KEGG ORTHOLOGY: K04781

ORTHOLOGY: K04781

Entry

K04781                      KO

Symbol

mbtI, irp9, ybtS

Name

salicylate synthetase [EC:5.4.4.2 4.2.99.21]

Pathway

map01053

Biosynthesis of siderophore group nonribosomal peptides

map01110

Biosynthesis of secondary metabolites

Reaction

R06602

isochorismate pyruvate-lyase (salicylate-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01053 Biosynthesis of siderophore group nonribosomal peptides
    K04781  mbtI, irp9, ybtS; salicylate synthetase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.99  Other carbon-oxygen lyases
    4.2.99.21  isochorismate lyase
     K04781  mbtI, irp9, ybtS; salicylate synthetase
5. Isomerases
  5.4  Intramolecular transferases
   5.4.4  Transferring hydroxy groups
    5.4.4.2  isochorismate synthase
     K04781  mbtI, irp9, ybtS; salicylate synthetase

Other DBs

COG:

COG0147

GO:

0008909

Genes

MAW:

MAC_07797

MAJ:	MAA_03348 MAA_04435

PCHM:

VFPPC_03779

VAL:	VDBG_09508

VDA:	VDAG_04743

PSCO:

LY89DRAFT_694557

AFM:	AFUA_6G12110

ACT:	ACLA_062890

NFI:	NFIA_005290

AOR:	AO090026000117

ANG:	An08g01420 An12g07110

AFV:	AFLA_006187

ALUC:

AKAW2_30838S AKAW2_61073S

POU:	POX_e07207

ESL:

O3K_09730

ESO:

O3O_15895

ESM:

O3M_09695

ECK:	EC55989_2202(irp)

ELH:

ETEC_2076

ECP:

ECP_1937

ENA:	ECNA114_2040

ECOS:

EC958_2284(ybtS)

ECV:	APECO1_1052

ECQ:	ECED1_2244(irp)

EUM:	ECUMN_2268(irp)

ECT:	ECIAI39_1080(irp)

EOC:	CE10_2256(ybtS)

ECI:	UTI89_C2178(ybtS)

ECZ:	ECS88_2032(irp)

ECC:

c2419

ELO:	EC042_2208(ybtS)

ELN:	NRG857_09865

ESE:

ECSF_1825

EAB:	ECABU_c22360(ybtS)

ELU:	UM146_07315

ELC:

i14_2236

ELD:

i02_2236

ELF:

LF82_295

ECOI:

ECOPMV1_02066(mbtI)

ECOJ:

P423_11035

SETC:

CFSAN001921_24665

KPU:	KP1_3583(ybtS)

KPM:	KPHS_34610

KPP:	A79E_1711(ybtS)

KPG:	KPNIH32_17590

KPT:	VK055_5126(ybtS)

KPX:	PMK1_04849(mbtI)

KPNK:

BN49_3582(ybtS)

KOX:

KOX_20605

KOE:

A225_2987

KOY:	J415_17005

KOM:	HR38_18920

KMI:	VW41_14150

KOK:	KONIH1_14670

EAR:

CCG29278

KLL:	BJF97_14825

KPAS:

LUW96_21165

KLC:	K7H21_14320

KLM:	BWI76_14505

REE:	electrica_01772(mbtI)

ROR:	RORB6_02530

RAO:	DSD31_08925(ybtS)

CKO:	CKO_00916 CKO_01253

CIE:	AN232_14395(ybtS)

SYM:	K6K13_09605

YPE:	YPO1916(irp9)

YPK:	y2394(ybtS)

YPA:

YPA_1294

YPM:	YP_1659(ybtS)

YPP:	YPDSF_1209

YPD:	YPD4_1683(ybtS)

YPX:	YPD8_1864(ybtS)

YPW:

CH59_3710

YPV:

BZ15_1628

YPL:

CH46_3201

YPS:	YPTB1601(ybtS)

YPO:

YPB:

YPU:

YPC:

YEN:	YE2612(ybtS)

YEW:

YFR:

YKR:

SERM:

PCAC:

PAO:	Pat9b_4767

LGU:	LG3211_4750

VCT:	JV59_22220

VMI:	AL543_04300

VQI:	CCZ37_14455

PPR:	PBPRA1663(MBTI)

SPSW:

Sps_01769

SPSH:

FM037_18480

PBW:	D172_020550

CEB:	B0D95_19970

TLO:	J9253_01245

MPC:	Mar181_2531

TCAR:

U0034_27670

RTU:	PR017_20100

DEO:	CAY53_06490

SCU:	SCE1572_43425

SHU:	SHYC_00310

SSAC:

I6I31_03940

LFB:	C1X05_14720

CSB:	CLSA_c16880

CLD:	CLSPO_c20050(mbtI)

RPAY:

P0092_11145

EHA:	Ethha_0620

DSY:

DSY2818

DHD:

Dhaf_3962

THYR:

P4S50_07115

MTU:	Rv2386c(mbtI)

MTV:	RVBD_2386c

MTC:

MT2454

MRA:	MRA_2409(mbtI)

MTF:	TBFG_12411

MTB:	TBMG_01589

MTK:	TBSG_01599

MTZ:	TBXG_001575

MTG:	MRGA327_14705

MTE:	CCDC5079_2206

MTUR:

CFBS_2525(mbtI)

MTL:	CCDC5180_2177

MTO:	MTCTRI2_2429(mbtI)

MTD:	UDA_2386c(mbtI)

MTN:	ERDMAN_2621(mbtI)

MTJ:	J112_12800

MTUB:

MT7199_2417

MTUE:

J114_12775

MTX:	M943_12320

MTUL:

TBHG_02324

MTUT:

HKBT1_2516(mbtI)

MTUU:

HKBT2_2519(mbtI)

MTQ:	HKBS1_2523(mbtI)

MBO:	BQ2027_MB2407C(mbtI)

MBB:	BCG_2400c(mbtI)

MBT:	JTY_2394(mbtI)

MBM:	BCGMEX_2389c(mbtI)

MBK:	K60_024720

MBX:

BCGT_2210

MAF:	MAF_24000(mbtI)

MMIC:

RN08_2645

MCE:	MCAN_24181(mbtI)

MCQ:	BN44_50353(mbtI)

MCV:	BN43_40031(mbtI)

MCX:	BN42_40319(mbtI)

MCZ:	BN45_50756(mbtI)

MORY:

MO_002499(mbtI)

MPA:	MAP_2205c(trpE2)

MAO:

MAVU:

MAV:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MMAN_23110(mbtI)

MUL:	MUL_3648(mbtI)

MMI:	MMAR_3706(mbtI)

MMAE:

MMARE11_36130(mbtI)

MLI:	MULP_03956(mbtI)

MPSE:

MPSD_37730(mbtI)

MSHO:

MSHO_32370(mbtI)

MMM:

W7S_07910

MKN:	MKAN_04925

MYV:	G155_19270

MYE:	AB431_02295

MDX:	BTO20_12330

MSHG:

MSG_03385(mbtI)

MFJ:	MFLOJ_53200(mbtI)

MSTO:

MSTO_57330(mbtI)

MSIM:

MSIM_42480(mbtI)

MSAK:

MSAS_15890(mbtI)

MKU:	I2456_17865

MXE:	MYXE_18740(mbtI)

MNV:	MNVI_00870(mbtI)

MPAG:

C0J29_20675

MGOR:

H0P51_18730

MCOO:

MCOO_14370(mbtI)

MBAI:

MB901379_03289(mbtI)

MSEO:

MSEO_21920(mbtI)

MHEK:

JMUB5695_01985(mbtI)

MLJ:	MLAC_24620(mbtI)

MBRD:

MBRA_34360(mbtI)

MSHJ:

MSHI_08180(mbtI)

MMAM:

K3U93_15815

MOT:	LTS72_06215

MPAA:

MKK62_08830

MKY:	IWGMT90018_20960(mbtI)

MWU:	PT015_08190

MSM:	MSMEG_4524

MSG:	MSMEI_4412

MSB:	LJ00_22380

MSN:	LI99_22385

MSH:	LI98_22390

MFT:	XA26_39320(mbtI)

MFX:	MFAL_15680

MAIC:

MAIC_52380

MIJ:	MINS_34590

MSAR:

MAUB:

MPHU:

MMUC:

MMAT:

MBOK:

MFG:	K6L26_12490

MSEN:

K3U95_16655

MPAE:

K0O64_01920

MCRO:

MI149_02500

MKR:	MKOR_03740

MPAK:

MIU77_06145

MAB:

MAB_2245

MMV:	MYCMA_1202

MABB:

MASS_2175

MABL:

MMASJCM_2200

MCHE:

BB28_11295

MIZ:	BAB75_12015

MSTE:

MSTE_02184

MSAO:

MYCSP_09665

MSAL:

DSM43276_01958(mbtI)

MTER:

4434518_01420(mbtI)

MMIN:

MMIN_31200(mbtI)

MHIB:

MHIB_09750(mbtI)

MHER:

K3U94_08345

MVM:	MJO54_08420

CDUR:

CDUR_01020(mbtI)

CBOV:

CBOVI_00295(mbtI)

NFA:	NFA_6190(nbtS)

NFR:	ERS450000_00758(mbtI_1) ERS450000_03588(mbtI_2)

NCY:	NOCYR_0625(mbtI) NOCYR_2581(mbtI)

NBR:	O3I_003490

NNO:	NONO_c06820 NONO_c49360(mbtI)

NSL:	BOX37_17040

NSR:	NS506_07818(mbtI)

NTP:	CRH09_03995 CRH09_09675

NOZ:	DMB37_24460

NOD:	FOH10_15050 FOH10_27925

NAH:	F5544_03425

NAD:	NCTC11293_01413(mbtI)

NWL:	NWFMUON74_06270 NWFMUON74_24260

NIE:	KV110_03810 KV110_35875

NHU:	H0264_04670

NYA:	LTV02_28120

NGP:	LTT66_16360(nbtS)

NSPU:

IFM12276_03560

NYU:	D7D52_05215

ROP:

ROP_23300

RHB:

NY08_2677

RFA:	A3L23_00822(mbtI)

RHS:	A3Q41_02530(mbtI)

WHR:	OG579_16175

GBR:

Gbro_0621

GOR:

KTR9_0492

GOQ:	ACH46_18435

GTA:	BCM27_03295

GOC:	CXX93_05340

GRU:	GCWB2_02935(mbtI)

GOM:	D7316_02888(mbtI)

GAV:	C5O27_02090

GOD:	GKZ92_02745

GAM:	GII34_03145

GPD:	GII33_20225

GJI:	H1R19_02590

GHN:	MVF96_03065

GAMI:

IHQ52_05570

GMG:	NWF22_13255

GSI:	P5P27_16915

TPR:

Tpau_4330

SRT:

Srot_0738

SCO:	SCO7691(SC4C2.26)

SCB:

SCAB_1381

SSX:	SACTE_0732 SACTE_1758

SRC:	M271_09900

SVE:

SVEN_0506

SLV:	SLIV_00845

SGU:	SGLAU_04415

STRE:

GZL_00986

SPHW:

NFX46_19215

SLS:	SLINC_1329

STRD:

NI25_03930

SGD:	ELQ87_35715

SCYA:

EJ357_41770

SNQ:	CP978_29915

SHAR:

HUT13_23975

SFEU:

IM697_24255

SROI:

IAG44_38720

STUB:

MMF93_04770 MMF93_23490

SYUN:

MOV08_10155

SFIY:

F0344_07330

SCOA:

QU709_01690

YIA:	LO772_29025

CMI:

CMM_0334

CMH:	VO01_01510

CMC:

CCAF:

NAKE:

SNAH:

TCU:

AGRA:

AMAZ:

ACIR:

AOI:	AORI_5432(trpE)

AJA:	AJAP_35475(mbtI)

AMQ:	AMETH_0593(trpE)

AMYC:

CU254_13000

AORI:

SD37_07295 SD37_10115

AACD:

LWP59_02780

ATHM:

L1857_05475

PSEH:

XF36_13480

PHH:	AFB00_29560

KAL:

KALB_5549

AHM:	TL08_14405

ACTU:

Actkin_03282(mbtI)

CROS:

N8J89_12060

ASE:	ACPL_6155(trpE)

ACTS:

ACWT_6023

ACTL:

L3i22_066120

AOU:	ACTOB_004301

CMP:	Cha6605_2629

AMR:

AM1_A0247

PSER:

ABRG53_e066(mbtI)

GLP:	Glo7428_4813

MIC:	Mic7113_1759

NOE:	CLI64_03750

ACY:	Anacy_5465

CSG:	Cylst_3838

CALO:

CALH:

CTHE:

Reference

PMID:16923875

Authors

Harrison AJ, Yu M, Gardenborg T, Middleditch M, Ramsay RJ, Baker EN, Lott JS

Title

The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase.

Journal

J Bacteriol 188:6081-91 (2006)
DOI:10.1128/JB.00338-06

Sequence

[mtu:Rv2386c]

LinkDB

DBGET integrated database retrieval system