KEGG ORTHOLOGY: K04420

ORTHOLOGY: K04420

Entry

K04420                      KO

Symbol

MAP3K2, MEKK2

Name

mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04540

Gap junction

map04912

GnRH signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2

Other DBs

GO:

0004709

Genes

HSA:	10746(MAP3K2)

PTR:	736244(MAP3K2)

PPS:	100973371(MAP3K2)

GGO:	101149805(MAP3K2)

PON:	100450054(MAP3K2)

NLE:	100601802(MAP3K2)

HMH:	116462992(MAP3K2)

MCC:	100424131(MAP3K2)

MCF:	102138136(MAP3K2)

MTHB:

126933061

MNI:	105492428(MAP3K2)

CSAB:

103216879(MAP3K2)

CATY:

105592087(MAP3K2)

PANU:

101009475(MAP3K2)

TGE:	112635784(MAP3K2)

MLEU:

105539998(MAP3K2)

RRO:	104662431(MAP3K2)

RBB:	108533000(MAP3K2)

TFN:	117095159(MAP3K2)

PTEH:

111551574(MAP3K2)

CANG:

105511521(MAP3K2)

CJC:	100406711(MAP3K2)

SBQ:	101035799(MAP3K2)

CIMI:

108317750(MAP3K2)

CSYR:

103276598(MAP3K2)

MMUR:

105857534(MAP3K2)

LCAT:

123643354(MAP3K2)

PCOQ:

105814842(MAP3K2)

OGA:	100959913(MAP3K2)

MMU:	26405(Map3k2)

MCAL:

110284747(Map3k2)

MPAH:

110333106(Map3k2)

RNO:	171492(Map3k2)

MCOC:

116086949(Map3k2)

ANU:	117719731(Map3k2)

MUN:	110553443(Map3k2)

CGE:	100772559(Map3k2)

MAUA:

101841854(Map3k2)

PROB:

127235127(Map3k2)

PLEU:

114691643(Map3k2)

MORG:

121445789 121453706(Map3k2)

MFOT:

126497096

AAMP:

119814348(Map3k2)

NGI:	103732132(Map3k2)

HGL:	101726195(Map3k2)

CPOC:

100723690(Map3k2)

CCAN:

109699113(Map3k2)

DORD:

105988946(Map3k2)

DSP:	122112321(Map3k2)

PLOP:

125350813(Map3k2)

NCAR:

124979813

MMMA:

107136789(Map3k2)

OCU:

100355693

OPI:	101520350(MAP3K2)

TUP:	102485186(MAP3K2)

GVR:	103591821(MAP3K2)

CFA:	612902(MAP3K2)

CLUD:

112652434(MAP3K2)

VVP:	112932690(MAP3K2)

VLG:	121481972(MAP3K2)

NPO:	129503742(MAP3K2)

AML:	100475426(MAP3K2)

UMR:	103658571(MAP3K2)

UAH:	113263482(MAP3K2)

UAR:	123779518(MAP3K2)

ELK:

111160868

LLV:

125096067

MPUF:

101680578(MAP3K2)

MNP:	132013979(MAP3K2)

MLK:	131826895(MAP3K2)

NVS:	122902757(MAP3K2)

ORO:	101368270(MAP3K2)

EJU:	114207235(MAP3K2)

ZCA:	113919414(MAP3K2)

MLX:	118012568(MAP3K2)

NSU:	110585725(MAP3K2)

LWW:	102728069(MAP3K2)

FCA:	101096406(MAP3K2)

PYU:	121030401(MAP3K2)

PCOO:

112865537(MAP3K2)

PBG:	122481226(MAP3K2)

PVIV:

125172033(MAP3K2)

LRUF:

124514585

PTG:	102957925(MAP3K2)

PPAD:

109278797(MAP3K2)

PUC:

125911703

AJU:

106966378

HHV:	120245944(MAP3K2)

BTA:	504592(MAP3K2)

BOM:	102273125(MAP3K2)

BIU:	109565311(MAP3K2)

BBUB:

102406531(MAP3K2)

BBIS:

105005036(MAP3K2)

CHX:	102175623(MAP3K2)

OAS:	101109858(MAP3K2)

BTAX:

128071523(MAP3K2)

ODA:	120854033(MAP3K2)

CCAD:

122453931(MAP3K2)

MBEZ:

129538502(MAP3K2)

SSC:	100621234(MAP3K2)

CFR:	102505073(MAP3K2)

CBAI:

105068597(MAP3K2)

CDK:	105084487(MAP3K2)

VPC:	102530654(MAP3K2)

BACU:

103017845(MAP3K2)

BMUS:

118897825(MAP3K2)

LVE:	103083140(MAP3K2)

OOR:	101270305(MAP3K2)

DLE:	111183352(MAP3K2)

PCAD:

102985391(MAP3K2)

PSIU:

116756540(MAP3K2)

NASI:

112394996(MAP3K2)

ECB:	100050628(MAP3K2)

EPZ:	103562194(MAP3K2)

EAI:	106834092(MAP3K2)

MYB:	102245865(MAP3K2)

MYD:	102753581(MAP3K2)

MMYO:

118661831(MAP3K2)

MLF:	102421812(MAP3K2)

PKL:	118708818(MAP3K2)

EFUS:

103301216(MAP3K2)

MNA:	107528582(MAP3K2)

DRO:	112313010(MAP3K2)

AJM:	119045211(MAP3K2)

PDIC:

114494679(MAP3K2)

PHAS:

123810283(MAP3K2)

MMF:	118625228(MAP3K2)

PPAM:

129071749(MAP3K2)

HAI:	109371823(MAP3K2)

RFQ:	117020093(MAP3K2)

PALE:

102880422(MAP3K2)

PGIG:

120593428(MAP3K2)

PVP:	105294444(MAP3K2)

RAY:	107516884(MAP3K2)

MJV:	108400895(MAP3K2)

TOD:	119255707(MAP3K2)

SARA:

101544873(MAP3K2)

SETR:

126008841(MAP3K2)

LAV:	100665139(MAP3K2)

TMU:

101349577

ETF:	101647418(MAP3K2)

DNM:	101441585(MAP3K2)

MDO:	100026735(MAP3K2)

GAS:	123242307(MAP3K2)

SHR:	100916713(MAP3K2)

AFZ:

127554294

PCW:	110194666(MAP3K2)

OAA:	100087843(MAP3K2)

GGA:	424225(MAP3K2)

PCOC:

116227346(MAP3K2)

MGP:	100543830(MAP3K2)

CJO:	107316800(MAP3K2)

TPAI:

128076663(MAP3K2)

LMUT:

125697180(MAP3K2)

NMEL:

110399799(MAP3K2)

APLA:

101798043(MAP3K2)

ACYG:

106045922(MAP3K2)

CATA:

118259964(MAP3K2)

AFUL:

116490728(MAP3K2)

TGU:	100219827(MAP3K2) 116808715

LSR:	110468326(MAP3K2)

SCAN:

103814336(MAP3K2)

PMOA:

120508525(MAP3K2)

OTC:	121337177(MAP3K2)

PRUF:

121356542(MAP3K2)

GFR:	102033648(MAP3K2)

FAB:	101811653(MAP3K2)

OMA:	130255601(MAP3K2)

PHI:	102113050(MAP3K2)

PMAJ:

107207590(MAP3K2)

CCAE:

111932210(MAP3K2)

CCW:	104693990(MAP3K2)

CBRC:

103625418(MAP3K2)

ETL:	114055550(MAP3K2)

ZAB:	102062111(MAP3K2)

ZLE:	135450129(MAP3K2)

ACHL:

103810253(MAP3K2)

SVG:	106861393(MAP3K2)

MMEA:

130572822(MAP3K2)

HRT:	120755028(MAP3K2)

FPG:	101921462(MAP3K2)

FCH:	102052668(MAP3K2)

CLV:	102092494(MAP3K2)

EGZ:	104133722(MAP3K2)

NNI:	104018989(MAP3K2)

PCRI:

104031282(MAP3K2)

PLET:

104613902(MAP3K2)

EHS:	104511742(MAP3K2)

PCAO:

104040558(MAP3K2)

ACUN:

113482266(MAP3K2)

TALA:

104364725(MAP3K2)

PADL:

103916532(MAP3K2)

AFOR:

103895391(MAP3K2)

ACHC:

115342457(MAP3K2)

HALD:

104325911(MAP3K2)

HLE:	104832345(MAP3K2)

AGEN:

126037983

GCL:

127018205

CCRI:

104162623(MAP3K2)

CSTI:

104555134(MAP3K2)

CMAC:

104479327(MAP3K2)

MUI:	104535681(MAP3K2)

BREG:

104630430(MAP3K2)

FGA:	104071445(MAP3K2)

GSTE:

104251916(MAP3K2)

LDI:	104349527(MAP3K2)

MNB:	103768947(MAP3K2)

OHA:	104335225(MAP3K2)

NNT:	104400882(MAP3K2)

SHAB:

115607962(MAP3K2)

DPUB:

104309758(MAP3K2)

PGUU:

104467138(MAP3K2)

ACAR:

104519825(MAP3K2)

CPEA:

104387320(MAP3K2)

AVIT:

104275935(MAP3K2)

CVF:	104288477(MAP3K2)

RTD:	128913043(MAP3K2)

CUCA:

104056213(MAP3K2)

TEO:	104379869(MAP3K2)

BRHI:

104494824(MAP3K2)

AAM:	106499278(MAP3K2)

AROW:

112972018(MAP3K2)

NPD:	112950071(MAP3K2)

TGT:	104568405(MAP3K2)

DNE:	112980569(MAP3K2)

SCAM:

104139599(MAP3K2)

ASN:	102379289 102381161

AMJ:	102574412(MAP3K2)

CPOO:

109322513 109322639

GGN:	109301455 109301576

PSS:	102448094(MAP3K2)

CMY:	102941356(MAP3K2)

CCAY:

125644755(MAP3K2)

DCC:	119863684(MAP3K2)

CPIC:

101934711(MAP3K2)

TST:	117884687(MAP3K2)

CABI:

116828386(MAP3K2)

MRV:	120374714(MAP3K2)

ACS:	100558170(map3k2)

ASAO:

132774169(MAP3K2)

PVT:	110085271(MAP3K2)

SUND:

121919144(MAP3K2)

PBI:	103049938(MAP3K2)

PMUR:

107302054(MAP3K2)

CTIG:

120298299(MAP3K2)

TSR:	106548568(MAP3K2)

PGUT:

117668232(MAP3K2)

APRI:

131204514(MAP3K2)

PTEX:

113441211(MAP3K2)

NSS:	113410690(MAP3K2)

VKO:	123027569(MAP3K2)

PMUA:

114603537(MAP3K2)

PRAF:

128420767(MAP3K2)

ZVI:	118091365(MAP3K2)

HCG:	128345545(MAP3K2)

GJA:	107117807(MAP3K2)

STOW:

125425883(MAP3K2)

EMC:	129323747(MAP3K2)

XLA:	108701261(map3k2.L) 108702901(map3k2.S)

XTR:	100493570(map3k2)

NPR:	108785393(MAP3K2)

RTEM:

120944245(MAP3K2)

BBUF:

121008685(MAP3K2)

BGAR:

122923875(MAP3K2)

MUO:	115474821(MAP3K2)

DRE:	558321(map3k2)

SRX:	107705487 107706666

SANH:

107660022 107677576

SGH:	107581346 107584801

CCAR:

109057196(map3k2) 109089690

CAUA:

113050870 113092298

CGIB:

127959585 128016158

PTET:

122346889(map3k2)

LROH:

127166627(map3k2)

OMC:	131542360(map3k2)

PPRM:

120491364(map3k2)

RKG:	130101312(map3k2)

MAMB:

125274238(map3k2)

CIDE:

127514127

MASI:

127446267 127448770

TROS:

130556647(map3k2)

TDW:	130424759(map3k2)

MANU:

129451169(map3k2)

IPU:

108272715

IFU:	128615724(map3k2)

PHYP:

113538380(map3k2)

SMEO:

124390226(map3k2)

TFD:	113651071(map3k2)

TVC:	132844940(map3k2)

TRN:	134316512(map3k2)

AMEX:

103026704(map3k2)

CMAO:

118807844(map3k2)

EEE:	113584100(map3k2)

TRU:	101069746(map3k2)

TFS:	130522343(map3k2)

TNG:	GSTEN00003091G001 GSTEN00031843G001

LCO:	104934606(map3k2)

TBEN:

117499194(map3k2)

CGOB:

115017317

PGEO:

117440886

EMAC:

134860973(map3k2)

ELY:	117249877(map3k2)

EFO:	125884821(map3k2)

PLEP:

121962696(map3k2)

SLUC:

116044770(map3k2)

ECRA:

117939603(map3k2)

ESP:	116673862(map3k2)

PFLV:

114550986(map3k2)

GAT:	120821828(map3k2)

PPUG:

119220166(map3k2)

AFB:	129111508(map3k2)

CLUM:

117741848(map3k2)

PSWI:

130204412(map3k2)

MSAM:

119900363(map3k2)

SCHU:

122871834(map3k2)

CUD:	121506159(map3k2)

ALAT:

119015229(map3k2)

MZE:	101464541(map3k2)

ONL:	100705497(map3k2)

OAU:	116317140(map3k2)

OLA:	101160297(map3k2)

OML:	112156757(map3k2)

CSAI:

133425187(map3k2)

XMA:	102232571(map3k2)

XCO:	114140552(map3k2)

XHE:	116715804(map3k2)

PRET:

103457092(map3k2)

PFOR:

103154108

PLAI:

106949502

PMEI:

106919573(map3k2)

GAF:	122826942(map3k2)

PPRL:

129356975(map3k2)

CVG:	107103639(map3k2)

CTUL:

119794653(map3k2)

GMU:	124861929(map3k2)

NFU:	107384647(map3k2)

KMR:	108246834(map3k2)

ALIM:

106531440(map3k2)

NWH:	119428919(map3k2)

AOCE:

111562626(map3k2)

MCEP:

125000989(map3k2)

CSEM:

103389509(map3k2)

POV:	109640231(map3k2)

SSEN:

122764665(map3k2)

HHIP:

117778062(map3k2)

HSP:	118103322(map3k2)

PPLT:

128430817(map3k2)

SMAU:

118317047(map3k2)

LCF:

108873167

SDU:	111222725(map3k2)

SLAL:

111672426(map3k2)

XGL:	120798063(map3k2)

HCQ:	109520183(map3k2)

SSCV:

125987743

SBIA:

133505770(map3k2)

PEE:	133402519(map3k2)

PTAO:

133478744(map3k2)

BPEC:

110165688(map3k2)

MALB:

109955649(map3k2)

BSPL:

114845767(map3k2)

SJO:	128354521(map3k2)

SASA:

106574243 106575171

STRU:

115179118 115196032

OTW:	112253822 112266510

OMY:	110495870 110527482

OGO:	124008084 124010861

ONE:	115129705 115133479

OKI:	109878173 109906717

OKE:	118363754 118370219

SALP:

111953393 111971080

SNH:	120033319 120051283

CCLU:

121540883(map3k2)

ELS:	105019952(map3k2)

SFM:	108920647(map3k2)

PKI:	111840805(map3k2)

AANG:

118214016(map3k2)

LOC:	102696072(map3k2)

PSPA:

121322029

ARUT:

117409171(map3k2) 117414908

PSEX:

120531266(map3k2)

LCM:	102350566(MAP3K2)

CMK:	103189809(map3k2)

CPLA:

122551845(map3k2)

HOC:	132817695(map3k2)

LERI:

129695189(map3k2)

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

BMY:	BM_BM5676(Bm5676)

LOA:	LOAG_05805

LGI:	LOTGIDRAFT_139776

PVUL:

126807869

PCAN:

112574465

BGT:	106060316 106068194 106075259

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

DPOL:

OBI:

OSN:

LAK:

NVE:	116609751 116619341 5513186

EPA:	110240989 110253938

ATEN:

116292986

ADF:

107347933

AMIL:

114948103 114970263

PDAM:

113665784 113672621 113682181

SPIS:

111327565 111330209 111337057 111341664

DGT:	114525673 114542461

HSY:

130641830

TAD:	TRIADDRAFT_22456

AQU:

100632568

SLY:	101263809 101264176

SPEN:

107011869 107015984

SOT:	102583428 102594279 102600645

SSTN:

125848269 125855456

SDUL:

129873982 129902968

CANN:

107853292 107867121

LBB:	132622602 132627912

NTA:	107759622 107794142 107798149 107802508 107805689

NSY:	104210273 104236972

NTO:	104094695 104095169 104105448

NAU:	109217874 109224935 109225188

SIND:

SSPL:

SMIL:

SHIS:

HAN:

LSV:

CCAV:

CSIN:

RVL:

MBR:	MONBRDRAFT_1800

JAG:

GJA_3447

» show all

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

LinkDB

DBGET integrated database retrieval system