PLEU:

114681542(Map3k10)

PMAV:

102915848(Map3k10)

MORG:

121449139(Map3k10)

MFOT:

126492541

AAMP:

119820456(Map3k10)

CNL:	130862148(Map3k10)

NGI:	103750755(Map3k10)

HGL:	101718471(Map3k10)

CPOC:

100716869(Map3k10)

CCAN:

109688533(Map3k10)

DORD:

105998021(Map3k10)

DSP:	122097612(Map3k10)

DMER:

138811224 138813204

PLOP:

125338601(Map3k10)

NCAR:

124967089

SVUL:

306647848(MAP3K10)

MMMA:

107151641(Map3k10)

ITI:	101954678(Map3k10)

OCU:

100343621

OPI:	101517205(MAP3K10)

OCZ:	121153648(MAP3K10)

TUP:	102471323(MAP3K10)

GVR:	103598580(MAP3K10)

CFA:	484504(MAP3K10)

CLUD:

112645461(MAP3K10)

VVP:	112928296(MAP3K10)

VLG:	121484923(MAP3K10)

NPO:	129501025(MAP3K10)

AML:	100473197(MAP3K10)

UMR:	103661092(MAP3K10)

UAH:	113243573(MAP3K10)

UAR:	123784117(MAP3K10)

ELK:

111161402

LLV:

125089071

MPUF:

101688180(MAP3K10)

MNP:	132005771(MAP3K10)

MLK:	131817505(MAP3K10)

NVS:	122912031(MAP3K10)

ORO:	101375908(MAP3K10)

EJU:	114203660 114203668

ZCA:	113935534(MAP3K10)

MLX:	118022659(MAP3K10)

MANO:

123855662(MAP3K10)

NSU:	110590249(MAP3K10)

LWW:	102749094(MAP3K10)

FCA:	101089731(MAP3K10)

PYU:	121011333(MAP3K10)

PCOO:

112851311(MAP3K10)

PBG:	122494287(MAP3K10)

PVIV:

125152909(MAP3K10)

LRUF:

124511121

LGF:	123578938(MAP3K10)

AJU:

106979597

PTG:	102961509(MAP3K10)

PPAD:

109256635(MAP3K10)

PUC:

125915804

PLEZ:

122208521(MAP3K10)

HHV:	120244690(MAP3K10)

CCRU:

144239732(MAP3K10)

BTA:	781037(MAP3K10)

BOM:	102274152(MAP3K10)

BIU:	109572644(MAP3K10)

BJV:	133230601(MAP3K10)

BBUB:

102409579(MAP3K10)

BKE:	129630581(MAP3K10)

BBIS:

104995454(MAP3K10)

CHX:	102186147(MAP3K10)

OAS:	101118723(MAP3K10)

OCAN:

138418861(MAP3K10)

BTAX:

128063002(MAP3K10)

CSUM:

138096066(MAP3K10)

ODA:	120872378(MAP3K10)

CCAD:

122420917(MAP3K10)

MREE:

136161333(MAP3K10)

OVR:	110150155(MAP3K10)

MBEZ:

129546816(MAP3K10)

SSC:	100521453(MAP3K10)

CFR:	102509143(MAP3K10)

CBAI:

105062853(MAP3K10)

CDK:	105093336(MAP3K10)

VPC:	102543177(MAP3K10)

BACU:

103005548(MAP3K10)

BMUS:

118885932(MAP3K10)

LVE:	103085713(MAP3K10)

OOR:	101273274(MAP3K10)

LALB:

132509702(MAP3K10)

GMF:	115862434(MAP3K10)

DDP:	132417338(MAP3K10)

SCOO:

307179464(MAP3K10)

DLE:	111180858(MAP3K10)

PCAD:

102989373(MAP3K10)

PSIU:

116743895(MAP3K10)

PPHC:

136140236(MAP3K10)

NASI:

112415628(MAP3K10)

EPZ:	103560489(MAP3K10)

EAI:	106843249(MAP3K10)

MYB:	102240442(MAP3K10)

MYD:	102751509(MAP3K10)

MMYO:

118674387(MAP3K10)

MLF:	102428921(MAP3K10)

MDT:	132216892(MAP3K10)

MYUM:

138997066(MAP3K10)

PKL:	118702380(MAP3K10)

EFUS:

103284314(MAP3K10)

POTS:

308235168(MAP3K10)

MNA:	107534150(MAP3K10)

DRO:	112320192(MAP3K10)

SHON:

118988092(MAP3K10)

AJM:	119040450(MAP3K10)

PDIC:

114511012(MAP3K10)

PHAS:

123823790(MAP3K10)

MMF:	118639287(MAP3K10)

PPAM:

129076640(MAP3K10)

HAI:	109374860(MAP3K10)

RFQ:	117035063(MAP3K10)

PALE:

102885138(MAP3K10)

PGIG:

120595736(MAP3K10)

PVP:	105300213(MAP3K10)

RAY:	107521797(MAP3K10)

MJV:	108390480(MAP3K10)

TOD:	119249319(MAP3K10)

SARA:

101549242(MAP3K10)

SFUM:

130043394(MAP3K10)

SETR:

126028105(MAP3K10)

LAV:	100673821(MAP3K10)

TMU:

101358909

ETF:	101644379(MAP3K10)

DNM:	101416245(MAP3K10)

MDO:	100017495(MAP3K10)

GAS:	123240884(MAP3K10)

SHR:	100932009(MAP3K10)

AFZ:

127556187

PCW:	110202681(MAP3K10)

TVP:	118837975(MAP3K10)

PBRV:

138153996(MAP3K10)

MLAO:

141491782(MAP3K10)

OAA:	100092507(MAP3K10)

TACU:

119945911(MAP3K10)

AROW:

112961750

CIZ:	142024298(MAP3K10)

CMY:	114022375(MAP3K10)

CCAY:

125628105(MAP3K10)

LKP:	140902009(MAP3K10)

NDS:	141976644(MAP3K10)

CPIC:

101950530(MAP3K10)

CABI:

116833839(MAP3K10)

MRV:

120388410

EMQ:	137158747(MAP3K10)

ACS:	100565973(map3k10)

ASAO:

132780126(MAP3K10)

PVT:	110075665(MAP3K10)

SUND:

121915050(MAP3K10)

PBI:	112541949(MAP3K10)

PCAE:

139321301(MAP3K10)

PMUA:

114603188(MAP3K10)

PRAF:

128418225(MAP3K10)

ZVI:	118086153(MAP3K10)

HCG:	128332579(MAP3K10)

GJA:	107107364(MAP3K10)

EMC:	129342843(MAP3K10)

XLA:	398612(map3k10.L)

XTR:	100488058(map3k10)

NPR:	108794093(MAP3K10)

RTEM:

120913286(MAP3K10)

ACAT:

141107626(MAP3K10)

PADS:

140343980(MAP3K10)

BBUF:

120977238(MAP3K10)

BGAR:

122946351(MAP3K10)

DTC:	141052098(MAP3K10)

HSQ:	130290683(MAP3K10)

PCOB:

134949210(MAP3K10)

PWL:	138259474(MAP3K10)

MUO:	115480744(MAP3K10)

GSH:	117365642(MAP3K10)

DRE:	560932(map3k10)

DAES:

130246079(map3k10)

SRX:	107756783 107758231

SANH:

107662148(map3k10) 107668271

SGH:	107554498 107560156

CCAR:

109110162(map3k10) 109112840

CAUA:

113061670 113118465

CGIB:

127934616 127977587

PTET:

122363095(map3k10)

LROH:

127181196(map3k10)

GRF:	141345730(map3k10)

OMC:	131524139(map3k10)

PPRM:

120487726(map3k10)

RKG:	130089155(map3k10)

SCEP:

307160201(map3k10)

MAMB:

125254091(map3k10)

CIDE:

127500049

CERY:

137023433(map3k10)

MASI:

127416803 127456068

TROS:

130562926(map3k10)

TDW:	130435449(map3k10)

MANU:

129419578(map3k10)

PDAB:

135769707(map3k10)

IPU:

108264755

IFU:	128606519(map3k10)

PHYP:

113526695(map3k10)

SMEO:

124395773(map3k10)

TFD:	113636998(map3k10)

TVC:	132850977(map3k10)

CGAR:

128527416(map3k10)

NGRA:

132887774(map3k10)

TRN:	134323585(map3k10)

AMEX:

103031546(map3k10)

CMAO:

118817968(map3k10)

EEE:	113579053(map3k10)

CHAR:

105903203(map3k10)

SPIL:

134099571(map3k10)

ASAD:

121684059(map3k10)

TRU:	101068242(map3k10)

TFS:	130534981(map3k10)

TNG:	GSTEN00014792G001

NCC:	104966770(map3k10)

TBEN:

117470326(map3k10)

CGOB:

115018000(map3k10)

PGEO:

117457542(map3k10)

GACU:

117554808(map3k10)

EMAC:

134880776(map3k10)

ELY:	117260032(map3k10)

EFO:	125889246(map3k10)

PLEP:

121943265(map3k10)

SLUC:

116047708(map3k10)

SVIT:

144515351(map3k10)

ECRA:

117941825(map3k10)

ESP:	116677434(map3k10)

PFLV:

114553209(map3k10)

PFLT:

120545766(map3k10)

GAT:	120830641(map3k10)

PPUG:

119210483(map3k10)

AFB:	129094201(map3k10)

CLUM:

117741992(map3k10)

PSWI:

130210589(map3k10)

CANA:

137790332(map3k10)

CVE:	137873097(map3k10)

AMIR:

142958959(map3k10)

MSAM:

119882953(map3k10)

SCHU:

122879654(map3k10)

EARM:

139285252(map3k10)

CUD:	121527255(map3k10)

SPUL:

138596874(map3k10)

LMIX:

132980632(map3k10)

HTC:	141797758(map3k10)

ALAT:

119033342(map3k10)

ASTR:

137597214(map3k10)

PKLU:

139200602(map3k10)

LCO:	104931623(map3k10)

MZE:	101477145(map3k10)

ONL:	100704108(map3k10)

OAU:	116323631(map3k10)

OLA:	101161665(map3k10)

OML:	112149570(map3k10)

CSAI:

133441787(map3k10)

XMA:	102222970(map3k10)

XCO:	114133159(map3k10)

XHE:	116707763(map3k10)

PRET:

103474653(map3k10)

PFOR:

103136302(map3k10)

PLAI:

106939278(map3k10)

PMEI:

106927225(map3k10)

GAF:	122833271(map3k10)

PPRL:

129369998(map3k10)

CVG:	107096867(map3k10)

CTUL:

119797331(map3k10)

GMU:	124883831(map3k10)

NFU:	107380271(map3k10)

KMR:	108240940(map3k10)

ALIM:

106527840(map3k10)

NWH:	119410626(map3k10)

LTU:	140314267(map3k10)

MCEP:

125014002(map3k10)

AOCE:

111581163(map3k10)

EJA:	138197376(map3k10)

BFRE:

138625441(map3k10)

LCF:

108900869

CSEM:

103378455(map3k10)

POV:	109630421(map3k10)

SSEN:

122773365(map3k10)

SSOE:

131462495(map3k10)

HHIP:

117772640(map3k10)

HSP:	118106588(map3k10)

PPLT:

128440669(map3k10)

SMAU:

118299643(map3k10)

SDU:	111238128(map3k10)

SLAL:

111654131(map3k10)

XGL:	120792141(map3k10)

HCQ:	109526404(map3k10)

SSCV:

125972681(map3k10)

SBIA:

133505138(map3k10)

PEE:	133405456(map3k10)

PTAO:

133482173(map3k10)

BPEC:

110163573(map3k10)

ENY:	140378110(map3k10)

MALB:

109974338(map3k10)

BSPL:

114867833(map3k10)

SJO:	128360584(map3k10)

SSCO:

133980830(map3k10)

TTY:	137186140(map3k10)

SASA:

106612493(map3k10)

STRU:

115162967 115205926(map3k10)

OTW:	112244698 112267356

OMY:	110503560(map3k10) 110507406

OGO:	123993083 124005679

ONE:	115137098 115141518

OKI:	109904763 109909348

OKE:	118357376(map3k10) 118397116

OMM:	135546089 135552560

OCLA:

139382829 139386247

SALP:

111949618(map3k10)

SNH:	120018414 120029063

SFON:

129821825 129832403

CCLU:

121560514 121568443

ELS:	105011943(map3k10)

OEP:	134029074(map3k10)

SFM:	108932174(map3k10)

PKI:	111844900(map3k10)

AANG:

118209705(map3k10)

AROT:

135236064(map3k10)

CCOG:

133107880(map3k10)

LOC:	102696038(map3k10)

PSPA:

121303891(map3k10) 121304857

ARUT:

117394801 117416186

PSEX:

120538708(map3k10)

CMK:	103190243(map3k10)

CPLA:

122542684(map3k10)

CPUN:

140454609(map3k10)

HOC:	132836671(map3k10)

SCAU:

119957917(map3k10)

LERI:

129714134(map3k10)

HAKA:

140737378(map3k10)

LPIC:

LVG:

AJC:

AGRG:

APLN:

PPYR:

FAS:

HHAL:

106682573(slpr)

CSEC:

PPOI:

HRF:

RPHI:

EPA:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

Reference

PMID:8536694

Authors

Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ

Title

Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.

Journal

Eur J Biochem 234:492-500 (1995)
DOI:10.1111/j.1432-1033.1995.492_b.x

Sequence

[hsa:4294]

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

LinkDB

DBGET integrated database retrieval system