KEGG ORTHOLOGY: K05304

ORTHOLOGY: K05304

Entry

K05304                      KO

Symbol

NANS, SAS

Name

sialic acid synthase [EC:2.5.1.56 2.5.1.57 2.5.1.132]

Pathway

map00520

Amino sugar and nucleotide sugar metabolism

map01100

Metabolic pathways

map01250

Biosynthesis of nucleotide sugars

Reaction

R04435

phosphoenolpyruvate:N-acetyl-D-mannosamine-6-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)

R11439

phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase

Disease

H02187

Spondyloepimetaphyseal dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K05304  NANS, SAS; sialic acid synthase
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.56  N-acetylneuraminate synthase
     K05304  NANS, SAS; sialic acid synthase
    2.5.1.57  N-acylneuraminate-9-phosphate synthase
     K05304  NANS, SAS; sialic acid synthase
    2.5.1.132  3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase
     K05304  NANS, SAS; sialic acid synthase

Other DBs

GO:	0050462 0047444

Genes

HSA:	54187(NANS)

PTR:	743934(NANS)

PPS:	100982112(NANS)

GGO:	101124502(NANS)

PON:	100446862(NANS)

NLE:	100603154(NANS)

HMH:	116475313(NANS)

MCC:	715459(NANS)

MCF:	102120030(NANS)

MTHB:

126938070

MNI:	105477199(NANS)

CSAB:

103219150(NANS)

CATY:

105593048(NANS)

PANU:

101020165(NANS)

TGE:	112607835(NANS)

MLEU:

105549289(NANS)

RRO:	104657773(NANS)

RBB:	108539113(NANS)

TFN:	117098940(NANS)

PTEH:

111536614(NANS)

CANG:

105509947(NANS)

CJC:	100411585(NANS)

SBQ:	101027621(NANS)

CIMI:

108303891(NANS)

CSYR:

103273474(NANS)

MMUR:

105873791(NANS)

LCAT:

123645941(NANS)

PCOQ:

105805371(NANS)

OGA:	100951418(NANS)

MMU:	94181(Nans)

MCAL:

110292645(Nans)

MPAH:

110323062(Nans)

RNO:	298071(Nans)

MCOC:

116095967(Nans)

ANU:	117709646(Nans)

MUN:	110551128(Nans)

CGE:	100767837(Nans)

MAUA:

101830178(Nans)

PROB:

127224641(Nans)

PLEU:

114702354(Nans)

MORG:

121458558(Nans)

MFOT:

126509881

AAMP:

119826497(Nans)

NGI:	103749137(Nans)

HGL:	101721582(Nans)

CPOC:

100716456(Nans)

CCAN:

109697287(Nans)

DORD:

105990839(Nans)

DSP:	122121805(Nans)

PLOP:

125345837(Nans)

NCAR:

124964919

MMMA:

107147766(Nans)

OCU:

100356934

OPI:	101522937(NANS)

TUP:	102496776(NANS)

GVR:	103590728(NANS)

CFA:	481624(NANS)

CLUD:

112649641(NANS)

VVP:	112930767(NANS)

VLG:	121494904(NANS)

NPO:	129495242(NANS)

AML:	100471912(NANS)

UMR:	103678504(NANS)

UAH:	113260417(NANS)

UAR:	123781029(NANS)

ELK:

111146174

LLV:

125083268

MPUF:

101687668(NANS)

MNP:	132024576(NANS)

MLK:	131812492(NANS)

NVS:	122917426(NANS)

ORO:	101377441(NANS)

EJU:	114213569(NANS)

ZCA:	113934273(NANS)

MLX:	118017911(NANS)

NSU:	110581438(NANS)

LWW:	102730978(NANS)

FCA:	101092303(NANS)

PYU:	121034713(NANS)

PCOO:

112872235(NANS)

PBG:	122474611(NANS)

PVIV:

125149821(NANS)

LRUF:

124502196

PTG:	102952743(NANS)

PPAD:

109270098(NANS)

PUC:

125920084

AJU:

106981299

HHV:	120233531(NANS)

BTA:	540602(NANS)

BOM:	102266035(NANS)

BIU:	109563072(NANS)

BBUB:

102402717(NANS)

BBIS:

104993691(NANS)

CHX:	102171423(NANS)

OAS:	101104048(NANS)

BTAX:

128052274(NANS)

ODA:	120862645(NANS)

CCAD:

122452923(NANS)

MBEZ:

129556850(NANS)

SSC:	100155883(NANS)

CFR:	102511644(NANS)

CBAI:

105067382(NANS)

CDK:	105086903(NANS)

VPC:	102528094(NANS)

BACU:

103016138(NANS)

BMUS:

118897102(NANS)

LVE:	103074242(NANS)

OOR:	101286113(NANS)

DLE:	111187968(NANS)

PCAD:

102975186(NANS)

PSIU:

116755813(NANS)

NASI:

112392669(NANS)

ECB:	100064126(NANS)

EPZ:	103550229(NANS)

EAI:	106842931(NANS)

MYB:	102254698(NANS)

MYD:	102770256(NANS)

MMYO:

118667273(NANS)

MLF:	102435662(NANS)

PKL:	118716275(NANS)

EFUS:

103286401(NANS)

MNA:	107544993(NANS)

DRO:	112304493(NANS)

SHON:

118979589(NANS)

AJM:	119045927(NANS)

PDIC:

114509777(NANS)

PHAS:

123819942(NANS)

MMF:	118629683(NANS)

PPAM:

129079673(NANS)

HAI:	109386412(NANS)

RFQ:	117032312(NANS)

PALE:

102882391(NANS)

PGIG:

120597479(NANS)

PVP:	105296243(NANS)

RAY:	107511690(NANS)

MJV:	108386331(NANS)

TOD:	119231857(NANS)

SARA:

101558462(NANS)

SETR:

126023700(NANS)

LAV:	100659127(NANS)

TMU:

101361417

ETF:	101653381(NANS)

DNM:	101415935(NANS)

MDO:	100014569(NANS)

GAS:	123231260(NANS)

SHR:	100915225(NANS)

AFZ:

127560750

PCW:	110220562(NANS)

OAA:	100074951(NANS)

GGA:	427283(NANS)

PCOC:

116234839(NANS)

MGP:	100540972(NANS)

CJO:	107306381(NANS)

TPAI:

128089605 128089615

LMUT:

125687047 125687392

NMEL:

110389693(NANS)

APLA:

101793548(NANS)

ACYG:

106046483(NANS)

CATA:

118256861(NANS)

AFUL:

116500909(NANS)

TGU:	100227675(NANS)

LSR:	110472303(NANS)

SCAN:

103821217(NANS)

PMOA:

120509468(NANS)

OTC:	121334701(NANS)

PRUF:

121355663(NANS)

GFR:	102036907(NANS)

FAB:	101817049(NANS)

OMA:	130264714(NANS)

PHI:	102108606(NANS)

PMAJ:

107198262(NANS)

CCAE:

111940921(NANS)

CCW:	104689769(NANS)

CBRC:

103616433(NANS)

ETL:	114056942(NANS)

ZAB:	102065706(NANS)

ACHL:

103804865(NANS)

SVG:	106859673(NANS)

MMEA:

130577596(NANS)

HRT:	120765301(NANS)

FPG:	101910977(NANS)

FCH:	102058691(NANS)

CLV:	102088004(NANS)

EGZ:	104135026(NANS)

NNI:	104014067(NANS)

PCRI:

104025538(NANS)

PLET:

104620779(NANS)

EHS:	104517044(NANS)

PCAO:

104046970(NANS)

ACUN:

113489989(NANS)

TALA:

104366421(NANS)

PADL:

103923247(NANS)

AFOR:

103896158(NANS)

ACHC:

115336739(NANS)

HALD:

104312067(NANS)

HLE:	104830508(NANS)

AGEN:

126036494

GCL:

127027665

CCRI:

104155775(NANS)

CSTI:

104550675(NANS)

CMAC:

104481639(NANS)

FGA:	104074239(NANS)

GSTE:

104263825(NANS)

LDI:	104355132(NANS)

MNB:	103774718(NANS)

OHA:	104331297(NANS)

NNT:	104409114(NANS)

SHAB:

115601192(NANS)

DPUB:

104304859(NANS)

PGUU:

104469406(NANS)

ACAR:

104518859(NANS)

CPEA:

104394483(NANS)

AVIT:

104274354(NANS)

CVF:	104285719(NANS)

RTD:	128902703(NANS)

CUCA:

104059924(NANS)

TEO:	104375228(NANS)

BRHI:

104489142(NANS)

AAM:	106487451(NANS)

AROW:

112968978(NANS)

NPD:	112946284(NANS)

TGT:	104577698(NANS)

DNE:	112982754(NANS)

SCAM:

104151902(NANS)

ASN:	102371122(NANS)

AMJ:	102562418(NANS)

CPOO:

109323518(NANS)

CMY:	102930222(NANS)

CCAY:

125636602(NANS)

DCC:	119855742(NANS)

CPIC:

101940249(NANS)

TST:	117878892(NANS)

CABI:

116832497(NANS)

MRV:	120408042(NANS)

ACS:	100558551(nans)

ASAO:

132768113(NANS)

PVT:	110077827(NANS)

SUND:

121924222(NANS)

PBI:	103051012(NANS)

PMUR:

107293127(NANS)

CTIG:

120308567(NANS)

TSR:	106556782(NANS)

PGUT:

117661676(NANS)

APRI:

131193653(NANS)

PTEX:

113444069(NANS)

NSS:	113415520(NANS)

VKO:	123030229(NANS)

PMUA:

114587657(NANS)

PRAF:

128405086(NANS)

ZVI:	118097903(NANS)

HCG:	128346307(NANS)

GJA:	107122992(NANS)

STOW:

125437185(NANS)

EMC:	129334514(NANS)

XLA:	432051(nans.S) 447417(nans.L)

XTR:	100492893(nans)

NPR:	108783786(NANS)

RTEM:

120946942(NANS)

BBUF:

120989333(NANS)

BGAR:

122920937(NANS)

MUO:	115459142 115463653

GSH:	117347248 117347256

DRE:	322780(nansa) 492779(nansb)

SRX:	107723182 107754352 107754390 107758866

SANH:

107665955 107686966 107686967 107692601

SGH:	107557947 107566238 107566239

CCAR:

109076464 109090623 109090659

CAUA:

113044320 113066551 113066555 113066556 113066635 113085422 113105679

CGIB:

127946856 127946857 127948763 127975766

PTET:

122322880(nansa)

LROH:

127156361(nansb) 127172436(nansa)

OMC:	131524664 131534998(nansb) 131541588(nansa)

PPRM:

120475377(nansb) 120475384 120475385 120475386 120478311(nansa)

RKG:	130097610 130097653 130106509 130106510

MAMB:

125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)

CIDE:

127507296 127519832

MASI:

127443667 127445253

TROS:

130553152(nansa)

TDW:	130407907(nansa) 130414328 130414329 130414351 130414352 130414355 130414375

MANU:

129433135 129433751 129444857(nansa) 129445965

IPU:	100528493(nansa) 108260162

IFU:	128603812 128604222(nansa)

PHYP:

113531522(nans)

SMEO:

124378730 124381237(nansa)

TFD:	113635339(nansa)

TVC:	132842025(nansa)

AMEX:

111195185(nans)

CMAO:

118811935 118811936 118816978(nansa)

EEE:	113568448(nans) 113589926

CHAR:

105903578(nansa)

TRU:	778024(nans)

TFS:	130527938(nansa)

TNG:	GSTEN00033532G001

LCO:	104922341(nans)

TBEN:

117474709(nansa)

CGOB:

115010173 115010214

PGEO:

117439291(nansa) 117450755

GACU:

117555257 117561263(nansa) 117561638

EMAC:

134864542(nansa)

ELY:	117254746(nansa)

EFO:	125885917(nansa)

PLEP:

121942582(nansa)

SLUC:

116042899(nansa)

ECRA:

117956637(nansa)

ESP:	116698406(nans)

PFLV:

114570372(nans)

GAT:	120825501 120825503

PPUG:

119218410(nansa)

AFB:	129095925 129096028(nansa)

CLUM:

117737471(nansa)

PSWI:

130190092(nansa)

MSAM:

119884880 119899378 119899379

SCHU:

122873785 122873786

CUD:	121507902 121508708 121508709

ALAT:

119028006

MZE:	101481190 106674567

ONL:	100695579 100695847 100696106

OAU:	116310552 116310553 116310587

OLA:	101166198(nans)

OML:	112137589(nansa)

CSAI:

133444310(nansa)

XMA:	102234709(nans)

XCO:	114145362(nans)

XHE:	116720640(nans)

PRET:

103467988(nans) 103472627

PFOR:

103148741(nans)

PLAI:

106938624(nans)

PMEI:

106905478(nans)

GAF:	122829775(nansa)

PPRL:

129367361(nansa)

CVG:	107083396(nans) 107083415 107083416

CTUL:

119787144 119787154 119787177

GMU:	124868545 124868562

NFU:	107390917 107390934

KMR:	108241432 108241509

ALIM:

106528334(nans)

NWH:	119422378 119422379

AOCE:

111575007(nans)

MCEP:

125003896 125004087 125004788

CSEM:

103384124 103384125

POV:	109627210 109627438

SSEN:

122770577 122771631

HHIP:

117769790 117769798

HSP:	118122966 118126039

SMAU:

118312620 118312971

LCF:	108885367 108885368

SDU:	111229256 111229269

SLAL:

111659703

XGL:	120800959(nansa)

HCQ:	109519806 109519931

SSCV:

125969199 125969200

SBIA:

133506019 133506020

PEE:	133404376 133404378

PTAO:

133476244 133476245

BPEC:

110166192 110166235

MALB:

109953770(nans)

BSPL:

114858266 114858277 114858282

SJO:	128374734(nansa)

SASA:

100195066(sias) 106594767 106609889

STRU:

115191851 115202178 115202179 115202180 115202181

OTW:	112231840 112261351

OMY:	110497423 110497424 110534455

OGO:	124001941 124001943 124012735

ONE:	115137363 115137722 115145762 115146546

OKI:	109894131 109901155

OKE:	118362993 118362994 118395463

SALP:

111971593 112068285 112080022

SNH:	120034903 120051990 120052901

CCLU:

121534521 121535761 121535762

ELS:	105022900(nans)

SFM:

108920829

PKI:	111855408(nans)

AANG:

118227907(nansa)

LOC:	102687418(nans)

PSPA:

121319344(nansa)

ARUT:

117420829(nansa)

PSEX:

120532357 120532358 120532359

CMK:	103177631(nansa) 103177633

RTP:	109938218(nansa)

CPLA:

122539555(nansa) 122547124

HOC:	132833232(nansa)

LERI:

129702205(nansa)

PMRN:

116951617(NANS)

LRJ:

133340871

BFO:	118412951 118412952

BBEL:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100367009 100376912

DME:	Dmel_CG5232(NANS)

DER:

6553702

DSE:

6606666

DSI:	Dsimw501_GD18832(Dsim_GD18832)

DYA:	Dyak_GE26192

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24828

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ013964

CPII:

CNS:

BCOO:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201756

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:	106124172 106124788

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113496613 113506267

SLIU:

111353605

OFU:

114364386

PXY:

105391284

PGW:	126373167 126377162

CCRN:

123298907

API:	100166349 100570600

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM018360

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_300651

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

PPOI:

VDE:

VJA:

TUT:

CSCU:

PTEP:

ABRU:

129958113 129958114 129958115

UDV:

SDM:

LPOL:

MMER:

AAF:	AURANDRAFT_30675

EHX:	EMIHUDRAFT_437804(NEUB)

NCO:	AAW31_00110

NMU:	Nmul_A0408

NLC:	EBAPG3_000870

SLAC:

SKTS_36140

EAK:	EKH55_4784

EAH:	FA04_24335

RLG:

Rleg_0440

RHV:	BA939_07200

RRG:	J3P73_04755

RPE:

RPE_4236

MMYR:

MXMO3_03623

BVR:

BVIR_1970

BLAG:

BLTE_00400(neuB)

HDI:	HDIA_0896(pseI)

LABR:

LAGG:

MALG:

PSEB:

CBOT:

SPAN:

SPZR:

PALG:

CMAN:

RCE:	RC1_3771(nans)

DEX:	HWD60_03420

ARC:

ABLL_2687

AHS:	AHALO_2546

AMYT:

AMYT_2597

HEBR:

AEBR_0577 AEBR_2874

PCA:	Pcar_1277(neuB)

DFL:

DFE_1272

DMA:

DMR_13530

DCB:	C3Y92_14295

DGG:

DGI_4066

DMS:	E8L03_20250

DAF:	Desaf_0142

DAS:

Daes_2970

DPI:

BN4_12645

DEJ:	AWY79_17810

PPRF:

DPRO_1430

PSEL:

GM415_02085 GM415_02270

DDN:	DND132_2824

PSEF:

PPOR:

PNW:

PTHE:

DSX:	GD604_00905

DSD:	GD606_11120

DVM:

DvMF_1832

TAV:	G4V39_08720

HLI:

HLI_08585

GRC:	GI584_08485

BOU:	I5818_06175

PYG:	AWM70_17110

ACEL:

acsn021_05140

TTO:	Thethe_00855

CLC:	Calla_1077

SLAU:

SLA_6887

RTX:	TI83_02490

RTC:	APU90_03985

RRY:	C1O28_12555

MPRO:

BJP34_26850

TBE:	Trebr_1643

SSM:	Spirs_4263

BHP:	BHAMNSH16_00325

BHL:	Bache_2153

BFE:	K6V30_22135

BSA:	Bacsa_3466

PCLR:

PC1C4_16490 PC1C4_23910

PGIN:

FRZ67_17740

MUC:

MuYL_3260

MGK:	FSB76_19830

RHOZ:

GXP67_24460

RSI:	Runsl_2328

RUN:	DR864_20420

RUP:	DTQ70_21560

FJG:	BB050_02206(legI)

FCO:	FCOL_12635

FGL:	EM308_00620

FCM:	BIW12_03115

FFA:	FFWV33_07925

FCR:	HYN56_01615

FEN:	J0383_14490

FCV:	AWN65_10295

FCS:	TRV642_0311

FPEC:

Q1W71_13450

CAT:	CA2559_07305

KDI:	Krodi_2064

DOK:	MED134_13631(neuB)

DDO:	I597_1525(legI)

DOD:	DCS32_01450

LNU:	N7U66_19210

NDO:

DDD_2293

NOM:	AAT17_10860

NSD:	BST91_07935

NOB:	CW736_00515

NUL:	R1T42_01410

PRN:	BW723_03025 BW723_09690

LUT:	Lupro_02285

OLL:	CW732_09090

FAY:	Q4Q34_01095

TAJ:	C1A40_00900

AUE:	C5O00_09755

AQA:	D1815_16910

EMAR:

MESQ:

SABU:

ALUT:

HWS:	RNZ46_01605

FBQ:	D1817_12910

BBAU:

AEM51_01345

BGW:	VE98_C0001G0439

MAC:

MA_3767

MVC:	MSVAZ_0733

MEK:	MSKOL_0716

MHAZ:

BHR79_03025

MAX:	MMALV_05370

» show all

Reference

PMID:10749855

Authors

Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ

Title

Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.

Journal

J Biol Chem 275:17869-77 (2000)
DOI:10.1074/jbc.M000217200

Sequence

[hsa:54187]

Reference

PMID:10873658

Authors

Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K

Title

Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.

Journal

Biochem Biophys Res Commun 273:642-8 (2000)
DOI:10.1006/bbrc.2000.2983

Sequence

[mmu:94181]

LinkDB

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