KEGG   ORTHOLOGY: K04444
Entry
K04444                      KO                                     
Symbol
MAPKAPK3
Name
mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
Pathway
map04010  MAPK signaling pathway
map04370  VEGF signaling pathway
Disease
H01890  Pattern dystrophies of the retinal pigment epithelium
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
   04370 VEGF signaling pathway
    K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Genes
HSA: 7867(MAPKAPK3)
PTR: 460400(MAPKAPK3)
PPS: 100968829(MAPKAPK3)
GGO: 101131430(MAPKAPK3)
PON: 100449366(MAPKAPK3)
NLE: 100597822(MAPKAPK3)
HMH: 116473432(MAPKAPK3)
MCC: 701320(MAPKAPK3)
MCF: 102120448(MAPKAPK3)
MTHB: 126948703
MNI: 105480500(MAPKAPK3)
CSAB: 103227685(MAPKAPK3) 103227687
CATY: 105573733(MAPKAPK3)
PANU: 101001248(MAPKAPK3)
TGE: 112619102(MAPKAPK3)
MLEU: 105548966(MAPKAPK3)
RRO: 104666815(MAPKAPK3)
RBB: 108526941(MAPKAPK3)
TFN: 117082188(MAPKAPK3)
PTEH: 111555437(MAPKAPK3)
CANG: 105509657(MAPKAPK3)
CJC: 100410636(MAPKAPK3)
SBQ: 101035301(MAPKAPK3)
CIMI: 108282077(MAPKAPK3)
CSYR: 103255446(MAPKAPK3)
MMUR: 105875013(MAPKAPK3)
LCAT: 123623228(MAPKAPK3)
PCOQ: 105805652(MAPKAPK3)
OGA: 100940882(MAPKAPK3)
MMU: 102626(Mapkapk3)
MCAL: 110301239(Mapkapk3)
MPAH: 110327440(Mapkapk3)
RNO: 315994(Mapkapk3)
MCOC: 116073034(Mapkapk3)
ANU: 117693694(Mapkapk3)
MUN: 110564553(Mapkapk3)
CGE: 100774379(Mapkapk3)
MAUA: 101826372(Mapkapk3)
PROB: 127216370 127237091(Mapkapk3)
PLEU: 114710980(Mapkapk3)
MORG: 121464491(Mapkapk3)
MFOT: 126499921
AAMP: 119810646(Mapkapk3)
NGI: 103750143(Mapkapk3)
HGL: 101717099(Mapkapk3)
CPOC: 100719631(Mapkapk3)
CCAN: 109693236(Mapkapk3)
DORD: 105994624(Mapkapk3)
DSP: 122095647(Mapkapk3)
PLOP: 125342420(Mapkapk3)
NCAR: 124993289
MMMA: 107143437(Mapkapk3)
OCU: 100342292
OPI: 101535681(MAPKAPK3)
TUP: 102493562(MAPKAPK3)
GVR: 103601056(MAPKAPK3)
CFA: 484756(MAPKAPK3)
CLUD: 112665838(MAPKAPK3)
VVP: 112910865(MAPKAPK3)
VLG: 121495653(MAPKAPK3)
NPO: 129521652(MAPKAPK3)
AML: 100484361(MAPKAPK3)
UMR: 103674786(MAPKAPK3)
UAH: 113256922(MAPKAPK3)
UAR: 123798705(MAPKAPK3)
ELK: 111144154
LLV: 125079510
MPUF: 101678280(MAPKAPK3)
MNP: 132011367(MAPKAPK3)
MLK: 131823979(MAPKAPK3)
NVS: 122909386(MAPKAPK3)
ORO: 101374104(MAPKAPK3)
EJU: 114224952(MAPKAPK3)
ZCA: 113918470(MAPKAPK3)
MLX: 118006008(MAPKAPK3)
NSU: 110577533(MAPKAPK3)
LWW: 102737770(MAPKAPK3)
FCA: 101096794(MAPKAPK3)
PYU: 121011253(MAPKAPK3)
PCOO: 112852461(MAPKAPK3)
PBG: 122487271(MAPKAPK3)
PVIV: 125160177(MAPKAPK3)
LRUF: 124523155
PTG: 102970828(MAPKAPK3)
PPAD: 109247859(MAPKAPK3)
PUC: 125929406
AJU: 106979271
HHV: 120229382(MAPKAPK3)
BTA: 615215(MAPKAPK3)
BOM: 102283364(MAPKAPK3)
BIU: 109576279(MAPKAPK3)
BBUB: 102395502(MAPKAPK3)
BBIS: 104997167(MAPKAPK3)
CHX: 102175629(MAPKAPK3)
OAS: 101118996(MAPKAPK3)
BTAX: 128049452(MAPKAPK3)
ODA: 120868315(MAPKAPK3)
CCAD: 122424725(MAPKAPK3)
MBEZ: 129547876(MAPKAPK3)
SSC: 100233192(MAPKAPK3)
CFR: 102518308(MAPKAPK3)
CBAI: 105080216(MAPKAPK3)
CDK: 105087288(MAPKAPK3)
VPC: 102525643(MAPKAPK3)
BACU: 103001513(MAPKAPK3)
BMUS: 118903111(MAPKAPK3)
LVE: 103077980(MAPKAPK3)
OOR: 101281812(MAPKAPK3)
DLE: 111174347(MAPKAPK3)
PCAD: 102990377(MAPKAPK3)
PSIU: 116762564(MAPKAPK3)
NASI: 112400772(MAPKAPK3)
ECB: 100061475(MAPKAPK3)
EPZ: 103559274(MAPKAPK3)
EAI: 106830742(MAPKAPK3)
MYB: 102241413(MAPKAPK3)
MYD: 102757924(MAPKAPK3)
MMYO: 118668437(MAPKAPK3)
MLF: 102431540(MAPKAPK3)
PKL: 118715628(MAPKAPK3)
EFUS: 103298493(MAPKAPK3)
MNA: 107540204(MAPKAPK3)
DRO: 112309920(MAPKAPK3)
SHON: 118989433(MAPKAPK3)
AJM: 119036687(MAPKAPK3)
PDIC: 114501585(MAPKAPK3)
PHAS: 123830827(MAPKAPK3)
MMF: 118633152(MAPKAPK3)
PPAM: 129087549(MAPKAPK3)
HAI: 109378052(MAPKAPK3)
RFQ: 117037106(MAPKAPK3)
PALE: 102882134(MAPKAPK3)
PGIG: 120582400(MAPKAPK3)
PVP: 105295137(MAPKAPK3)
RAY: 107504157(MAPKAPK3)
MJV: 108404719(MAPKAPK3)
TOD: 119260756(MAPKAPK3)
SARA: 101556913(MAPKAPK3)
SETR: 126014065(MAPKAPK3)
LAV: 100666073(MAPKAPK3)
TMU: 101346344
ETF: 101644731(MAPKAPK3)
DNM: 101447774(MAPKAPK3)
MDO: 100028919(MAPKAPK3)
GAS: 123230767(MAPKAPK3)
SHR: 100918613(MAPKAPK3)
AFZ: 127554323
PCW: 110217001(MAPKAPK3)
OAA: 100075476(MAPKAPK3)
GGA: 415917(MAPKAPK3)
PCOC: 116232302(MAPKAPK3)
MGP: 100544877
CJO: 107319569(MAPKAPK3)
TPAI: 128078384(MAPKAPK3)
LMUT: 125698554(MAPKAPK3)
NMEL: 110404941(MAPKAPK3)
APLA: 101801666(MAPKAPK3)
ACYG: 106042816(MAPKAPK3)
CATA: 118248286(MAPKAPK3)
AFUL: 116493128(MAPKAPK3)
TGU: 100225000(MAPKAPK3)
LSR: 110469924(MAPKAPK3)
SCAN: 103816963(MAPKAPK3)
PMOA: 120495678(MAPKAPK3)
OTC: 121347385(MAPKAPK3)
PRUF: 121352486(MAPKAPK3)
GFR: 102043737(MAPKAPK3)
FAB: 101806698(MAPKAPK3)
OMA: 130258212(MAPKAPK3)
PHI: 102114178(MAPKAPK3)
PMAJ: 107210185(MAPKAPK3)
CCAE: 111935195(MAPKAPK3)
CCW: 104683208(MAPKAPK3)
CBRC: 103614252(MAPKAPK3)
ETL: 114058782(MAPKAPK3)
ZAB: 102073183(MAPKAPK3)
ZLE: 135453257(MAPKAPK3)
ACHL: 103805527(MAPKAPK3)
SVG: 106849234(MAPKAPK3)
MMEA: 130574672(MAPKAPK3)
HRT: 120758253(MAPKAPK3)
FPG: 101919073(MAPKAPK3)
FCH: 102047898(MAPKAPK3)
CLV: 102094261(MAPKAPK3)
EGZ: 104126764(MAPKAPK3)
NNI: 104008716(MAPKAPK3)
PCRI: 104037021(MAPKAPK3)
PLET: 104625367(MAPKAPK3)
EHS: 104504001(MAPKAPK3)
PCAO: 104041409(MAPKAPK3)
ACUN: 113484830(MAPKAPK3)
TALA: 104362018(MAPKAPK3)
PADL: 103915070(MAPKAPK3)
AFOR: 103898264(MAPKAPK3)
ACHC: 115333423(MAPKAPK3)
HALD: 104317816(MAPKAPK3)
HLE: 104828110(MAPKAPK3)
AGEN: 126049865
GCL: 127021398
CCRI: 104166074(MAPKAPK3)
CSTI: 104562864(MAPKAPK3)
CMAC: 104486084(MAPKAPK3)
MUI: 104547631(MAPKAPK3)
BREG: 104639188(MAPKAPK3)
FGA: 104074915(MAPKAPK3)
GSTE: 104256984(MAPKAPK3)
LDI: 104344331
MNB: 103777549(MAPKAPK3)
OHA: 104334109(MAPKAPK3)
NNT: 104405753(MAPKAPK3)
DPUB: 104300390(MAPKAPK3)
PGUU: 104464756(MAPKAPK3)
ACAR: 104532792
CPEA: 104388105(MAPKAPK3)
AVIT: 104273823(MAPKAPK3)
CVF: 104291950(MAPKAPK3)
RTD: 128915467(MAPKAPK3)
CUCA: 104059070(MAPKAPK3)
TEO: 104378043(MAPKAPK3)
BRHI: 104497213(MAPKAPK3)
AAM: 106492166(MAPKAPK3)
AROW: 112960622(MAPKAPK3)
NPD: 112949140(MAPKAPK3)
TGT: 104577188(MAPKAPK3)
DNE: 112987010(MAPKAPK3)
SCAM: 104147858(MAPKAPK3)
ASN: 102380990(MAPKAPK3)
AMJ: 106736633(MAPKAPK3)
CPOO: 109318305(MAPKAPK3)
GGN: 109289203(MAPKAPK3)
PSS: 102463404(MAPKAPK3)
CMY: 102940828(MAPKAPK3)
CCAY: 125640058(MAPKAPK3)
DCC: 119859300(MAPKAPK3)
CPIC: 101934644(MAPKAPK3)
TST: 117880785(MAPKAPK3)
CABI: 116839713(MAPKAPK3)
MRV: 120369337(MAPKAPK3)
ACS: 100565363(mapkapk3)
ASAO: 132769146(MAPKAPK3)
PVT: 110076526(MAPKAPK3)
SUND: 121921163(MAPKAPK3)
PBI: 103057187(MAPKAPK3)
PMUR: 107285863
CTIG: 120297234(MAPKAPK3)
TSR: 106551121(MAPKAPK3)
PGUT: 117678741(MAPKAPK3)
APRI: 131193615(MAPKAPK3)
PTEX: 113453848(MAPKAPK3)
NSS: 113415738(MAPKAPK3)
VKO: 123034304(MAPKAPK3)
PMUA: 114591548(MAPKAPK3)
PRAF: 128408169(MAPKAPK3)
ZVI: 118080598(MAPKAPK3)
HCG: 128345068(MAPKAPK3)
GJA: 107123857(MAPKAPK3)
STOW: 125429657(MAPKAPK3)
EMC: 129328640(MAPKAPK3)
XLA: 108714604(mapkapk3.L) 779225(mapkapk3.S)
XTR: 780323(mapkapk3)
NPR: 108802832
RTEM: 120944956(MAPKAPK3)
BBUF: 120978706(MAPKAPK3)
BGAR: 122922602(MAPKAPK3)
GSH: 117351258(MAPKAPK3)
DRE: 790934(mapkapk3)
SRX: 107715803(mapkapk3) 107718207
SANH: 107677509 107685966
SGH: 107551779 107574676
CCAR: 109092988 109098873
CAUA: 113055334 113110933
CGIB: 127968495 128022173
PTET: 122353599(mapkapk3)
LROH: 127172743(mapkapk3)
OMC: 131549572(mapkapk3)
PPRM: 120480411(mapkapk3)
RKG: 130083547(mapkapk3)
MAMB: 125256230(mapkapk3)
CIDE: 127522641
MASI: 127425868 127428097
TROS: 130571239(mapkapk3)
TDW: 130410213(mapkapk3)
MANU: 129427332(mapkapk3)
IPU: 108281044(mapkapk3)
IFU: 128624852(mapkapk3)
PHYP: 113539717(mapkapk3)
SMEO: 124402526(mapkapk3)
TFD: 113648564(mapkapk3)
TVC: 132838201(mapkapk3)
TRN: 134301962(mapkapk3)
AMEX: 103038695(mapkapk3)
CMAO: 118799535(mapkapk3)
EEE: 113591863(mapkapk3)
CHAR: 122130789(mapkapk3)
TRU: 101066672 101067125
TFS: 130524668 130524679(mapkapk3)
TNG: GSTEN00013642G001 GSTEN00027280G001
LCO: 104938962
NCC: 104949939 104967103
TBEN: 117475496(mapkapk3) 117489854
CGOB: 115008376 115008781
PGEO: 117446708(mapkapk3) 117447345
GACU: 117543798(mapkapk3) 117551021
EMAC: 134882315 134882908(mapkapk3)
ELY: 117256432 117257514(mapkapk3)
EFO: 125893311 125897632(mapkapk3)
PLEP: 121949472 121955130(mapkapk3)
SLUC: 116035485(mapkapk3) 116041679
ECRA: 117942755(mapkapk3) 117944034
ESP: 116687813 116688394
PFLV: 114553593 114554214
GAT: 120834796(mapkapk3) 120835777
PPUG: 119194074(mapkapk3) 119194141
AFB: 129105543(mapkapk3) 129105830
CLUM: 117730555(mapkapk3) 117731025
PSWI: 130208312(mapkapk3) 130208716
MSAM: 119885927 119885965(mapkapk3) 119918257
SCHU: 122864641 122888902(mapkapk3)
CUD: 121506953 121507185(mapkapk3)
ALAT: 119020732 119021517(mapkapk3)
MZE: 101466307 101473327
ONL: 100696070 100703699(mapkapk3)
OAU: 116327112(mapkapk3) 116333887
OLA: 101156158 101159256
OML: 112144491(mapkapk3) 112145684
CSAI: 133448680 133449023(mapkapk3)
XMA: 102227849 102230176
XCO: 114135944 114136162
XHE: 116710018 116711131
PRET: 103465075 103465238
PFOR: 103143227 103145789
PLAI: 106953261 106958420
PMEI: 106923225 106929790
GAF: 122834342(mapkapk3) 122834690
PPRL: 129353858(mapkapk3) 129358168
CVG: 107094001 107102019
CTUL: 119776638 119790062(mapkapk3)
GMU: 124856272 124857349(mapkapk3)
NFU: 107384936 107385717
KMR: 108235731 108241209(mapkapk3)
ALIM: 106518005 106525176
NWH: 119412274(mapkapk3) 119412538
AOCE: 111572314 111587207
MCEP: 125007007 125007461
CSEM: 103385927 103386161
POV: 109628905 109629054
SSEN: 122761459 122765638 122768603(mapkapk3)
HHIP: 117761056 117761377(mapkapk3)
HSP: 118104912(mapkapk3) 118105351
PPLT: 128424779 128425679(mapkapk3)
SMAU: 118309112 118309338(mapkapk3)
LCF: 108881501 108885626(mapkapk3)
SDU: 111221435 111221682
SLAL: 111667875 111670948
XGL: 120783442(mapkapk3) 120807144
HCQ: 109522155(mapkapk3) 109522187
SSCV: 125977184 125977733
SBIA: 133507163 133508049(mapkapk3)
PEE: 133408814 133409166(mapkapk3)
PTAO: 133483280 133483348(mapkapk3)
BPEC: 110168388 110171186
MALB: 109955902 109964541
BSPL: 114855106(mapkapk3) 114855186
SJO: 128355040(mapkapk3) 128355515
SASA: 100194763(mapk3) 106565558 106565813(MAPK3)
STRU: 115150800 115207630 115207865
OTW: 112217286 112219466 112254407 112254631
OMY: 110494290 110494522 110527941 110528145
OGO: 124003425 124003589 124031447
ONE: 115131462 115137994 115142321 115143340
OKI: 109890985 109891570 109895564 109897309
OKE: 118388406 118388595 118399776 118400142
SALP: 111966545 111968617 111969916 111970673
SNH: 120060471 120061422 120065083 120065209
CCLU: 121574612 121574975 121578215 121578773
ELS: 105017185 105017320
SFM: 108929806 108936916
PKI: 111837588 111840606
AANG: 118207697 118211992(mapkapk3)
LOC: 102688366(mapkapk3)
PSPA: 121298112 121329221
ARUT: 117411920 117963486 117963531
PSEX: 120540463(mapkapk3)
LCM: 102347953(MAPKAPK3)
CMK: 103176715
CPLA: 122559149
HOC: 132822404
LERI: 129704584
CIN: 100178703
SCLV: 120326860
PPOI: 119112687
TSP: Tsp_10399 Tsp_10984
 » show all
Reference
PMID:8626550
  Authors
McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR
  Title
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.
  Journal
J Biol Chem 271:8488-92 (1996)
DOI:10.1074/jbc.271.14.8488
  Sequence
[hsa:7867]
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