KEGG ORTHOLOGY: K04443

ORTHOLOGY: K04443

Entry

K04443                      KO

Symbol

MAPKAPK2

Name

mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]

Pathway

map04010

MAPK signaling pathway

map04148

Efferocytosis

map04218

Cellular senescence

map04361

Axon regeneration

map04370

VEGF signaling pathway

map04625

C-type lectin receptor signaling pathway

map04722

Neurotrophin signaling pathway

map05167

Kaposi sarcoma-associated herpesvirus infection

map05203

Viral carcinogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
   04370 VEGF signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09143 Cell growth and death
   04218 Cellular senescence
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09158 Development and regeneration
   04361 Axon regeneration
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2

Genes

HSA:	9261(MAPKAPK2)

PTR:	744091(MAPKAPK2)

PPS:	100968858(MAPKAPK2)

GGO:	101151250(MAPKAPK2)

PON:	100446757(MAPKAPK2)

NLE:	100579643(MAPKAPK2)

HMH:	116457332(MAPKAPK2)

MCC:	695044(MAPKAPK2)

MCF:	102131033(MAPKAPK2)

MTHB:

126949445

MNI:	105484848(MAPKAPK2)

CSAB:

103230194(MAPKAPK2)

CATY:

105576691(MAPKAPK2)

PANU:

101024625(MAPKAPK2)

TGE:	112629024(MAPKAPK2)

MLEU:

105554633(MAPKAPK2)

RRO:	104661739(MAPKAPK2)

RBB:	108535144(MAPKAPK2)

TFN:	117076159(MAPKAPK2)

PTEH:

111522809(MAPKAPK2)

CANG:

105509458(MAPKAPK2)

CJC:	100393258(MAPKAPK2)

SBQ:	101052249(MAPKAPK2)

CIMI:

108302080(MAPKAPK2)

CSYR:

103258003(MAPKAPK2)

MMUR:

105869016(MAPKAPK2)

LCAT:

123627136(MAPKAPK2)

PCOQ:

105805879(MAPKAPK2)

OGA:	100966784(MAPKAPK2)

MMU:	17164(Mapkapk2)

MCAL:

110294905(Mapkapk2)

MPAH:

110321250(Mapkapk2)

RNO:	289014(Mapkapk2)

MCOC:

116098772(Mapkapk2)

ANU:	117716254(Mapkapk2)

MUN:	110550321(Mapkapk2)

CGE:	100762218(Mapkapk2)

MAUA:

101840678(Mapkapk2)

PROB:

127236351(Mapkapk2)

PLEU:

114698053(Mapkapk2)

MORG:

121446223(Mapkapk2)

MFOT:

126505043

AAMP:

119825282 119827858(Mapkapk2)

NGI:	103725934(Mapkapk2)

HGL:	101708612(Mapkapk2)

CPOC:

100715906(Mapkapk2)

CCAN:

109688375(Mapkapk2)

DORD:

105986431(Mapkapk2)

DSP:	122109435(Mapkapk2)

PLOP:

125359327(Mapkapk2)

NCAR:

124962236

MMMA:

107140607(Mapkapk2)

OCU:

100009438

OPI:	101529341(MAPKAPK2)

TUP:	102483974(MAPKAPK2)

GVR:	103600441(MAPKAPK2)

CFA:	490263(MAPKAPK2)

CLUD:

112648298(MAPKAPK2)

VVP:	112910998(MAPKAPK2)

VLG:	121492957(MAPKAPK2)

NPO:	129505876(MAPKAPK2)

AML:	100483931(MAPKAPK2)

UMR:	103657756(MAPKAPK2)

UAH:	113242594(MAPKAPK2)

UAR:	123785786(MAPKAPK2)

ELK:

111151153

LLV:

125085671

MPUF:

101672433(MAPKAPK2)

MNP:	132025572(MAPKAPK2)

MLK:	131814368(MAPKAPK2)

NVS:	122918746(MAPKAPK2)

ORO:	101380197(MAPKAPK2)

EJU:	114221927(MAPKAPK2)

ZCA:	113932093(MAPKAPK2)

MLX:	118014249(MAPKAPK2)

NSU:	110574092(MAPKAPK2)

LWW:	102748160(MAPKAPK2)

FCA:	101090833(MAPKAPK2)

PYU:	121022432(MAPKAPK2)

PCOO:

112857691(MAPKAPK2)

PBG:	122476270(MAPKAPK2)

PVIV:

125155226(MAPKAPK2)

LRUF:

124510055

PTG:	102961644(MAPKAPK2)

PPAD:

109250406(MAPKAPK2)

PUC:

125925352

AJU:

106981771

HHV:	120245595(MAPKAPK2)

BTA:	788091(MAPKAPK2)

BOM:	102274647(MAPKAPK2)

BIU:	109570101(MAPKAPK2)

BBUB:

102401914(MAPKAPK2)

BBIS:

104998875(MAPKAPK2)

CHX:	102184079(MAPKAPK2)

OAS:	101118118(MAPKAPK2)

BTAX:

128061864(MAPKAPK2)

ODA:	120879875(MAPKAPK2)

MBEZ:

129551733(MAPKAPK2)

SSC:	100521986(MAPKAPK2)

CFR:	102508766(MAPKAPK2)

CBAI:

105075427(MAPKAPK2)

CDK:	105098610(MAPKAPK2)

VPC:	102537860(MAPKAPK2)

BACU:

102999332(MAPKAPK2)

BMUS:

118892494(MAPKAPK2)

LVE:	103082742(MAPKAPK2)

OOR:	101272142(MAPKAPK2)

DLE:	111184749(MAPKAPK2)

PCAD:

102974346(MAPKAPK2)

PSIU:

116751460(MAPKAPK2)

NASI:

112403447(MAPKAPK2)

ECB:	100055510(MAPKAPK2) 102147500

EPZ:	103567219(MAPKAPK2)

EAI:

106823339

MYB:	102245701 102261760

MYD:	102775090(MAPKAPK2)

MMYO:

118672767(MAPKAPK2)

MLF:	102430855(MAPKAPK2)

PKL:	118721314(MAPKAPK2)

EFUS:

103297477(MAPKAPK2)

MNA:	107538913(MAPKAPK2)

DRO:	112318256(MAPKAPK2)

SHON:

119001642(MAPKAPK2)

AJM:	119056790(MAPKAPK2)

PDIC:

114511988(MAPKAPK2)

PHAS:

123820667(MAPKAPK2)

MMF:	118637117(MAPKAPK2)

PPAM:

129062278(MAPKAPK2)

HAI:	109374513(MAPKAPK2)

RFQ:	117015230(MAPKAPK2)

PALE:

102887540(MAPKAPK2)

PGIG:

120617932(MAPKAPK2)

PVP:	105308925(MAPKAPK2)

RAY:	107502219(MAPKAPK2)

MJV:	108403019(MAPKAPK2)

TOD:	119234496(MAPKAPK2)

SARA:

101552098(MAPKAPK2)

SETR:

126004547(MAPKAPK2)

LAV:	100658205(MAPKAPK2)

TMU:

101342996

ETF:	101650104(MAPKAPK2)

DNM:	101415355(MAPKAPK2)

MDO:	100014871(MAPKAPK2)

GAS:	123247441(MAPKAPK2)

SHR:	100917693(MAPKAPK2)

AFZ:

127562627

PCW:	110219609(MAPKAPK2)

OAA:	100092220(MAPKAPK2)

GGA:	419847(MAPKAPK2)

PCOC:

116236993(MAPKAPK2)

MGP:	100548519(MAPKAPK2)

CJO:	107324781(MAPKAPK2)

TPAI:

128088076(MAPKAPK2)

LMUT:

125684182(MAPKAPK2)

NMEL:

110388241(MAPKAPK2)

APLA:

101789944(MAPKAPK2)

ACYG:

106041349(MAPKAPK2)

CATA:

118255301(MAPKAPK2)

AFUL:

116498743(MAPKAPK2)

TGU:	115498549(MAPKAPK2)

LSR:	110473090(MAPKAPK2)

SCAN:

103822392(MAPKAPK2)

PMOA:

120497623(MAPKAPK2)

OTC:	121345510(MAPKAPK2)

PRUF:

121349766(MAPKAPK2)

GFR:	102044089(MAPKAPK2)

OMA:	130263566(MAPKAPK2)

PHI:	102106065(MAPKAPK2)

PMAJ:

107214766(MAPKAPK2)

CCAE:

111939739(MAPKAPK2)

CCW:	104692513(MAPKAPK2)

CBRC:

103620366(MAPKAPK2)

ETL:	114063132(MAPKAPK2)

ZLE:	135458215(MAPKAPK2)

ACHL:

103811596(MAPKAPK2)

SVG:	106850906(MAPKAPK2)

MMEA:

130587039

HRT:	120762891(MAPKAPK2)

FPG:	101911197(MAPKAPK2)

FCH:	102050830(MAPKAPK2)

CLV:	102085947(MAPKAPK2)

EGZ:	104134508(MAPKAPK2)

NNI:	104013194(MAPKAPK2)

PCRI:

104027126

PLET:

104623800(MAPKAPK2)

EHS:

104507758

ACUN:

113488889(MAPKAPK2)

TALA:

104362712(MAPKAPK2)

PADL:

103919783(MAPKAPK2)

AFOR:

103893587(MAPKAPK2)

ACHC:

115335241(MAPKAPK2)

HLE:	104839534(MAPKAPK2)

AGEN:

GCL:

CCRI:

CSTI:

MUI:	104539783(MAPKAPK2)

LDI:	104351286(MAPKAPK2)

MNB:

103781888

NNT:	104412612(MAPKAPK2)

SHAB:

115602353(MAPKAPK2)

DPUB:

104297262(MAPKAPK2)

PGUU:

104464214(MAPKAPK2)

ACAR:

104530635

CPEA:

104388631(MAPKAPK2)

AVIT:

104274487(MAPKAPK2)

CVF:	104289341(MAPKAPK2)

RTD:	128900347(MAPKAPK2)

CUCA:

104061882(MAPKAPK2)

TEO:	104384488(MAPKAPK2)

BRHI:

104501961(MAPKAPK2)

AAM:	106495796(MAPKAPK2)

AROW:

112971664(MAPKAPK2)

NPD:	112944579(MAPKAPK2)

TGT:	104573365(MAPKAPK2)

DNE:	112990346(MAPKAPK2)

SCAM:

104142331(MAPKAPK2)

ASN:	102383452(MAPKAPK2)

AMJ:	102563674(MAPKAPK2)

CPOO:

109317923(MAPKAPK2)

GGN:	109295089(MAPKAPK2)

PSS:	102445709(MAPKAPK2)

CMY:	102948283(MAPKAPK2)

CCAY:

125625189(MAPKAPK2)

DCC:	119846462(MAPKAPK2)

CPIC:

101936401(MAPKAPK2)

TST:	117875763(MAPKAPK2)

CABI:

116832084(MAPKAPK2)

MRV:	120403398(MAPKAPK2)

ACS:	100562891(mapkapk2)

ASAO:

132773604(MAPKAPK2)

PVT:	110088404(MAPKAPK2)

SUND:

121928398(MAPKAPK2)

PBI:	103050162(MAPKAPK2)

CTIG:

120297440(MAPKAPK2)

TSR:	106544613(MAPKAPK2)

PGUT:

117663862(MAPKAPK2)

PTEX:

113446087(MAPKAPK2)

NSS:	113418093(MAPKAPK2)

VKO:	123031422(MAPKAPK2)

PMUA:

114599328(MAPKAPK2)

PRAF:

128416136(MAPKAPK2)

ZVI:	118088174(MAPKAPK2)

HCG:	128324853(MAPKAPK2)

GJA:	107124264(MAPKAPK2)

STOW:

125433172(MAPKAPK2)

EMC:	129331073(MAPKAPK2)

XLA:	432084(mapkapk2.L) 495118(mapkapk2.S)

XTR:	550101(mapkapk2)

NPR:	108793180(MAPKAPK2)

RTEM:

120927097(MAPKAPK2)

BBUF:

120995002(MAPKAPK2)

BGAR:

122933460(MAPKAPK2)

MUO:	115481669(MAPKAPK2)

GSH:	117347502(MAPKAPK2)

DRE:	327321(mapkapk2a) 557648(mapkapk2b)

SRX:	107726784 107728630 107739280 107747217

SANH:

107656016 107675839 107683909

SGH:	107549293 107550950 107576554 107590153

CCAR:

109054809 109058686 109084739

CAUA:

113055239 113107370 113111235

CGIB:

127963067 127967843 128022384

PTET:

122350734(mapkapk2b) 122354673(mapkapk2a)

LROH:

127169970(mapkapk2b) 127173203(mapkapk2a)

OMC:	131546350(mapkapk2b) 131549437(mapkapk2a)

PPRM:

120480446(mapkapk2a) 120492589(mapkapk2b)

RKG:	130081812(mapkapk2b)

MAMB:

125256441(mapkapk2a) 125280223(mapkapk2b)

CIDE:

127517896 127517920 127522414

MASI:

127424549 127426150 127428287

TROS:

130568382(mapkapk2b) 130571246(mapkapk2a)

TDW:	130407033(mapkapk2b) 130410257(mapkapk2a)

MANU:

129413647(mapkapk2b) 129427710(mapkapk2a) 129427711

IPU:	108255116(mapkapk2a)

IFU:	128624803(mapkapk2a)

PHYP:

113539676(mapkapk2)

SMEO:

124402585(mapkapk2a)

TFD:	113641569(mapkapk2a)

TVC:	132838072(mapkapk2a)

TRN:	134301910(mapkapk2a)

AMEX:

103024512 103033501

CMAO:

118799279(mapkapk2a) 118813618(mapkapk2b)

EEE:	113578783 113579161(mapkapk2)

CHAR:

105904174 105906811 116220526(mapkapk2a)

TRU:

101074595

TFS:	130524273(mapkapk2a)

TNG:	GSTEN00014009G001

LCO:	104925241 104927913

NCC:	104956322 104959968

TBEN:

117479549 117486461(mapkapk2a)

CGOB:

115007960 115011375

PGEO:

117446409(mapkapk2a) 117450142

GACU:

117540774 117547517(mapkapk2a)

EMAC:

134864923 134882886(mapkapk2a)

ELY:	117257264(mapkapk2a) 117257781

EFO:	125891405(mapkapk2a) 125892100

PLEP:

121947328 121953644(mapkapk2a)

SLUC:

116062189 116066885(mapkapk2a)

ECRA:

117943571(mapkapk2a) 117947996

ESP:	116687726 116693173

PFLV:

114554459(mapkapk2) 114559084

GAT:	120829843 120835200(mapkapk2a)

PPUG:

119223602 119229917(mapkapk2a)

AFB:	129100266 129105498(mapkapk2a)

CLUM:

117730311(mapkapk2a) 117734039

PSWI:

130208500(mapkapk2a)

MSAM:

119885911(mapkapk2a) 119905857

SCHU:

122867750(mapkapk2a) 122883345(mapkapk2b)

CUD:	121504519(mapkapk2a) 121517754

ALAT:

119021341(mapkapk2a) 119022666

MZE:

101471444

ONL:	100695012(mapkapk2)

OAU:	116326443(mapkapk2a)

OLA:	101157364(mapkapk2)

OML:	112145422(mapkapk2a)

CSAI:

133448778(mapkapk2a)

XMA:	102228209(mapkapk2)

XCO:	114135726(mapkapk2)

XHE:	116710744(mapkapk2)

PRET:

103464872

PFOR:

103144319(mapkapk2)

PLAI:

106958310(mapkapk2)

PMEI:

106933928(mapkapk2)

GAF:	122833449(mapkapk2a)

PPRL:

129358334

CVG:

107083314

CTUL:

119791790(mapkapk2a)

GMU:	124857538(mapkapk2a)

NFU:	107385601(mapkapk2)

KMR:	108235782(mapkapk2a)

ALIM:

106513301(mapkapk2)

NWH:	119411956(mapkapk2a)

AOCE:

111566562

MCEP:

124998785 125006714

CSEM:

103386073(mapkapk2)

POV:

109629213

SSEN:

122768478

HHIP:

117762104(mapkapk2a)

HSP:	118104584(mapkapk2a)

PPLT:

128452820(mapkapk2a)

SMAU:

118309419(mapkapk2a)

LCF:	108889533 108890003(mapkapk2a)

SDU:	111217307 111221767

SLAL:

111667188 111667810(mapkapk2)

XGL:	120783136(mapkapk2a) 120804154

HCQ:

109522522

SSCV:

125976833

SBIA:

133507829(mapkapk2a)

PEE:	133408756(mapkapk2a)

PTAO:

133483357(mapkapk2a)

BPEC:

110171263

MALB:

109956193

BSPL:

114855768(mapkapk2a)

SJO:	128355764(mapkapk2a) 128357613

SASA:

106566648(MAPK2) 106571864(MAPK2) 106583822

STRU:

115149935 115166326 115168456

OTW:	112215728 112222267 112239434

OMY:	110492466 110528685 110531961

OGO:	124024279 124031662 124045652

ONE:	115102048 115124292 115131842

OKI:	109868940 109882374 109907733

OKE:	118359606 118361436 118380621

SALP:

111966168 111972575

SNH:	120059520 120061372

CCLU:

121545358 121577855(mapkapk2a)

ELS:

105013205

SFM:	108938257 108940276

PKI:	111834362 111854424(mapkapk2)

AANG:

118207922 118211116(mapkapk2a)

LOC:	102692535(mapkapk2)

PSPA:

121299655 121304669

ARUT:

117394845 117428195(mapkapk2a)

PSEX:

120526148(mapkapk2a)

LCM:	102362783(MAPKAPK2)

CMK:

CPLA:

HOC:

LERI:

PMRN:

116942411 116947452 116949410

LRJ:	133342579 133349427 133351634

BFO:

BBEL:

SPU:

LPIC:

APLC:

AJC:

DME:	Dmel_CG3086(MAPk-Ak2)

DER:

6550842

DSE:

116802035

DSI:	Dsimw501_GD16235(Dsim_GD16235)

DYA:	Dyak_GE16789

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16155

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108372764 108381919

AOQ:

129237495

TDA:	119671813 119671838

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012619 CpipJ_CPIJ015645

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

CGLO:

FAS:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202974B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

ATRA:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM025040

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

126299382 126354099 126354107

BROR:

134528911

IEL:

124171899

FCD:

110861760

DPX:	DAPPUDRAFT_309371

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:	118194228 118194767

LPOL:

106463465 106466784

PMEO:

129599209

CEL:	CELE_C44C8.6(mak-2)

CBR:	CBG_13977(Cbr-mak-2)

CRQ:	GCK72_015742

NAI:	NECAME_13078

HRO:	HELRODRAFT_108666 HELRODRAFT_80203

LGI:	LOTGIDRAFT_137255

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111107795 111108226

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_053560

SHX:	MS3_00007604(MAPKAPK2_1)

OVI:	T265_09663

EGL:

LLON:

NVE:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

HSY:

TAD:	TRIADDRAFT_56817

AQU:

100640836

» show all

Reference

PMID:8179591

Authors

Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK

Title

The primary structure of a human MAP kinase activated protein kinase 2.

Journal

Biochem Biophys Res Commun 200:1118-24 (1994)
DOI:10.1006/bbrc.1994.1566

Sequence

[hsa:9261]

LinkDB

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