KEGG ORTHOLOGY: K05869

ORTHOLOGY: K05869

Entry

K05869                      KO

Symbol

CAMK4

Name

calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]

Pathway

map04020

Calcium signaling pathway

map04024

cAMP signaling pathway

map04211

Longevity regulating pathway

map04371

Apelin signaling pathway

map04380

Osteoclast differentiation

map04720

Long-term potentiation

map04722

Neurotrophin signaling pathway

map04725

Cholinergic synapse

map04921

Oxytocin signaling pathway

map04925

Aldosterone synthesis and secretion

map05031

Amphetamine addiction

map05034

Alcoholism

map05214

Glioma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
   04020 Calcium signaling pathway
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
   04024 cAMP signaling pathway
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
   04925 Aldosterone synthesis and secretion
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
  09156 Nervous system
   04725 Cholinergic synapse
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
   04720 Long-term potentiation
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
   04722 Neurotrophin signaling pathway
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
  09149 Aging
   04211 Longevity regulating pathway
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
09160 Human Diseases
  09162 Cancer: specific types
   05214 Glioma
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
  09165 Substance dependence
   05031 Amphetamine addiction
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
   05034 Alcoholism
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  CAMK1 family [OT]
   K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV

Other DBs

GO:

0004683

Genes

HSA:	814(CAMK4)

PTR:	461992(CAMK4)

PPS:	100970371(CAMK4)

GGO:	101140371(CAMK4)

PON:	100461605(CAMK4)

NLE:	100583900(CAMK4)

HMH:	116470946(CAMK4)

MCC:	712322(CAMK4)

MCF:	101864901(CAMK4)

MTHB:

126956231

MNI:	105471123(CAMK4)

CSAB:

103244326(CAMK4)

CATY:

105576638(CAMK4)

PANU:

101009081(CAMK4)

TGE:	112626099(CAMK4)

MLEU:

105546263(CAMK4)

RRO:	104677657(CAMK4)

RBB:	108540302(CAMK4)

TFN:	117064830(CAMK4)

PTEH:

111542684(CAMK4)

CANG:

105523476(CAMK4)

CJC:	100388410(CAMK4)

SBQ:	101053463(CAMK4)

CIMI:

108303390(CAMK4)

CSYR:

103253937 103264715(CAMK4)

MMUR:

105865738(CAMK4)

LCAT:

123648496(CAMK4)

PCOQ:

105822534(CAMK4)

OGA:	100963188(CAMK4)

MMU:	12326(Camk4)

MCAL:

110284636(Camk4)

MPAH:

110333240(Camk4)

RNO:	25050(Camk4)

MCOC:

116086957(Camk4)

ANU:	117720132(Camk4)

MUN:	110564828(Camk4)

CGE:	100774010(Camk4)

MAUA:

101841141(Camk4)

PROB:

127235144(Camk4)

PLEU:

114691636(Camk4)

MORG:

121445161(Camk4) 121453240

MFOT:

126497098

AAMP:

119814676(Camk4)

NGI:	103752296(Camk4)

HGL:	101700365(Camk4)

CPOC:

100723881(Camk4)

CCAN:

109696025(Camk4)

DORD:

105988651(Camk4)

DSP:	122118075(Camk4)

PLOP:

125339862(Camk4)

NCAR:

124987181

MMMA:

107150398(Camk4)

OCU:

103345118

OPI:	101525109(CAMK4)

TUP:	102479520(CAMK4)

GVR:	103603361(CAMK4)

CFA:	100684140(CAMK4)

CLUD:

112653311(CAMK4)

VVP:	112915439(CAMK4)

VLG:	121489316(CAMK4)

NPO:	129503274(CAMK4)

AML:	100473015(CAMK4)

UMR:	103675811(CAMK4)

UAH:	113254999(CAMK4)

UAR:	123779312(CAMK4)

ELK:

111148267

LLV:

125099686

MPUF:

101677801(CAMK4)

MNP:	132028842(CAMK4)

MLK:	131832524(CAMK4)

NVS:	122916928(CAMK4)

ORO:	101369425(CAMK4)

EJU:	114208735(CAMK4)

ZCA:	113929737(CAMK4)

MLX:	118017609(CAMK4)

NSU:	110588632(CAMK4)

LWW:

102749725

FCA:	101095400(CAMK4)

PYU:	121012085(CAMK4)

PCOO:

112861108(CAMK4)

PBG:	122491922(CAMK4)

PVIV:

125161805(CAMK4)

LRUF:

124519754

PTG:	102954895(CAMK4)

PPAD:

109267609(CAMK4)

PUC:

125934364

AJU:

106975674

HHV:	120224722(CAMK4)

BTA:	100337083(CAMK4)

BOM:	102264521(CAMK4)

BBUB:

102389738(CAMK4)

BBIS:

104993058(CAMK4)

CHX:	102187484(CAMK4)

OAS:	101108308(CAMK4)

BTAX:

128051498(CAMK4)

ODA:	120863455(CAMK4)

CCAD:

122439461(CAMK4)

MBEZ:

129559029(CAMK4)

SSC:	100515364(CAMK4)

CFR:	102503715(CAMK4)

CBAI:

105082027(CAMK4)

CDK:	105095388(CAMK4)

VPC:	102539084(CAMK4)

BACU:

102998672(CAMK4)

BMUS:

118892321(CAMK4)

LVE:	103081119(CAMK4)

OOR:	101273696(CAMK4)

DLE:	111183716(CAMK4)

PCAD:

102984487(CAMK4)

PSIU:

116751210(CAMK4)

NASI:

112398652(CAMK4)

ECB:	100073192(CAMK4)

EPZ:	103550069(CAMK4)

EAI:	106832342(CAMK4)

MYB:	102254489(CAMK4)

MYD:	102761359(CAMK4)

MMYO:

118656630(CAMK4)

MLF:	102433506(CAMK4)

PKL:	118702878(CAMK4)

EFUS:

103288726(CAMK4)

MNA:	107546482(CAMK4)

DRO:	112307173(CAMK4)

SHON:

118977337(CAMK4)

AJM:	119065119(CAMK4)

PDIC:

114511230(CAMK4)

PHAS:

123818083(CAMK4)

MMF:	118641608(CAMK4)

PPAM:

129083913(CAMK4)

HAI:	109391534(CAMK4)

RFQ:	117024996(CAMK4)

PALE:

102879333(CAMK4)

PGIG:

120590812(CAMK4)

PVP:	105295473(CAMK4)

RAY:	107506545(CAMK4)

MJV:	108390709(CAMK4)

TOD:	119260183(CAMK4)

SARA:

101540320(CAMK4)

SETR:

126001942(CAMK4)

LAV:	100671333(CAMK4)

TMU:

101343253

ETF:	101662137(CAMK4)

DNM:	101428221(CAMK4)

MDO:	100015956(CAMK4)

GAS:	123231353(CAMK4)

SHR:	100920792(CAMK4)

AFZ:

127560098

PCW:	110222132(CAMK4)

OAA:	100076517 100082421(CAMK4)

GGA:	427267(CAMK4L) 723973(CAMK4)

PCOC:

116235788 116239726(CAMK4)

MGP:	100545142 100551031(CAMK4)

CJO:	107306359(CAMK4) 107325456

TPAI:

128088935 128089507(CAMK4)

LMUT:

125685071 125686863(CAMK4)

NMEL:

110388918 110389600(CAMK4)

APLA:

101802471(CAMK4) 101804940

ACYG:

106042351(CAMK4) 106048195

CATA:

118255982(CAMK4) 118260861

AFUL:

116498973 116500451(CAMK4)

TGU:	100219262(CAMK4) 100220416

LSR:	110467596(CAMK4) 110480196

SCAN:

103822052 103824116(CAMK4)

PMOA:

120513733(CAMK4) 120513887

OTC:	121333115(CAMK4) 121341470

PRUF:

121353393(CAMK4) 121360792

GFR:	102038357 102040809(CAMK4)

FAB:	101810211(CAMK4) 101818551

OMA:	130264294 130265177(CAMK4)

PHI:	102112643 102114009(CAMK4)

PMAJ:

107215374 107216227(CAMK4)

CCAE:

111940603(CAMK4) 111944618

CCW:	104693208(CAMK4) 104697064

CBRC:

103611663(CAMK4) 103622189

ETL:	114054669(CAMK4) 114066382

ZAB:	102063028(CAMK4)

ZLE:	135458856 135459418(CAMK4)

ACHL:

103800810

SVG:	106853819(CAMK4) 106857045

MMEA:

130574336(CAMK4) 130580214

HRT:	120763566 120765760(CAMK4)

FPG:	101913113(CAMK4) 101917352

FCH:	102050248(CAMK4) 102054662

CLV:	102093272 102098059(CAMK4)

EGZ:	104128295 104135038(CAMK4)

NNI:	104016286 104022203(CAMK4)

PLET:

104622422

EHS:	104515751(CAMK4)

PCAO:

104045524(CAMK4)

ACUN:

113489308 113489531(CAMK4)

TALA:

104364147(CAMK4) 116960315

PADL:

103920872(CAMK4)

AFOR:

103899408 103903069(CAMK4)

ACHC:

115337069(CAMK4) 115348857

HALD:

104324104(CAMK4)

HLE:	104829168 104829298(CAMK4)

AGEN:

126035845 126041759

GCL:	127025546 127027598

CSTI:

104555091 104563992

CMAC:

104483561(CAMK4) 104484995

MUI:	104540957(CAMK4)

BREG:

104642658(CAMK4)

FGA:

104082746

MNB:	103769875 103777649

OHA:	104332557 104337839(CAMK4)

NNT:	104404861 104406576(CAMK4)

SHAB:

115618033 115619346(CAMK4)

DPUB:

104299058(CAMK4)

PGUU:

104469449(CAMK4)

CPEA:

104397286(CAMK4)

CVF:	104286012 104294250(CAMK4)

RTD:	128900684 128902617(CAMK4)

CUCA:

104058747(CAMK4) 104065755

TEO:

104378921

AROW:

112963117(CAMK4)

NPD:	112958903(CAMK4)

TGT:	104575874(CAMK4)

DNE:	112995231(CAMK4)

SCAM:

104150975(CAMK4)

ASN:	102370467(CAMK4) 102377785

AMJ:	102566359(CAMK4) 102571105

CPOO:

109308169(CAMK4) 109312309

GGN:	109294946 109298085(CAMK4)

PSS:	102459794 102460870(CAMK4)

CMY:	102942278 102943759(CAMK4)

CCAY:

125627091 125636549(CAMK4)

DCC:	119848485 119856358(CAMK4)

CPIC:

101930944 101933258(CAMK4)

TST:	117869013 117879161(CAMK4)

CABI:

116830148 116834738

MRV:	120391518 120407698(CAMK4)

ACS:	100559276(camk4) 100564355

ASAO:

132767197(CAMK4) 132781075

PVT:	110072022(CAMK4) 110072612

SUND:

121923953(CAMK4) 121937118

PBI:	103064291 103065530

PMUR:

107282846 107298153

CTIG:

120310720 120318077(CAMK4)

TSR:	106551954 106553245(CAMK4)

PGUT:

117668620 117674636(CAMK4)

APRI:

131188317 131191382(CAMK4)

PTEX:

113435328 113448979(CAMK4)

NSS:	113415637(CAMK4) 113423650

VKO:	123031477(CAMK4) 123036575

PMUA:

114588515 114606108(CAMK4)

PRAF:

128405815 128423018(CAMK4)

ZVI:	118077001(CAMK4) 118086017

HCG:	128342354 128343358(CAMK4)

GJA:	107119217 107123524

STOW:

125436723(CAMK4)

EMC:	129330726 129334184(CAMK4)

XLA:	108707217(camk4.S) 108712576 373837(camk4.L)

XTR:	100490912(camk4) 100496389

NPR:	108792885(CAMK4) 108793483

RTEM:

120913605 120931671(CAMK4)

BBUF:

120989445 120992568(CAMK4)

BGAR:

122930211 122935459(CAMK4)

MUO:	115463189(CAMK4)

GSH:	117352585(CAMK4)

DRE:	550270(camk4)

SRX:	107723863 107728216(camk4) 107730302

SANH:

107656080 107674560 107684339 107691717

SGH:	107593134 107596018 107600594 107602811

CCAR:

109053483 109108254(camk4)

CAUA:

113049834 113055062 113084214 113110968

CGIB:

127957000 127993832

PTET:

122345342(camk4)

LROH:

127165651(camk4)

OMC:	131541613(camk4)

PPRM:

120472259(camk4)

RKG:	130099682(camk4)

MAMB:

125267898(camk4)

CIDE:

127513486

MASI:

127430794 127439888

TROS:

130545995(camk4)

TDW:	130420120(camk4)

MANU:

129441148(camk4)

IPU:

108260461

IFU:	128603404(camk4)

PHYP:

113531350(camk4)

SMEO:

124378883(camk4)

TFD:	113640876(camk4)

TVC:	132840858(camk4)

AMEX:

103044753(camk4)

CMAO:

118814587(camk4)

EEE:	113586933(camk4)

CHAR:

105890927(camk4) 105896420(si:ch73-60h1.1)

TRU:	101066536(camk4)

TFS:	130528791(si:ch73-60h1.1)

NCC:

104962492

TBEN:

117497740(si:ch73-60h1.1)

CGOB:

115007617

PGEO:

117442292(si:ch73-60h1.1)

GACU:

117540393(si:ch73-60h1.1)

EMAC:

134869946(si:ch73-60h1.1)

ELY:	117253336(si:ch73-60h1.1)

EFO:	125895572(si:ch73-60h1.1)

PLEP:

121939058

SLUC:

116059162(si:ch73-60h1.1)

PFLV:

114561522(camk4)

GAT:	120823668(si:ch73-60h1.1)

PPUG:

119216309(si:ch73-60h1.1)

AFB:	129094119(si:ch73-60h1.1)

CLUM:

117729794(si:ch73-60h1.1)

PSWI:

130193818(si:ch73-60h1.1)

MSAM:

119888480 119888860(si:ch73-60h1.1)

SCHU:

122877851(si:ch73-60h1.1)

CUD:	121512456(si:ch73-60h1.1)

ALAT:

119028565(si:ch73-60h1.1)

MZE:	101488047(camk4)

ONL:	100695240(camk4)

OAU:	116333055(si:ch73-60h1.1)

OLA:

101155594

OML:	112150356(si:ch73-60h1.1)

CSAI:

133458687(si:ch73-60h1.1)

XMA:

102236877

XCO:

114150793

XHE:	116725306(camk4)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122838543(si:ch73-60h1.1)

PPRL:

129375845(si:ch73-60h1.1)

CVG:	107103959(camk4)

CTUL:

119784688(si:ch73-60h1.1)

GMU:	124873458(si:ch73-60h1.1)

NFU:

107393094

KMR:	108248674(si:ch73-60h1.1)

ALIM:

106531135(camk4)

NWH:	119430477(si:ch73-60h1.1)

AOCE:

111575981(camk4)

MCEP:

125009788(si:ch73-60h1.1)

CSEM:

103399037(camk4)

POV:

109644251

SSEN:

122780873(si:ch73-60h1.1)

HHIP:

117759836(si:ch73-60h1.1)

HSP:	118121571(si:ch73-60h1.1)

PPLT:

128448638(si:ch73-60h1.1)

SMAU:

118318298(si:ch73-60h1.1)

LCF:	108891760(si:ch73-60h1.1)

SDU:

111231823

SLAL:

111671585

XGL:	120790665(si:ch73-60h1.1)

HCQ:	109506827(camk4)

SSCV:

125975389(si:ch73-60h1.1)

SBIA:

133503289(si:ch73-60h1.1)

PEE:	133406865(si:ch73-60h1.1)

PTAO:

133481429(si:ch73-60h1.1)

BPEC:

110162797

MALB:

109965258(camk4)

BSPL:

114853345(si:ch73-60h1.1)

SJO:	128361843(si:ch73-60h1.1)

SASA:

106562078(camk4) 106568343 106574056 106613573

STRU:

115149339 115151258 115158046 115159212(camk4)

OTW:	112214468(camk4) 112235408 112250683 112257434

OMY:	110486637 110523883(camk4) 110524086 110537048

OGO:	123996827 123997650 124000352 124047785(camk4)

ONE:	115105940 115108127 115109085 115126712(camk4)

OKI:	109868065(camk4) 109888589 109892409 109902328

OKE:	118372585 118387605 118387854(camk4) 118391495

SALP:

111952601 111961323(camk4) 111975601 111981716

SNH:	120026046(camk4) 120044212 120053921(si:ch73-60h1.1)

CCLU:

121533711 121576450 121583405 123491562

ELS:	105011406 105027933(camk4)

SFM:	108925114(camk4) 108930508

PKI:	111836089(camk4) 111844630

AANG:

118213173(camk4) 118226327(si:ch73-60h1.1)

LOC:	102690113(camk4) 102698371

PSPA:

121300614 121301879 121315921

ARUT:

117401199 117408477 117964180 117966160

PSEX:

120532928(camk4)

LCM:	102361440 102362167(CAMK4)

CMK:	103181151 103182089

RTP:	109915733 109929793(camk4)

CPLA:

122560168(camk4) 122565403

HOC:	132827736(camk4) 132828977

LERI:

BFO:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM114650

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

HRO:	HELRODRAFT_194833

LGI:	LOTGIDRAFT_178957 LOTGIDRAFT_215945

PVUL:

126826660

PCAN:

112554592

BGT:	106070381 106072050

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:	110441565 110451195

PMAX:

MCAF:

DPOL:

OBI:

LAK:

NVE:	5499623 5514176

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_60371

AAF:	AURANDRAFT_28074

PIF:	PITG_04938

PSOJ:

PHYSODRAFT_296630 PHYSODRAFT_456799

SPAR:

SPRG_04033 SPRG_04395

EHX:	EMIHUDRAFT_444735

GTT:	GUITHDRAFT_158278

TVA:	TVAG_2v0630890

» show all

Reference

PMID:8065343

Authors

Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, McKnight GS

Title

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

Journal

Mol Cell Biol 14:6107-16 (1994)
DOI:10.1128/MCB.14.9.6107

Sequence

[rno:25050]

Reference

PMID:8107230

Authors

Mosialos G, Hanissian SH, Jawahar S, Vara L, Kieff E, Chatila TA

Title

A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.

Journal

J Virol 68:1697-705 (1994)
DOI:10.1128/JVI.68.3.1697-1705.1994

Sequence

[hsa:814]

LinkDB

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