ORTHOLOGY: K04500
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Entry
K04500 KO
Symbol
SMAD2
Name
mothers against decapentaplegic homolog 2
Pathway
map04110
Cell cycle
map04144
Endocytosis
map04218
Cellular senescence
map04350
TGF-beta signaling pathway
map04371
Apelin signaling pathway
map04390
Hippo signaling pathway
map04550
Signaling pathways regulating pluripotency of stem cells
map04659
Th17 cell differentiation
map04926
Relaxin signaling pathway
map04933
AGE-RAGE signaling pathway in diabetic complications
map05142
Chagas disease
map05166
Human T-cell leukemia virus 1 infection
map05200
Pathways in cancer
map05205
Proteoglycans in cancer
map05210
Colorectal cancer
map05212
Pancreatic cancer
map05225
Hepatocellular carcinoma
map05226
Gastric cancer
map05321
Inflammatory bowel disease
map05415
Diabetic cardiomyopathy
Disease
H00020
Colorectal cancer
H00800
Loeys-Dietz syndrome
H02199
Congenital heart defects, multiple type
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04350 TGF-beta signaling pathway
K04500 SMAD2; mothers against decapentaplegic homolog 2
04390 Hippo signaling pathway
K04500 SMAD2; mothers against decapentaplegic homolog 2
04371 Apelin signaling pathway
K04500 SMAD2; mothers against decapentaplegic homolog 2
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
K04500 SMAD2; mothers against decapentaplegic homolog 2
09143 Cell growth and death
04110 Cell cycle
K04500 SMAD2; mothers against decapentaplegic homolog 2
04218 Cellular senescence
K04500 SMAD2; mothers against decapentaplegic homolog 2
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
K04500 SMAD2; mothers against decapentaplegic homolog 2
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
K04500 SMAD2; mothers against decapentaplegic homolog 2
09152 Endocrine system
04926 Relaxin signaling pathway
K04500 SMAD2; mothers against decapentaplegic homolog 2
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04500 SMAD2; mothers against decapentaplegic homolog 2
05205 Proteoglycans in cancer
K04500 SMAD2; mothers against decapentaplegic homolog 2
09162 Cancer: specific types
05210 Colorectal cancer
K04500 SMAD2; mothers against decapentaplegic homolog 2
05212 Pancreatic cancer
K04500 SMAD2; mothers against decapentaplegic homolog 2
05225 Hepatocellular carcinoma
K04500 SMAD2; mothers against decapentaplegic homolog 2
05226 Gastric cancer
K04500 SMAD2; mothers against decapentaplegic homolog 2
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
K04500 SMAD2; mothers against decapentaplegic homolog 2
09174 Infectious disease: parasitic
05142 Chagas disease
K04500 SMAD2; mothers against decapentaplegic homolog 2
09163 Immune disease
05321 Inflammatory bowel disease
K04500 SMAD2; mothers against decapentaplegic homolog 2
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
K04500 SMAD2; mothers against decapentaplegic homolog 2
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
K04500 SMAD2; mothers against decapentaplegic homolog 2
BRITE hierarchy
Other DBs
GO:
0070410
Genes
HSA:
4087
(SMAD2)
PTR:
455407
(SMAD2)
PPS:
100980706
(SMAD2)
GGO:
101154310
(SMAD2)
PON:
100173357
(SMAD2)
NLE:
100589735
(SMAD2)
HMH:
116468563
(SMAD2)
MCC:
697581
(SMAD2)
MCF:
101925163
(SMAD2)
MTHB:
126941494
MNI:
105489370
(SMAD2)
CSAB:
103222457
(SMAD2)
CATY:
105592520
(SMAD2)
PANU:
101004882
(SMAD2)
TGE:
112611391
(SMAD2)
MLEU:
105531149
(SMAD2)
RRO:
104657832
(SMAD2)
RBB:
108519603
(SMAD2)
TFN:
117063928
(SMAD2)
PTEH:
111539679
(SMAD2)
CANG:
105517011
(SMAD2)
CJC:
100396826
(SMAD2)
SBQ:
101040653
(SMAD2)
CIMI:
108305119
(SMAD2)
CSYR:
103255534
MMUR:
105860538
(SMAD2)
LCAT:
123621890
(SMAD2)
PCOQ:
105808878
(SMAD2)
OGA:
100960336
(SMAD2)
MMU:
17126
(Smad2)
MCAL:
110284497
(Smad2)
MPAH:
110332834
(Smad2)
RNO:
29357
(Smad2)
MCOC:
116087365
(Smad2)
ANU:
117719725
(Smad2)
MUN:
110550301
(Smad2)
CGE:
100771578
(Smad2)
MAUA:
101831324
(Smad2)
PROB:
127234906
(Smad2)
PLEU:
114694883
(Smad2)
MORG:
121438761
(Smad2)
MFOT:
126507311
AAMP:
119814613
(Smad2)
NGI:
103727836
(Smad2)
HGL:
101714203
(Smad2)
CPOC:
100726958
(Smad2)
CCAN:
109700302
DORD:
105987654
(Smad2)
DSP:
122104270
(Smad2)
PLOP:
125364233
(Smad2)
NCAR:
124965420
MMMA:
107139517
(Smad2)
OCU:
100359137
OPI:
101529841
(SMAD2)
TUP:
102499541
(SMAD2)
GVR:
103595293
(SMAD2)
CFA:
480144
(SMAD2)
CLUD:
112647773
(SMAD2)
VVP:
112918856
(SMAD2)
VLG:
121484675
(SMAD2)
NPO:
129508622
(SMAD2)
AML:
100467069
(SMAD2)
UMR:
103663939
(SMAD2)
UAH:
113253394
(SMAD2)
UAR:
123787367
(SMAD2)
ELK:
111142395
LLV:
125081717
MPUF:
101691860
(SMAD2)
MNP:
132023610
(SMAD2)
MLK:
131811852
(SMAD2)
NVS:
122902898
(SMAD2)
ORO:
101385419
(SMAD2)
EJU:
114204964
(SMAD2)
ZCA:
113913242
(SMAD2)
MLX:
118004611
(SMAD2)
NSU:
110577095
(SMAD2)
110583310
LWW:
102730764
(SMAD2)
FCA:
101087179
(SMAD2)
PYU:
121032957
(SMAD2)
PCOO:
112868176
(SMAD2)
PBG:
122470746
(SMAD2)
PVIV:
125148749
(SMAD2)
LRUF:
124517096
PTG:
102971687
(SMAD2)
PPAD:
109275745
(SMAD2)
PUC:
125914628
AJU:
106972947
HHV:
120229672
(SMAD2)
BTA:
516010
(SMAD2)
BOM:
102286495
(SMAD2)
BBUB:
102406564
(SMAD2)
BBIS:
104989326
(SMAD2)
CHX:
102188455
(SMAD2)
OAS:
101114231
(SMAD2)
BTAX:
128067292
(SMAD2)
ODA:
120881010
(SMAD2)
CCAD:
122425874
(SMAD2)
MBEZ:
129549831
(SMAD2)
SSC:
100155304
(SMAD2)
CFR:
102508588
(SMAD2)
CBAI:
105074009
(SMAD2)
CDK:
105097587
(SMAD2)
VPC:
102538474
(SMAD2)
BACU:
103005078
(SMAD2)
BMUS:
118906922
(SMAD2)
LVE:
103069124
(SMAD2)
OOR:
101278299
(SMAD2)
DLE:
111180276
(SMAD2)
PCAD:
102978015
(SMAD2)
PSIU:
116738762
(SMAD2)
NASI:
112407460
(SMAD2)
ECB:
100033843
(SMAD2)
EPZ:
103548562
(SMAD2)
EAI:
106831216
(SMAD2)
MYB:
102256193
(SMAD2)
MYD:
102758819
(SMAD2)
MMYO:
118662725
(SMAD2)
MLF:
102429768
(SMAD2)
PKL:
118707412
(SMAD2)
MNA:
107546622
(SMAD2)
DRO:
112322688
(SMAD2)
SHON:
118978461
(SMAD2)
AJM:
119063624
(SMAD2)
PDIC:
114506330
(SMAD2)
PHAS:
123826060
(SMAD2)
MMF:
118618734
(SMAD2)
PPAM:
129078704
(SMAD2)
HAI:
109388212
(SMAD2)
RFQ:
117011743
(SMAD2)
PALE:
102893928
(SMAD2)
PGIG:
120585764
(SMAD2)
PVP:
105292640
(SMAD2)
RAY:
107512663
(SMAD2)
MJV:
108400736
(SMAD2)
TOD:
119243064
(SMAD2)
SARA:
101547889
(SMAD2)
SETR:
126020080
(SMAD2)
LAV:
100663495
(SMAD2)
TMU:
101348656
ETF:
101642964
(SMAD2)
DNM:
101429090
(SMAD2)
MDO:
100014493
(SMAD2)
GAS:
123237729
(SMAD2)
SHR:
100914956
(SMAD2)
AFZ:
127543521
PCW:
110207982
(SMAD2)
GGA:
395247
(SMAD2Z)
769000
(SMAD2W)
PCOC:
116231370
(SMAD2)
CJO:
107305704
(SMAD2)
TPAI:
128074324
(SMAD2)
LMUT:
125686954
(SMAD2)
NMEL:
110389836
(SMAD2)
APLA:
101803787
101805334
(SMAD2)
ACYG:
106037327
125179633
CATA:
118254572
(SMAD2)
AFUL:
116500445
(SMAD2)
TGU:
100225108
(SMAD2)
116806871
LSR:
110473205
(SMAD2)
SCAN:
103820639
(SMAD2)
103824734
PMOA:
120513693
(SMAD2)
OTC:
121346084
(SMAD2)
PRUF:
121357871
GFR:
102040865
102044404
(SMAD2)
FAB:
101818681
(SMAD2)
OMA:
130265087
(SMAD2)
PHI:
102100805
(SMAD2)
PMAJ:
107198156
(SMAD2)
CCAE:
111941053
(SMAD2)
CCW:
104695695
(SMAD2)
CBRC:
103620409
103622031
(SMAD2)
ETL:
114058469
(SMAD2)
114067837
ZAB:
102065531
ZLE:
135459514
(SMAD2)
135460627
ACHL:
103809583
103809640
SVG:
106865043
(SMAD2)
MMEA:
130574534
(SMAD2)
HRT:
120764834
120765388
(SMAD2)
FPG:
101918546
(SMAD2)
FCH:
102059402
(SMAD2)
CLV:
102085910
(SMAD2)
EGZ:
104134175
(SMAD2)
PCRI:
104034862
(SMAD2)
PLET:
104622665
(SMAD2)
EHS:
104516400
(SMAD2)
PCAO:
104046813
(SMAD2)
ACUN:
113489639
(SMAD2)
TALA:
104361429
(SMAD2)
PADL:
103916021
(SMAD2)
AFOR:
103898213
(SMAD2)
ACHC:
115336932
(SMAD2)
HALD:
104322122
(SMAD2)
HLE:
104841375
(SMAD2)
AGEN:
126036392
GCL:
127027686
CCRI:
104157677
(SMAD2)
CSTI:
104555523
CMAC:
104481715
(SMAD2)
BREG:
104631251
(SMAD2)
FGA:
104082329
(SMAD2)
GSTE:
104250830
LDI:
104343998
(SMAD2)
MNB:
103776919
103781455
OHA:
104335579
(SMAD2)
NNT:
104399512
SHAB:
115619142
115619623
(SMAD2)
DPUB:
104301321
(SMAD2)
PGUU:
104469004
CPEA:
104394605
104395034
AVIT:
104269454
(SMAD2)
CVF:
104291926
(SMAD2)
RTD:
128902009
128902618
CUCA:
104063566
(SMAD2)
TEO:
104374688
(SMAD2)
BRHI:
104493505
AAM:
106497650
(SMAD2)
AROW:
112978607
(SMAD2)
NPD:
112947301
(SMAD2)
TGT:
104564687
104575154
DNE:
112994477
(SMAD2)
SCAM:
104138497
(SMAD2)
ASN:
102370509
(SMAD2)
AMJ:
102564903
(SMAD2)
CPOO:
109307739
(SMAD2)
GGN:
109298011
(SMAD2)
PSS:
102457921
(SMAD2)
CMY:
102940642
(SMAD2)
CCAY:
125636648
(SMAD2)
DCC:
119855698
(SMAD2)
CPIC:
101939963
(SMAD2)
TST:
117879187
(SMAD2)
CABI:
116835549
(SMAD2)
MRV:
120408025
(SMAD2)
ACS:
100554929
(smad2)
ASAO:
132766861
(SMAD2)
PVT:
110085053
(SMAD2)
SUND:
121921670
(SMAD2)
PBI:
103058841
CTIG:
120317890
TSR:
106551732
PGUT:
117655967
(SMAD2)
APRI:
131192146
(SMAD2)
PTEX:
113445546
(SMAD2)
VKO:
123023962
(SMAD2)
PMUA:
114606122
(SMAD2)
PRAF:
128423642
(SMAD2)
ZVI:
118077093
(SMAD2)
HCG:
128344917
(SMAD2)
GJA:
107118628
(SMAD2)
STOW:
125436221
(SMAD2)
EMC:
129334390
(SMAD2)
XLA:
399442
(smad2.L)
432023
(smad2.S)
XTR:
496586
(smad2)
NPR:
108786433
(SMAD2)
RTEM:
120926551
(SMAD2)
BBUF:
120992261
(SMAD2)
BGAR:
122924840
(SMAD2)
MUO:
115462866
(SMAD2)
GSH:
117355800
(SMAD2)
DRE:
30639
(smad2)
SRX:
107738844
107743055
SANH:
107653131
107667259
(smad2)
SGH:
107558710
(smad2)
CCAR:
109062884
109062952
CAUA:
113054041
113109436
113109601
CGIB:
127966259
128021490
PTET:
122352813
(smad2)
LROH:
127172601
(smad2)
OMC:
131547906
(smad2)
PPRM:
120482166
(smad2)
RKG:
130076575
(smad2)
MAMB:
125258281
(smad2)
CIDE:
127520704
MASI:
127432353
127433145
TROS:
130546549
(smad2)
TDW:
130411392
(smad2)
MANU:
129447399
(smad2)
IPU:
108277249
IFU:
128620319
(smad2)
PHYP:
113544066
(smad2)
SMEO:
124393264
(smad2)
TFD:
113639291
(smad2)
TVC:
132862990
(smad2)
TRN:
134332106
(smad2)
AMEX:
103025750
(smad2)
CMAO:
118824416
(smad2)
EEE:
113590822
(smad2)
CHAR:
105912572
(smad2)
TRU:
101072871
TFS:
130525690
TNG:
GSTEN00021584G001
LCO:
104924990
TBEN:
117484765
CGOB:
115014050
115014051
PGEO:
117453143
GACU:
117536909
(smad2)
EMAC:
134873821
ELY:
117252759
EFO:
125889973
PLEP:
121943925
SLUC:
116050506
ECRA:
117945084
ESP:
116689665
PFLV:
114556042
GAT:
120830694
PPUG:
119224982
AFB:
129100693
CLUM:
117736183
PSWI:
130196843
MSAM:
119891755
SCHU:
122877070
CUD:
121509725
ALAT:
119019135
MZE:
101470473
ONL:
100693777
100710325
OAU:
116322660
116324976
(smad2)
OLA:
101159109
OML:
112148478
CSAI:
133451420
XMA:
102224322
XCO:
114155259
XHE:
116730162
PRET:
103469777
PFOR:
103146727
103152383
PLAI:
106934411
106940894
PMEI:
106909348
106930500
GAF:
122828856
PPRL:
129373108
CVG:
107098523
(smad2)
107098778
CTUL:
119775604
GMU:
124877669
NFU:
107393511
KMR:
108235010
ALIM:
106513591
(smad2)
106527493
NWH:
119413553
AOCE:
111571476
111583068
MCEP:
125012238
CSEM:
103397451
POV:
109626315
(smad2)
109633657
SSEN:
122769602
HHIP:
117767782
HSP:
118115022
PPLT:
128438118
SMAU:
118313368
LCF:
108878489
(smad2)
SDU:
111228088
SLAL:
111648020
111655756
(smad2)
XGL:
120804852
120806316
(smad2)
HCQ:
109525024
SSCV:
125994718
SBIA:
133499624
PEE:
133400362
PTAO:
133474713
BPEC:
110161051
MALB:
109959661
BSPL:
114862382
SJO:
128364387
SASA:
106580048
106585370
STRU:
115164783
115199870
OTW:
112248205
112263143
OMY:
101268919
101867532
OGO:
124034501
124036100
ONE:
115111387
115139828
OKI:
109877018
109895715
(smad2)
OKE:
118358127
118392988
SALP:
111957603
111973863
SNH:
120053749
120063104
CCLU:
121550213
121584646
ELS:
105014505
SFM:
108936291
(smad2)
108938101
PKI:
111842093
(smad2)
111856558
AANG:
118237532
(smad2)
LOC:
102689511
(smad2)
PSPA:
121303852
121314339
(smad2)
ARUT:
117421319
(smad2)
PSEX:
120533041
(smad2)
LCM:
102360430
(SMAD2)
CMK:
103187354
(smad2)
RTP:
109914262
(smad2)
CPLA:
122563388
(smad2)
HOC:
132830054
(smad2)
LERI:
129711150
(smad2)
SCLV:
120348023
» show all
Taxonomy
UniProt
Reference
PMID:
8752209
Authors
Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L
Title
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Journal
Cell 86:543-52 (1996)
DOI:
10.1016/S0092-8674(00)80128-2
Sequence
[hsa:
4087
]
LinkDB
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DBGET
integrated database retrieval system