KEGG ORTHOLOGY: K04716

ORTHOLOGY: K04716

Entry

K04716                      KO

Symbol

SGPP1

Name

sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-]

Pathway

map00600

Sphingolipid metabolism

map01100

Metabolic pathways

map04071

Sphingolipid signaling pathway

Reaction

R06520

3-sn-phosphatidate phosphohydrolase

R06521

3-sn-phosphatidate phosphohydrolase

R06522

3-sn-phosphatidate phosphohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K04716  SGPP1; sphingosine-1-phosphate phosphatase 1
09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K04716  SGPP1; sphingosine-1-phosphate phosphatase 1

Other DBs

GO:

0042392

Genes

HSA:	81537(SGPP1)

PTR:	467479(SGPP1)

PPS:	100979353(SGPP1)

GGO:	101140990(SGPP1)

PON:	100458471(SGPP1)

NLE:	100591437(SGPP1)

HMH:	116484788(SGPP1)

MCC:	709364(SGPP1)

MCF:	102142274(SGPP1)

MTHB:

126959023

MNI:	105473685(SGPP1)

CSAB:

103229157(SGPP1)

CATY:

105582818(SGPP1)

PANU:

101009539(SGPP1)

TGE:	112629436(SGPP1)

MLEU:

105538458(SGPP1)

RRO:	104678442(SGPP1)

RBB:	108542435(SGPP1)

TFN:	117069489(SGPP1)

PTEH:

111555760(SGPP1)

CANG:

105526093(SGPP1)

CJC:	100414910(SGPP1)

SBQ:	101044802(SGPP1)

CIMI:

108308228(SGPP1)

CSYR:

103268166(SGPP1)

MMUR:

105878330(SGPP1)

LCAT:

123648208(SGPP1)

PCOQ:

105819798(SGPP1)

OGA:	100943893(SGPP1)

MMU:	81535(Sgpp1)

MCAL:

110307304(Sgpp1)

MPAH:

110324488(Sgpp1)

RNO:	81536(Sgpp1)

MCOC:

116080196(Sgpp1)

ANU:	117697390(Sgpp1)

MUN:	110557569(Sgpp1)

CGE:	100766871(Sgpp1)

MAUA:

101831227(Sgpp1)

PROB:

127230701(Sgpp1)

PLEU:

114683641(Sgpp1)

MORG:

121452527(Sgpp1)

MFOT:

126508455

AAMP:

119819059(Sgpp1)

NGI:	103747973(Sgpp1)

HGL:	101697333 101698443 101710628(Sgpp1)

CPOC:

100715609(Sgpp1)

CCAN:

109697372(Sgpp1)

DORD:

105983794(Sgpp1)

DSP:	122110036(Sgpp1)

PLOP:

125363184(Sgpp1)

NCAR:

124977848

MMMA:

107145970(Sgpp1)

OCU:

108178643

OPI:	101527797(SGPP1)

TUP:	102491372(SGPP1)

CFA:	490728(SGPP1)

CLUD:

112657079(SGPP1)

VVP:	112921349(SGPP1)

VLG:	121493754(SGPP1)

NPO:	129496365(SGPP1)

AML:	109488741(SGPP1)

UMR:	121105228(SGPP1)

UAH:	113246295 113246334

UAR:	123800638(SGPP1)

ELK:

111161192

LLV:

125104831

MPUF:

101673418(SGPP1)

MNP:	132000019(SGPP1)

MLK:	131836665(SGPP1)

NVS:	122892886(SGPP1)

ORO:	101379255(SGPP1)

EJU:	114206788(SGPP1)

ZCA:	113908641(SGPP1)

NSU:	110590597(SGPP1)

LWW:	102745068(SGPP1)

FCA:	101095345(SGPP1)

PYU:	121031883(SGPP1)

PCOO:

112855797(SGPP1)

PBG:	122469196(SGPP1)

PVIV:

125168860(SGPP1)

LRUF:

124512132

PTG:	102967184(SGPP1)

PPAD:

109268345(SGPP1)

PUC:

125909442

AJU:

106971302

HHV:	120238431(SGPP1)

BTA:	516881(SGPP1)

BOM:	102277496(SGPP1)

BIU:	109565238(SGPP1)

BBUB:

102390378(SGPP1)

BBIS:

104993515(SGPP1)

CHX:	102174749(SGPP1)

OAS:	101108492(SGPP1)

BTAX:

128054605(SGPP1)

ODA:	120852820(SGPP1)

CCAD:

122443737(SGPP1)

MBEZ:

129562822(SGPP1)

SSC:	100626032(SGPP1)

CFR:	102505600(SGPP1)

CBAI:

105074658(SGPP1)

CDK:	105086202(SGPP1)

VPC:	102535101(SGPP1)

BACU:

103012286(SGPP1)

BMUS:

118890636(SGPP1)

LVE:	103069005(SGPP1)

OOR:	101274550(SGPP1)

DLE:	111173079(SGPP1)

PCAD:

102973214(SGPP1)

PSIU:

116749890(SGPP1)

ECB:	100061850(SGPP1)

EPZ:	103554332(SGPP1)

EAI:	106839161(SGPP1)

MYB:	102253110(SGPP1)

MYD:	102772311(SGPP1)

MMYO:

118656325(SGPP1)

MLF:	102430160(SGPP1)

PKL:	118716981(SGPP1)

EFUS:

103283664(SGPP1)

MNA:	107545698(SGPP1)

DRO:	112311133(SGPP1)

SHON:

118976591(SGPP1)

AJM:	119034866(SGPP1)

PDIC:

114491641(SGPP1)

PHAS:

123808935(SGPP1)

MMF:	118628276(SGPP1)

PPAM:

129065971(SGPP1)

HAI:	109375914(SGPP1)

RFQ:	117023463(SGPP1)

PALE:

102878079(SGPP1)

PGIG:

120603814(SGPP1)

PVP:	105310002(SGPP1)

RAY:	107509326(SGPP1)

MJV:	108395651(SGPP1)

TOD:	119239172(SGPP1)

SARA:

101558610(SGPP1)

LAV:	100676598(SGPP1)

TMU:

101350524

ETF:	101643560(SGPP1)

DNM:	101413948(SGPP1)

MDO:	100027518(SGPP1)

GAS:	123237747(SGPP1)

SHR:	100918515(SGPP1)

AFZ:

127549614

PCW:	110208454(SGPP1)

OAA:	100080900(SGPP1)

PCOC:

116236795(SGPP1)

MGP:	100543310(SGPP1)

CJO:	107315352(SGPP1)

TPAI:

128086189(SGPP1)

LMUT:

125694876(SGPP1)

NMEL:

110401289(SGPP1)

APLA:

101801150(SGPP1)

ACYG:

106037176(SGPP1)

CATA:

118250340(SGPP1)

AFUL:

116489655(SGPP1)

TGU:	100221899(SGPP1)

LSR:	110484105(SGPP1)

SCAN:

103826857(SGPP1)

PMOA:

120513518(SGPP1)

OTC:	121332582(SGPP1)

PRUF:

121358243(SGPP1)

GFR:	102040480(SGPP1)

FAB:	101808981(SGPP1)

OMA:	130254207(SGPP1)

PHI:	102108318(SGPP1)

PMAJ:

107206227(SGPP1)

CCAE:

111929534(SGPP1)

CCW:	104688935(SGPP1)

CBRC:

103618871(SGPP1)

ETL:	114063206(SGPP1)

ZAB:	102072788(SGPP1)

ACHL:

103798335(SGPP1)

SVG:	106850277(SGPP1)

MMEA:

130584858(SGPP1)

HRT:	120754654(SGPP1)

FPG:	101912992(SGPP1)

FCH:	102059905(SGPP1)

CLV:	102098480(SGPP1)

EGZ:	104131675(SGPP1)

NNI:	104010142(SGPP1)

PLET:

104623680(SGPP1)

EHS:	104510193(SGPP1)

PCAO:

104050633(SGPP1)

ACUN:

113480421(SGPP1)

TALA:

104356661(SGPP1)

PADL:

103924257(SGPP1)

AFOR:

103894074(SGPP1)

ACHC:

115336220(SGPP1)

HALD:

104322139(SGPP1)

HLE:	104842090(SGPP1)

AGEN:

126050671

GCL:

127016944

CSTI:

104553929(SGPP1)

CMAC:

104481401(SGPP1)

MUI:	104543308(SGPP1)

BREG:

104633058(SGPP1)

FGA:	104082035(SGPP1)

GSTE:

104261922(SGPP1)

LDI:	104340479(SGPP1)

MNB:	103769917(SGPP1)

OHA:	104330068(SGPP1)

NNT:	104405899(SGPP1)

SHAB:

115607232(SGPP1)

DPUB:

104303276(SGPP1)

PGUU:

104472005(SGPP1)

ACAR:

104531814(SGPP1)

CPEA:

104391421(SGPP1)

AVIT:

104278959(SGPP1)

CVF:	104291914(SGPP1)

RTD:	128909207(SGPP1)

CUCA:

104062364(SGPP1)

TEO:	104377478(SGPP1)

BRHI:

104491160(SGPP1)

AAM:	106483101(SGPP1)

AROW:

112976905(SGPP1)

NPD:	112959665(SGPP1)

TGT:	104575709(SGPP1)

DNE:	112991634(SGPP1)

ASN:	102377319(SGPP1)

AMJ:	102576958(SGPP1)

CPOO:

109320652(SGPP1)

GGN:	109299291(SGPP1)

CMY:	102948002(SGPP1)

CCAY:

125638565(SGPP1)

DCC:	119857212(SGPP1)

CPIC:

101941158(SGPP1)

TST:	117876194(SGPP1)

CABI:

116830007(SGPP1)

MRV:	120404350(SGPP1)

ACS:	100554530(sgpp1)

ASAO:

132761429(SGPP1)

PVT:	110087858(SGPP1)

SUND:

121914804(SGPP1)

PBI:	103050345(SGPP1)

PMUR:

107285160 107293309

CTIG:

120297182(SGPP1)

TSR:	106543021(SGPP1)

PGUT:

117675170(SGPP1)

APRI:

131188001(SGPP1)

PTEX:

113435066(SGPP1)

NSS:	113413686(SGPP1)

VKO:	123026512(SGPP1)

PMUA:

114603505(SGPP1)

PRAF:

128422385(SGPP1)

ZVI:	118079830(SGPP1)

HCG:	128341211(SGPP1)

GJA:	107121444(SGPP1)

STOW:

125427055(SGPP1)

EMC:	129324528(SGPP1)

XLA:

101027287

XTR:	549040(sgpp1)

NPR:	108786892(SGPP1)

RTEM:

120920032(SGPP1)

BBUF:

120981946(SGPP1)

BGAR:

122921812(SGPP1)

MUO:	115477503(SGPP1)

GSH:

117363353

DRE:	100003745(sgpp1) 556439(si:ch211-212g7.6)

SRX:	107716492 107726595 107736834(sgpp1) 107743975

SANH:

107654933(sgpp1) 107683631 107697306 107701492

SGH:	107553224 107563688 107589063 107602978

CCAR:

109073161 109082491(sgpp1) 109101722

CAUA:

113056817 113063371 113112461 113121036

CGIB:

127938542 127970182 127984425 128025999

PTET:

122343244(sgpp1a) 122356636(sgpp1b)

LROH:

127175276(sgpp1b) 127183094(sgpp1a)

OMC:	131552456(sgpp1b)

PPRM:

120463111(sgpp1) 120493748(si:ch211-212g7.6)

RKG:	130088231(sgpp1b) 130097560(sgpp1a)

MAMB:

125277322(sgpp1b) 125277761 125277764 125277788

CIDE:

127502370 127525072

MASI:

127409801 127411654 127414070 127416415

TROS:

130558853(sgpp1b) 130566080(sgpp1a)

TDW:	130431387(sgpp1b) 130431390 130434352(sgpp1a)

MANU:

129415766(sgpp1b) 129430093(sgpp1a)

IPU:	108257884(sgpp1a) 108263245(sgpp1b)

IFU:	128601275(sgpp1a) 128605141(sgpp1b)

PHYP:

113541943(sgpp1) 113545242

SMEO:

124376660(sgpp1a) 124398703(sgpp1b)

TFD:	113644517(sgpp1a) 113656550(sgpp1b)

TVC:	132843325(sgpp1a) 132846901(sgpp1b)

TRN:	134314920(sgpp1b) 134320053(sgpp1a)

AMEX:

103033561 103043414(sgpp1)

CMAO:

118810966(sgpp1) 118815525(si:ch211-212g7.6)

EEE:	113573005 113575535(sgpp1)

CHAR:

105890348(sgpp1b) 105897768(sgpp1a)

TRU:	101069308 101073941(sgpp1)

TFS:	130513129(sgpp1b) 130516441

TNG:	GSTEN00023278G001 GSTEN00030340G001

LCO:	104930364(sgpp1) 104930546

NCC:	104951070 104956487(sgpp1)

TBEN:

117492646 117494616

CGOB:

115003595 115005059

PGEO:

117439906 117467628(sgpp1)

GACU:

117533817 117540524(sgpp1)

EMAC:

134877139 134881697

ELY:	117266618(sgpp1) 117271282

EFO:	125896703 125901195(sgpp1b)

PLEP:

121953821(sgpp1b) 121955641 121963384

SLUC:

116036777(sgpp1) 116065956

ECRA:

117935889(sgpp1) 117961121

ESP:	116670210 116706552

PFLV:

114546634 114573551

GAT:	120808106 120814132 120832846(sgpp1)

PPUG:

119194793 119227401(sgpp1)

AFB:	129103661 129107153

CLUM:

117727564 117751193(sgpp1)

PSWI:

130201470(sgpp1b) 130202462

MSAM:

119909573 119919153

SCHU:

122861493(sgpp1b) 122862800

CUD:	121521592 121526083(sgpp1b)

ALAT:

119004480(sgpp1) 119012176

MZE:	101480011(sgpp1) 101484831

ONL:	100700490(sgpp1) 100711669

OAU:	116310692(sgpp1) 116310703

OLA:	101166766 101173595(sgpp1)

OML:	112140558 112149495(sgpp1) 112158315

CSAI:

133462433(sgpp1b) 133464391

XMA:	102217671 102236212

XCO:	114155583 114158888

XHE:	116709640 116734139

PRET:

103457586 103458086

PFOR:

103138616 103147754

PLAI:

106939204 106949072

PMEI:

106906725 106919673(sgpp1)

GAF:	122825836 122846008

PPRL:

129351222 129377422

CVG:	107082722 107084889

CTUL:

119785105 119792147

GMU:	124855645 124882539

NFU:	107377578 107391642(sgpp1)

KMR:	108242494 108251518(sgpp1)

ALIM:

106516927 106531564(sgpp1)

NWH:	119418191 119427091(sgpp1b)

AOCE:

111566662 111568813(sgpp1)

MCEP:

124999119 125023490(sgpp1b)

CSEM:

103380814 103382704(sgpp1)

POV:	109636161(sgpp1) 109648136

SSEN:

122761556 122783399(sgpp1b)

HHIP:

117756720(sgpp1) 117758166

HSP:	118099589 118116512(sgpp1b)

PPLT:

128450973(sgpp1b) 128460144

SMAU:

118285947(sgpp1b) 118290544

LCF:	108895644 108901642(sgpp1b)

SDU:	111225386 111239742

SLAL:

111652673 111654330

XGL:	120789376 120795346(sgpp1)

HCQ:	109520744 109524863

SSCV:

125990696

SBIA:

133496772 133501519(sgpp1b)

PEE:	133401902(sgpp1b) 133417276

PTAO:

133467950 133480104(sgpp1b)

BPEC:

110153074 110153456

MALB:

109954458 109966615

BSPL:

114849114(sgpp1b) 114850089

SJO:	128375660(sgpp1b)

SASA:

106571509 106599021(sgpp1)

STRU:

115172521(sgpp1)

OTW:	112250420(sgpp1a) 112261702

OMY:	110497831 110529718(si:ch211-212g7.6)

OGO:	123990853 124001379(sgpp1b)

ONE:	115107859 115146155(sgpp1)

OKI:	109894442 109900841

OKE:	118362585 118398552(sgpp1a)

SALP:

111954355 111968653(sgpp1)

SNH:	120024085(si:ch211-212g7.6) 120060345(sgpp1)

CCLU:

121539359 121544457 121552384

ELS:	105015553 105017650

SFM:	108919425(sgpp1) 108941948

PKI:	111844461 111851059(sgpp1)

AANG:

118215330(sgpp1) 118230775(si:ch211-212g7.6)

LOC:	102683932(sgpp1)

PSPA:

121324557 121330252

ARUT:

117430327 117974017

PSEX:

120518501(sgpp1)

LCM:	102367084(SGPP1)

CMK:	103185418(sgpp1b)

RTP:	109914447(sgpp1b)

CPLA:

122553448(sgpp1b)

HOC:	132818373(sgpp1b)

PMRN:

116947247(SGPP1)

LRJ:	133360764(SGPP1)

BFO:

118410290

BBEL:

109469942

CIN:	100182290 100182465

SCLV:

120326238 120328410

APLC:

110982172

SKO:	100367222 100367374

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ009138

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209451

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM323580

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:	124158036 124163045

FCD:

110843083

DPX:	DAPPUDRAFT_251767

DMK:

116928372

DPZ:	124328532 124340525

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

EAF:

PPOI:

RMP:

DPTE:

CSCU:

PTEP:

ABRU:

UDV:	129222939 129233221

SDM:

118180155

LPOL:

106465598

PMEO:

129584583

HRO:	HELRODRAFT_122845

LGI:	LOTGIDRAFT_140415 LOTGIDRAFT_54296

PVUL:

126807880 126820595

PCAN:

112564569 112570185

BGT:	106057009 106057010 106069578 106074606

GAE:	121372716 121380615 121381749

HRF:	124145460 124146650

HRJ:	124267147 124276789

CRG:	105333032 105334190

CVN:

111129840

CANU:

128177333

OED:	125650000 125666804

MYI:	110441852 110446509

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106165271 106181304

NVE:	5499548 5515990

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_33901

AQU:	100639563 100641496

MBR:	MONBRDRAFT_31293

» show all

Reference

PMID:10859351

Authors

Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S

Title

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death.

Journal

Proc Natl Acad Sci U S A 97:7859-64 (2000)
DOI:10.1073/pnas.120146897

Sequence

[hsa:81537]

LinkDB

DBGET integrated database retrieval system