KEGG ORTHOLOGY: K04635

ORTHOLOGY: K04635

Entry

K04635                      KO

Symbol

GNA11

Name

guanine nucleotide-binding protein subunit alpha-11

Pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04270

Vascular smooth muscle contraction

map04540

Gap junction

map04725

Cholinergic synapse

map04730

Long-term depression

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04928

Parathyroid hormone synthesis, secretion and action

map04929

GnRH secretion

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05142

Chagas disease

map05146

Amoebiasis

map05163

Human cytomegalovirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Disease

H02026

Familial hypocalciuric hypercalcemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04022 cGMP-PKG signaling pathway
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04929 GnRH secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04912 GnRH signaling pathway
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04935 Growth hormone synthesis, secretion and action
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04928 Parathyroid hormone synthesis, secretion and action
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04925 Aldosterone synthesis and secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04927 Cortisol synthesis and secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09156 Nervous system
   04725 Cholinergic synapse
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04730 Long-term depression
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   05163 Human cytomegalovirus infection
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   05142 Chagas disease
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04031 GTP-binding proteins
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  Exosomal proteins of melanoma cells
   K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
GTP-binding proteins [BR:ko04031]
Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 3 (Gq/11) [OT]
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11

Genes

HSA:	2767(GNA11)

PTR:	100611153(GNA11)

PPS:	100972605(GNA11)

GGO:	101129671(GNA11) 101149632

PON:	100460338(GNA11)

NLE:	100584446(GNA11)

HMH:	116483096(GNA11)

MCC:	721649(GNA11)

MCF:	102123885(GNA11)

MTHB:

126942698

MNI:	105485659(GNA11)

CSAB:

103233670(GNA11)

CATY:

105591769(GNA11)

PANU:

101019734(GNA11)

TGE:	112612879(GNA11)

MLEU:

105530008(GNA11)

RRO:	104665456(GNA11)

RBB:	108512657(GNA11)

TFN:	117074394(GNA11)

PTEH:

111520693(GNA11)

CANG:

105527658(GNA11)

CJC:	100386734(GNA11)

SBQ:	101032578(GNA11)

CIMI:

108288490(GNA11)

CSYR:

103252789

MMUR:

105873966(GNA11)

LCAT:

123633418(GNA11)

PCOQ:

105811873(GNA11)

OGA:	100949562(GNA11)

MMU:	14672(Gna11)

MCAL:

110303103(Gna11)

MPAH:

110326239(Gna11)

RNO:	81662(Gna11)

MCOC:

116075890(Gna11)

ANU:	117696350(Gna11)

MUN:	110548534(Gna11)

CGE:	100689065(Gna11)

MAUA:

101839416(Gna11)

PROB:

127216566(Gna11)

PLEU:

114688160(Gna11)

MORG:

121459559(Gna11)

MFOT:

126489320

AAMP:

119827968(Gna11)

NGI:	103737243(Gna11)

HGL:	101722520(Gna11)

CPOC:

100715351(Gna11)

CCAN:

109691040(Gna11)

DORD:

105990272(Gna11)

DSP:	122099338(Gna11)

PLOP:

125348648(Gna11)

NCAR:

124968563

MMMA:

107157430(Gna11)

OPI:	101518174(GNA11)

TUP:	102479071(GNA11)

GVR:

103604359

CFA:	403914(GNA11)

CLUD:

112666259(GNA11)

VVP:	112935541(GNA11)

VLG:	121495327(GNA11)

NPO:	129522061(GNA11)

AML:	100469689(GNA11)

UMR:	103681813(GNA11)

UAH:	113242780(GNA11)

UAR:	123793965(GNA11)

ELK:

111161857

LLV:

125087086

MPUF:

101681131(GNA11)

MNP:	132010764(GNA11)

MLK:	131823276(GNA11)

NVS:	122909893(GNA11)

ORO:	101385358(GNA11)

EJU:	114226318(GNA11)

ZCA:	113917830(GNA11)

MLX:	118005532(GNA11)

NSU:	110594139(GNA11)

LWW:	102732710(GNA11)

FCA:	101086541(GNA11)

PYU:	121021509(GNA11)

PBG:	122486676(GNA11)

PVIV:

125155799(GNA11)

LRUF:

124524235

PTG:	107181018(GNA11)

PPAD:

109255970(GNA11)

PUC:

125930520

AJU:

106982140

HHV:	120242104(GNA11)

BTA:	281788(GNA11)

BOM:	102287661(GNA11)

BIU:	109561778(GNA11)

BBUB:

102391819(GNA11)

BBIS:

104979885(GNA11)

CHX:	102177328(GNA11)

OAS:	101119215(GNA11)

BTAX:

128050674(GNA11)

ODA:	120864791(GNA11)

CCAD:

122440204(GNA11)

MBEZ:

129558678(GNA11)

SSC:	733588(GNA11)

CFR:	102508599(GNA11)

CBAI:

105078179(GNA11)

CDK:	105106041(GNA11)

VPC:	116276519(GNA11)

BACU:

103000262(GNA11)

BMUS:

118892955(GNA11)

LVE:	103076924(GNA11)

OOR:	101269696(GNA11)

DLE:	111166066(GNA11)

PCAD:

102995887(GNA11)

PSIU:

116751212(GNA11)

NASI:

112396330(GNA11)

ECB:	100067327(GNA11)

EPZ:

103543382

EAI:	106832309(GNA11)

MYB:	102259944(GNA11)

MYD:	102771954(GNA11)

MMYO:

118658361(GNA11)

MLF:	102424028(GNA11)

PKL:	118731318(GNA11)

EFUS:

103294255(GNA11)

MNA:	107544328(GNA11)

DRO:	112312418(GNA11)

SHON:

118984473(GNA11)

AJM:	119063760(GNA11)

PDIC:

114502886(GNA11)

PHAS:

123813822(GNA11)

MMF:	118615876(GNA11)

PPAM:

129074308(GNA11)

HAI:	109388624(GNA11)

RFQ:	117037515(GNA11)

PALE:

102888619(GNA11)

PGIG:

120583757(GNA11)

PVP:	105300436(GNA11)

RAY:	107520124(GNA11)

MJV:	108403596(GNA11)

TOD:	119240551(GNA11)

SARA:

101544809(GNA11)

SETR:

126030452(GNA11)

LAV:

100675896

TMU:

101345890

ETF:	101648105(GNA11)

MDO:	100009763(GNA11)

GAS:

123244152

SHR:	100920179(GNA11)

AFZ:

127545247

PCW:	110223412(GNA11)

OAA:	100084804(GNA11) 114808753

GGA:	374077(GNA11)

PCOC:

116236152

MGP:	100151748(GNA11)

CJO:	107325609(GNA11)

TPAI:

128090368(GNA11)

LMUT:

125685047

NMEL:

110388935

APLA:

101802177(GNA11)

ACYG:

106049557

CATA:

118260042(GNA11)

AFUL:

116498997(GNA11)

TGU:	100219505(GNA11)

LSR:	110475762(GNA11)

SCAN:

103821936

PMOA:

120498075(GNA11)

OTC:	121341550(GNA11)

PRUF:

121360852

GFR:	102043661(GNA11)

FAB:	101818273(GNA11)

OMA:	130264470(GNA11)

PHI:	102102102(GNA11)

PMAJ:

107215591(GNA11)

CCAE:

111940370

CCW:	104697002(GNA11)

CBRC:

103622123

ETL:

114066350

ZAB:

102068726

ZLE:	135458744(GNA11)

ACHL:

103800863

SVG:	106857133(GNA11)

MMEA:

130580238(GNA11)

HRT:	120763365(GNA11)

FPG:	101923890(GNA11)

FCH:

102051778

CLV:	102092243(GNA11)

EGZ:	104124382(GNA11)

NNI:	104016271(GNA11)

PCRI:

104025944(GNA11)

PLET:

104615213(GNA11)

EHS:	104507746(GNA11)

PCAO:

104044867(GNA11)

ACUN:

113489339

TALA:

104358520(GNA11)

PADL:

103923466(GNA11)

AFOR:

103899343

ACHC:

115349102(GNA11)

HALD:

104323367(GNA11)

HLE:	104829070(GNA11)

AGEN:

126041819

GCL:

127025653

CCRI:

104157544(GNA11)

CSTI:

104560855

CMAC:

104483865

MUI:	104542203(GNA11)

BREG:

104633747

FGA:	104071101(GNA11)

GSTE:

104258204(GNA11)

LDI:

104347925

MNB:

103770336

OHA:	104335025(GNA11)

NNT:

104406567

SHAB:

115618049

DPUB:

104300262(GNA11)

PGUU:

104465457(GNA11)

ACAR:

104518533

CPEA:

104397500(GNA11)

AVIT:

104270213(GNA11)

CVF:	104294373(GNA11)

RTD:	128900713(GNA11)

CUCA:

104064195(GNA11)

TEO:	104376190(GNA11)

BRHI:

104492235(GNA11)

AAM:	106486396(GNA11)

AROW:

112973885(GNA11)

NPD:

112946801

TGT:	104580087(GNA11)

DNE:

112988073

SCAM:

104151006(GNA11)

ASN:	102385893(GNA11)

AMJ:	102565314(GNA11)

CPOO:

109320468(GNA11)

GGN:	109294697(GNA11)

PSS:

102455465

CMY:	102945827(GNA11)

DCC:	119848260(GNA11)

CPIC:

101946431

TST:

117869019

CABI:

116824631(GNA11)

MRV:	120391557(GNA11)

ACS:	100566521(gna11)

ASAO:

132781065(GNA11)

PVT:	110079229(GNA11)

SUND:

121936291

PBI:

103050016

PMUR:

107295332(GNA11)

CTIG:

120297072(GNA11)

TSR:

106556348

PGUT:

117668645(GNA11)

APRI:

131188349(GNA11)

PTEX:

113434991(GNA11)

NSS:

113426434

VKO:	123035340(GNA11)

PMUA:

114588282

PRAF:

128405531(GNA11)

ZVI:

118086473

HCG:	128344392(GNA11)

GJA:

107120591

STOW:

125433216(GNA11)

EMC:	129330695(GNA11)

XLA:	380535(gna11.S) 779103(gna11.L)

XTR:	394755(gna11)

NPR:	108791250(GNA11)

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	493613(gna11b)

SRX:	107729972 107750923

SANH:

107667855 107696027

SGH:	107558284 107600186

CCAR:

109105347 109109034

CAUA:

113040036 113079298 113082387 113112706 113113987

CGIB:

127937615 127950782 127987912

PTET:

122327736(gna11a) 122335667(gna11b)

LROH:

127153994 127176505(gna11b)

OMC:	131529876 131554152(gna11b)

PPRM:

120487915(gna11b) 120495270(gna11a)

RKG:	130071973(gna11a) 130105591(gna11b)

MAMB:

125249962(gna11b) 125263822(gna11a)

CIDE:

127520230 127522861

MASI:

127439306 127440684 127443198

TROS:

130548375 130553984(gna11b)

TDW:	130418195(gna11b) 130429531

MANU:

129443147(gna11b) 129453546(gna11a)

IPU:	108271202 108280682(gna11b)

IFU:	128614279 128623927(gna11b)

PHYP:

113527868 113533313

SMEO:

124390834 124403004(gna11b)

TFD:	113645165(gna11b) 113657743

TVC:	132845898(gna11b) 132853215

TRN:	134302773(gna11b) 134331788

AMEX:

103033252(gna11b) 125782213

CMAO:

118796732(gna11b) 118818804

EEE:	113583372 113591267

CHAR:

105889474(gna11b)

TRU:	101063826 101064679

TFS:	130528330 130540421(gna11b)

TNG:	GSTEN00028786G001 GSTEN00031921G001

LCO:

104923650

NCC:

104967393

CGOB:

115006572 115027534

PGEO:

117445871 117467600(gna11b)

GACU:

117540532(gna11b) 117550896

EMAC:

134869391 134882003(gna11b)

ELY:	117253564 117267243(gna11b)

EFO:	125900696(gna11b)

PLEP:

121938034 121953479(gna11b)

SLUC:

116055441 116057356(gna11b)

ECRA:

117935998(gna11b) 117951130

ESP:	116670588 116695435

PFLV:

114547460 114561099

GAT:	120823903 120833304(gna11b)

PPUG:

119216773 119227252(gna11b)

AFB:	129094874 129103986(gna11b)

CLUM:

117751460(gna11b)

PSWI:

130201190(gna11b)

MSAM:

119889655 119900765

ALAT:

119028320 119034345(gna11b)

MZE:

101483097

ONL:	100709052 100710383

OAU:	116317322 116318011(gna11b)

OLA:

101161353

OML:	112143250(gna11b) 112150368

CSAI:

133458368 133462577(gna11b)

XMA:

102238377

XCO:

114133767

XHE:	116708893 116725378

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122838816 122846253(gna11b)

PPRL:

129371651

CVG:

107100829

CTUL:

119775695(gna11b) 119794270

GMU:	124855443(gna11b) 124873810

NFU:

107393186

KMR:	108230762 108235078(gna11b)

ALIM:

106521552 106528393

NWH:	119427143(gna11b) 119430669

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

117755958(gna11b) 117760645

HSP:	118116483(gna11b) 118120798

PPLT:

128451488

SMAU:

118285680 118318614

LCF:	108874918(gna11b)

SDU:

111232198

SLAL:

111654261

XGL:

120790386

HCQ:	109517351 109532023

SSCV:

125965761

PEE:	133406857 133413257

BPEC:

110160176

MALB:

109952059 109964012

BSPL:

114848961(gna11b) 114854707

SJO:	128361278 128375275

SASA:

106574495 106575390 106584406 106613802

STRU:

115158280 115179716 115192595 115196175

OTW:	112235116 112250892 112266387

OMY:	110495735 110521465 110528895

OGO:	124007768 124010445

ONE:	115108339 115120284 115144916

OKI:	109879717 109890384 109897876

OKE:	118363868 118390019 127916701

SALP:

111953718 111972124 111975535

SNH:	120033549 120051355 120052454 120054794

CCLU:

121533502 121540335 121560172

ELS:	105011594 105019863

SFM:

108919906

PKI:	111836597 111860249

AANG:

LOC:

PSPA:

ARUT:

PSEX:

CPLA:

HOC:

PMRN:

SCLV:

RZE:

LSQ:	119612549 119614530

HAME:

TCF:

VDE:

VJA:

PMEO:

PVUL:

RPHI:

OBI:

OSN:

Reference

PMID:1902575

Authors

Jiang M, Pandey S, Tran VT, Fong HK

Title

Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.

Journal

Proc Natl Acad Sci U S A 88:3907-11 (1991)
DOI:10.1073/pnas.88.9.3907

Sequence

[hsa:2767]

Reference

PMID:16183910

Authors

Wettschureck N, Offermanns S.

Title

Mammalian G proteins and their cell type specific functions.

Journal

Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

LinkDB

DBGET integrated database retrieval system